Prof. Dr. Anna-Leena Sirén

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  • 2020 Journal Article
    ​ ​The life history of human foraging: Cross-cultural and individual variation​
    Koster, J.; McElreath, R.; Hill, K.; Yu, D.; Shepard, G.; van Vliet, N. & Gurven, M. et al.​ (2020) 
    Science Advances6(26) pp. eaax9070​.​ DOI: 
    Details  DOI 
  • 2016 Journal Article | With Fulltext​ | 
    ​ ​Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus​
    Hassouna, I. ; Ott, C.; Wüstefeld, L.; Offen, N.; Neher, R. A.; Mitkovski, M. & Winkler, D. et al.​ (2016) 
    Molecular Psychiatry21(12) pp. 1752​-1767​.​ DOI: 
    Details  DOI 
  • 2015 Journal Article
    ​ ​Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke​
    Zerche, M.; Weißenborn, K.; Ott, C.; Dere, E. ; Asif, A. R. ; Worthmann, H. & Hassouna, I.  et al.​ (2015) 
    Stroke46(5) pp. 1180​-1186​.​ DOI: 
    Details  DOI 
  • 2014 Journal Article
    ​ ​Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity​
    Hammer, C. ; Stepniak, B. ; Schneider, A. ; Papiol, S. ; Tantra, M. ; Begemann, M.   & Sirén, A.-L.  et al.​ (2014) 
    Molecular Psychiatry19(10) pp. 1143​-1149​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2013 Journal Article | With Fulltext​ | 
    ​ ​Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells​
    Offen, N.; Flemming, J.; Kamawal, H.; Ahmad, R.; Wolber, W.; Geis, C. & Zaehres, H. et al.​ (2013) 
    Molecular Medicine19(1) pp. 399​-408​.​ DOI: 
    Details  DOI 
  • 2010 Journal Article
    ​ ​Erythropoietin: not just about erythropoiesis​
    Ghezzi, P.; Bernaudin, M.; Bianchi, R.; Blomgren, K.; Brines, M.; Campana, W. & Cavaletti, G. et al.​ (2010) 
    The Lancet375(9732).​ DOI: 
    Details  DOI 
  • 2009 Journal Article
    ​ ​Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system​
    Sirén, A.-L. ; Faßhauer, T.; Bartels, C.   & Ehrenreich, H. ​ (2009) 
    Neurotherapeutics6(1) pp. 108​-127​.​ DOI: 
    Details  DOI 
  • 2009 Journal Article
    ​ ​Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion​
    Sargin, D. ; Hassouna, I. ; Sperling, S. ; Sirén, A.-L.   & Ehrenreich, H. ​ (2009) 
    GLIA57(7) pp. 693​-702​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2008 Journal Article
    ​ ​Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling​
    Samoylenko, A.; Byts, N.; Rajalingam, K.; von Ahsen, N. ; Rapp, U. R.; Ehrenreich, H.   & Sirén, A.-L. ​ (2008) 
    Cellular Signalling20(1) pp. 154​-162​.​ DOI: 
    Details  DOI 
  • 2008 Book Chapter
    ​ ​Brain trauma​
    Ehrenreich, H. ; Krampe, H.  & Sirén, A.-L. ​ (2008)
    In:​Felthous, Alan; Sass, Henning​ (Eds.), The International Handbook of Psychopathic Disorders and the Law, Vol. 1 pp. 217​-236. ​Chichester: ​Wiley.
  • 2008 Journal Article | With Fulltext​ | 
    ​ ​Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin​
    Byts, N.; Samoylenko, A.; Faßhauer, T.; Ivanisevic, M.; Hennighausen, L.; Ehrenreich, H.   & Sirén, A.-L. ​ (2008) 
    Cell Death and Differentiation15(4) pp. 783​-792​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2007 Journal Article
    ​ ​Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis​
    Ehrenreich, H. ; Fischer, B.; Norra, C.; Schellenberger, F.; Stender, N.; Stiefel, M.   & Sirén, A.-L.  et al.​ (2007) 
    Brain130(10) pp. 2577​-2588​.​ DOI: 
    Details  DOI 
  • 2007 Journal Article
    ​ ​Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin​
    Ehrenreich, H. ; Hinze-Selch, D.; Stawicki, S. ; Aust, C. ; Knolle-Veentjer, S.; Wilms, S. & Heinz, G. et al.​ (2007) 
    Molecular Psychiatry12(2) pp. 206​-220​.​ DOI: 
    Details  DOI 
  • 2006 Journal Article
    ​ ​Reduced oxidative damage in ALS by high-dose enteral melatonin treatment​
    Weishaupt, J. H. ; Bartels, C. ; Pölking, E. ; Dietrich, J.; Rohde, G. ; Poeggeler, B.   & Mertens, N. et al.​ (2006) 
    Journal of Pineal Research41(4) pp. 313​-323​.​ DOI: 
    Details  DOI 
  • 2006 Journal Article
    ​ ​Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin​
    Sirén, A.-L. ; Radyushkin, K.; Boretius, S. ; Kämmer, D. ; Riechers, C.-C. ; Natt, O.   & Sargin, D.  et al.​ (2006) 
    Brain129(2) pp. 480​-489​.​ DOI: 10.1093/brain/awh703 
    Details  DOI; DOI 
  • 2006 Journal Article
    ​ ​The brain erythropoietin system and its potential for therapeutic exploitation in brain disease​
    Hasselblatt, M. ; Ehrenreich, H.   & Sirén, A.-L. ​ (2006) 
    Journal of Neurosurgical Anesthesiology18(2) pp. 132​-138​.​
    Details  PMID  PMC 
  • 2006 Journal Article
    ​ ​Cell type specific signalling by hematopoietic growth factors in neural cells​
    Byts, N.; Samoylenko, A.; Woldt, H. ; Ehrenreich, H.   & Sirén, A.-L. ​ (2006) 
    Neurochemical Research,(10) pp. 1219​-1230​.​
  • 2005 Journal Article
    ​ ​Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: A neuroprotective substitution effect?​
    Unzicker, C. ; Erberich, H. ; Moldrich, G. ; Woldt, H. ; Bulla, J.; Mechoulam, R. & Ehrenreich, H.  et al.​ (2005) 
    Neurochemical Research30(10) pp. 1305​-1309​.​ DOI: 
    Details  DOI 
  • 2005 Journal Article
    ​ ​In vitro gender differences in neuronal survival on hypoxia and in 17 beta-estradiol-mediated neuroprotection​
    Heyer, A. ; Hasselblatt, M. ; von Ahsen, N. ; Häfner, H.; Sirén, A.-L.   & Ehrenreich, H. ​ (2005) 
    Journal of Cerebral Blood Flow and Metabolism25(4) pp. 427​-430​.​ DOI: 
    Details  DOI 
  • 2005 Journal Article
    ​ ​A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain​
    Hasselblatt, M. ; Knerlich, F. ; von Ahsen, N. ; Jacob, S. ; Sperling, S. ; Woldt, H.   & Vehmeyer, K.  et al.​ (2005) 
    Proceedings of the National Academy of Sciences of the United States of America102(3) pp. 862​-867​.​ DOI: 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Expression patterns of erythropoietin and its receptor in the developing spinal cord and dorsal root ganglia​
    Knabe, W. ; Sirén, A.-L. ; Ehrenreich, H.   & Kuhn, H.-J. ​ (2005) 
    Anatomy and Embryology210 pp. 209​-219​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2004 Journal Article | Research Paper
    ​ ​Effect of Erythropoietin Axotomy-Induced Apoptosis in Rat Retinal Ganglion Cells​
    Weishaupt, J. H. ; Rohde, G. ; Pölking, E. ; Sirén, A.-L. ; Ehrenreich, H.   & Bähr, M. ​ (2004) 
    Investigative Ophthalmology & Visual Science45(5) pp. 1514​-1522​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2004 Journal Article
    ​ ​Endothelins regulate astrocyte gap junctions in rat hippocampal slices​
    Blomstrand, F.; Venance, L.; Sirén, A.-L. ; Ezan, P.; Hanse, E.; Glowinski, J. & Ehrenreich, H.  et al.​ (2004) 
    European Journal of Neuroscience : European Neuroscience Association,(4) pp. 1005​-1015​.​
  • 2004 Journal Article
    ​ ​Endothelin B receptor deficient transgenic rescue rats: A rescue phenomenon in the brain​
    Riechers, C.-C. ; Knabe, W. ; Sirén, A.-L. ; Gariepy, C. E.; Yanagisawa, M. & Ehrenreich, H. ​ (2004) 
    Neuroscience,(4) pp. 719​-723​.​
    Details  PMID  PMC 
  • 2004 Journal Article
    ​ ​A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia​
    Ehrenreich, H. ; Timner, W. & Sirén, A.-L. ​ (2004) 
    Transfusion and Apheresis Science,(1) pp. 39​-44​.​
  • 2004 Journal Article
    ​ ​Erythropoietin: Novel approaches to neuroprotection in human brain disease​
    Ehrenreich, H. ; Aust, C. ; Krampe, H. ; Jahn, H. ; Jacob, S. ; Herrmann, M. & Sirén, A.-L. ​ (2004) 
    Metabolic Brain Disease19(3-4) pp. 195​-206​.​
  • 2004 Journal Article
    ​ ​Erythropoietin: a candidate compound for neuroprotection in schizophrenia​
    Ehrenreich, H. ; Degner, D. ; Meller, J. ; Brines, M.; Behe, M.; Hasselblatt, M.   & Woldt, H.  et al.​ (2004) 
    Molecular Psychiatry9(1) pp. 42​-54​.​ DOI: 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Soccer, neurotrauma and amyotrophic lateral sclerosis: is there a connection?​
    Piazza, O.; Siren, A.-L.   & Ehrenreich, H. ​ (2004) 
    Current Medical Research and Opinion20(4) pp. 505​-508​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2003 Journal Article
    ​ ​EPO - Neuroprotektion bei Hirnerkrankungen​
    Ehrenreich, H.   & Sirén, A.-L. ​ (2003) 
    Georgia Augusta,(1) pp. 111​-115​.​
  • 2003 Journal Article
    ​ ​Effect of endothelin-1 on astrocytic protein content​
    Hasselblatt, M. ; Bunte, M.; Dringen, R.; Tabernero, A.; Medina, J. M.; Giaume, C. & Sirén, A.-L.  et al.​ (2003) 
    Glia42(4) pp. 390​-397​.​ DOI: 
    Details  DOI 
  • 2002 Journal Article
    ​ ​Erytropoietin treatment for human stroke is safe and beneficial​
    Ehrenreich, H. ; Hasselblatt, M. ; Cepek, L. ; Jacob, S. ; Knerlich, F.   & Sirén, A.-L. ​ (2002) 
    Molecular Medicine8(8).​
  • 2002 Journal Article | Research Paper
    ​ ​EPO bei Patienten mit akuter zerebraler Ischämie : ein neues Therapiekonzept​
    Ehrenreich, H. ; Sirén, A.-L. ; Kochen, M. M.   & Prange, H. ​ (2002) 
    Zeitschrift für Allgemeinmedizin, pp. 508​-511​.​
  • 2002 Journal Article
    ​ ​Endothelin B receptor deficiency augments neuronal damage upon exposure to hypoxia-ischemia in vivo​
    Siren, A. L. ; Lewczuk, P. ; Hasselblatt, M. ; Dembowski, C. ; Schilling, L. & Ehrenreich, H. ​ (2002) 
    Brain Research,(1) pp. 144​-149​.​
    Details  PMID  PMC 
  • 2002 Journal Article | Research Paper
    ​ ​Erythropoietin therapy for acute stroke is both safe and beneficial​
    Ehrenreich, H. ; Hasselblatt, M. ; Dembowski, C. ; Cepek, L. ; Lewczuk, P. ; Stiefel, M.   & Rustenbeck, H.-H.  et al.​ (2002) 
    Molecular Medicine8(8) pp. 495​-505​.​
  • 2002 Journal Article
    ​ ​Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients​
    Jacob, S. ; Poeggeler, B. ; Weishaupt, J. H. ; Sirén, A.-L. ; Hardeland, R. ; Bähr, M.   & Ehrenreich, H. ​ (2002) 
    Journal of Pineal Research33(3) pp. 186​-187​.​ DOI: 
    Details  DOI 
  • 2001 Journal Article
    ​ ​Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress​
    Sirén, A.-L. ; Fratelli, M.; Brines, M.; Goemans, C.; Casagrande, S.; Lewczuk, P.   & Keenan, S. et al.​ (2001) 
    Proceedings of the National Academy of Sciences of the United States of America98(7) pp. 4044​-4049​.​ DOI: 
    Details  DOI 

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