Origins of Cardiac Fibroblasts

2010 | journal article

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​Origins of Cardiac Fibroblasts​
Zeisberg, E. M.   & Kalluri, R.​ (2010) 
Circulation Research107(11) pp. 1304​-1312​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.110.231910 

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Authors
Zeisberg, Elisabeth M. ; Kalluri, Raghu
Abstract
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that cardiac fibroblasts are a heterogeneous population and likely derive from various distinct tissue niches in health and disease. Here, we review our emerging understanding of where cardiac fibroblasts come from, as well as how we can possibly use this knowledge to develop novel therapies for cardiac fibrosis.
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that cardiac fibroblasts are a heterogeneous population and likely derive from various distinct tissue niches in health and disease. Here, we review our emerging understanding of where cardiac fibroblasts come from, as well as how we can possibly use this knowledge to develop novel therapies for cardiac fibrosis.
Issue Date
2010
Journal
Circulation Research 
ISSN
0009-7330
eISSN
1524-4571
Language
English

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