Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice

2015 | journal article; research paper

Jump to: Cite & Linked | Documents & Media | Details | Version history

Cite this publication

​Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice​
Gogiraju, R.; Xu, X.; Bochenek, M. L.; Steinbrecher, J. H.; Lehnart, S. E. ; Wenzel, P. & Kessel, M.  et al.​ (2015) 
Journal of the American Heart Association4(2) art. e001770​.​ DOI: https://doi.org/10.1161/JAHA.115.001770 

Documents & Media

License

Published Version

Attribution-NonCommercial 4.0 CC BY-NC 4.0

Details

Authors
Gogiraju, Rajinikanth; Xu, Xingbo; Bochenek, Magdalena L.; Steinbrecher, Julia H.; Lehnart, Stephan E. ; Wenzel, Philip; Kessel, Michael ; Zeisberg, Elisabeth M. ; Dobbelstein, Matthias ; Schäfer, Katrin 
Abstract
Cardiac dysfunction developing in response to chronic pressure overload is associated with apoptotic cell death and myocardial vessel rarefaction. We examined whether deletion of tumor suppressor p53 in endothelial cells may prevent the transition from cardiac hypertrophy to heart failure.
Issue Date
2015
Journal
Journal of the American Heart Association 
Project
SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz 
SFB 1002 | C01: Epigenetische Kontrolle der Herzfibrose 
SFB 1002 | C06: Mechanismen und Regulation der koronaren Gefäßneubildung 
Working Group
RG Lehnart (Cellular Biophysics and Translational Cardiology Section) 
RG Schäfer (Translationale Vaskuläre Biologie) 
RG E. Zeisberg (Kardiales Stroma) 
ISSN
2047-9980; 2047-9980
eISSN
2047-9980
Language
English

Reference

Citations


Social Media