CSF Biomarkers and Neuropsychological Profiles in Patients with Cerebral Small-Vessel Disease

2014 | journal article. A publication with affiliation to the University of Göttingen.

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​CSF Biomarkers and Neuropsychological Profiles in Patients with Cerebral Small-Vessel Disease​
Hermann, P.; Romero, C.; Schmidt, C. D.; Reis, C. & Zerr, I.​ (2014) 
PLoS ONE9(8) art. e105000​.​ DOI: https://doi.org/10.1371/journal.pone.0105000 

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Authors
Hermann, Peter; Romero, Carlos; Schmidt, Christian D.; Reis, Clemens; Zerr, Inga
Abstract
Despite existing criteria, differential diagnosis of Vascular Dementia (VD) and Alzheimer's disease (AD) remains difficult. The aim of this study is to figure out cognitive and biomarker profiles that may help to distinguish between VD, AD and AD + Cerebral Small Vessel Disease (CSVD). We examined a cohort of patients with CSVD (n = 92). After stratification of cognitive impaired patients (n = 59) using the standard CSF beta-amyloid 42/40 ratio cut-off point of 0.975, we obtained two groups which differed with respect to several features: 32 patients with normal beta-amyloid 42/40 ratio (>0.975) showed markedly impaired blood-brain-barrier function as indicated by an elevated albumin ratio (median 8.35). They also differed in cognitive profiles when compared to 27 patients with AD typical beta-amyloid ratio and normal albumin ratio. We also enrolled an additional group of patients with AD (no significant CSVD on MRI, n = 27) which showed no impairment of the blood-brain-barrier. We showed a negative correlation between the albumin ratio and executive cognitive function (p = 0.016) and a negative correlation between memory function and typical AD markers like Tau (p = 0.004) and p181-Tau (p = 0.023) in our cohort. We suppose that the group of patients with normal beta-amyloid ratio represents VD while patients in the other groups represent AD+CSVD and pure AD. Our results support the idea that a dysfunction of the blood-brain-barrier might be contributing factor in the development of cognitive decline in CSVD as it seems to be of more importance than the severity of white matter lesions.
Issue Date
2014
Status
published
Publisher
Public Library Science
Journal
PLoS ONE 
ISSN
1932-6203
Sponsor
Open Access Publikationsfonds 2014
mobility exchange program BMBF [ARG 07/008]

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