The Journal of Clinical Investigation

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American Society for Clinical Investigation
 
 
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  • 2023 Journal Article | 
    ​ ​Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, et al. ​Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination​. ​​The Journal of Clinical Investigation. ​2023;​133​(7). ​doi:10.1172/JCI164223. 
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  • 2023 Journal Article | 
    ​ ​Bonifacius A, Lamottke B, Tischer-Zimmermann S, Schultze-Florey R, Goudeva L, Heuft, Hans-Gert, et al. ​Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors​. ​​Journal of Clinical Investigation. ​2023;. ​doi:10.1172/JCI163548. 
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  • 2023 Journal Article | 
    ​ ​Dai Y, Zhu C, Xiao W, Huang K, Wang X, Shi C, et al. ​Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth​. ​​Journal of Clinical Investigation. ​2023;​133​(8). ​doi:10.1172/JCI159941. 
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  • 2023 Journal Article
    ​ ​Singh M, Kondraskhina AM, Hurst LD, Izsvák Z. ​Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH​. ​​Journal of Clinical Investigation. ​2023;​133​(14). ​doi:10.1172/JCI172278. 
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  • 2023 Journal Article | 
    ​ ​Spinelli R, Baboota RK, Gogg S, Beguinot F, Blüher M, Nerstedt A, et al. ​Increased cell senescence in human metabolic disorders​. ​​Journal of Clinical Investigation. ​2023;​133​(12). ​doi:10.1172/JCI169922. 
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  • 2023 Journal Article
    ​ ​Li D, Wang Q, Bayat A, Battig MR, Zhou Y, Bosch DG, et al. ​Spliceosome malfunction causes neurodevelopmental disorders with overlapping features​. ​​Journal of Clinical Investigation. ​2023;. ​doi:10.1172/JCI171235. 
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  • 2022 Journal Article | 
    ​ ​Demel UM, Böger M, Yousefian S, Grunert C, Zhang L, Hotz PW, et al. ​Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer​. ​​Journal of Clinical Investigation. ​2022;​132​(9). ​doi:10.1172/JCI152383. 
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  • 2022 Journal Article | Research Paper | 
    ​ ​Fan Y, Murgia M, Linder MI, Mizoguchi Y, Wang C, Łyszkiewicz M, et al. ​HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation​. ​​Journal of Clinical Investigation. ​2022;​132​(9). ​doi:10.1172/JCI153153. 
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  • 2020 Journal Article | 
    ​ ​Li Z, Korhonen EA, Merlini A, Strauss J, Wihuri E, Nurmi H, et al. ​Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS​. ​​Journal of Clinical Investigation. ​2020;​130​(4):​​1977​-1990​. ​doi:10.1172/JCI130308. 
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  • 2019 Journal Article | 
    ​ ​N’diaye M, Brauner S, Flytzani S, Kular L, Warnecke A, Adzemovic MZ, et al. ​C-type lectin receptors Mcl and Mincle control development of multiple sclerosis–like neuroinflammation​. ​​Journal of Clinical Investigation. ​2019;​130​(2):​​838​-852​. ​doi:10.1172/JCI125857. 
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  • 2018 Journal Article | 
    ​ ​Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, et al. ​Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice​. ​​Journal of Clinical Investigation. ​2018;​128​(8):​​3265​-3279​. ​doi:10.1172/JCI96636. 
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  • 2018 Journal Article | 
    ​ ​Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, et al. ​Microglia ablation alleviates myelin-associated catatonic signs in mice​. ​​Journal of Clinical Investigation. ​2018;​128​(2):​​734​-745​. ​doi:10.1172/JCI97032. 
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  • 2018 Journal Article | Research Paper | 
    ​ ​Tampe B, Tampe D, Nyamsuren G, Klöpper F, Rapp G, Kauffels A, et al. ​Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure​. ​​The Journal of Clinical Investigation. ​2018;​128​(7):​​3053​-3070​. ​doi:10.1172/JCI89632. 
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  • 2017 Journal Article
    ​ ​Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, et al. ​Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder​. ​​The Journal of Clinical Investigation. ​2017;​127​(3):​​1005​-1018​. ​doi:10.1172/JCI90259. 
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  • 2017 Journal Article | 
    ​ ​Wild PS, Felix JF, Schillert A, Teumer A, Chen, Ming-Huei, Leening MJ, et al. ​Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function​. ​​Journal of Clinical Investigation. ​2017;​127​(5):​​1798​-1812​. ​doi:10.1172/JCI84840. 
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  • 2016 Journal Article | 
    ​ ​Storck SE, Meister S, Nahrath J, Meissner JN, Schubert N, Di Spiezio A, et al. ​Endothelial LRP1 transports amyloid-beta(1-42) across the blood-brain barrier​. ​​Journal of Clinical Investigation. ​2016;​126​(1):​​123​-136​. ​doi:10.1172/JCI81108. 
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  • 2016 Journal Article | Research Paper
    ​ ​Brandenburg S, Kohl T, Williams GSB, Gusev K, Wagner E, Rog-Zielinska EA, et al. ​Axial tubule junctions control rapid calcium signaling in atria​. ​​Journal of Clinical Investigation. ​2016;​126​(10):​​3999​-4015​. ​doi:10.1172/JCI88241. 
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  • 2016 Journal Article | 
    ​ ​Schindler RFR, Scotton C, Zhang J, Passarelli C, Ortiz-Bonnin B, Simrick S, et al. ​POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking​. ​​Journal of Clinical Investigation. ​2016;​126​(1):​​239​-253​. ​doi:10.1172/JCI79562. 
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  • 2015 Journal Article | Research Paper
    ​ ​Benito-Garagorri E, Urbanke H, Ramachandran B, Barth J, Haider R, Awasthi A, et al. ​HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models​. ​​Journal of Clinical Investigation. ​2015;​125​(9):​​3572​-3584​. ​doi:10.1172/JCI79942. 
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  • 2015 Journal Article | Research Paper
    ​ ​Boegershausen N, Tsai, I-Chun, Pohl E, Kiper POS, Beleggia F, Percin EF, et al. ​RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome​. ​​Journal of Clinical Investigation. ​2015;​125​(9):​​3585​-3599​. ​doi:10.1172/JCI80102. 
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  • 2014 Journal Article | Research Paper
    ​ ​Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Schulz AM, et al. ​Optogenetic stimulation of the auditory pathway​. ​​Journal of Clinical Investigation. ​2014;​124​(3):​​1114​-1129​. ​doi:10.1172/JCI69050. 
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  • 2014 Journal Article
    ​ ​Greiser M, Kerfant, Benoît-Gilles, Williams GS, Voigt N, Harks E, Dibb KM, et al. ​Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes​. ​​Journal of Clinical Investigation. ​2014;​124​(11):​​4759​-4772​. ​doi:10.1172/JCI70102. 
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  • 2014 Journal Article
    ​ ​Kido-Nakahara M, Buddenkotte J, Kempkes C, Ikoma A, Cevikbas F, Akiyama T, et al. ​Neural peptidase endothelin-converting enzyme 1-regulates endothelin induced pruritus​. ​​Journal of Clinical Investigation. ​2014;​124​(6):​​2683​-2695​. ​doi:10.1172/JCI67323. 
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  • 2014 Journal Article | Research Paper
    ​ ​Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, et al. ​Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy​. ​​Journal of Clinical Investigation. ​2014;​124​(5):​​2136​-2146​. ​doi:10.1172/JCI70577. 
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  • 2014 Journal Article
    ​ ​Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, et al. ​IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis​. ​​Journal of Clinical Investigation. ​2014;​124​(4):​​1853​-1867​. ​doi:10.1172/JCI73531. 
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  • 2013 Journal Article | Research Paper
    ​ ​Kostareli E, Holzinger D, Bogatyrova O, Hielscher T, Wichmann G, Keck M, et al. ​HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas​. ​​The Journal of Clinical Investigation. ​2013;​123​(6):​​2488​-2501​. ​doi:10.1172/JCI67010. 
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  • 2013 Journal Article | Research Paper
    ​ ​Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, et al. ​Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​. ​​Journal of Clinical Investigation. ​2013;​123​(3):​​1262​-1274​. ​doi:10.1172/JCI65268. 
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  • 2013 Journal Article | Research Paper
    ​ ​Didie M, Christalla P, Rubart M, Muppala V, Doeker S, Unsoeld BW, et al. ​Parthenogenetic stem cells for tissue-engineered heart repair​. ​​Journal of Clinical Investigation. ​2013;​123​(3):​​1285​-1298​. ​doi:10.1172/JCI66854. 
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  • 2012 Journal Article
    ​ ​Begus-Nahrmann Y, Hartmann D, Kraus J, Eshraghi P, Scheffold A, Grieb M, et al. ​Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis​. ​​Journal of Clinical Investigation. ​2012;​122​(6):​​2283​-2288​. ​doi:10.1172/JCI61745. 
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  • 2011 Journal Article | 
    ​ ​Hansen C, Angot E, Bergström, Ann-Louise, Steiner JA, Pieri L, Paul G, et al. ​α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.​. ​​The Journal of clinical investigation. ​2011;​121​(2):​​715​-25​. ​doi:10.1172/JCI43366. 
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  • 2011 Journal Article
    ​ ​Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, et al. ​Oxidized CaMKII causes cardiac sinus node dysfunction in mice​. ​​Journal of Clinical Investigation. ​2011;​121​(8):​​3277​-3288​. ​doi:10.1172/JCI57833. 
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  • 2011 Journal Article
    ​ ​Wakili R, Voigt N, Kääb S, Dobrev D, Nattel S. ​Recent advances in the molecular pathophysiology of atrial fibrillation​. ​​Journal of Clinical Investigation. ​2011;​121​(8):​​2955​-2968​. ​doi:10.1172/JCI46315. 
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  • 2011 Journal Article | 
    ​ ​Zibert JR, Wallbrecht K, Schon M, Mir LM, Jacobsen GK, Trochon-Joseph V, et al. ​Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions​. ​​Journal of Clinical Investigation. ​2011;​121​(1):​​410​-421​. ​doi:10.1172/JCI41295. 
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  • 2010 Journal Article | 
    ​ ​Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lindegger N, et al. ​Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice​. ​​Journal of Clinical Investigation. ​2010;​120​(12):​​4388​-4398​. ​doi:10.1172/JCI32726. 
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  • 2010 Journal Article | 
    ​ ​Manzke T, Niebert M, Koch UR, Caley A, Vogelgesang S, Huelsmann S, et al. ​Serotonin receptor 1A-modulated phosphorylation of glycine receptor alpha 3 controls breathing in mice​. ​​Journal of Clinical Investigation. ​2010;​120​(11):​​4118​-4128​. ​doi:10.1172/JCI43029. 
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  • 2010 Journal Article | Research Paper | 
    ​ ​Wittoepper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsoeld BW, et al. ​Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​. ​​Journal of Clinical Investigation. ​2010;​120​(2):​​617​-626​. ​doi:10.1172/JCI40545. 
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  • 2010 Journal Article | 
    ​ ​Nemajerova A, Petrenko O, Truemper LH, Palacios G, Moll UM. ​Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice​. ​​Journal of Clinical Investigation. ​2010;​120​(6):​​2070​-2080​. ​doi:10.1172/JCI40331. 
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  • 2009 Journal Article | Research Paper
    ​ ​Zeisberg M, Neilson EG. ​Biomarkers for epithelial-mesenchymal transitions​. ​​The Journal of Clinical Investigation. ​2009;​119​(6):​​1429​-1437​. ​doi:10.1172/JCI36183. 
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  • 2008 Journal Article
    ​ ​Lueth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, et al. ​Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs​. ​​Journal of Clinical Investigation. ​2008;​118​(10):​​3403​-3410​. ​doi:10.1172/JCI32132. 
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  • 2008 Journal Article
    ​ ​Frey N, Frank D, Lippl S, Kuhn C, Koegler H, Barrientos T, et al. ​Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation​. ​​Journal of Clinical Investigation. ​2008;​118​(11):​​3598​-3608​. ​doi:10.1172/JCI36277. 
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  • 2008 Journal Article | 
    ​ ​Mueller N, van den Brandt J, Odoardi F, Tischner D, Herath J, Fluegel A, et al. ​A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats​. ​​Journal of Clinical Investigation. ​2008;​118​(4):​​1405​-1416​. ​doi:10.1172/JCI32698. 
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  • 2008 Journal Article
    ​ ​Lehnart SE, Mongillo M, Bellinger A, Lindegger N, Chen, Bi-Xing, Hsueh W, et al. ​Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice​. ​​Journal of Clinical Investigation. ​2008;​118​(6):​​2230​-2245​. ​doi:10.1172/JCI35346. 
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  • 2008 Journal Article
    ​ ​Weber YG, Storch A, Wuttke TV, Brockmann K, Kempfle J, Maljevic S, et al. ​GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak​. ​​Journal of Clinical Investigation. ​2008;​118​(6):​​2157​-2168​. ​doi:10.1172/JCI34438. 
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  • 2007 Journal Article | Research Paper
    ​ ​Teng Y, Zeisberg M, Kalluri R. ​Transcriptional regulation of epithelial-mesenchymal transition​. ​​The Journal of Clinical Investigation. ​2007;​117​(2):​​304​-306​. ​doi:10.1172/JCI31200. 
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  • 2007 Journal Article
    ​ ​Steidl U, Steidl C, Ebralidze A, Chapuy B, Han, Hye-Jung, Will B, et al. ​A distal single nucleotide polymorphism alters long-range reguiavon of the PU-1 gene in acute myeloid leukemia​. ​​Journal of Clinical Investigation. ​2007;​117​(9):​​2611​-2620​. ​doi:10.1172/JCI30525. 
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  • 2007 Journal Article
    ​ ​Tuckermann JP, Kleiman A, Moriggl R, Spanbroek R, Neumann A, Illing A, et al. ​Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy​. ​​Journal of Clinical Investigation. ​2007;​117​(5):​​1381​-1390​. ​doi:10.1172/JCI28034. 
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  • 2006 Journal Article
    ​ ​Merkler D, Horvath E, Bruck WW, Zinkernagel RM, de la Torre JC, Pinschewer DD. ​"Viral deja vu" elicits organ-specific immune disease independent of reactivity to self​. ​​Journal of Clinical Investigation. ​2006;​116​(5):​​1254​-1263​. ​doi:10.1172/JCI27372. 
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  • 2006 Journal Article
    ​ ​Prinz MR, Garbe F, Schmidt H, Mildner A, Gutcher I, Wolter K, et al. ​Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis​. ​​Journal of Clinical Investigation. ​2006;​116​(2):​​456​-464​. ​doi:10.1172/JCI26078. 
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  • 2006 Journal Article
    ​ ​Kumar V, Ali SR, Konrad S, Zwirner J, Verbeek JS, Schmidt RE, et al. ​Cell-derived anaphylatoxins as key mediators of anti body-dependent type II autoimmunity in mice​. ​​Journal of Clinical Investigation. ​2006;​116​(2):​​512​-520​. ​doi:10.1172/JCI25536. 
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  • 2006 Journal Article
    ​ ​Kohl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang LH, et al. ​A regulatory role for the C5a anaphylatoxin in, type 2 immunity in asthma​. ​​Journal of Clinical Investigation. ​2006;​116​(3):​​783​-796​. ​doi:10.1172/JCI26582. 
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  • 2006 Journal Article | Research Paper
    ​ ​Wagner S, Dybkova N, Rasenack ECL, Jacobshagen C, Fabritz L, Kirchhof P, et al. ​Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels​. ​​Journal of Clinical Investigation. ​2006;​116​(12):​​3127​-3138​. ​doi:10.1172/JCI26620. 
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  • 2004 Journal Article
    ​ ​Thomzig A, Schulz-Schaeffer WJ, Kratzel C, Mai J, Beekes M. ​Preclinical deposition of pathological prion protein PrPSc in muscles of hamsters orally exposed to scrapie​. ​​Journal of Clinical Investigation. ​2004;​113​(10):​​1465​-1472​. ​doi:10.1172/JCI200421083. 
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  • 2003 Journal Article
    ​ ​Friedrich B, Tepel C, Reinheckel T, Deussing JM, von Figura K, Herzog V, et al. ​Thyroid functions of mouse cathepsins B, K, and L​. ​​Journal of Clinical Investigation. ​2003;​111​(11):​​1733​-1745​. ​doi:10.1172/JCI200315990. 
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  • 2002 Journal Article | 
    ​ ​Hanßke B, Thiel C, Lübke T, Hasilik M, Höning S, Peters V, et al. ​Deficiency of UDP-galactose:N-acetylglucosamine β-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId​. ​​Journal of Clinical Investigation. ​2002;​109​:​​725​-733​. ​doi:10.1172/JCI200214010.. 
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  • 2002 Journal Article
    ​ ​Shushakova N, Skokowa J, Schulman J, Baumann U, Zwirner J, Schmidt RE, et al. ​C5a anaphylatoxin is a major regulator of activating versus inhibitory Fc gamma Rs in immune complex-induced lung disease​. ​​Journal of Clinical Investigation. ​2002;​110​(12):​​1823​-1830​. ​doi:10.1172/JCI200216577. 
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  • 2002 Journal Article
    ​ ​Anders H, Vielhauer V, Frink M, Linde Y, Cohen CD, Blattner SM, et al. ​A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation​. ​​Journal of Clinical Investigation. ​2002;​109​(2):​​251​-259​. ​doi:10.1172/JCI14040. 
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  • 2002 Journal Article
    ​ ​Le Berre L, Godfrin Y, Gunther E, Buzelin F, Perretto S, Smit H, et al. ​Extrarenal effects on the pathogenesis and relapse of idiopathic nephrotic syndrome in Buffalo/Mna rats​. ​​Journal of Clinical Investigation. ​2002;​109​(4):​​491​-498​. ​doi:10.1172/JCI12858. 
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  • 2002 Journal Article
    ​ ​Hansske B, Thiel C, Lubke T, Hasilik M, Honing S, Peters V, et al. ​Deficiency of UDP-galactose : N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId​. ​​Journal of Clinical Investigation. ​2002;​109​(6):​​725​-733​. ​doi:10.1172/JCI200214010. 
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  • 1996 Journal Article | Research Paper
    ​ ​Pieske B, Sutterlin , Schmidt-Schweda S, Minami K, Meyer M, Olschewski M, et al. ​Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy - Functional evidence for alterations in intracellular Ca2+ handling​. ​​Journal of Clinical Investigation. ​1996;​98​(3):​​764​-776​. ​doi:10.1172/JCI118849. 
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  • 1974 Journal Article | 
    ​ ​Figura K, Kresse H. ​Quantitative Aspects of Pinocytosis and the Intracellular Fate of N-acetyl-α-D-glucosaminidase in Sanfilippo B Fibroblasts​. ​​The Journal of Clinical Investigation. ​1974;​83​:​​85​-90​. ​
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