Water-Mediated Protein-Protein Interactions at High Pressures are Controlled by a Deep-Sea Osmolyte
2018-07-20 | journal article; research paper
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Water-Mediated Protein-Protein Interactions at High Pressures are Controlled by a Deep-Sea Osmolyte
Julius, K.; Weine, J.; Berghaus, M.; König, N.; Gao, M.; Latarius, J. & Paulus, M. et al. (2018)
Physical Review Letters, 121(3) art. 038101. DOI: https://doi.org/10.1103/PhysRevLett.121.038101
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Details
- Authors
- Julius, Karin; Weine, Jonathan; Berghaus, Melanie; König, Nico; Gao, Mimi; Latarius, Jan; Paulus, Michael; Schroer, Martin A.; Tolan, Metin ; Winter, Roland
- Abstract
- The influence of natural cosolvent mixtures on the pressure-dependent structure and protein-protein interaction potential of dense protein solutions is studied and analyzed using small-angle X-ray scattering in combination with a liquid-state theoretical approach. The deep-sea osmolyte trimethylamine-N-oxide is shown to play a crucial and singular role in its ability to not only guarantee sustainability of the native protein's folded state under harsh environmental conditions, but it also controls water-mediated intermolecular interactions at high pressure, thereby preventing contact formation and hence aggregation of proteins.
- Issue Date
- 20-July-2018
- Journal
- Physical Review Letters
- ISSN
- 0031-9007
- eISSN
- 1079-7114
- Language
- English