Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe consortium
2008 | journal article. A publication with affiliation to the University of Göttingen.
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Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe consortium
Alafuzoff, I.; Arzberger, T.; Al-Sarraj, S.; Bodi, I.; Bogdanovic, N.; Braak, H. & Bugiani, O. et al. (2008)
Brain Pathology, 18(4) pp. 484-496. DOI: https://doi.org/10.1111/j.1750-3639.2008.00147.x
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Details
- Authors
- Alafuzoff, Irina; Arzberger, Thomas; Al-Sarraj, Safa; Bodi, Istvan; Bogdanovic, Nenad; Braak, Heiko; Bugiani, Orso; Del-Tredici, Kelly; Ferrer, Isidro; Gelpi, Ellen; Giaccone, Giorgio; Graeber, Manuel B.; Ince, Paul G.; Kamphorst, Wouter; King, Andrew J.; Korkolopoulou, Penelope; Kovacs, Gabor G.; Larionov, Sergey; Meyronet, David; Monoranu, Camelia; Parchi, Piero; Patsouris, Efstratios; Roggendorf, Wolfgang; Seilhean, Danielle; Tagliavini, Fabrizio; Stadelmann, Christine ; Streichenberger, Nathalie; Thal, Dietmar Rudolf; Wharton, Stephen B.; Kretzschmar, Hans A.
- Abstract
- It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-mu m-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V-VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I-II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
- Issue Date
- 2008
- Status
- published
- Publisher
- Wiley-blackwell
- Journal
- Brain Pathology
- ISSN
- 1015-6305
- Sponsor
- European Union grant FP6 [LSHM-CT2004-503039]