Micro-Structural Brain Alterations in Aviremic HIV plus Patients with Minor Neurocognitive Disorders: A Multi-Contrast Study at High Field
2013 | journal article. A publication with affiliation to the University of Göttingen.
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Micro-Structural Brain Alterations in Aviremic HIV plus Patients with Minor Neurocognitive Disorders: A Multi-Contrast Study at High Field
Granziera, C.; Daducci, A.; Simioni, S.; Cavassini, M.; Roche, A.; Meskaldji, D. & Kober, T. et al. (2013)
PLoS ONE, 8(9) art. e72547. DOI: https://doi.org/10.1371/journal.pone.0072547
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Details
- Authors
- Granziera, Cristina; Daducci, Alessandro; Simioni, Samanta; Cavassini, Matthias; Roche, Alexis; Meskaldji, Djalel; Kober, Tobias; Metral, Melanie; Calmy, Alexandra; Helms, Gunther; Hirschel, Bernard; Lazeyras, Francois; Meuli, Reto; Krueger, Gunnar; Du Pasquier, Renaud A.
- Abstract
- Objective: Mild neurocognitive disorders (MND) affect a subset of HIV+ patients under effective combination antiretroviral therapy (cART). In this study, we used an innovative multi-contrast magnetic resonance imaging (MRI) approach at high-field to assess the presence of micro-structural brain alterations in MND+ patients. Methods: We enrolled 17 MND+ and 19 MND- patients with undetectable HIV-1 RNA and 19 healthy controls (HC). MRI acquisitions at 3T included: MP2RAGE for T1 relaxation times, Magnetization Transfer (MT), T2 and Susceptibility Weighted Imaging (SWI) to probe micro-structural integrity and iron deposition in the brain. Statistical analysis used permutation-based tests and correction for family-wise error rate. Multiple regression analysis was performed between MRI data and (i) neuropsychological results (ii) HIV infection characteristics. A linear discriminant analysis (LDA) based on MRI data was performed between MND+ and MND- patients and cross-validated with a leave-one-out test. Results: Our data revealed loss of structural integrity and micro-oedema in MND+ compared to HC in the global white and cortical gray matter, as well as in the thalamus and basal ganglia. Multiple regression analysis showed a significant influence of sub-cortical nuclei alterations on the executive index of MND+ patients (p = 0.04 he and R-2 = 95.2). The LDA distinguished MND+ and MND- patients with a classification quality of 73% after cross-validation. Conclusion: Our study shows micro-structural brain tissue alterations in MND+ patients under effective therapy and suggests that multi-contrast MRI at high field is a powerful approach to discriminate between HIV+ patients on cART with and without mild neurocognitive deficits.
- Issue Date
- 2013
- Status
- published
- Publisher
- Public Library Science
- Journal
- PLoS ONE
- ISSN
- 1932-6203