Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501

2021-10-08 | journal article; research paper. A publication with affiliation to the University of Göttingen.

Jump to: Cite & Linked | Documents & Media | Details | Version history

Cite this publication

​Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501​
Goldberg, M.; Islam, M. R.; Kerimoglu, C.; Lancelin, C.; Gisa, V.; Burkhardt, S. & Krüger, D. M. et al.​ (2021) 
Translational Psychiatry11(1) art. 514​.​ DOI: https://doi.org/10.1038/s41398-021-01627-w 

Details

Authors
Goldberg, Maria; Islam, Md Rezaul; Kerimoglu, Cemil; Lancelin, Camille; Gisa, Verena; Burkhardt, Susanne; Krüger, Dennis M.; Marquardt, Till; Malchow, Berend; Schmitt, Andrea; Falkai, Peter; Sananbenesi, Farahnaz; Fischer, André 
Abstract
MicroRNAs have been linked to synaptic plasticity and memory function and are emerging as potential biomarkers and therapeutic targets for cognitive diseases. Most of these data stem from the analysis of model systems or postmortem tissue from patients which mainly represents an advanced stage of pathology. Due to the in-accessibility of human brain tissue upon experimental manipulation, it is still challenging to identify microRNAs relevant to human cognition, which is however a key step for future translational studies. Here, we employ exercise as an experimental model for memory enhancement in healthy humans with the aim to identify microRNAs linked to memory function. By analyzing the circulating smallRNAome we find a cluster of 18 microRNAs that are highly correlated to cognition. MicroRNA-409-5p and microRNA-501-3p were the most significantly regulated candidates. Functional analysis revealed that the two microRNAs are important for neuronal integrity, synaptic plasticity, and morphology. In conclusion, we provide a novel approach to identify microRNAs linked to human memory function.
Issue Date
8-October-2021
Journal
Translational Psychiatry 
Project
EXC 2067: Multiscale Bioimaging 
SFB 1286: Quantitative Synaptologie 
SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration 
Working Group
RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases) 
eISSN
2158-3188
Language
English

Reference

Citations


Social Media