Molecular Biology of Alzheimer’s Dementia and Its Clinical Relevance to Early Diagnosis and New Therapeutic Strategies

2001 | journal article. A publication with affiliation to the University of Göttingen.

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​Molecular Biology of Alzheimer’s Dementia and Its Clinical Relevance to Early Diagnosis and New Therapeutic Strategies​
Wiltfang, J. ; Esselmann, H. ; Maler, J. M. ; Bleich, S. ; Hüther, G.   & Kornhuber, J. ​ (2001) 
Gerontology47(2) pp. 65​-71​.​ DOI: https://doi.org/10.1159/000052775 

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Authors
Wiltfang, Jens ; Esselmann, Hermann ; Maler, Juan Manuel ; Bleich, Stefan ; Hüther, Gerald ; Kornhuber, Johannes 
Abstract
Over the past few years, molecular biological research has considerably deepened our understanding of the pathophysiological basis of Alzheimer’s dementia (AD). Although different genetic origins of the disease have been identified, all of the findings point to a common terminal sequence in familial AD. This consists of an increased production of β-amyloid peptides from β-amyloid precursor protein. For the cases of sporadic AD, which far outweigh the number of cases of familial AD, an impaired catabolism of the β-amyloid peptides may also be pathophysiologically decisive according to the latest findings. Research into the molecular level of AD makes it possible to identify points of attack for rational drug treatment of the disease, while molecular markers of AD are increasingly being used as a part of early and differential neurochemical diagnostics.
Issue Date
2001
Journal
Gerontology 
ISSN
0304-324X
Language
English

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