Coming together to define membrane contact sites

2019 | journal article; overview

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​Coming together to define membrane contact sites​
Scorrano, L.; De Matteis, M. A.; Emr, S.; Giordano, F.; Hajnóczky, G.; Kornmann, B. & Lackner, L. L. et al.​ (2019) 
Nature Communications10(1) pp. 1287​.​ DOI: https://doi.org/10.1038/s41467-019-09253-3 

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Authors
Scorrano, Luca; De Matteis, Maria Antonietta; Emr, Scott; Giordano, Francesca; Hajnóczky, György; Kornmann, Benoît; Lackner, Laura L.; Levine, Tim P.; Pellegrini, Luca; Reinisch, Karin; Rizzuto, Rosario; Simmen, Thomas; Stenmark, Harald; Ungermann, Christian; Schuldiner, Maya 
Abstract
Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell biology. The diversity of approaches warrants a unified vocabulary for the field. Such definitions would facilitate laying the foundations of this field, streamlining communication and resolving semantic controversies. This opinion, written by a panel of experts in the field, aims to provide this burgeoning area with guidelines for the experimental definition and analysis of contact sites. It also includes suggestions on how to operationally and tractably measure and analyze them with the hope of ultimately facilitating knowledge production and dissemination within and outside the field of contact-site research.
Issue Date
2019
Journal
Nature Communications 
Project
SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente 
SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel 
Working Group
RG Schuldiner (Functional Genomics of Organelles) 
ISSN
2041-1723
Language
English

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