Dynamic Quantitative Iodine Myocardial Perfusion Imaging with Dual-Layer CT using a Porcine Model

2019 | journal article. A publication with affiliation to the University of Göttingen.

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​Dynamic Quantitative Iodine Myocardial Perfusion Imaging with Dual-Layer CT using a Porcine Model​
Scherer, K.; Hammel, J.; Sellerer, T.; Mechlem, K.; Renger, B.; Bähr, A. & Kupatt, C. et al.​ (2019) 
Scientific Reports9(1).​ DOI: https://doi.org/10.1038/s41598-019-52458-1 

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Authors
Scherer, Kai; Hammel, Johannes; Sellerer, Thorsten; Mechlem, Korbinian; Renger, Bernhard; Bähr, Andrea; Kupatt, Christian; Hinkel, Rabea; Herzen, Julia; Pfeiffer, Franz; Rummeny, Ernst; Pfeiffer, Daniela
Abstract
Ischemic heart disease is the globally leading cause of death. When using coronary CT angiography, the functional hemodynamics within the myocardium remain uncertain. In this study myocardial CT perfusion imaging using iodine contrast agent demonstrated to strongly improve the assessment of myocardial disorders. However, a retrieval of such dynamics using Hounsfield units from conventional CT poses concerns with respect to beam-hardening effects and low contrast-to-noise ratio (CNR). Dual-energy CT offers novel approaches to overcome aforementioned limitations. Quantitative peak enhancement, perfusion, time to peak and iodine volume measurements inside the myocardium were determined resulting in 0.92 mg/ml, 0.085 mg/ml/s 17.12 s and 29.89 mg/ml s, respectively. We report on the first extensive quantitative and iodine-based analysis of myocardial dynamics in a healthy porcine model using a dual-layer spectral CT. We further elucidate on the potential of reducing the radiation dose from 135 to 18 mGy and the contrast agent volume from 60 to 30 mL by presenting a two-shot acquisition approach and measuring iodine concentrations in the myocardium in-vivo down to 1 mg/ml, respectively. We believe that dynamic quantitative iodine perfusion imaging may
Issue Date
2019
Journal
Scientific Reports 
Organization
Deutsches Primatenzentrum 
ISSN
2045-2322
eISSN
2045-2322
Language
English

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