Enantioselective Total Synthesis of Blennolide H and Phomopsis-H76 A and Determination of Their Structure
2018 | journal article. A publication with affiliation to the University of Göttingen.
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Enantioselective Total Synthesis of Blennolide H and Phomopsis-H76 A and Determination of Their Structure
Valdomir, G.; Senthilkumar, S.; Ganapathy, D.; Zhang, Y. & Tietze, L. F. (2018)
Chemistry - A European Journal, 24(35) pp. 8760-8763. DOI: https://doi.org/10.1002/chem.201801323
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- Authors
- Valdomir, Guillermo; Senthilkumar, Soundararasu; Ganapathy, Dhandapany; Zhang, Yun; Tietze, Lutz F.
- Abstract
- Abstract This work reports on the enantioselective total synthesis of the two dimeric natural chromanone lactones phomopsis‐H76 A ( 5 ) and blennolide H ( 6 ). Both syntheses could be achieved from chromane 11, which was obtained by an enantioselective Wacker‐type cyclization with >99 % ee . The dimerization of the corresponding monomers was performed using a palladium‐catalyzed Suzuki reaction. Moreover, within this work it was possible to revise the absolute configuration of phomopsis‐H76 A and determine the relative as well as absolute configuration of blennolide H.
- Issue Date
- 2018
- Journal
- Chemistry - A European Journal
- ISSN
- 0947-6539
- ISSN
- 0947-6539
- eISSN
- 1521-3765
- Language
- English
