Prof. Dr. Hans A. Kretzschmar

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  • 2015 Journal Article | 
    ​ ​Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies​
    Wagner, J. ; Krauss, S.; Shi, S.; Ryazanov, S. ; Steffen, J.; Miklitz, C. & Leonov, A.  et al.​ (2015) 
    Acta Neuropathologica130(5) pp. 619​-631​.​ DOI: https://doi.org/10.1007/s00401-015-1483-3 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Conference Abstract
    ​ ​The oligomer modulator anle138b is effective in the prodromal phase of a transgenic mouse model of Parkinson's disease​
    Prix, C.; Schmidt, F.; Levin, J.; Schinke, K.; Shi, S.; Ryazanov, S.   & Leonov, A.  et al.​ (2014)
    ​European Journal of Neurology. ​Joint Congress of European Neurology​, Istanbul, Turkey.
    Details 
  • 2014 Journal Article | Research Paper
    ​ ​MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease​
    Banzhaf-Strathmann, J.; Benito-Garagorri, E.; May, S.; Arzberger, T.; Tahirovic, S.; Kretzschmar, H. A.   & Fischer, A.  et al.​ (2014) 
    EMBO Journal33(15) pp. 1667​-1680​.​ DOI: https://doi.org/10.15252/embj.201387576 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease​
    Wagner, J. ; Ryazanov, S. ; Leonov, A. ; Levin, J.; Shi, S.; Schmidt, F. & Prix, C. et al.​ (2013) 
    Acta Neuropathologica125(6) pp. 795​-813​.​ DOI: https://doi.org/10.1007/s00401-013-1114-9 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article
    ​ ​Decreased  β-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease​
    Otto, M. ; Esselmann, H. ; Schulz-Schaeffer, W. ; Neumann, M.; Schröter, A. ; Ratzka, P.   & Cepek, L.  et al.​ (2012) 
    Neurology54(5) pp. 1099​-1102​.​ DOI: https://doi.org/10.1212/wnl.54.5.1099 
    Details  DOI 
  • 2012 Journal Article
    ​ ​Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease​
    Otto, M. ; Wiltfang, J. ; Cepek, L. ; Neumann, M.; Mollenhauer, B. ; Steinacker, P.   & Ciesielczyk, B.  et al.​ (2012) 
    Neurology58(2) pp. 192​-197​.​ DOI: https://doi.org/10.1212/wnl.58.2.192 
    Details  DOI 
  • 2012 Journal Article
    ​ ​Decreased CSF amyloid  42 and normal tau levels in dementia with Lewy bodies​
    Tschampa, H. J.; Schulz-Schaeffer, W. ; Wiltfang, J. ; Poser, S. ; Otto, M. ; Neumann, M. & Kretzschmar, H. A.  et al.​ (2012) 
    Neurology56(4).​ DOI: https://doi.org/10.1212/wnl.56.4.576 
    Details  DOI 
  • 2011 Journal Article
    ​ ​Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study​
    Otto, M. ; Wiltfang, J. ; Schütz, E. ; Zerr, I. ; Otto, A.; Pfahlberg, A.   & Gefeller, O.  et al.​ (2011) 
    BMJ316(7131) pp. 577​-582​.​ DOI: https://doi.org/10.1136/bmj.316.7131.577 
    Details  DOI 
  • 2008 Journal Article
    ​ ​Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease​
    Brechlin, P.; Jahn, O. ; Steinacker, P. ; Cepek, L. ; Kratzin, H. D. ; Lehnert, S. & Jesse, S. et al.​ (2008) 
    Proteomics8(20) pp. 4357​-4366​.​ DOI: https://doi.org/10.1002/pmic.200800375 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article
    ​ ​Proteomic analysis of the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease​
    Cepek, L. ; Brechlin, P.; Steinacker, P. ; Mollenhauer, B. ; Klingebiel, E.; Bibl, M.   & Kretzschmar, H. A.  et al.​ (2007) 
    Dementia and Geriatric Cognitive Disorders23(1) pp. 22​-28​.​ DOI: https://doi.org/10.1159/000096589 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article
    ​ ​Unaltered apoptotic behaviour of mononuclear cells from patients with sporadic Creutzfeldt-Jakob disease​
    Ratzka, P. ; Schröter, A. ; Cepek, L. ; Henkel, K. ; Wiltfang, J. ; Kretzschmar, H. A.   & Prange, H.  et al.​ (2006) 
    Journal of Neurology248(8) pp. 690​-694​.​ DOI: https://doi.org/10.1007/pl00007834 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Tau protein, A beta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies​
    Mollenhauer, B. ; Cepek, L.; Bibl, M. ; Wiltfang, J.; Schulz-Schaeffer, W. J. ; Ciesielczyk, B.   & Neumann, M. et al.​ (2005) 
    Dementia and Geriatric Cognitive Disorders19(2-3) pp. 164​-170​.​ DOI: https://doi.org/10.1159/000083178 
    Details  DOI  PMID  PMC  WoS 
  • 2003 Journal Article
    ​ ​Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt–Jakob disease​
    Ratzka, P. ; Döhlinger, S.; Cepek, L. ; Steinacker, P. ; Arlt, S.; Jacobi, C. & Schröter, A.  et al.​ (2003) 
    Neuroscience Letters343(1) pp. 29​-32​.​ DOI: https://doi.org/10.1016/S0304-3940(03)00315-X 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article
    ​ ​Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease​
    Itoh, N.; Arai, H.; Urakami, K.; Ishiguro, K.; Ohno, H.; Hampel, H. & Buerger, K. et al.​ (2001) 
    Annals of Neurology50(2) pp. 150​-156​.​ DOI: https://doi.org/10.1002/ana.1054 
    Details  DOI 
  • 2001 Journal Article
    ​ ​Elevation of β-Amyloid Peptide 2–42 in Sporadic and Familial Alzheimer's Disease and Its Generation in PS1 Knockout Cells​
    Jahn, H.; Kornhuber, J.; Wiltfang, J. ; Esselmann, H. ; Cupers, P.; Neumann, M. & Kretzschmar, H.  et al.​ (2001) 
    Journal of Biological Chemistry276(46) pp. 42645​-42657​.​ DOI: https://doi.org/10.1074/jbc.M102790200 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article
    ​ ​Creutzfeldt-Jakob disease and oxidative stress​
    Bleich, S. ; Kropp, S. ; Degner, D. ; Zerr, I. ; Pilz, J. ; Gleiter, C. H.   & Otto, M.  et al.​ (2000) 
    Acta Neurologica Scandinavica101(5) pp. 332​-334​.​ DOI: https://doi.org/10.1034/j.1600-0404.2000.9s290a.x 
    Details  DOI  PMID  PMC 
  • 1999 Journal Article
    ​ ​Laborchemische Verfahren in der Differentialdiagnose der Creutzfeldt-Jakob-Krankheit​
    Otto, M. ; Zerr, I. ; Wiltfang, J. ; Weber, T.; Kretzschmar, H. ; Poser, S.   & Felgenhauer, K. ​ (1999) 
    Deutsches Ärzteblatt33.​
    Details 
  • 1999 Journal Article | Research Paper
    ​ ​Evidence of presynaptic location and function of the prion protein​
    Herms, J.; Tings, T.; Gall, S.; Madlung, A.; Giese, A.; Siebert, H.   & Schurmann, P. et al.​ (1999) 
    The Journal of neuroscience19(20) pp. 8866​-8875​.​ DOI: https://doi.org/10.1523/JNEUROSCI.19-20-08866.1999 
    Details  DOI  PMID  PMC  WoS 
  • 1999 Journal Article
    ​ ​Isoform Pattern of 14-3-3 Proteins in the Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease​
    Wiltfang, J. ; Otto, M. ; Baxter, H. C.; Bodemer, M. ; Steinacker, P. ; Bahn, E.   & Zerr, I.  et al.​ (1999) 
    Journal of Neurochemistry73(6) pp. 2485​-2490​.​ DOI: https://doi.org/10.1046/j.1471-4159.1999.0732485.x 
    Details  DOI  PMID  PMC 
  • 1998 Journal Article
    ​ ​Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease​
    Zerr, I. ; Bodemer, M. ; Gefeller, O. ; Otto, M. ; Poser, S. ; Wiltfang, J.   & Windl, O.  et al.​ (1998) 
    Annals of Neurology43(1) pp. 32​-40​.​ DOI: https://doi.org/10.1002/ana.410430109 
    Details  DOI 
  • 1998 Journal Article
    ​ ​Authors reply; Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study​
    Otto, M. ; Wiltfang, J. ; Schütz, E. ; Zerr, I. ; Otto, A.; Pfahlberg, A.   & Gefeller, O.  et al.​ (1998) 
    British Medical Journal317 art. 472​.​
    Details 

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