Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation
2019 | journal article. A publication with affiliation to the University of Göttingen.
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Ruthenium(II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation
Müller, V.; Weck, R.; Derdau, V. & Ackermann, L. (2019)
ChemCatChem, 12(11) pp. 1-6. DOI: https://doi.org/10.1002/cctc.201902051
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Details
- Authors
- Müller, Valentin; Weck, Remo; Derdau, Volker; Ackermann, Lutz
- Abstract
- Well-defined ruthenium(II) biscarboxylate complexes enabled selective ortho-deuteration with weakly-coordinating, synthetically useful carboxylic acid with outstanding levels of isotopic labeling. The robust nature of the catalytic system was reflected by a broad functional group tolerance in an operationallysimple manner, allowing the isotope labeling of challenging pharmaceuticals and bioactive heterocyclic motifs. The synthetic power of our method was highlighted by the selective tritium-labeling of repaglinide, an antidiabetic drug, providing access to defined tritium labeled therapeutics.
- Issue Date
- 2019
- Journal
- ChemCatChem
- Organization
- Fakultät für Chemie
- ISSN
- 1867-3880
- eISSN
- 1867-3899
- ISSN
- 1867-3899; 1867-3880
- eISSN
- 1867-3899
- Language
- English