Stem Cell Research

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  • 2024 | Journal Article
    ​ ​Generation of Pelizaeus-Merzbacher disease (PMD) mutant (PLP1-C33Y) in induced pluripotent stem cell (iPSC) by CRISPR/Cas9 genome editing​
    Schreiber, M.-K. & Zafeiriou, M.-P.​ (2024) 
    Stem Cell Research, 74 art. 103276​.​ DOI: https://doi.org/10.1016/j.scr.2023.103276 
    ​Details  DOI  PMID  PMC 
  • 2024 | Journal Article
    ​ ​Generation of an RBM20-mutation-associated left-ventricular non-compaction cardiomyopathy iPSC line (UMGi255-A) into a DCM genetic background to investigate monogenetic cardiomyopathies​
    Eberl, H.; Rebs, S.; Hoppe, S.; Sedaghat-Hamedani, F.; Kayvanpour, E.; Meder, B. & Streckfuss-Bömeke, K.​ (2024) 
    Stem Cell Research, 74 art. 103290​.​ DOI: https://doi.org/10.1016/j.scr.2023.103290 
    ​Details  DOI 
  • 2024 | Journal Article
    ​ ​Generation of a pluripotent stem cell line (UMGi270-A) and a corresponding CRISPR/Cas9 modified isogenic control (UMGi270-A-1) from a patient with sudden onset dilated cardiomyopathy harboring a FLNC p.R2187P mutation​
    Maurer, W.; Rebs, S.; Köhne, S.; Eberl, H.; Wollnik, B.; Zibat, A. & Streckfuss-Bömeke, K.​ (2024) 
    Stem Cell Research, 77 art. 103409​.​ DOI: https://doi.org/10.1016/j.scr.2024.103409 
    ​Details  DOI 
  • 2024 | Journal Article
    ​ ​Human induced pluripotent stem cells for live cell cycle monitoring and endogenous gene activation​
    Kim, R.; Nagel, S. H.; Liaw, N. Y.; Zimmermann, W.-H.; Zelarayán, L. C. & Schoger, E.​ (2024) 
    Stem Cell Research, 80 art. 103531​.​ DOI: https://doi.org/10.1016/j.scr.2024.103531 
    ​Details  DOI 
  • 2024 | Journal Article
    ​ ​Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line​
    Aline Schmoll, K.; Mager, T.; Tse, T. P. Tse, Timothy Pok-man; Alameldeen, A.; Zimmermann, W.-H. & Zafeiriou, M.-P.​ (2024) 
    Stem Cell Research, 75 art. 103317​.​ DOI: https://doi.org/10.1016/j.scr.2024.103317 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​Generation of a fluorescent oligodendrocyte reporter line in human induced pluripotent stem cells​
    Schreiber, M.-K. & Zafeiriou, M.-P.​ (2023) 
    Stem Cell Research, 75 art. 103295​.​ DOI: https://doi.org/10.1016/j.scr.2023.103295 
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  • 2023 | Journal Article | 
    ​ ​Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​
    Priesmeier, L.; Schoger, E.; Cyganek, L. & Zelarayán, L. C. ​ (2023) 
    Stem Cell Research, 71 pp. 103163​.​ DOI: https://doi.org/10.1016/j.scr.2023.103163 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V​
    Busley, A. V.; Kleinsorge, M. & Cyganek, L.​ (2023) 
    Stem Cell Research, 69 art. 103105​.​ DOI: https://doi.org/10.1016/j.scr.2023.103105 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V​
    Busley, A. V. & Cyganek, L.​ (2023) 
    Stem Cell Research, 69 art. 103108​.​ DOI: https://doi.org/10.1016/j.scr.2023.103108 
    ​Details  DOI  null 
  • 2022 | Journal Article
    ​ ​Generation of homozygous Nav1.8 knock-out iPSC lines by CRISPR Cas9 genome editing to investigate a potential new antiarrhythmic strategy​
    Maurer, W.; Hartmann, N.; Argyriou, L.; Sossalla, S. & Streckfuss-Bömeke, K.​ (2022) 
    Stem Cell Research, 60 art. S1873506122000265​.​ DOI: https://doi.org/10.1016/j.scr.2022.102677 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Generation of iPSC lines from CPVT patient carrying heterozygous mutation p.A2254V in the ryanodine receptor 2 gene​
    Li, W.; Henze, S.; Luo, X.; Ulbricht, Y.; Richter, A.; Di Donato, N. & Wilde, A. A. et al.​ (2021) 
    Stem Cell Research, 53 art. S1873506121001057​.​ DOI: https://doi.org/10.1016/j.scr.2021.102259 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy​
    Rebs, S.; Beier, J.; Argyriou, L.; Schill, T.; Hasenfuß, G. ; Vollmann, D. & Sossalla, S. et al.​ (2021) 
    Stem Cell Research, 53 pp. 102263​.​ DOI: https://doi.org/10.1016/j.scr.2021.102263 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 56 art. S1873506121003652​.​ DOI: https://doi.org/10.1016/j.scr.2021.102518 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 55 art. S1873506121003202​.​ DOI: https://doi.org/10.1016/j.scr.2021.102473 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article
    ​ ​Generation of iPSC-lines from two independent Takotsubo syndrome patients with recurrent Takotsubo events​
    Hübscher, D. ; Rebs, S. ; Maurer, W.; Ghadri, J. R.; Dressel, R. ; Templin, C. & Streckfuss-Bömeke, K. ​ (2020) 
    Stem Cell Research, 44 pp. 101746​.​ DOI: https://doi.org/10.1016/j.scr.2020.101746 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation​
    Schoger, E.; Argyriou, L.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2020) 
    Stem Cell Research, 48 pp. 101944​.​ DOI: https://doi.org/10.1016/j.scr.2020.101944 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Generation of a human induced pluripotent stem cell line (BIHi002-A) from a patient with CLCN7-related infantile malignant autosomal recessive osteopetrosis​
    Hennig, A. F.; Rössler, U.; Boiti, F.; von der Hagen, M.; Gossen, M.; Kornak, U.   & Stachelscheid, H.​ (2019) 
    Stem Cell Research, 35 art. 101367​.​ DOI: https://doi.org/10.1016/j.scr.2018.101367 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation​
    Noack, C. ; Haupt, L. P. ; Zimmermann, W.-H. ; Streckfuss-Bömeke, K.   & Zelarayán, L. C. ​ (2017) 
    Stem Cell Research, 23 pp. 127​-131​.​ DOI: https://doi.org/10.1016/j.scr.2017.07.007 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Generation of human induced pluripotent stem cells using non-synthetic mRNA​
    Rohani, L.; Fabian, C.; Holland, H.; Naaldijk, Y.; Dressel, R. ; Loeffler-Wirth, H. & Binder, H. et al.​ (2016) 
    Stem Cell Research, 16(3) pp. 662​-672​.​ DOI: https://doi.org/10.1016/j.scr.2016.03.008 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8​
    Helmke, C.; Raab, M.; Roedel, F.; Matthess, Y.; Oellerich, T.; Mandal, R. & Sanhaji, M. et al.​ (2016) 
    Cell Research, 26(8) pp. 914​-934​.​ DOI: https://doi.org/10.1038/cr.2016.78 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling​
    Nyamsuren, G.; Kata, A.; Xu, X.; Raju, P.; Dressel, R. ; Engel, W. & Pantakani, D. V. K.  et al.​ (2014) 
    Stem Cell Research, 13(1) pp. 61​-74​.​ DOI: https://doi.org/10.1016/j.scr.2014.04.011 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome​
    Dudek, J. ; Cheng, I.-F. ; Balleininger, M.; Vaz, F. M.; Streckfuss-Bömeke, K. ; Hübscher, D.   & Vukotic, M.  et al.​ (2013) 
    Stem Cell Research, 11(2) pp. 806​-819​.​ DOI: https://doi.org/10.1016/j.scr.2013.05.005 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells​
    Tan, X.; Xu, X.; Elkenani, M.; Smorag, L.; Zechner, U.; Nolte, J. & Engel, W. et al.​ (2013) 
    Stem Cell Research, 11(3) pp. 1045​-1059​.​ DOI: https://doi.org/10.1016/j.scr.2013.07.006 
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  • 2013 | Journal Article | 
    ​ ​Reconsidering pluripotency tests: Do we still need teratoma assays?​
    Buta, C.; David, R.; Dressel, R.; Emgard, M.; Fuchs, C.; Gross, U. & Healy, L. et al.​ (2013) 
    Stem Cell Research, 11(1) pp. 552​-562​.​ DOI: https://doi.org/10.1016/j.scr.2013.03.001 
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  • 2009 | Journal Article | Research Paper
    ​ ​Generation of functional neurons and glia from multipotent adult mouse germ-line stem cells​
    Streckfuss-Boemeke, K. ; Vlasov, A.; Huelsmann, S. ; Yin, D.; Nayernia, K.; Engel, W. & Hasenfuß, G.  et al.​ (2009) 
    Stem Cell Research, 2(2) pp. 139​-154​.​ DOI: https://doi.org/10.1016/j.scr.2008.09.001 
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  • 2008 | Journal Article | 
    ​ ​p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity​
    Wolff, S.; Erster, S.; Palacios, G. & Moll, U. M.​ (2008) 
    Cell Research, 18(7) pp. 733​-744​.​ DOI: https://doi.org/10.1038/cr.2008.62 
    ​Details  DOI  PMID  PMC  WoS 

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