Analysis of CD4(+)CD8(+) double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions
2014 | journal article. A publication with affiliation to the University of Göttingen.
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Analysis of CD4(+)CD8(+) double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions
Waschbisch, A.; Sammet, L.; Schroeder, S.; Lee, D.-H.; Barrantes-Freer, A.; Stadelmann, C. & Linker, R. A. (2014)
Clinical & Experimental Immunology, 177(2) pp. 404-411. DOI: https://doi.org/10.1111/cei.12345
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Details
- Authors
- Waschbisch, Anne; Sammet, Laura; Schroeder, S.; Lee, D.-H.; Barrantes-Freer, Alonso; Stadelmann, Christine ; Linker, Ralf Andreas
- Abstract
- T cells with a CD4(+) CD8(+) double-positive (DP) phenotype are present in small numbers in the peripheral blood of healthy humans and may have anti-viral capacities. Here we investigate numbers and function of DP T cells in patients with relapsing-remitting multiple sclerosis (MS), either treatment-naive or under therapy with natalizumab. Flow cytometry analysis revealed that frequencies of circulating DP T cells in treatment-naive and natalizumab-treated MS patients are comparable to healthy controls. These cells have a memory phenotype with cytotoxic potential, express high levels of CD49d and are similarly functional in treatment-naive as well as natalizumab-treated MS patients. DP T cells were enriched in the cerebrospinal fluid, but do not invade acutely inflamed MS lesions. In conclusion, DP T cells are functional in MS and may play a role in the immune surveillance of the central nervous system, but do not display functional impairment under natalizumab therapy.
- Issue Date
- 2014
- Status
- published
- Publisher
- Wiley-blackwell
- Journal
- Clinical & Experimental Immunology
- ISSN
- 1365-2249; 0009-9104
- Sponsor
- Biogen Idec GmbH; Else Kroner-Fresenius Stiftung [2011_A123]