Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis
2013 | journal article. A publication with affiliation to the University of Göttingen.
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Involvement of IL-9 in Th17-Associated Inflammation and Angiogenesis of Psoriasis
Singh, T. P.; Schoen, M. P.; Wallbrecht, K.; Gruber-Wackernagel, A.; Wang, X. & Wolf, P. (2013)
PLoS ONE, 8(1) art. e51752. DOI: https://doi.org/10.1371/journal.pone.0051752
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Details
- Authors
- Singh, Tej Pratap; Schoen, Michael Peter; Wallbrecht, Katrin; Gruber-Wackernagel, Alexandra; Wang, X.; Wolf, Peter
- Abstract
- It is thought that a Th1/Th17-weighted immune response plays a predominant role in the pathogenesis of psoriasis. Our findings now indicate a link between IL-9, a Th2 and Th9 cytokine, and Th17 pathway in psoriasis. In K5.hTGF-beta 1 transgenic mice, exhibiting a psoriasis-like phenotype, we found increased IL-9R and IL-9 expression in the skin and intradermal IL-9 injection induced Th17-related inflammation. IL-9 also promoted angiogenesis and VEGF and CD31 overexpression in mice in vivo and increased tube formation of human endothelial cells in vitro. Injecting anti-IL-9 antibody into K5.hTGF-beta 1 transgenic mice not only diminished inflammation (including skin infiltration by T cells, monocytes/macrophages, and mast cells) and angiogenesis but also delayed the psoriasis-like skin phenotype. Notably, injection of anti-psoriatic acting anti-IL17 antibody reduced skin IL-9 mRNA and serum IL-9 protein levels in K5.hTGF-beta 1 transgenic mice and prevented IL-9-induced epidermal hyperplasia and inflammation of the skin of wild type mice. In addition, we observed that IL-9R expression in lesional skin from psoriasis patients was markedly higher than in healthy skin from control subjects. Moreover, IL-9 significantly enhanced IL-17A production by cultured human peripheral blood mononuclear cells or CD4+ T cells, especially in psoriasis patients. Thus, IL-9 may play a role in the development of psoriatic lesions through Th17-associated inflammation and angiogenesis.
- Issue Date
- 2013
- Status
- published
- Publisher
- Public Library Science
- Journal
- PLoS ONE
- ISSN
- 1932-6203