Prof. Dr. Jürgen Brockmöller

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  • 2022 | Journal Article
    ​ ​Substrates and Inhibitors of the Organic Cation Transporter 3 and Comparison with OCT1 and OCT2​
    Gebauer, L.; Jensen, O. ; Brockmöller, J.   & Dücker, C.​ (2022) 
    Journal of Medicinal Chemistry, 65(18) pp. 12403​-12416​.​ DOI: https://doi.org/10.1021/acs.jmedchem.2c01075 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1​
    Jensen, O.; Gebauer, L.; Brockmöller, J.   & Dücker, C.​ (2022) 
    International Journal of Molecular Sciences, 23(4) pp. 2007​.​ DOI: https://doi.org/10.3390/ijms23042007 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Substrates of the Human Brain Proton-Organic Cation Antiporter and Comparison with Organic Cation Transporter 1 Activities​
    Doetsch, D. A.; Ansari, S.; Jensen, O. ; Gebauer, L.; Dücker, C.; Brockmöller, J.   & Sachkova, A.​ (2022) 
    International Journal of Molecular Sciences, 23(15) pp. 8430​.​ DOI: https://doi.org/10.3390/ijms23158430 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​The mystery of the human proton-organic cation antiporter: One transport protein or many?​
    Sachkova, A.; Jensen, O. ; Dücker, C.; Ansari, S. & Brockmöller, J. ​ (2022) 
    Pharmacology & Therapeutics, 239 art. 108283​.​ DOI: https://doi.org/10.1016/j.pharmthera.2022.108283 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​How precise is quantitative prediction of pharmacokinetic effects due to drug-drug interactions and genotype from in vitro data? A comprehensive analysis on the example CYP2D6 and CYP2C19 substrates​
    Dücker, C. & Brockmöller, J. ​ (2021) 
    Pharmacology & Therapeutics, 217 pp. 107629​.​ DOI: https://doi.org/10.1016/j.pharmthera.2020.107629 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation​
    Jensen, O. ; Brockmöller, J.   & Dücker, C.​ (2021) 
    Journal of Medicinal Chemistry, 64(5) pp. 2762​-2776​.​ DOI: https://doi.org/10.1021/acs.jmedchem.0c02047 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines​
    Rossi, S.; Antal, A. ; Bestmann, S.; Bikson, M.; Brewer, C.; Brockmöller, J.   & Carpenter, L. L. et al.​ (2021) 
    Clinical Neurophysiology, 132(1) pp. 269​-306​.​ DOI: https://doi.org/10.1016/j.clinph.2020.10.003 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?​
    Jensen, O. ; Rafehi, M. ; Gebauer, L. & Brockmöller, J. ​ (2021) 
    Frontiers in Pharmacology, 11.​ DOI: https://doi.org/10.3389/fphar.2020.609811 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​A double-Flp-in method for stable overexpression of two genes​
    Jensen, O. ; Ansari, S.; Gebauer, L.; Müller, S. F.; Lowjaga, K. A. A. T.; Geyer, J. & Tzvetkov, M. V.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-71051-5 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans​
    Matthaei, J. ; Bonat, W. H.; Kerb, R.; Tzvetkov, M. V. ; Strube, J.; Brunke, S. & Sachse-Seeboth, C. et al.​ (2020) 
    Frontiers in Genetics, 11.​ DOI: https://doi.org/10.3389/fgene.2020.00944 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters​
    Jensen, O. ; Rafehi, M. ; Tzvetkov, M. V.   & Brockmöller, J. ​ (2020) 
    Biochemical Pharmacology, 171 pp. 113731​.​ DOI: https://doi.org/10.1016/j.bcp.2019.113731 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1​
    Meyer, M. J. ; Neumann, V. E.; Friesacher, H. R.; Zdrazil, B.; Brockmöller, J.   & Tzvetkov, M. V. ​ (2019) 
    Journal of Medicinal Chemistry, 62(21) pp. 9890​-9905​.​ DOI: https://doi.org/10.1021/acs.jmedchem.9b01301 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression​
    Amare, A. T.; Schubert, K. O.; Tekola-Ayele, F.; Hsu, Y.-H.; Sangkuhl, K.; Jenkins, G. & Whaley, R. M. et al.​ (2019) 
    Journal of Neural Transmission, 126(1) pp. 35​-45​.​ DOI: https://doi.org/10.1007/s00702-018-01966-x 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families​
    CHEN, J.-Y.; Brockmöller, J. ; Tzvetkov, M. V. ; Wang, L.-J. & Chen, X.-J.​ (2019) 
    Chinese Journal of Natural Medicines, 17(7) pp. 490​-497​.​ DOI: https://doi.org/10.1016/S1875-5364(19)30070-6 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Why Z-drugs are used even if doctors and nurses feel unable to judge their benefits and risks—a hospital survey​
    Heinemann, S. ; Brockmöller, J. ; Hagmayer, Y. & Himmel, W. ​ (2019) 
    European Journal of Clinical Pharmacology, 76(2) pp. 285​-290​.​ DOI: https://doi.org/10.1007/s00228-019-02783-1 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil​
    Matthaei, J. ; Seitz, T. ; Jensen, O. ; Tann, A.; Prukop, T. ; Tadjerpisheh, S. & Brockmöller, J.  et al.​ (2019) 
    Clinical Pharmacology and Therapeutics, 105(1) pp. 190​-200​.​ DOI: https://doi.org/10.1002/cpt.1128 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Variability and heritability of thiamine pharmacokinetics with focus on OCT1 effects on membrane transport and pharmacokinetics in humans​
    Jensen, O. ; Matthaei, J. ; Blome, F.; Schwab, M.; Tzvetkov, M. V.   & Brockmöller, J. ​ (2019) 
    Clinical Pharmacology and Therapeutics, 107(3) pp. 628​-638​.​ DOI: https://doi.org/10.1002/cpt.1666 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A​
    Rafehi, M. ; Faltraco, F.; Matthaei, J. ; Prukop, T. ; Jensen, O. ; Grytzmann, A. & Berger, R. G. et al.​ (2019) 
    Frontiers in Pharmacology, 10 pp. 1297​.​ DOI: https://doi.org/10.3389/fphar.2019.01297 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder​
    Amare, A. T.; Schubert, K. O.; Tekola-Ayele, F.; Hsu, Y.-H.; Sangkuhl, K.; Jenkins, G. & Whaley, R. M. et al.​ (2018) 
    Frontiers in Psychiatry, 9.​ DOI: https://doi.org/10.3389/fpsyt.2018.00065 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age- vs. Genotype-Related Differences​
    Dücker, C. M. & Brockmöller, J. ​ (2018) 
    Clinical Pharmacology & Therapeutics, 105(3) pp. 625​-640​.​ DOI: https://doi.org/10.1002/cpt.1057 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1)​
    Bokelmann, K.; Brockmöller, J.   & Tzvetkov, M. ​ (2018) 
    Journal of Personalized Medicine, 8(4) pp. 42​.​ DOI: https://doi.org/10.3390/jpm8040042 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Population nutrikinetics of green tea extract​
    Scholl, C.; Lepper, A.; Lehr, T.; Hanke, N.; Schneider, K. L.; Brockmöller, J.   & Seufferlein, T. et al.​ (2018) 
    PLoS One, 13(2) pp. e0193074​.​ DOI: https://doi.org/10.1371/journal.pone.0193074 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Falls: the adverse drug reaction of the elderly and the impact of pharmacogenetics​
    Just, K. S.; Schneider, K. L.; Schurig, M.; Stingl, J. C. & Brockmöller, J. ​ (2017) 
    Pharmacogenomics, 18(13) pp. 1281​-1297​.​ DOI: https://doi.org/10.2217/pgs-2017-0018 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines​
    Antal, A. ; Alekseichuk, I. ; Bikson, M.; Brockmöller, J. ; Brunoni, A.; Chen, R. & Cohen, L. et al.​ (2017) 
    Clinical Neurophysiology, 128(9) pp. 1774​-1809​.​ DOI: https://doi.org/10.1016/j.clinph.2017.06.001 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Pharmacogenomic aspects of bipolar disorder: An update​
    Budde, M. ; Degner, D. ; Brockmöller, J.   & Schulze, T.​ (2017) 
    European Neuropsychopharmacology, 27(6) pp. 599​-609​.​ DOI: https://doi.org/10.1016/j.euroneuro.2017.02.001 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency​
    Tzvetkov, M. V. ; Matthaei, J. ; Pojar, S.; Faltraco, F.; Vogler, S.; Prukop, T.   & Seitz, T.  et al.​ (2017) 
    Clinical Pharmacology & Therapeutics, 103(5) pp. 868​-878​.​ DOI: https://doi.org/10.1002/cpt.812 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine​
    Meyer, M. J. ; Seitz, T. ; Brockmöller, J.   & Tzvetkov, M. V. ​ (2017) 
    PLOS ONE, 12(12) art. e0189521​.​ DOI: https://doi.org/10.1371/journal.pone.0189521 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study​
    Schütz, E. ; Fischer, A.; Beck, J.; Harden, M. ; Koch, M.; Wuensch, T. & Stockmann, M. et al.​ (2017) 
    PLoS Medicine, 14(4) art. e1002286​.​ DOI: https://doi.org/10.1371/journal.pmed.1002286 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption​
    Stamer, U. M.; Frank, M.; Stüber, F.; Brockmöller, J. ; Steffens, M. & Tzvetkov, M. V.​ (2016) 
    Pain, 157(11) pp. 2467​-2475​.​ DOI: https://doi.org/10.1097/j.pain.0000000000000662 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Heritability of Metoprolol and Torsemide Pharmacokinetics​
    Matthaei, J. ; Brockmöller, J. ; Tzvetkov, M. V. ; Sehrt, D.; Sachse-Seeboth, C.; Hjelmborg, J. B. & Möller, S. et al.​ (2015) 
    Clinical Pharmacology & Therapeutics, 98(6) pp. 611​-621​.​ DOI: https://doi.org/10.1002/cpt.258 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant​
    Schirmer, M. A. ; Mergler, C. P. N.; Rave-Fränk, M. ; Herrmann, M. K. A.; Hennies, S.; Gaedcke, J.   & Conradi, L.-C.  et al.​ (2012) 
    International Journal of Radiation Oncology*Biology*Physics, 83(1) pp. 149​-157​.​ DOI: https://doi.org/10.1016/j.ijrobp.2011.05.063 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Halogenated volatile anesthetics alter brain metabolism as revealed by proton magnetic resonance spectroscopy of mice in vivo​
    Boretius, S. ; Tammer, R. ; Michaelis, T. ; Brockmöller, J.   & Frahm, J. ​ (2012) 
    NeuroImage, 69 pp. 244​-255​.​ DOI: https://doi.org/10.1016/j.neuroimage.2012.12.020 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype​
    Seegers, J.; Vos, M. A.; Flevari, P.; Willems, R.; Sohns, C.; Vollmann, D. & Luethje, L.  et al.​ (2012) 
    EP Europace, 14(3) pp. 416​-422​.​ DOI: https://doi.org/10.1093/europace/eur352 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​TGFB1 Pro25 allele as a risk marker for higher-grade acute Organ toxicity (CTC >= Grad2) during neoadjuvant Chemoradiotherapy in patients with locally advanced Rectal cancer (UICC Stage II/III)​
    Christiansen, H.; Schirmer, M. A. ; Mergler, C. P. N.; Rave-Fränk, M. ; Hennies, S.; Gaedcke, J.   & Conradi, L.-C.  et al.​ (2011)
    Strahlentherapie und Onkologie, 187 , Wiesbaden, GERMANY.
    Munich​: Urban & Vogel.
    ​Details  WoS 
  • 2011 | Journal Article | 
    ​ ​A PUTATIVELY FUNCTIONAL HAPLOTYPE IN THE GENE ENCODING TRANSFORMING GROWTH FACTOR BETA-1 AS A POTENTIAL BIOMARKER FOR RADIOSENSITIVITY​
    Schirmer, M. A.; Brockmöller, J. ; Rave-Fränk, M. ; Virsik, P.; Wilken, B.; Kühnle, E. & Campean, R. et al.​ (2011) 
    International Journal of Radiation Oncology*Biology*Physics, 79(3) pp. 866​-874​.​ DOI: https://doi.org/10.1016/j.ijrobp.2010.08.040 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article
    ​ ​Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol​
    Kirchheiner, J.; Keulen, J. Keulen, Jan-Tobias H. A.; Bauer, S.; Roots, I. & Brockmoeller, J. ​ (2008) 
    Journal of Clinical Psychopharmacology, 28(1) pp. 78​-83​.​ DOI: https://doi.org/10.1097/JCP.0b013e318160f827 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article
    ​ ​Genetic variants in FKBP5 affecting response to antidepressant drug treatment​
    Kirchheiner, J.; Lorrh, R.; Lebedeva, E. V.; Seeringe, A.; Roots, I.; Sasse, J. & Brockmdller, J. ​ (2008) 
    Pharmacogenomics, 9(7) pp. 841​-846​.​ DOI: https://doi.org/10.2217/14622416.9.7.841 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article
    ​ ​Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma​
    Mössner, R. ; Anders, N.; König, I. R.; Krüger, U. ; Schmidt, D.; Berking, C. & Ziegler, A. et al.​ (2007) 
    Archives of Dermatological Research, 298(8) pp. 371​-379​.​ DOI: https://doi.org/10.1007/s00403-006-0708-7 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article
    ​ ​Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms​
    Vormfelde, S. V.; Hoell, I.; Tzvetkov, M.; Jamrozinski, K.; Sehrt, D.; Brockmöller, J.   & Leibing, E.​ (2006) 
    Journal of Psychiatric Research, 40(6) pp. 568​-576​.​ DOI: https://doi.org/10.1016/j.jpsychires.2005.10.002 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity​
    Wojnowski, L.; Kulle, B.; Schirmer, M. ; Schlüter, G.; Schmidt, A.; Rosenberger, A.   & Vonhof, S. et al.​ (2005) 
    Circulation, 112(24) pp. 3754​-3762​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.576850 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Application of genomewide SNP arrays for detection of simulated susceptibility loci​
    Kulle, B.; Schirmer, M. ; Toliat, M. R.; Suk, A.; Becker, C.; Tzvetkov, M.   & Brockmöller, J.  et al.​ (2005) 
    Human Mutation, 25(6) pp. 557​-565​.​ DOI: https://doi.org/10.1002/humu.20174 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article
    ​ ​Association of metabolic gene polymorphisms with tobacco consumption in healthy controls​
    Smits, K. M.; Benhamou, S.; Garte, S.; Weijenberg, M. P.; Alamanos, Y.; Ambrosone, C. & Autrup, H. et al.​ (2004) 
    International Journal of Cancer, 110(2) pp. 266​-270​.​ DOI: https://doi.org/10.1002/ijc.20114 
    ​Details  DOI  PMID  PMC  WoS 
  • 2001 | Review
    ​ ​CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages​
    Kirchheiner, J.; Brøsen, K.; Dahl, M. L.; Gram, L. F.; Kasper, S.; Roots, I.& Sjöqvist, F. et al.​ (2001)
    Acta Psychiatrica Scandinavica, 104​(3) pp. 173​-192​.​ DOI: https://doi.org/10.1034/j.1600-0447.2001.00299.x 
    ​Details  DOI  PMID  PMC  WoS 

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