Distinctive patterns in the human antibody response to Staphylococcus aureus bacteremia in carriers and non-carriers

2011 | journal article

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​Distinctive patterns in the human antibody response to Staphylococcus aureus bacteremia in carriers and non-carriers​
Kolata, J.; Bode, L. G. M.; Holtfreter, S.; Steil, L.; Kusch, H. ; Holtfreter, B.   & Albrecht, D. et al.​ (2011) 
Proteomics11(19) pp. 3914​-3927​.​ DOI: https://doi.org/10.1002/pmic.201000760 

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Authors
Kolata, Julia; Bode, Lonneke G. M.; Holtfreter, Silva; Steil, Leif; Kusch, Harald ; Holtfreter, Birte ; Albrecht, Dirk; Hecker, Michael; Engelmann, Susanne; van Belkum, Alex; Volker, Uwe ; Bröker, Barbara M.
Abstract
Staphylococcus aureus is both a prominent cause of nosocomial infections with significant morbidity and mortality and a commensal with nasal carriage in around 30% of the population. The rapid spread of multi-resistant strains necessitates novel therapeutic strategies, a challenging task because the species S. aureus and the host response against it are highly variable. In a prospective study among 2023 surgical and non-surgical patients, 12 patients developed S. aureus bacteremia. They were analysed in detail using a personalized approach. For each patient, the extracellular proteins of the infecting S. aureus strain were identified and the developing antibody response was assessed on 2-D immunoblots. S. aureus carriers showed clear evidence of strain-specific pre-immunization. In all immune-competent bacteremia patients, antibody binding increased strongly, in most cases already at diagnosis. In endogenous infections, the pattern of antibody binding was similar to the pre-infection pattern. In exogenous infections, in contrast, the pre-infection pattern was radically altered with the acquisition of new specificities. These were characteristic for individual patients. Nevertheless, a common signature of 11 conserved S. aureus proteins, recognized in at least half of the bacteremic patients, was identified. All patients mounted a dynamic antibody response to a subset of these proteins.
Issue Date
2011
Journal
Proteomics 
ISSN
1615-9853
eISSN
1615-9861
Language
English

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