Principles of connectivity among morphologically defined cell types in adult neocortex
2015 | journal article
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- Authors
- Jiang, Xiaolong; Shen, Shan; Cadwell, Cathryn R.; Berens, Philipp; Sinz, Fabian ; Ecker, Alexander S. ; Patel, Saumil; Tolias, Andreas S.
- Abstract
- Since the work of Ramón y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.
- Issue Date
- 2015
- Journal
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English