High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts
2006 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts
Schillinger, W. ; Teucher, N. ; Christians, C.; Kohlhaas, M.; Sossalla, S. ; Van Nguyen, P. & Schmidt, A. G. et al. (2006)
European Journal of Heart Failure, 8(7) pp. 673-680. DOI: https://doi.org/10.1016/j.ejheart.2006.01.013
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- Authors
- Schillinger, Wolfgang ; Teucher, Nils ; Christians, Claus; Kohlhaas, Michael; Sossalla, Samuel ; Van Nguyen, Phuc; Schmidt, Albrecht G.; Schunck, Ortwin; Nebendahl, Klaus; Maier, Lars S. ; Zeitz, Oliver; Hasenfuß, Gerd
- Abstract
- We investigated the hypothesis that increased intracellular [Na+](i) in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as compared to Sham-operated animals. Furthermore, PHF rabbits demonstrated reduced SR Ca2+-ATPase protein levels (-37%, p < 0.04) but unchanged Na+/Ca2+ exchanger protein levels. At 0.25 Hz, isometric force was similar in cardiac trabeculae from PHF rabbits as compared to control (PHF, 3.6 +/- 1.3; Sham, 4.4 +/- 0.6 mN/mm(2)). Rapid cooling contractures (RCCs) were unchanged indicating preserved SR Ca2+ load at this frequency. In Sham, isometric twitch force increased with rising frequencies to 29.0 +/- 2.8 mN/mm(2) at 3.0 Hz (p < 0.05) as compared to 0.25 Hz. RCCs showed a parallel increase by 186 +/- 47% (p < 0.01). In PHF, frequency-dependent increase in force (15.8 +/- 4.7 mN/mm(2) at 3.0 Hz) and RCCs (increase by 70 +/- 40%) were significantly blunted. Thus, in PHF in rabbits SR Ca2+ load is preserved at low frequencies despite decreased SR Ca2+-ATPase expression. This may result from [Na+](i)-dependent changes in Na+/Ca2+ exchanger activity. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
- Issue Date
- 2006
- Publisher
- Elsevier Science Bv
- Journal
- European Journal of Heart Failure
- ISSN
- 1388-9842