Dr. Melina Schuh

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  • 2023 Lecture | 
    ​ ​Von der Erforschung der Eizelle bis zum Kinderwunsch​
    Schuh, M. ​ (2023)
    Herz und Hirn - Gemeinsam im Fokus; 2023-12-12​, Göttingen.
  • 2022 Journal Article | Research Paper
    ​ ​Mechanism of spindle pole organization and instability in human oocytes​
    So, C.; Menelaou, K.; Uraji, J.; Harasimov, K.; Steyer, A. M.; Seres, K. B. & Bucevičius, J. et al.​ (2022) 
    Science375(6581) art. eabj3944​.​ DOI: https://doi.org/10.1126/science.abj3944 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article
    ​ ​Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment​
    Cheng, S.; Altmeppen, G.; So, C.; Welp, L. M.; Penir, S.; Ruhwedel, T. & Menelaou, K. et al.​ (2022) 
    Science378(6617) art. eabq4835​.​ DOI: https://doi.org/10.1126/science.abq4835 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Overview
    ​ ​Aneuploidy in mammalian oocytes and the impact of maternal ageing​
    Charalambous, C.; Webster, A. & Schuh, M. ​ (2022) 
    Nature Reviews Molecular Cell Biology, pp. 27​-44​.​ DOI: https://doi.org/10.1038/s41580-022-00517-3 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Overview | 
    ​ ​Aneuploidy in human eggs: contributions of the meiotic spindle​
    Thomas, C.; Cavazza, T. & Schuh, M. ​ (2021) 
    Biochemical Society Transactions49(1) pp. 107​-118​.​ DOI: https://doi.org/10.1042/BST20200043 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Two mechanisms drive pronuclear migration in mouse zygotes​
    Scheffler, K.; Uraji, J.; Jentoft, I.; Cavazza, T.; Mönnich, E.; Mogessie, B. & Schuh, M. ​ (2021) 
    Nature Communications12(1) pp. 841​.​ DOI: https://doi.org/10.1038/s41467-021-21020-x 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Overview | 
    ​ ​Origins and mechanisms leading to aneuploidy in human eggs​
    Wartosch, L.; Schindler, K.; Schuh, M. ; Gruhn, J. R.; Hoffmann, E. R.; McCoy, R. C. & Xing, J.​ (2021) 
    Prenatal Diagnosis41(5) pp. 620​-630​.​ DOI: https://doi.org/10.1002/pd.5927 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Overview | 
    ​ ​Phase Separation during Germline Development​
    So, C.; Cheng, S. & Schuh, M. ​ (2021) 
    Trends in Cell Biology31(4) pp. 254​-268​.​ DOI: https://doi.org/10.1016/j.tcb.2020.12.004 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Parental genome unification is highly error-prone in mammalian embryos​
    Cavazza, T.; Takeda, Y.; Politi, A. Z.; Aushev, M.; Aldag, P.; Baker, C. & Choudhary, M. et al.​ (2021) 
    Cell184(11) pp. 2860.e22​-2877.e22​.​ DOI: https://doi.org/10.1016/j.cell.2021.04.013 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | 
    ​ ​The EXOTIME project: signals in the O–C diagrams of the rapidly pulsating subdwarfs DW Lyn, V1636 Ori, QQ Vir, and V541 Hya​
    Mackebrandt, F.; Schuh, S. ; Silvotti, R.; Kim, S.-L.; Kilkenny, D.; Green, E. M. & Lutz, R. et al.​ (2020) 
    Astronomy and Astrophysics638 pp. A108​.​ DOI: https://doi.org/10.1051/0004-6361/201937172 
    Details  DOI 
  • 2020 Preprint
    ​ ​Parental genome unification is highly erroneous in mammalian embryos​
    Cavazza, T.; Politi, A. Z.; Aldag, P.; Baker, C.; Elder, K.; Blayney, M.& Lucas-Hahn, A. et al.​ (2020). DOI: https://doi.org/10.1101/2020.08.27.269779 
    Details  DOI 
  • 2019 Journal Article
    ​ ​A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes​
    So, C.; Seres, K. B.; Steyer, A. M.; Mönnich, E.; Clift, D.; Pejkovska, A. & Möbius, W.  et al.​ (2019) 
    Science364(6447).​ DOI: https://doi.org/10.1126/science.aat9557 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs​
    Zielinska, A. P.; Bellou, E.; Sharma, N.; Frombach, A.-S.; Seres, K. B.; Gruhn, J. R. & Blayney, M. et al.​ (2019) 
    Current Biology29(22) pp. 3749​-3765.e7​.​ DOI: https://doi.org/10.1016/j.cub.2019.09.006 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Assembly and Positioning of the Oocyte Meiotic Spindle​
    Mogessie, B.; Scheffler, K. & Schuh, M. ​ (2018) 
    Annual Review of Cell and Developmental Biology34(1) pp. 381​-403​.​ DOI: https://doi.org/10.1146/annurev-cellbio-100616-060553 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Double trouble at the beginning of life​
    Zielinska, A. P. & Schuh, M. ​ (2018) 
    Science361(6398) pp. 128​-129​.​ DOI: https://doi.org/10.1126/science.aau3216 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Actin Disassembly: How to Contract without Motors?​
    Harasimov, K. & Schuh, M. ​ (2018) 
    Current Biology28(6) pp. R275​-R277​.​ DOI: https://doi.org/10.1016/j.cub.2018.02.019 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Publisher Correction: Acute and rapid degradation of endogenous proteins by Trim-Away​
    Clift, D.; So, C.; McEwan, W. A.; James, L. C. & Schuh, M. ​ (2018) 
    Nature Protocols14(8) pp. 2596​-2596​.​ DOI: https://doi.org/10.1038/s41596-018-0092-8 
    Details  DOI 
  • 2018 Book Chapter
    ​ ​A microscopy-based approach for studying meiosis in live and fixed human oocytes​
    Zielinska, A. P.& Schuh, M. ​ (2018)
    In: Mitosis and Meiosis Part B pp. 315​-333. ​Elsevier. DOI: https://doi.org/10.1016/bs.mcb.2018.03.039 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Acute and rapid degradation of endogenous proteins by Trim-Away​
    Clift, D.; So, C.; McEwan, W. A.; James, L. C. & Schuh, M. ​ (2018) 
    Nature Protocols13(10) pp. 2149​-2175​.​ DOI: https://doi.org/10.1038/s41596-018-0028-3 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Taking a confident leap into uncertainty​
    Schuh, M. ​ (2018) 
    Nature Cell Biology20(9) pp. 1007​-1007​.​ DOI: https://doi.org/10.1038/s41556-018-0177-1 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Functions of actin in mouse oocytes at a glance​
    Uraji, J.; Scheffler, K. & Schuh, M. ​ (2018) 
    Journal of Cell Science131(22).​ DOI: https://doi.org/10.1242/jcs.218099 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Actin protects mammalian eggs against chromosome segregation errors​
    Mogessie, B. & Schuh, M. ​ (2017) 
    Science357(6353) art. eaal1647​.​ DOI: https://doi.org/10.1126/science.aal1647 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article
    ​ ​Mechanisms of Aneuploidy in Human Eggs​
    Webster, A. & Schuh, M. ​ (2017) 
    Trends in Cell Biology27(1) pp. 55​-68​.​ DOI: https://doi.org/10.1016/j.tcb.2016.09.002 
    Details  DOI 
  • 2017 Journal Article
    ​ ​A Method for the Acute and Rapid Degradation of Endogenous Proteins​
    Clift, D.; McEwan, W. A.; Labzin, L. I.; Konieczny, V.; Mogessie, B.; James, L. C. & Schuh, M. ​ (2017) 
    Cell171(7) pp. 1692.e18​-1706.e18​.​ DOI: https://doi.org/10.1016/j.cell.2017.10.033 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article | Research Paper
    ​ ​The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs​
    Pasternak, M.; Pfender, S.; Santhanam, B. & Schuh, M. ​ (2016) 
    Open Biology6 art. 160184​.​ DOI: https://doi.org/10.1098/rsob.160184 
    Details  DOI  WoS 
  • 2016 Journal Article | 
    ​ ​Two pathways regulate cortical granule translocation to prevent polyspermy in mouse oocytes​
    Cheeseman, L. P.; Boulanger, J.; Bond, L. M. & Schuh, M. ​ (2016) 
    Nature Communications7 art. 13726​.​ DOI: https://doi.org/10.1038/ncomms13726 
    Details  DOI 
  • 2016 Journal Article | Letter Note
    ​ ​Cell scientist to watch - Melina Schuh​
    Bobrowska, A. & Schuh, M. ​ (2016) 
    Journal of Cell Science129(1) pp. 7​-8​.​ DOI: https://doi.org/10.1242/jcs.182717 
    Details  DOI  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes​
    Tischer, T. & Schuh, M. ​ (2016) 
    Cell Reports17(5) pp. 1426​-1437​.​ DOI: https://doi.org/10.1016/j.celrep.2016.10.007 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Error-Prone Chromosome-Mediated Spindle Assembly Favors Chromosome Segregation Defects in Human Oocytes​
    Holubcová, Z.; Blayney, M.; Elder, K. & Schuh, M. ​ (2015) 
    Obstetrical & Gynecological Survey70(9) pp. 572​-573​.​ DOI: https://doi.org/10.1097/OGX.0000000000000240 
    Details  DOI 
  • 2015 Journal Article | Research Paper | 
    ​ ​Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect​
    Zielinska, A. P; Holubcova, Z.; Blayney, M.; Elder, K. & Schuh, M. ​ (2015) 
    eLife4 art. e11389​.​ DOI: https://doi.org/10.7554/eLife.11389 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes​
    Pfender, S.; Kuznetsov, V.; Pasternak, M.; Tischer, T.; Santhanam, B. & Schuh, M. ​ (2015) 
    Nature524.​ DOI: https://doi.org/10.1038/nature14568 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes​
    Clift, D. & Schuh, M. ​ (2015) 
    Nature Communications6 art. 7217​.​ DOI: https://doi.org/10.1038/ncomms8217 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes​
    Holubcová, Z.; Blayney, M.; Elder, K. & Schuh, M. ​ (2015) 
    Science348(6239) pp. 1143​-1147​.​ DOI: https://doi.org/10.1126/science.aaa9529 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Letter Note
    ​ ​Melina Schuh: First comes the egg​
    Schuh, M.   & Sedwick, C.​ (2014) 
    The Journal of Cell Biology204(7) pp. 1080​-1081​.​ DOI: https://doi.org/10.1083/jcb.2047pi 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Spire and Formin 2 Synergize and Antagonize in Regulating Actin Assembly in Meiosis by a Ping-Pong Mechanism​
    Montaville, P.; Jégou, A.; Pernier, J.; Compper, C.; Guichard, B.; Mogessie, B. & Schuh, M.  et al.​ (2014) 
    PLoS Biology12(2) art. e1001795​.​ DOI: https://doi.org/10.1371/journal.pbio.1001795 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Letter Note
    ​ ​Nuclear Envelope Breakdown: Actin' Quick to Tear Down the Wall​
    Mogessie, B. & Schuh, M. ​ (2014) 
    Current Biology24(13) pp. R605​-R607​.​ DOI: https://doi.org/10.1016/j.cub.2014.05.059 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Vesicles modulate an actin network for asymmetric spindle positioning​
    Holubcová, Z.; Howard, G. & Schuh, M. ​ (2013) 
    Nature Cell Biology15(8).​ DOI: https://doi.org/10.1038/ncb2802 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Review
    ​ ​Restarting life: fertilization and the transition from meiosis to mitosis​
    Clift, D.& Schuh, M. ​ (2013)
    Nature Reviews Molecular Cell Biology, 14​ pp. 549​-562​.​ DOI: https://doi.org/10.1038/nrm3643 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Letter Note | 
    ​ ​Goodbye homunculus​
    Schuh, M. ​ (2012) 
    Nature Reviews Molecular Cell Biology13(7) art. 410​.​ DOI: https://doi.org/10.1038/nrm3370 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper
    ​ ​The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development​
    Courtois, A.; Schuh, M. ; Ellenberg, J. & Hiiragi, T.​ (2012) 
    The Journal of Cell Biology198(3) pp. 357​-370​.​ DOI: https://doi.org/10.1083/jcb.201202135 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​An actin-dependent mechanism for long-range vesicle transport​
    Schuh, M. ​ (2011) 
    Nature Cell Biology13(12).​ DOI: https://doi.org/10.1038/ncb2353 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Spire-Type Actin Nucleators Cooperate with Formin-2 to Drive Asymmetric Oocyte Division​
    Pfender, S.; Kuznetsov, V.; Pleiser, S.; Kerkhoff, E. & Schuh, M. ​ (2011) 
    Current Biology21(11) pp. 955​-960​.​ DOI: https://doi.org/10.1016/j.cub.2011.04.029 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​A New Model for Asymmetric Spindle Positioning in Mouse Oocytes​
    Schuh, M.   & Ellenberg, J.​ (2008) 
    Current Biology18(24) pp. 1986​-1992​.​ DOI: https://doi.org/10.1016/j.cub.2008.11.022 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Self-Organization of MTOCs Replaces Centrosome Function during Acentrosomal Spindle Assembly in Live Mouse Oocytes​
    Schuh, M.   & Ellenberg, J.​ (2007) 
    Cell130(3) pp. 484​-498​.​ DOI: https://doi.org/10.1016/j.cell.2007.06.025 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Incorporation of Drosophila CID/CENP-A and CENP-C into Centromeres during Early Embryonic Anaphase​
    Schuh, M. ; Lehner, C. F. & Heidmann, S.​ (2007) 
    Current Biology17(3) pp. 237​-243​.​ DOI: https://doi.org/10.1016/j.cub.2006.11.051 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Resolution of Chiasmata in Oocytes Requires Separase-Mediated Proteolysis​
    Kudo, N. R.; Wassmann, K.; Anger, M.; Schuh, M. ; Wirth, K. G.; Xu, H. & Helmhart, W. et al.​ (2006) 
    Cell126(1) pp. 135​-146​.​ DOI: https://doi.org/10.1016/j.cell.2006.05.033 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Letter Note
    ​ ​Nuclear Actin: A Lack of Export Allows Formation of Filaments​
    Schuh, M.   & Ellenberg, J.​ (2006) 
    Current Biology16(9) pp. R321​-R323​.​ DOI: https://doi.org/10.1016/j.cub.2006.03.081 
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