The role of promoter hypermethylation in fibroblast activation and fibrogenesis

2013 | journal article; overview. A publication with affiliation to the University of Göttingen.

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​The role of promoter hypermethylation in fibroblast activation and fibrogenesis​
Zeisberg, E. M.   & Zeisberg, M. ​ (2013) 
Journal of Pathology229(2) pp. 264​-273​.​ DOI: https://doi.org/10.1002/path.4120 

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Authors
Zeisberg, Elisabeth M. ; Zeisberg, Michael 
Abstract
The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.
Issue Date
2013
Journal
Journal of Pathology 
Project
SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz 
SFB 1002 | C01: Epigenetische Kontrolle der Herzfibrose 
Working Group
RG E. Zeisberg (Kardiales Stroma) 
RG M. Zeisberg (Renale Fibrogenese) 
External URL
https://sfb1002.med.uni-goettingen.de/production/literature/publications/78
ISSN
0022-3417; 1096-9896
Language
English

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