Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication
2005 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication
Goodman, R.; Schaap, I. A. T. ; Tardin, C. F.; Erben, C. M.; Berry, R. M.; Schmidt, C. & Turberfield, A. J. (2005)
Science, 310(5754) pp. 1661-1665. DOI: https://doi.org/10.1126/science.1120367
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Details
- Authors
- Goodman, Robert; Schaap, Iwan A. T. ; Tardin, C. F.; Erben, C. M.; Berry, R. M.; Schmidt, Christoph ; Turberfield, A. J.
- Abstract
- Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.
- Issue Date
- 2005
- Publisher
- Amer Assoc Advancement Science
- Journal
- Science
- ISSN
- 0036-8075
