The role of promoter hypermethylation in fibroblast activation and fibrogenesis
2013 | journal article; overview. A publication with affiliation to the University of Göttingen.
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- Authors
- Zeisberg, Elisabeth M. ; Zeisberg, Michael
- Abstract
- The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.
- Issue Date
- 2013
- Journal
- Journal of Pathology
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | C01: Epigenetische Kontrolle der Herzfibrose - Working Group
- RG E. Zeisberg (Kardiales Stroma)
RG M. Zeisberg (Renale Fibrogenese) - External URL
- https://sfb1002.med.uni-goettingen.de/production/literature/publications/78
- ISSN
- 0022-3417; 1096-9896
- Language
- English