Targeting altered calcium physiology in the heart: Translational approaches to excitation, contraction, and transcription
2007 | review. A publication with affiliation to the University of Göttingen.
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Targeting altered calcium physiology in the heart: Translational approaches to excitation, contraction, and transcription
Seidler, T. ; Hasenfuß, G. & Maier, L. S. (2007)
Physiology, 22(5) pp. 328-334.
Amer Physiological Soc. DOI: https://doi.org/10.1152/physiol.00015.2007
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Details
- Authors
- Seidler, Tim ; Hasenfuß, Gerd ; Maier, Lars S.
- Abstract
- Calcium (Ca) is essential for excitation- contraction coupling. At the same time, Ca is of pivotal importance as a second messenger in cardiac signal transduction, where it regulates cardiac growth and function by activation of kinases and phosphatases, ultimately driving transcriptional responses and feeding back on Ca handling proteins, a phenomenon termed excitation- transcription coupling. Cardiac Ca home-ostasis thus needs to be maintained via a delicate interplay of proteins to allow physiological function and adaptation, whereas disturbed Ca- handling and Ca-dependent signaling are hallmarks of heart failure. In this review, we will discuss the most recent mechanistic findings in Ca- handling and Ca- signaling proteins in the development of cardiac pathology with a focus on translational aspects.
- Issue Date
- 2007
- Publisher
- Amer Physiological Soc
- Journal
- Physiology
- ISSN
- 1548-9213