Human Glioma-Initiating Cells Show a Distinct Immature Phenotype Resembling but Not Identical to NG2 Glia
2013 | journal article. A publication with affiliation to the University of Göttingen.
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Human Glioma-Initiating Cells Show a Distinct Immature Phenotype Resembling but Not Identical to NG2 Glia
Barrantes-Freer, A.; Kim, E. L.; Bielanska, J.; Giese, A.; Mortensen, L. S.; Schulz-Schaeffer, W. J. & Stadelmann, C. et al. (2013)
Journal of Neuropathology and Experimental Neurology, 72(4) pp. 307-324. DOI: https://doi.org/10.1097/NEN.0b013e31828afdbd
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- Authors
- Barrantes-Freer, Alonso; Kim, Ella L.; Bielanska, Joanna; Giese, Alf; Mortensen, Lena Suenke; Schulz-Schaeffer, Walter J.; Stadelmann, Christine ; Brueck, Wolfgang; Pardo, Luis A.
- Abstract
- Glioma-initiating cells (GICs) represent a potential important therapeutic target because they are likely to account for the frequent recurrence of malignant gliomas; however, their identity remains unsolved. Here, we characterized the cellular lineage fingerprint of GICs through a combination of electrophysiology, lineage marker expression, and differentiation assays of 5 human patient-derived primary GIC lines. Most GICs coexpressed nestin, NG2 proteoglycan, platelet-derived growth factor receptor-alpha, and glial fibrillary acidic protein. Glioma-initiating cells could be partially differentiated into astrocytic but not oligodendroglial or neural lineages. We also demonstrate that GICs have a characteristic electrophysiologic profile distinct from that of well-characterized tumor bulk cells. Together, our results suggest that GICs represent a unique type of cells reminiscent of an immature phenotype that closely resembles but is not identical to NG2 glia with respect to marker expression and functional membrane properties.
- Issue Date
- 2013
- Status
- published
- Publisher
- Lippincott Williams & Wilkins
- Journal
- Journal of Neuropathology and Experimental Neurology
- ISSN
- 0022-3069