A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer

2016 | journal article. A publication with affiliation to the University of Göttingen.

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​A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer​
Yuan, H.; Liu, H.; Liu, Z.; Owzar, K.; Han, Y.; Su, L. I. & Wei, Y. et al.​ (2016) 
Scientific Reports6 art. 34234​.​ DOI: https://doi.org/10.1038/srep34234 

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Authors
Yuan, Hua; Liu, Hongliang; Liu, Zhensheng; Owzar, Kouros; Han, Younghun; Su, L. I.; Wei, Yongyue; Hung, Rayjean J.; McLaughlin, John R.; Brhane, Yonathan; Brennan, P. C.; Bickeboeller, Heike ; Rosenberger, Albert ; Houlston, Richard S.; Caporaso, Neil E.; Landi, Maria Teresa; Heinrich, Joachim; Risch, Angela; Christiani, David C.; Gumus, Zeynep H.; Klein, Robert J.; Amos, Christopher I.; Wei, Qingyi
Abstract
Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 x 10(-7)) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio = 1.17; 95% confidence interval = 1.11-1.24; P = 8.31 x 10(-9)). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.
Issue Date
2016
Status
published
Publisher
Nature Publishing Group
Journal
Scientific Reports 
ISSN
2045-2322

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