Alzheimer's Research & Therapy

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  • 2024 Journal Article | 
    ​ ​Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study​
    Menze, I.; Bernal, J.; Kaya, P.; Aki, Ç.; Pfister, M.; Geisendörfer, J. & Yakupov, R. et al.​ (2024) 
    Alzheimer's Research & Therapy16(1) art. 242​.​ DOI: https://doi.org/10.1186/s13195-024-01603-8 
    Details  DOI 
  • 2024 Journal Article | 
    ​ ​Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults​
    Bernal, J.; Menze, I.; Yakupov, R.; Peters, O.; Hellmann-Regen, J.; Freiesleben, S. D. & Priller, J. et al.​ (2024) 
    Alzheimer's Research & Therapy16(1) art. 240​.​ DOI: https://doi.org/10.1186/s13195-024-01606-5 
    Details  DOI 
  • 2024 Journal Article | 
    ​ ​Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia​
    Weise, C. M.; Engel, A.; Polyakova, M.; Wu, Q.; Mueller, K.; Herzig, S. & Jech, R. et al.​ (2024) 
    Alzheimer's Research & Therapy16(1) art. 237​.​ DOI: https://doi.org/10.1186/s13195-024-01596-4 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Biomarkers in Alzheimer’s disease: role in early and differential diagnosis and recognition of atypical variants​
    Dubois, B.; von Arnim, C. A. F.; Burnie, N.; Bozeat, S. & Cummings, J.​ (2023) 
    Alzheimer's Research & Therapy15(1) art. 175​.​ DOI: https://doi.org/10.1186/s13195-023-01314-6 
    Details  DOI 
  • 2023 Journal Article | Erratum | 
    ​ ​Correction: Comparative evaluation of clinical and cerebrospinal fluid biomarker characteristics in rapidly and non‑rapidly progressive Alzheimer’s disease​
    Herden, J. M.; Hermann, P.; Schmidt, I.; Dittmar, K.; Canaslan, S.; Weglage, L. & Nuhn, S. et al.​ (2023) 
    Alzheimer's Research & Therapy15 art. 116​.​ DOI: https://doi.org/10.1186/s13195-023-01263-0 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Comparative evaluation of clinical and cerebrospinal fluid biomarker characteristics in rapidly and non-rapidly progressive Alzheimer’s disease​
    Herden, J. M.; Hermann, P.; Schmidt, I.; Dittmar, K.; Canaslan, S.; Weglage, L. & Nuhn, S. et al.​ (2023) 
    Alzheimer's Research & Therapy15(1) art. 106​.​ DOI: https://doi.org/10.1186/s13195-023-01249-y 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study​
    Bernal, J.; Schreiber, S.; Menze, I.; Ostendorf, A.; Pfister, M.; Geisendörfer, J. & Nemali, A. et al.​ (2023) 
    Alzheimer's Research & Therapy15(1) art. 97​.​ DOI: https://doi.org/10.1186/s13195-023-01243-4 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Exploring the ATN classification system using brain morphology​
    Heinzinger, N.; Maass, A.; Berron, D.; Yakupov, R.; Peters, O.; Fiebach, J. & Villringer, K. et al.​ (2023) 
    Alzheimer's Research & Therapy15(1) art. 50​.​ DOI: https://doi.org/10.1186/s13195-023-01185-x 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Brain reserve contributes to distinguishing preclinical Alzheimer’s stages 1 and 2​
    Yildirim, Z.; Delen, F.; Berron, D.; Baumeister, H.; Ziegler, G.; Schütze, H. & Glanz, W. et al.​ (2023) 
    Alzheimer's Research & Therapy15(1) art. 43​.​ DOI: https://doi.org/10.1186/s13195-023-01187-9 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study​
    Brosseron, F.; Maass, A.; Kleineidam, L.; Ravichandran, K. A.; Kolbe, C.-C.; Wolfsgruber, S. & Santarelli, F. et al.​ (2023) 
    Alzheimer's Research & Therapy15(1) art. 13​.​ DOI: https://doi.org/10.1186/s13195-022-01118-0 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​Diagnostic performance of automated plasma amyloid-β assays combined with pre-analytical immunoprecipitation​
    Klafki, H.-W. ; Vogelgsang, J.; Manuilova, E.; Bauer, C.; Jethwa, A.; Esselmann, H.   & Jahn-Brodmann, A. et al.​ (2022) 
    Alzheimer's Research & Therapy14(1) art. 127​.​ DOI: https://doi.org/10.1186/s13195-022-01071-y 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers​
    Hermann, P.; Villar-Piqué, A.; Schmitz, M.; Schmidt, C.; Varges, D.; Goebel, S. & Bunck, T. et al.​ (2022) 
    Alzheimer's Research & Therapy14(1) art. 9​.​ DOI: https://doi.org/10.1186/s13195-021-00955-9 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer’s and other neurodegenerative diseases​
    Halbgebauer, S.; Steinacker, P.; Riedel, D.; Oeckl, P.; Anderl-Straub, S.; Lombardi, J. & von Arnim, C. A. F. et al.​ (2022) 
    Alzheimer's Research & Therapy14(1).​ DOI: https://doi.org/10.1186/s13195-022-01122-4 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease​
    Dyrba, M.; Hanzig, M.; Altenstein, S.; Bader, S.; Ballarini, T.; Brosseron, F. & Buerger, K. et al.​ (2021) 
    Alzheimer's Research & Therapy13(1) art. 191​.​ DOI: https://doi.org/10.1186/s13195-021-00924-2 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Efficacy and safety of pharmacotherapy for Alzheimer’s disease and for behavioural and psychological symptoms of dementia in older patients with moderate and severe functional impairments: a systematic review of controlled trials​
    Seibert, M.; Mühlbauer, V.; Holbrook, J.; Voigt-Radloff, S.; Brefka, S.; Dallmeier, D. & Denkinger, M. et al.​ (2021) 
    Alzheimer's Research & Therapy13(1) art. 131​.​ DOI: https://doi.org/10.1186/s13195-021-00867-8 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease​
    Aichholzer, F.; Klafki, H.-W.; Ogorek, I.; Vogelgsang, J.; Wiltfang, J.; Scherbaum, N. & Weggen, S. et al.​ (2021) 
    Alzheimer's Research & Therapy13(1) art. 94​.​ DOI: https://doi.org/10.1186/s13195-021-00828-1 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease​
    Zerr, I.; Villar-Piqué, A.; Hermann, P.; Schmitz, M.; Varges, D.; Ferrer, I. & Riggert, J. et al.​ (2021) 
    Alzheimer's Research & Therapy13(1) art. 86​.​ DOI: https://doi.org/10.1186/s13195-021-00815-6 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers—results from the DELCODE study​
    Sannemann, L.; Schild, A.-K.; Altenstein, S.; Bartels, C. ; Brosseron, F.; Buerger, K. & Cosma, N. C. et al.​ (2020) 
    Alzheimer's Research & Therapy12(1).​ DOI: https://doi.org/10.1186/s13195-020-00701-7 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Prevalence of abnormal Alzheimer’s disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples​
    Wolfsgruber, S.; Molinuevo, J. L; Wagner, M.; Teunissen, C. E; Rami, L.; Coll-Padrós, N. & Bouwman, F. H et al.​ (2019) 
    Alzheimer's Research & Therapy11(1) art. 8​.​ DOI: https://doi.org/10.1186/s13195-018-0463-y 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study​
    Miebach, L.; Wolfsgruber, S.; Polcher, A.; Peters, O.; Menne, F.; Luther, K. & Incesoy, E. et al.​ (2019) 
    Alzheimer's Research & Therapy11(1).​ DOI: https://doi.org/10.1186/s13195-019-0515-y 
    Details  DOI 
  • 2019 Journal Article | Research Paper | 
    ​ ​Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau​
    Brendel, M.; Deussing, M.; Blume, T.; Kaiser, L.; Probst, F.; Overhoff, F. & Peters, F. et al.​ (2019) 
    Alzheimer's Research & Therapy11(1).​ DOI: https://doi.org/10.1186/s13195-019-0522-z 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)​
    Jessen, F.; Spottke, A.; Boecker, H.; Brosseron, F.; Buerger, K.; Catak, C. & Fliessbach, K. et al.​ (2018) 
    Alzheimer's Research & Therapy10(1).​ DOI: https://doi.org/10.1186/s13195-017-0314-2 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation​
    Teunissen, C. E.; Otto, M. ; Engelborghs, S.; Herukka, S.-K.; Lehmann, S.; Lewczuk, P.   & Lleó, A. et al.​ (2018) 
    Alzheimer's Research & Therapy10(1).​ DOI: https://doi.org/10.1186/s13195-018-0359-x 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​A language-based sum score for the course and therapeutic intervention in primary progressive aphasia​
    Semler, E.; Anderl-Straub, S.; Uttner, I.; Diehl-Schmid, J.; Danek, A.; Einsiedler, B. & Fassbender, K. et al.​ (2018) 
    Alzheimer's Research & Therapy10(1).​ DOI: https://doi.org/10.1186/s13195-018-0345-3 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Interlaboratory proficiency processing scheme in CSF aliquoting: implementation and assessment based on biomarkers of Alzheimer’s disease​
    Lewczuk, P.; Gaignaux, A.; Kofanova, O.; Ermann, N.; Betsou, F.; Brandner, S. & Mroczko, B. et al.​ (2018) 
    Alzheimer's Research & Therapy10(1) art. 87​.​ DOI: https://doi.org/10.1186/s13195-018-0418-3 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease​
    Shahpasand-Kroner, H.; Klafki, H.-W.; Bauer, C.; Schuchhardt, J.; Hüttenrauch, M.; Stazi, M. & Bouter, C. et al.​ (2018) 
    Alzheimer's Research & Therapy10(1) art. 121​.​ DOI: https://doi.org/10.1186/s13195-018-0448-x 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia​
    Frölich, L.; Peters, O.; Lewczuk, P. ; Gruber, O. ; Teipel, S. J.; Gertz, H. J. & Jahn, H. et al.​ (2017) 
    Alzheimer's Research & Therapy9(1) art. 84​.​ DOI: https://doi.org/10.1186/s13195-017-0301-7 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models​
    Wirths, O. ; Walter, S.; Kraus, I. ; Klafki, H. W. ; Stazi, M.; Oberstein, T. J. & Ghiso, J. et al.​ (2017) 
    Alzheimer's Research & Therapy9(1) art. 80​.​ DOI: https://doi.org/10.1186/s13195-017-0309-z 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer’s disease core biomarkers in Lewy body disorders and Alzheimer’s dementia​
    Chiasserini, D.; Biscetti, L.; Eusebi, P.; Salvadori, N.; Frattini, G.; Simoni, S. & De Roeck, N. et al.​ (2017) 
    Alzheimer's Research & Therapy9(1).​ DOI: https://doi.org/10.1186/s13195-017-0276-4 
    Details  DOI 
  • 2015 Journal Article | 
    ​ ​Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study​
    Morgen, K.; Schneider, M.; Frölich, L.; Tost, H.; Plichta, M. M.; Kölsch, H. & Rakebrandt, F.  et al.​ (2015) 
    Alzheimer's Research & Therapy7(1).​ DOI: https://doi.org/10.1186/s13195-015-0111-8 
    Details  DOI 
  • 2014 Review | 
    ​ ​Biomarkers in biological fluids for dementia with Lewy bodies​
    Schade, S.& Mollenhauer, B.​ (2014)
    Alzheimer s Research & Therapy, 6​(5).​
    Biomed Central Ltd. DOI: https://doi.org/10.1186/s13195-014-0072-3 
    Details  DOI  PMID  PMC  WoS 

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