Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe consortium

2008 | journal article. A publication with affiliation to the University of Göttingen.

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​Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe consortium​
Alafuzoff, I.; Arzberger, T.; Al-Sarraj, S.; Bodi, I.; Bogdanovic, N.; Braak, H. & Bugiani, O. et al.​ (2008) 
Brain Pathology18(4) pp. 484​-496​.​ DOI: https://doi.org/10.1111/j.1750-3639.2008.00147.x 

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Authors
Alafuzoff, Irina; Arzberger, Thomas; Al-Sarraj, Safa; Bodi, Istvan; Bogdanovic, Nenad; Braak, Heiko; Bugiani, Orso; Del-Tredici, Kelly; Ferrer, Isidro; Gelpi, Ellen; Giaccone, Giorgio; Graeber, Manuel B.; Ince, Paul G.; Kamphorst, Wouter; King, Andrew J.; Korkolopoulou, Penelope; Kovacs, Gabor G.; Larionov, Sergey; Meyronet, David; Monoranu, Camelia; Parchi, Piero; Patsouris, Efstratios; Roggendorf, Wolfgang; Seilhean, Danielle; Tagliavini, Fabrizio; Stadelmann, Christine ; Streichenberger, Nathalie; Thal, Dietmar Rudolf; Wharton, Stephen B.; Kretzschmar, Hans A.
Abstract
It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-mu m-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V-VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I-II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
Issue Date
2008
Status
published
Publisher
Wiley-blackwell
Journal
Brain Pathology 
ISSN
1015-6305
Sponsor
European Union grant FP6 [LSHM-CT2004-503039]

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