Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
2018 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity
Joas, S.; Parrish, E. H.; Gnanadurai, C. W.; Lump, E.; Stürzel, C. M.; Parrish, N. F. & Learn, G. H. et al. (2018)
Nature Communications, 9(1) art. 1371. DOI: https://doi.org/10.1038/s41467-018-03762-3
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- Authors
- Joas, Simone; Parrish, Erica H.; Gnanadurai, Clement W.; Lump, Edina; Stürzel, Christina M.; Parrish, Nicholas F.; Learn, Gerald H.; Sauermann, Ulrike; Neumann, Berit; Rensing, Kerstin Mätz; Fuchs, Dietmar; Billingsley, James M.; Bosinger, Steven E.; Silvestri, Guido; Apetrei, Cristian; Huot, Nicolas; Garcia-Tellez, Thalia; Müller-Trutwin, Michaela; Hotter, Dominik; Sauter, Daniel; Stahl-Hennig, Christiane ; Hahn, Beatrice H.; Kirchhoff, Frank
- Abstract
- HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i.e., a Vpu protein that antagonizes tetherin and blocks NF-κB activation and a Nef protein that fails to suppress T cell activation via downmodulation of CD3, into a non-pathogenic SIVagm strain and test their impact on viral replication and pathogenicity in African green monkeys. Despite sustained high-level viremia over more than 4 years, moderately increased immune activation and transcriptional signatures of inflammation, the HIV-1-like SIVagm does not cause immunodeficiency or any other disease. These data indicate that species-specific host factors rather than intrinsic viral virulence factors determine the pathogenicity of primate lentiviruses.
- Issue Date
- 2018
- Journal
- Nature Communications
- Organization
- Deutsches Primatenzentrum
- ISSN
- 2041-1723
- Language
- English