Institut für Medizinische Statistik

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  • 2024 Journal Article | 
    ​ ​Bayesian random‐effects meta‐analysis with empirical heterogeneity priors for application in health technology assessment with very few studies​
    Lilienthal, J.; Sturtz, S.; Schürmann, C.; Maiworm, M.; Röver, C. ; Friede, T. & Bender, R.​ (2024) 
    Research Synthesis Methods15(2) art. jrsm.1685​.​ DOI: https://doi.org/10.1002/jrsm.1685 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article | Research Paper | 
    ​ ​Evaluating an app for digital medical history taking in urgent care practices: study protocol of the cluster-randomized interventional trial ‘DASI’​
    Noack, E. M. ; Zajontz, D.; Friede, T. ; Antweiler, K.; Hummers, E. ; Schmidt, T. & Roddewig, L. et al.​ (2023) 
    BMC Primary Care24(1) art. 108​.​ DOI: https://doi.org/10.1186/s12875-023-02065-x 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article | 
    ​ ​Optimizing the structure of interdisciplinary tumor boards for effective cancer care​
    Braulke, F.; Kober, K.; Arndt, A.; Papendick, M.; Strauss, A.; Kramm, C. M. & Thoms, K.-M. et al.​ (2023) 
    Frontiers in Oncology13.​ DOI: https://doi.org/10.3389/fonc.2023.1072652 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Summarizing empirical information on between‐study heterogeneity for Bayesian random‐effects meta‐analysis​
    Röver, C.; Sturtz, S.; Lilienthal, J.; Bender, R. & Friede, T.​ (2023) 
    Statistics in Medicine42(14) art. sim.9731​.​ DOI: https://doi.org/10.1002/sim.9731 
    Details  DOI  PMID  PMC  arXiv 
  • 2023 Journal Article | 
    ​ ​Using the bayesmeta R package for Bayesian random-effects meta-regression​
    Röver, C.   & Friede, T. ​ (2023) 
    Computer Methods and Programs in Biomedicine229 art. 107303​.​ DOI: https://doi.org/10.1016/j.cmpb.2022.107303 
    Details  DOI  PMID  PMC  arXiv 
  • 2023 Journal Article | Research Paper | 
    ​ ​Effect of face masks on salivary parameters and halitosis: Randomized controlled crossover trial​
    Kanzow, P. ; Rohland, B.; Barke, S.; Placzek, M.; Rammert, L. & Wiegand, A.​ (2023) 
    Journal of Oral Pathology & Medicine52(1) pp. 56​-62​.​ DOI: https://doi.org/10.1111/jop.13390 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article | Overview
    ​ ​Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections​
    Boecker, D.; Zhang, Z.; Breves, R.; Herth, F.; Kramer, A. & Bulitta, C.​ (2023) 
    GMS Hygiene and Infection Control18 art. Doc07​.​ DOI: https://doi.org/10.3205/dgkh000433 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Research Paper | 
    ​ ​“SpezPat”- common advance directives versus disease-centred advance directives: a randomised controlled pilot study on the impact on physicians’ understanding of non-small cell lung cancer patients’ end-of-life decisions​
    Koenig, J. F. L.; Asendorf, T. ; Simon, A. ; Bleckmann, A. ; Trümper, L. ; Wulf, G. G.   & Overbeck, T. R. ​ (2022) 
    BMC Palliative Care21(1) art. 167​.​ DOI: https://doi.org/10.1186/s12904-022-01057-5 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​A straightforward meta-analysis approach for oncology phase I dose-finding studies​
    Röver, C. ; Ursino, M.; Zohar, S. & Friede, T. ​ (2022) 
    Statistics in Medicine41(20) art. sim.9484​.​ DOI: https://doi.org/10.1002/sim.9484 
    Details  DOI  PMID  PMC  arXiv 
  • 2022 Journal Article | Research Paper | 
    ​ ​Double arcsine transform not appropriate for meta‐analysis​
    Röver, C.   & Friede, T.​ (2022) 
    Research Synthesis Methods13(5) art. jrsm.1591​.​ DOI: https://doi.org/10.1002/jrsm.1591 
    Details  DOI  arXiv 
  • 2022 Journal Article | Research Paper | 
    ​ ​Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis: treatment response by demographic, clinical, and biomarker subgroups (PROMISE)—a systematic review protocol​
    Lehnert, T.; Köpke, S.; Rio, J.; Chard, D.; Fittipaldo, A. V.; Heesen, C. & Rahn, A. C. et al.​ (2022) 
    Systematic Reviews11(1) art. 134​.​ DOI: https://doi.org/10.1186/s13643-022-01997-2 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​COPD mortality and exacerbations in the placebo group of clinical trials over two decades: a systematic review and meta-regression​
    Andreas, S.; Röver, C. ; Heinz, J.; Taube, C. & Friede, T.​ (2022) 
    ERJ Open Research8(1) art. 00261-2021​.​ DOI: https://doi.org/10.1183/23120541.00261-2021 
    Details  DOI 
  • 2022 Preprint
    ​ ​MetaStan: An R package for Bayesian (model-based) meta-analysis using Stan​
    Kürsad Günhan, B.; Röver, C.  & Friede, T. ​ (2022)
    Details 
  • 2022 Journal Article
    ​ ​Die Digitalisierung der Pneumologie und die Rolle der Fachgesellschaften​
    Wollsching-Strobel, M.; Butt, U.; Majorski, D. S.; Beissinger, T. ; Stachwitz, P.; Hagen, J. & Kroppen, D. et al.​ (2022) 
    Pneumologie76(08) pp. 560​-567​.​ DOI: https://doi.org/10.1055/a-1866-2507 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Restrictions and their reporting in systematic reviews of effectiveness: an observational study​
    Helbach, J.; Pieper, D.; Beissinger, T. ; Rombey, T.; Zeeb, H.; Allers, K. & Hoffmann, F.​ (2022) 
    BMC Medical Research Methodology22(1).​ DOI: https://doi.org/10.1186/s12874-022-01710-w 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​Assessing the quality of evidence on safety: specifications for application and suggestions for adaptions of the GRADE-criteria in the context of preparing a list of potentially inappropriate medications for older adults​
    Mathes, T. ; Mann, N.-K.; Thürmann, P.; Sönnichsen, A. & Pieper, D.​ (2022) 
    BMC Medical Research Methodology22(1) art. 234​.​ DOI: https://doi.org/10.1186/s12874-022-01715-5 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression​
    Hellmann-Regen, J.; Clemens, V.; Grözinger, M.; Kornhuber, J. ; Reif, A.; Prvulovic, D. & Goya-Maldonado, R.  et al.​ (2022) 
    JAMA Network Open5(9) art. e2230367​.​ DOI: https://doi.org/10.1001/jamanetworkopen.2022.30367 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Development and Validation of a Predictive Model for Toxicity of Neoadjuvant Chemoradiotherapy in Rectal Cancer in the CAO/ARO/AIO-04 Phase III Trial​
    Diefenhardt, M.; Martin, D.; Ludmir, E. B.; Fleischmann, M.; Hofheinz, R.-D.; Ghadimi, M.   & Kosmala, R. et al.​ (2022) 
    Cancers14(18) pp. 4425​.​ DOI: https://doi.org/10.3390/cancers14184425 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Left‐sided excess in the laterality of cutaneous melanocytic nevi and melanomas​
    Bauer‐Büntzel, C.; Kück, F.   & Kretschmer, L. ​ (2022) 
    JDDG: Journal der Deutschen Dermatologischen Gesellschaft20(10) pp. 1315​-1323​.​ DOI: https://doi.org/10.1111/ddg.14864 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Linksüberhang in der Verteilung von melanozytären Nävi und Melanomen​
    Bauer‐Büntzel, C.; Kück, F.   & Kretschmer, L. ​ (2022) 
    JDDG: Journal der Deutschen Dermatologischen Gesellschaft20(10) pp. 1315​-1324​.​ DOI: https://doi.org/10.1111/ddg.14864_g 
    Details  DOI 
  • 2022 Journal Article
    ​ ​POS1483-HPR Dysfunctional Coping Correlates with Depression and Anxiety and Predicts Worse Outcome in Patients with a High Disease Activity in Rheumatoid Arthritis​
    Hoeper, J. R.; Iliadis, I.; Richter, M.; Meyer, S. E.; Kahl, K.; Witte, T. & Hoeper, K. et al.​ (2022) 
    Annals of the Rheumatic Diseases81(Suppl 1) pp. 1087.2​-1088​.​ DOI: https://doi.org/10.1136/annrheumdis-2022-eular.3743 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Influence of Shear Stress, Inflammation and BRD4 Inhibition on Human Endothelial Cells: A Holistic Proteomic Approach​
    Jarausch, J.; Neuenroth, L.; Andag, R.; Leha, A. ; Fischer, A. ; Asif, A.   & Lenz, C.  et al.​ (2022) 
    Cells11(19) pp. 3086​.​ DOI: https://doi.org/10.3390/cells11193086 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Improving the statistical power of economic experiments using adaptive designs​
    Jobjörnsson, S.; Schaak, H.; Musshoff, O.   & Friede, T. ​ (2022) 
    Experimental Economics,.​ DOI: https://doi.org/10.1007/s10683-022-09773-8 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Influence of moisture content of frozen and embalmed human cadavers for identification of dentinal microcracks using micro-computed tomography​
    Rödig, T. ; Dullin, C. ; Kück, F. ; Krebs, M.; Hettwer-Steeger, I. & Haupt, F. ​ (2022) 
    Journal of the Mechanical Behavior of Biomedical Materials133 art. 105310​.​ DOI: https://doi.org/10.1016/j.jmbbm.2022.105310 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis​
    Brandenburg, S. ; Drews, L.; Schönberger, H.-L.; Jacob, C. F.; Paulke, N. J.; Beuthner, B. E. & Topci, R. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology173 pp. 1​-15​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.08.363 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection​
    Huber, C.; Friede, T.; Stingl, J. & Benda, N.​ (2021) 
    Therapeutic Innovation & Regulatory Science56(2) pp. 244​-254​.​ DOI: https://doi.org/10.1007/s43441-021-00352-2 
    Details  DOI 
  • 2021 Journal Article | Research Paper
    ​ ​Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial​
    Gágyor, I. ; Hummers, E. ; Schmiemann, G.; Friede, T. ; Pfeiffer, S.; Afshar, K. & Bleidorn, J.​ (2021) 
    Clinical Microbiology and Infection27(10) pp. 1441​-1447​.​ DOI: https://doi.org/10.1016/j.cmi.2021.05.032 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Risk factors for repeated general anesthesia for dental treatment of adult patients with intellectual and/or physical disabilities​
    Maes, M. S.; Kanzow, P. ; Biermann, J.; Leha, A.; Hrasky, V. & Wiegand, A.​ (2021) 
    Clinical Oral Investigations26(2) pp. 1695​-1700​.​ DOI: https://doi.org/10.1007/s00784-021-04142-w 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Prevalence of Back Pain among German Ophthalmologists​
    Bertelmann, T. ; Heutelbeck, A.; Bopp, S.; Sagebiel, L.-L.; Eichberg, S.; Hallier, E.   & Hilgers, R.  et al.​ (2021) 
    Ophthalmic Research64(6) pp. 974​-982​.​ DOI: https://doi.org/10.1159/000517574 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article
    ​ ​Erosion-Protective Capacity of the Salivary Pellicle of Female and Male Subjects Is Not Different.​
    Wiegand, A. ; Rosemann, A.; Hoch, M. ; Barke, S.; Dakna, M. & Kanzow, P. ​ (2019) 
    Caries Research53(6) pp. 636​-642​.​ DOI: https://doi.org/10.1159/000500046 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Data on differential multivariable risk prediction of appropriate shock vs. competing mortality​
    Bergau, L.; Willems, R.; Sprenkeler, D. J; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    Data in Brief21 pp. 2110​-2116​.​ DOI: https://doi.org/10.1016/j.dib.2018.11.025 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Model averaging for robust extrapolation in evidence synthesis​
    Röver, C. ; Wandel, S. & Friede, T.​ (2018) 
    Statistics in Medicine,.​ DOI: https://doi.org/10.1002/sim.7991 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Contribution to the discussion of "When should meta-analysis avoid making hidden normality assumptions?": A Bayesian perspective.​
    Röver, C.   & Friede, T.​ (2018) 
    Biometrical Journal,.​ DOI: https://doi.org/10.1002/bimj.201800179 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis​
    Kristof, K.; Büttner, B. ; Grimm, A.; Mewes, C.; Schmack, B.; Popov, A.-F. & Ghadimi, M. B.  et al.​ (2018) 
    BMC Research Notes11(1) art. 879​.​ DOI: https://doi.org/10.1186/s13104-018-3988-z 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Sample size calculation in multi-centre clinical trials​
    Harden, M. & Friede, T.​ (2018) 
    BMC Medical Research Methodology18(1) art. 156​.​ DOI: https://doi.org/10.1186/s12874-018-0602-y 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease​
    Halsband, C.; Zapf, A.; Sixel-Döring, F.; Trenkwalder, C. & Mollenhauer, B.​ (2018) 
    Movement Disorders Clinical PracticeEarly View Status pp. 1​-4​.​ DOI: https://doi.org/10.1002/mdc3.12591 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Whither systems medicine?​
    Apweiler, R.; Beißbarth, T. ; Berthold, M. R.; Blüthgen, N.; Burmeister, Y.; Dammann, O. & Deutsch, A. et al.​ (2018) 
    Experimental & Molecular Medicine50(3) art. e453​.​ DOI: https://doi.org/10.1038/emm.2017.290 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​The CTLA-4 rs231775 GG genotype is associated with favorable 90-day survival in Caucasian patients with sepsis​
    Mewes, C.; Büttner, B. ; Hinz, J. M. ; Alpert, A.; Popov, A.-F.; Ghadimi, M. B.   & Beißbarth, T.  et al.​ (2018) 
    Scientific Reports8(1).​ DOI: https://doi.org/10.1038/s41598-018-33246-9 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker​
    Graf, A. C.; Wassmer, G.; Friede, T. ; Gera, R. G.   & Posch, M.​ (2018) 
    Statistical Methods in Medical Research28(6) pp. 1879​-1892​.​ DOI: https://doi.org/10.1177/0962280218777538 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​The "rapid atrial swirl sign" for assessing central venous catheters: Performance by medical residents after limited training.​
    Korsten, P. ; Mavropoulou, E.; Wienbeck, S. ; Ellenberger, D. ; Patschan, D.; Zeisberg, M.   & Vasko, R. et al.​ (2018) 
    PloS one13(7) pp. e0199345​-e0199345​.​ DOI: https://doi.org/10.1371/journal.pone.0199345 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper | 
    ​ ​Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) – a double-blind, randomized, controlled comparative effectiveness trial​
    Afshar, K.; Fleischmann, N.; Schmiemann, G.; Bleidorn, J.; Hummers-Pradier, E. ; Friede, T. & Wegscheider, K. et al.​ (2018) 
    BMC Complementary and Alternative Medicine18(1) art. 203​.​ DOI: https://doi.org/10.1186/s12906-018-2266-x 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.​
    Wolff, A. ; Bayerlová, M. ; Gaedcke, J. ; Kube, D.   & Beißbarth, T. ​ (2018) 
    PLOS ONE13(5) art. e0197162​.​ DOI: https://doi.org/10.1371/journal.pone.0197162 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​High-frequency oscillatory ventilation guided by transpulmonary pressure in acute respiratory syndrome: an experimental study in pigs​
    Klapsing, P.; Moerer, O.; Wende, C.; Herrmann, P.; Quintel, M.; Bleckmann, A. & Heuer, J. F.​ (2018) 
    Critical Care22(1) art. 121​.​ DOI: https://doi.org/10.1186/s13054-018-2028-7 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​On estimands and the analysis of adverse events in the presence of varying follow‐up times within the benefit assessment of therapies​
    Unkel, S.; Amiri, M.; Benda, N.; Beyersmann, J.; Knoerzer, D.; Kupas, K. & Langer, F. et al.​ (2018) 
    Pharmaceutical Statistics18(2) pp. 166​-183​.​ DOI: https://doi.org/10.1002/pst.1915 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards​
    Perera-Bel, J. ; Hutter, B.; Heining, C.; Bleckmann, A. ; Fröhlich, M.; Fröhling, S. & Glimm, H. et al.​ (2018) 
    Genome Medicine10(1) pp. 18​.​ DOI: https://doi.org/10.1186/s13073-018-0529-2 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​mully: An R Package to Create, Modify and Visualize Multilayered Graphs​
    Hammoud, Z.   & Kramer, F. ​ (2018) 
    Genes9(11) art. 519​.​ DOI: https://doi.org/10.3390/genes9110519 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Proteome Profiling by Label‐Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81–176 to Sublethal Concentrations of Bile Acids​
    Masanta, W. O.; Zautner, A. E.; Lugert, R.; Bohne, W.; Gross, U.; Leha, A. & Dakna, M. et al.​ (2018) 
    PROTEOMICS – Clinical Applications13(3) art. 1800083​.​ DOI: https://doi.org/10.1002/prca.201800083 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​A design-by-treatment interaction model for network meta-analysis and meta-regression with integrated nested Laplace approximations​
    Günhan, B. K. ; Friede, T.   & Held, L.​ (2018) 
    Research Synthesis Methods9(2) pp. 179​-194​.​ DOI: https://doi.org/10.1002/jrsm.1285 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​
    Bergau, L.; Willems, R.; Sprenkeler, D. J.; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    International Journal of Cardiology272 pp. 102​-107​.​ DOI: https://doi.org/10.1016/j.ijcard.2018.06.103 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Crohn's disease patient serum changes protein expression in a human mesenchymal stem cell model in a linear relationship to patients' disease stage and to bone mineral density​
    Blaschke, M.; Koepp, R.; Lenz, C.; Kruppa, J.; Jung, K. & Siggelkow, H.​ (2018) 
    Journal of Clinical & Translational Endocrinology13 pp. 26​-38​.​ DOI: https://doi.org/10.1016/j.jcte.2018.06.002 
    Details  DOI  PMID  PMC 

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