Endogenous MHC class II processing of a viral nuclear antigen after autophagy
2005 | journal article. A publication with affiliation to the University of Göttingen.
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- Authors
- Paludan, C.; Schmid, D.; Landthaler, M.; Vockerodt, Martina; Kube, Dieter ; Tuschl, T.; Münz, Christian
- Abstract
- CD4(+) T cells classically recognize antigens that are endocytosed and processed in lysosomes for presentation on major histocompatibility complex (MHC) class II molecules. Here, endogenous Epstein-Barr virus nuclear antigen 1 (EBNA1) was found to gain access to this pathway by autophagy. On inhibition of lysosomal acidification, EBNA1, the dominant CD4(+) T cell antigen of latent Epstein-Barr virus infection, slowly accumulated in cytosolic autophagosomes. In addition, inhibition of autophagy decreased recognition by EBNA1-specific CD4(+) T cell clones. Thus, lysosomal processing after autophagy may contribute to MHC class II-restricted surveillance of long-lived endogenous antigens including nuclear proteins relevant to disease.
- Issue Date
- 2005
- Journal
- Science
- ISSN
- 0036-8075