Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

2021 | journal article; overview. A publication with affiliation to the University of Göttingen.

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​Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease​
Oliveira, L. M. A.; Gasser, T.; Edwards, R.; Zweckstetter, M. ; Melki, R.; Stefanis, L. & Lashuel, H. A. et al.​ (2021) 
npj Parkinson's Disease7(1) art. 65​.​ DOI: https://doi.org/10.1038/s41531-021-00203-9 

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Authors
Oliveira, Luis M. A.; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus ; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal A.; Sulzer, David; Vekrellis, Kostas; Halliday, Glenda M.; Outeiro, Tiago F. 
Abstract
Abstract With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of 1.9 billion in the US alone. Since the initial association with PD, hundreds of researchers have contributed to elucidating the functions of α-synuclein in normal and pathological states, and these remain critical areas for continued research. With this position paper the authors strive to achieve two goals: first, to succinctly summarize the critical features that define α-synuclein’s varied roles, as they are known today; and second, to identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in PD.
Issue Date
2021
Journal
npj Parkinson's Disease 
Project
EXC 2067: Multiscale Bioimaging 
SFB 1286: Quantitative Synaptologie 
SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration 
SFB 1286 | B08: Definition von Kaskaden molekularer Veränderungen bei Synucleinopathien während der Neurodegeneration 
Working Group
RG Outeiro (Experimental Neurodegeneration) 
eISSN
2373-8057
Language
English

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