Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice
2015 | journal article; research paper
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Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice
Gogiraju, R.; Xu, X.; Bochenek, M. L.; Steinbrecher, J. H.; Lehnart, S. E. ; Wenzel, P. & Kessel, M. et al. (2015)
Journal of the American Heart Association, 4(2) art. e001770. DOI: https://doi.org/10.1161/JAHA.115.001770
Documents & Media
Details
- Authors
- Gogiraju, Rajinikanth; Xu, Xingbo; Bochenek, Magdalena L.; Steinbrecher, Julia H.; Lehnart, Stephan E. ; Wenzel, Philip; Kessel, Michael ; Zeisberg, Elisabeth M. ; Dobbelstein, Matthias ; Schäfer, Katrin
- Abstract
- Cardiac dysfunction developing in response to chronic pressure overload is associated with apoptotic cell death and myocardial vessel rarefaction. We examined whether deletion of tumor suppressor p53 in endothelial cells may prevent the transition from cardiac hypertrophy to heart failure.
- Issue Date
- 2015
- Journal
- Journal of the American Heart Association
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | C01: Epigenetische Kontrolle der Herzfibrose
SFB 1002 | C06: Mechanismen und Regulation der koronaren Gefäßneubildung - Working Group
- RG Lehnart (Cellular Biophysics and Translational Cardiology Section)
RG Schäfer (Translationale Vaskuläre Biologie)
RG E. Zeisberg (Kardiales Stroma) - External URL
- https://sfb1002.med.uni-goettingen.de/production/literature/publications/81
- ISSN
- 2047-9980; 2047-9980
- eISSN
- 2047-9980
- Language
- English