Prof. Dr. Mikael Simons

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  • 2023 Journal Article
    ​ ​Membrane lipid remodeling modulates γ-secretase processivity​
    Dawkins, E.; Derks, R. J. E.; Schifferer, M. ; Trambauer, J.; Winkler, E.; Simons, M.   & Paquet, D. et al.​ (2023) 
    The Journal of Biological Chemistry, art. 103027​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article
    ​ ​Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry​
    Arends, M.; Weber, M.; Papan, C.; Damm, M.; Surma, M. A; Spiegel, C. & Djannatian, M. et al.​ (2022) 
    iScience25(11) art. 105323​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Overview
    ​ ​CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities​
    Franklin, R. J. M. & Simons, M. ​ (2022) 
    Neuron110(21) pp. 3549​-3565​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Overview
    ​ ​Reparative inflammation in multiple sclerosis​
    Cantuti-Castelvetri, L. ; Gokce, O.   & Simons, M. ​ (2022) 
    Seminars in Immunology59 art. 101630​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Research Paper
    ​ ​A fluorescence microscopy-based protocol for volumetric measurement of lysolecithin lesion-associated de- and re-myelination in mouse brain​
    Bosch-Queralt, M.; Tiwari, V.; Damkou, A.; Vaculčiaková, L.; Alexopoulos, I. & Simons, M. ​ (2022) 
    STAR Protocols3(1) art. 101141​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2021 Preprint
    ​ ​Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development​
    Djannatian, M.; Weikert, U.; Safaiyan, S.; Wrede, C.; Deichsel, C.; Kislinger, G.& Ruhwedel, T. et al.​ (2021). DOI: 
    Details  DOI 
  • 2021 Journal Article | Research Paper
    ​ ​Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination​
    Bosch-Queralt, M.; Cantuti-Castelvetri, L. ; Damkou, A.; Schifferer, M. ; Schlepckow, K.; Alexopoulos, I. & Lütjohann, D. et al.​ (2021) 
    Nature Metabolism3(2) pp. 211​-227​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper
    ​ ​TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination​
    Gouna, G.; Klose, C.; Bosch-Queralt, M.; Liu, L.; Gokce, O. ; Schifferer, M.   & Cantuti-Castelvetri, L.  et al.​ (2021) 
    Journal of Experimental Medicine218(10).​ DOI: 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper
    ​ ​Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing​
    Liu, L.; Besson-Girard, S.; Ji, H.; Gehring, K.; Bulut, B.; Kaya, T. & Usifo, F. et al.​ (2021) 
    STAR Protocols2(2) art. 100590​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper
    ​ ​Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery​
    Penkert, H.; Bertrand, A.; Tiwari, V.; Breimann, S.; Müller, S. A.; Jordan, P. M. & Gerl, M. J. et al.​ (2021) 
    Cell Reports37(4) art. 109898​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution​
    Kislinger, G.; Gnägi, H.; Kerschensteiner, M. ; Simons, M. ; Misgeld, T.   & Schifferer, M. ​ (2020) 
    iScience23(7) art. 101290​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity​
    Cantuti-Castelvetri, L.; Ojha, R.; Pedro, L. D.; Djannatian, M.; Franz, J.; Kuivanen, S. & van der Meer, F.  et al.​ (2020) 
    Science370(6518) pp. 856​-860​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis​
    Cunha, M. I.; Su, M.; Cantuti-Castelvetri, L. ; Müller, S. A.; Schifferer, M. ; Djannatian, M. & Alexopoulos, I. et al.​ (2020) 
    Journal of Experimental Medicine217(5).​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome​
    Fitzner, D.; Bader, J. M.; Penkert, H.; Bergner, C. G.; Su, M.; Weil, M.-T. & Surma, M. A. et al.​ (2020) 
    Cell Reports32(11) pp. 108132​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain​
    Mukherjee, C.; Kling, T.; Russo, B.; Miebach, K.; Kess, E.; Schifferer, M.   & Pedro, L. D. et al.​ (2020) 
    Cell Metabolism32(2) pp. 259.e10​-272.e10​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis​
    Berghoff, S. A.; Spieth, L.; Sun, T.; Hosang, L. ; Schlaphoff, L.; Depp, C. & Düking, T. et al.​ (2020) 
    Nature Neuroscience24(1) pp. 47​-60​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex​
    Kislinger, G.; Gnägi, H.; Kerschensteiner, M. ; Simons, M. ; Misgeld, T.   & Schifferer, M. ​ (2020) 
    STAR Protocols1(3) art. 100232​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Plasma lipidomics of monozygotic twins discordant for multiple sclerosis​
    Penkert, H.; Lauber, C.; Gerl, M. J.; Klose, C.; Damm, M.; Fitzner, D. & Flierl‐Hecht, A. et al.​ (2020) 
    Annals of Clinical and Translational Neurology7(12) pp. 2461​-2466​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | 
    ​ ​Myelin in the Central Nervous System: Structure, Function, and Pathology​
    Stadelmann, C. ; Timmler, S.; Barrantes-Freer, A.   & Simons, M. ​ (2019) 
    Physiological Reviews99(3) pp. 1381​-1431​.​ DOI: 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Polygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients​
    Papiol, S. ; Keeser, D.; Hasan, A.; Schneider-Axmann, T.; Raabe, F.; Degenhardt, F. & Rossner, M. J.  et al.​ (2019) 
    Translational Psychiatry9(1) art. 284​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article
    ​ ​Defective cholesterol clearance limits remyelination in the aged central nervous system​
    Cantuti-Castelvetri, L.; Fitzner, D.; Bosch-Queralt, M.; Weil, M.-T.; Su, M.; Sen, P. & Ruhwedel, T. et al.​ (2018) 
    Science359(6376) pp. 684​-688​.​ DOI: 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells​
    Page, N.; Klimek, B.; De Roo, M.; Steinbach, K.; Soldati, H.; Lemeille, S. & Wagner, I. et al.​ (2018) 
    Immunity48(5) pp. 937​-950.e8​.​ DOI: 
    Details  DOI 
  • 2017 Journal Article
    ​ ​BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions​
    Fard, M. K.; van der Meer, F. ; Sánchez, P.; Cantuti-Castelvetri, L.; Mandad, S. ; Jäkel, S. & Fornasiero, E. F.  et al.​ (2017) 
    Science Translational Medicine9(419) pp. eaam7816​.​ DOI: 
    Details  DOI 
  • 2016 Journal Article | Research Paper
    ​ ​Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy​
    Steshenko, O.; Andrade, D. M.; Honigmann, A.; Mueller, V.; Schneider, F.; Sezgin, E. & Hell, S.  et al.​ (2016) 
    Biophysical Journal110(11) pp. 2441​-2450​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​Subcortical cytoskeleton periodicity throughout the nervous system​
    d'Este, E. ; Kamin, D.; Velte, C.; Göttfert, F. ; Simons, M.   & Hell, S. ​ (2016) 
    Scientific Reports6 art. 22741​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation​
    Kunadt, M.; Eckermann, K.; Stuendl, A.; Gong, J.; Russo, B.; Strauss, K. & Rai, S. et al.​ (2015) 
    Acta Neuropathologica129(5) pp. 695​-713​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | 
    ​ ​Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma​
    Grapp, M.; Wrede, A.; Schweizer, M.; Huewel, S.; Galla, H.-J.; Snaidero, N. & Simons, M.  et al.​ (2013) 
    Nature Communications4 art. 2123​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Letter Note
    ​ ​Teaching NeuroImages: Ma2 encephalitis presenting as acute panhypopituitarism in a young man​
    Bergner, C. G.; Lang, C. ; Spreer, A. ; Bähr, M. ; Mohr, A.   & Simons, M. ​ (2013) 
    Neurology81(19) pp. E146​-E147​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension​
    Sandalon, S.; Könnecke, B. ; Levkovitch-Verbin, H.; Simons, M. ; Hein, K.; Sättler, M. B.   & Bähr, M.  et al.​ (2013) 
    Experimental Eye Research115 pp. 47​-56​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article
    ​ ​BACE1 in central nervous system myelination revisited​
    Treiber, H.; Hagemeyer, N.; Ehrenreich, H.   & Simons, M. ​ (2012) 
    Molecular Psychiatry17(3) pp. 237​-239​.​ DOI: 
    Details  DOI 
  • 2012 Journal Article
    ​ ​The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells​
    Karpiuk, O.; Najafova, Z. ; Kramer, F. ; Hennion, M. ; Galonska, C.; Koenig, A. & Snaidero, N. et al.​ (2012) 
    Molecular Cell46(5) pp. 705​-713​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | 
    ​ ​Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice​
    Hagemeyer, N.; Boretius, S. ; Ott, C. ; Von Streitberg, A.; Welpinghus, H.; Sperling, S.   & Frahm, J.  et al.​ (2012) 
    Molecular Medicine,(4) pp. 628​-635​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2011 Journal Article
    ​ ​Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B​
    Prenzel, T.; Begus-Nahrmann, Y.; Kramer, F. ; Hennion, M. ; Hsu, C.; Gorsler, T. & Hintermair, C. et al.​ (2011) 
    Cancer Research71(17) pp. 5739​-5753​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons​
    Schneider, A. ; Rajendran, L.; Honsho, M.; Gralle, M. ; Donnert, G.; Wouters, F. S.   & Hell, S.  et al.​ (2008) 
    The Journal of Neuroscience28(11) pp. 2874​-2882​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin​
    Fitzner, D.; Schneider, A. ; Kippert, A.; Möbius, W. ; Willig, K. I. ; Hell, S.   & Bunt, G. et al.​ (2006) 
    EMBO Journal25(21) pp. 5037​-5048​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 1999 Journal Article | Research Paper
    ​ ​Adenovirus-mediated gene transfer of inhibitors of apoptosis proteins delays apoptosis in cerebellar granule neurons​
    Simons, M. ; Beinroth, S.; Gleichmann, M.; Liston, P.; Korneluk, R. G.; MacKenzie, A. E. & Bähr, M.  et al.​ (1999) 
    Journal of Neurochemistry72(1) pp. 292​-301​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 

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