Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau

2013 | journal article

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​Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau​
Deuschle, M.; Schilling, C.; Leweke, F. M.; Enning, F.; Pollmächer, T.; Esselmann, H.   & Wiltfang, J.  et al.​ (2013) 
Neuroscience Letters561 pp. 41​-45​.​ DOI: https://doi.org/10.1016/j.neulet.2013.12.036 

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Authors
Deuschle, Michael; Schilling, Claudia; Leweke, F. Markus; Enning, Frank; Pollmächer, Thomas; Esselmann, Hermann ; Wiltfang, Jens ; Frölich, Lutz; Heuser, Isabella
Abstract
It has been suggested that sleep–wake regulation as well as hypocretins play a role in the pathophysiology of Alzheimer's disease. We analyzed Aβ40, Aβ42, Tau protein, phosphorylated Tau (pTau) protein as well as hypocretin-1 concentrations in the CSF of a detection sample of 10 patients with Alzheimer's disease (AD) as well as 10 age- and gender-matched patients with major depression as a comparison group of different pathology. In order to replicate the findings, we used a confirmation sample of 17 AD patients and 8 patients with major depression. We found hypocretin-1 concentrations in CSF not to differ between patients with depression and AD. However, hypocretin-1 was significantly related to Tau (r = 0.463, p < 0.001) and pTau (r = 0.630, p < 0.0001). These effects were more pronounced in depressed patients when compared to AD patients. We conclude that hypocretin-1 may play a role in the metabolism of Tau proteins across different diagnostic entities including AD. It has to be determined whether there is a causal relationship between hypocretin-1 and Tau as well as pTau.
Issue Date
2013
Journal
Neuroscience Letters 
ISSN
0304-3940
Language
English

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