Decreased β-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
2012 | journal article
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Decreased β-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
Otto, M. ; Esselmann, H. ; Schulz-Schaeffer, W. ; Neumann, M.; Schröter, A. ; Ratzka, P. & Cepek, L. et al. (2012)
Neurology, 54(5) pp. 1099-1102. DOI: https://doi.org/10.1212/wnl.54.5.1099
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- Authors
- Otto, Markus ; Esselmann, Hermann ; Schulz-Schaeffer, W. ; Neumann, Manuela; Schröter, A. ; Ratzka, P. ; Cepek, L. ; Zerr, Inga ; Steinacker, Petra ; Windl, O. ; Kornhuber, Johannes ; Kretzschmar, Hans A. ; Poser, Sigrid ; Wiltfang, Jens
- Abstract
- bjectives: Decreased levels of Aβ1-42 are found in CSF of patients with AD. Because early stages of Creutzfeldt-Jakob disease (CJD) and AD share several clinical features, we investigated Aβ1-42 levels in CSF of these groups, inferring that this might give additional help in differentiating patients with CJD from AD patients.Methods: We investigated 27 patients with CJD, 14 patients with AD, 19 patients with other dementias, and 20 nondemented controls (NDC) for Aβ1-42 in CSF. Twenty-four of the 27 CJD patients were neuropathologically verified. All the neuropathologically verified patients presented with a type 1 prion protein pattern. CJD patients were all homozygous for methionine at codon 129. Except in five CJD patients, no β-amyloid plaques were seen. Additionally, APOE status was determined in patients with CJD.Results: Levels of Aβ1-42 in CSF were decreased in patients with AD as well as in CJD. Levels of Aβ1-42 in CSF of patients with CJD and AD were significantly different from the other dementia and NDC groups. There was no substantial difference between the CJD and AD groups (p = 0.66). Decreased levels of Aβ1-42 did not correlate with the APOE ε4 load in patients with CJD.Conclusion: Low levels of Aβ1-42 in CSF do not exclude a diagnosis of CJD. Decreased levels of Aβ1-42 in CSF can occur without β-amyloid plaque formation in the brain. However, the underlying mechanism of this phenomenon must be elucidated.
- Issue Date
- 2012
- Journal
- Neurology
- ISSN
- 0028-3878
- Language
- English