Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment

2016 | journal article. A publication with affiliation to the University of Göttingen.

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​Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment​
Louwersheimer, E.; Wolfsgruber, S.; Espinosa, A.; Lacour, A.; Heilmann-Heimbach, S.; Alegret, M. & Hernández, I. et al.​ (2016) 
Alzheimer's & Dementia12(8) pp. 872​-881​.​ DOI: https://doi.org/10.1016/j.jalz.2016.01.006 

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Authors
Louwersheimer, Eva; Wolfsgruber, Steffen; Espinosa, Ana; Lacour, André; Heilmann-Heimbach, Stefanie; Alegret, Montserrat; Hernández, Isabel; Rosende-Roca, Maitée; Tárraga, Lluís; Boada, Mercè; Kornhuber, Johannes ; Peters, Oliver; Frölich, Lutz; Hüll, Michael; Rüther, Eckart ; Wiltfang, Jens ; Scherer, Martin; Riedel-Heller, Steffi; Jessen, Frank; Nöthen, Markus M.; Maier, Wolfgang; Koene, Ted; Scheltens, Philip; Holstege, Henne; Wagner, Michael; Ruiz, Agustín; van der Flier, Wiesje M.; Becker, Tim; Ramirez, Alfredo
Abstract
IntroductionWe evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).MethodsWe selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers (aβ, tau, ptau).ResultsPGS was modestly associated with cognitive decline over time, as measured by mini-mental state examination (MMSE) (β ± SE:−0.24 ± 0.10; P = .012), and with CSF levels of tau and ptau (tau: 1.38 ± 0.36, P = 1.21 × 10−4; ptau: 1.40 ± 0.36, P = 1.02 × 10−4).DiscussionIn MCI, we observed a joint effect of AD susceptibility loci on nonamyloid endophenotypes, suggesting a link of these genetic loci with neuronal degeneration in general rather than with Alzheimer-related amyloid deposition.
Issue Date
2016
Journal
Alzheimer's & Dementia 
ISSN
1552-5260
Language
English

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