Temporal trends in management and outcome of pulmonary embolism: a single-centre experience
2019 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Temporal trends in management and outcome of pulmonary embolism: a single-centre experience
Ebner, M.; Kresoja, K.-P.; Keller, K.; Hobohm, L.; Rogge, N. I. J.; Hasenfuß, G. & Pieske, B. et al. (2019)
Clinical Research in Cardiology, art. https://creativecommons.org/licenses/by/4.0/. DOI: https://doi.org/10.1007/s00392-019-01489-9
Documents & Media
Details
- Authors
- Ebner, Matthias; Kresoja, Karl-Patrik; Keller, Karsten; Hobohm, Lukas; Rogge, Nina I. J.; Hasenfuß, Gerd ; Pieske, Burkert; Konstantinides, Stavros V.; Lankeit, Mareike
- Abstract
- BACKGROUND: Real-world data on the impact of advances in risk-adjusted management on the outcome of patients with pulmonary embolism (PE) are limited. METHODS: To investigate temporal trends in treatment, in-hospital adverse outcomes and 1-year mortality, we analysed data from 605 patients [median age, 70 years (IQR 56-77) years, 53% female] consecutively enrolled in a single-centre registry between 09/2008 and 08/2016. RESULTS: Over the 8-year period, more patients were classified to lower risk classes according to the European Society of Cardiology (ESC) 2014 guideline algorithm while the number of high-risk patients with out-of-hospital cardiac arrest (OHCA) increased. Although patients with OHCA had an exceptionally high in-hospital mortality rate of 59.3%, the rate of PE-related in-hospital adverse outcomes (12.2%) in the overall patient cohort remained stable over time. The rate of reperfusion treatment was 9.6% and tended to increase in high-risk patients. We observed a decrease in the median duration of in-hospital stay from 10 (IQR 6-14) to 7 (IQR 4-15) days, an increase of patients discharged early from 2.1 to 12.2% and an increase in the use of non-vitamin K-dependent oral anticoagulants (NOACs) from 12.6 to 57.2% in the last 2 years (09/2014-08/2016) compared to first 6 years (09/2008-08/2014). The 1-year mortality rate (16.9%) remained stable throughout the study period. CONCLUSION: In-hospital adverse outcomes and 1-year mortality remained stable despite more patients with OHCA, shorter in-hospital stays, more patients discharged early and a more frequent NOAC use.
- Issue Date
- 2019
- Journal
- Clinical Research in Cardiology
- ISSN
- 1861-0692
- Language
- English