Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
2006 | journal article. A publication with affiliation to the University of Göttingen.
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Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
Kittel, R. J.; Wichmann, C. ; Rasse, T. M.; Fouquet, W.; Schmidt, M. ; Schmid, A. & Wagh, D. A. et al. (2006)
Science, 312(5776) pp. 1051-1054. DOI: https://doi.org/10.1126/science.1126308
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Details
- Authors
- Kittel, Robert J.; Wichmann, Carolin ; Rasse, T. M.; Fouquet, W.; Schmidt, Manuela ; Schmid, Andreas; Wagh, D. A.; Pawlu, C.; Kellner, Robert R. ; Willig, Katrin I. ; Hell, Stefan ; Buchner, E.; Heckmann, M.; Sigrist, Stephan J.
- Abstract
- The molecular organization of presynaptic active zones during calcium influx - triggered neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction resolution STED ( stimulated emission depletion) fluorescence microscopy. At brp mutant active zones, electron-dense projections (T-bars) were entirely lost, Ca2+ channels were reduced in density, evoked vesicle release was depressed, and short-term plasticity was altered. BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity.
- Issue Date
- 2006
- Journal
- Science
- ISSN
- 0036-8075
- Language
- English