Dr. Jochen Hans Weishaupt

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  • 2019 | Journal Article
    ​ ​Prognostic factors in ALS: a comparison between Germany and China​
    Dorst, J.; Chen, L.; Rosenbohm, A.; Dreyhaupt, J.; Hübers, A.; Schuster, J. & Weishaupt, J. H.  et al.​ (2019) 
    Journal of Neurology, 266(6) pp. 1516​-1525​.​ DOI: https://doi.org/10.1007/s00415-019-09290-4 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial​
    Ludolph, A. C; Schuster, J.; Dorst, J.; Dupuis, L.; Dreyhaupt, J.; Weishaupt, J. H   & Kassubek, J. et al.​ (2018) 
    The Lancet Neurology, 17(8) pp. 681​-688​.​ DOI: https://doi.org/10.1016/S1474-4422(18)30176-5 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies​
    Wagner, J. ; Krauss, S.; Shi, S.; Ryazanov, S. ; Steffen, J.; Miklitz, C. & Leonov, A.  et al.​ (2015) 
    Acta Neuropathologica, 130(5) pp. 619​-631​.​ DOI: https://doi.org/10.1007/s00401-015-1483-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity​
    Büchner, A.; Krumova, P.; Ganesan, S.; Bähr, M. ; Eckermann, K. & Weishaupt, J. H. ​ (2015) 
    NeuroMolecular Medicine, 17(1) pp. 12​-23​.​ DOI: https://doi.org/10.1007/s12017-014-8336-4 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation​
    Kunadt, M.; Eckermann, K.; Stuendl, A.; Gong, J.; Russo, B.; Strauss, K. & Rai, S. et al.​ (2015) 
    Acta Neuropathologica, 129(5) pp. 695​-713​.​ DOI: https://doi.org/10.1007/s00401-015-1408-1 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Rho Kinase Inhibition Modulates Microglia Activation and Improves Survival in a Model of Amyotrophic Lateral Sclerosis​
    Tönges, L. ; Günther, R. ; Suhr, M. ; Jansen, J.; Balck, A. ; Saal, K.-A.   & Barski, E.  et al.​ (2014) 
    Glia, 62(2) pp. 217​-232​.​ DOI: https://doi.org/10.1002/glia.22601 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration​
    Liman, J. ; Deeg, S. ; Voigt, A. ; Voßfeldt, H.; Dohm, C. P. ; Karch, A.   & Weishaupt, J.  et al.​ (2014) 
    Journal of Neurochemistry, 129(6) pp. 1013​-1023​.​ DOI: https://doi.org/10.1111/jnc.12684 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease​
    Wagner, J. ; Ryazanov, S. ; Leonov, A. ; Levin, J.; Shi, S.; Schmidt, F. & Prix, C. et al.​ (2013) 
    Acta Neuropathologica, 125(6) pp. 795​-813​.​ DOI: https://doi.org/10.1007/s00401-013-1114-9 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper
    ​ ​Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease​
    Frank, T. ; Klinker, F. ; Falkenburger, B. H.; Laage, R.; Lühder, F. ; Göricke, B. & Schneider, A. et al.​ (2012) 
    Brain, 135(6) pp. 1914​-1925​.​ DOI: https://doi.org/10.1093/brain/aws054 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Letter Note
    ​ ​Inflammatory demyelinating CNS disorder in a case of X-linked Charcot-Marie-Tooth disease: positive response to natalizumab​
    Weishaupt, J. H. ; Ganser, C. & Bähr, M. ​ (2012) 
    Journal of Neurology, 259(9) pp. 1967​-1969​.​ DOI: https://doi.org/10.1007/s00415-012-6467-9 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease​
    Tönges, L. ; Frank, T. ; Tatenhorst, L. ; Saal, K. A. ; Koch, J. C. ; Szego, E. M.   & Bähr, M.  et al.​ (2012) 
    Brain, 135(11) pp. 3355​-3370​.​ DOI: https://doi.org/10.1093/brain/aws254 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Sumoylation inhibits alpha-synuclein aggregation and toxicity​
    Krumova, P.; Meulmeester, E.; Garrido, M.; Tirard, M.; Hsiao, H.-H.; Bossis, G. & Urlaub, H.  et al.​ (2011) 
    The Journal of Cell Biology, 194(1) pp. 49​-60​.​ DOI: https://doi.org/10.1083/jcb.201010117 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper
    ​ ​CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis​
    Shevtsova, Z.; Garrido, M.; Weishaupt, J. ; Saftig, P. ; Bähr, M. ; Lühder, F.   & Kügler, S. ​ (2010) 
    The American Journal of Pathology, 177(1) pp. 271​-279​.​ DOI: https://doi.org/10.2353/ajpath.2010.091267 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | Research Paper
    ​ ​Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells​
    Bermel, C. ; Tönges, L. ; Planchamp, V. ; Gillardon, F.; Weishaupt, J. H. ; Dietz, G. P. H.   & Bähr, M.  et al.​ (2009) 
    Molecular and Cellular Neuroscience, 42(4) pp. 427​-437​.​ DOI: https://doi.org/10.1016/j.mcn.2009.09.005 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1(G93A)-transgenic mice​
    Rohde, G.; Kermer, P. ; Reed, J. C.; Bähr, M.   & Weishaupt, J. H. ​ (2008) 
    Neuroscience, 157(4) pp. 844​-849​.​ DOI: https://doi.org/10.1016/j.neuroscience.2008.09.055 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Membrane-permeable Bcl-x(L) prevents MPTP-induced dopaminergic neuronal loss in the substantia nigra​
    Dietz, G. P. H. ; Stockhausen (née Peters), K. V.; Dietz, B. ; Falkenburger, B. H.; Valbuena, P. ; Opazo, F.   & Lingor, P.  et al.​ (2008) 
    Journal of Neurochemistry, 104(3) pp. 757​-765​.​ DOI: https://doi.org/10.1111/j.1471-4159.2007.05028.x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper | 
    ​ ​Mutant SOD1 detoxification mechanisms in intact single cells​
    Ganesan, S.; Rohde, G.; Eckermann, K.; Sroka, K. ; Schaefer, M. K. E.; Dohm, C. P.   & Kermer, P.  et al.​ (2008) 
    Cell Death and Differentiation, 15(2) pp. 312​-321​.​ DOI: https://doi.org/10.1038/sj.cdd.4402262 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper | 
    ​ ​Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis​
    Meuer, K. ; Suppanz, I. E. ; Lingor, P. ; Planchamp, V. ; Göricke, B.; Fichtner, L.   & Braus, G. H.  et al.​ (2007) 
    Cell Death and Differentiation, 14(4) pp. 651​-661​.​ DOI: https://doi.org/10.1038/sj.cdd.4402087 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​A highly sensitive automated complex running wheel test to detect latent motor deficits in the mouse MPTP model of Parkinson's disease​
    Liebetanz, D. ; Baier, P. C.; Paulus, W. ; Meuer, K. ; Bähr, M.   & Weishaupt, J. H. ​ (2007) 
    Experimental Neurology, 205(1) pp. 207​-213​.​ DOI: https://doi.org/10.1016/j.expneurol.2007.01.030 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Review
    ​ ​Hematopoietic cytokines - on the verge of conquering neurology​
    Tönges, L. ; Schlachetzki, J. C. M.; Weishaupt, J. H.  & Bähr, M. ​ (2007)
    Current Molecular Medicine, 7​(2) pp. 157​-170​.​ DOI: https://doi.org/10.2174/156652407780059186 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article
    ​ ​Reduced oxidative damage in ALS by high-dose enteral melatonin treatment​
    Weishaupt, J. H. ; Bartels, C. ; Pölking, E. ; Dietrich, J.; Rohde, G. ; Poeggeler, B.   & Mertens, N. et al.​ (2006) 
    Journal of Pineal Research, 41(4) pp. 313​-323​.​ DOI: https://doi.org/10.1111/j.1600-079X.2006.00377.x 
    ​Details  DOI 
  • 2006 | Journal Article | Research Paper
    ​ ​Application of a blood-brain-barrier-penetrating form of GDNF in a mouse model for Parkinson's disease​
    Dietz, G. P. H. ; Valbuena, P. C. ; Dietz, B. ; Meuer, K. ; Müller, P. ; Weishaupt, J. H.   & Bähr, M. ​ (2006) 
    Brain Research, 1082(1) pp. 61​-66​.​ DOI: https://doi.org/10.1016/j.brainres.2006.01.083 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease​
    Meuer, K. ; Pitzer, C.; Teismann, P.; Krüger, C.; Göricke, B.; Laage, R. & Lingor, P.  et al.​ (2006) 
    Journal of Neurochemistry, 97(3) pp. 675​-686​.​ DOI: https://doi.org/10.1111/j.1471-4159.2006.03727.x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells​
    Weishaupt, J. H. ; Klocker, N. & Bähr, M. ​ (2005) 
    Journal of Molecular Neuroscience, 26(1) pp. 17​-25​.​ DOI: https://doi.org/10.1385/JMN:26:1:017 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article | Research Paper
    ​ ​Effect of Erythropoietin Axotomy-Induced Apoptosis in Rat Retinal Ganglion Cells​
    Weishaupt, J. H. ; Rohde, G. ; Pölking, E. ; Sirén, A.-L. ; Ehrenreich, H.   & Bähr, M. ​ (2004) 
    Investigative Ophthalmology & Visual Science, 45(5) pp. 1514​-1522​.​ DOI: https://doi.org/10.1167/iovs.03-1039 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article | Research Paper
    ​ ​The superoxide dismutase1 (SOD1) G93A mutation does not promote neuronal injury after focal brain ischemia and optic nerve transection in mice​
    Kilic, E. ; Weishaupt, J. H. ; Kilic, Ü.; Rohde, G. ; Yulug, B.; Peters, K. & Hermann, D. M. et al.​ (2004) 
    Neuroscience, 128(2) pp. 359​-364​.​ DOI: https://doi.org/10.1016/j.neuroscience.2004.06.064 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Review
    ​ ​Neuronal Apoptosis in Neurodegenerative Diseases: From Basic Research to Clinical Application​
    Kermer, P. ; Liman, J. ; Weishaupt, J. H.  & Bähr, M. ​ (2004)
    Neurodegenerative Diseases, 1​(1) pp. 9​-19​.​ DOI: https://doi.org/10.1159/000076665 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article
    ​ ​Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis​
    Jacob, S. ; Finsterbusch, J.; Weishaupt, J. H. ; Khorram-Sefat, D. ; Frahm, J.   & Ehrenreich, H. ​ (2003) 
    Neuroradiology,(9) pp. 598​-600​.​ DOI: https://doi.org/10.1007/s00234-003-1014-0 
    ​Details  DOI 
  • 2003 | Review
    ​ ​Kir channels in the CNS: emerging new roles and implications for neurological diseases​
    Neusch, C.; Weishaupt, J. H.  & Bähr, M. ​ (2003)
    Cell and Tissue Research, 311​(2) pp. 131​-138​.​ DOI: https://doi.org/10.1007/s00441-002-0669-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo​
    Weishaupt, J. H. ; Diem, R. ; Kermer, P. ; Krajewski, S.; Reed, J. C. & Bähr, M. ​ (2003) 
    Neurobiology of Disease, 13(2) pp. 124​-135​.​ DOI: https://doi.org/10.1016/S0969-9961(03)00032-9 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction​
    Weishaupt, J. H. ; Kussmaul, L.; Grotsch, P.; Hecke, A.; Rohde, G. ; Romig, H. & Bähr, M.  et al.​ (2003) 
    Molecular and Cellular Neuroscience, 24(2) pp. 489​-502​.​ DOI: https://doi.org/10.1016/S1044-7431(03)00221-5 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Review
    ​ ​Cyclin-dependent kinase 5 (CDK5) and neuronal cell death​
    Weishaupt, J. H. ; Neusch, C.& Bähr, M. ​ (2003)
    Cell and Tissue Research, 312​(1) pp. 1​-8​.​ DOI: https://doi.org/10.1007/s00441-003-0703-7 
    ​Details  DOI  PMID  PMC  WoS 
  • 2002 | Journal Article
    ​ ​Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients​
    Jacob, S. ; Poeggeler, B. ; Weishaupt, J. H. ; Sirén, A.-L. ; Hardeland, R. ; Bähr, M.   & Ehrenreich, H. ​ (2002) 
    Journal of Pineal Research, 33(3) pp. 186​-187​.​ DOI: https://doi.org/10.1034/j.1600-079X.2002.02943.x 
    ​Details  DOI 
  • 2001 | Journal Article | Research Paper
    ​ ​Degeneration of axotomized retinal ganglion cells as a model for neuronal apoptosis in the central nervous system - molecular death and survival pathways​
    Weishaupt, J. H.   & Bähr, M. ​ (2001) 
    Restorative neurology and neuroscience, 19(1-2) pp. 19​-27​.​
    ​Details  PMID  PMC  WoS 
  • 2001 | Journal Article | Research Paper
    ​ ​Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent Akt phosphorylation by tumor necrosis factor-alpha rescues axotomized retinal ganglion cells from retrograde cell death in vivo​
    Diem, R. ; Meyer, R. ; Weishaupt, J. H.   & Bähr, M. ​ (2001) 
    The Journal of neuroscience, 21(6) pp. 2058​-2066​.​
    ​Details  PMID  PMC  WoS 
  • 2001 | Journal Article | Research Paper
    ​ ​Transection of the optic nerve in rats: studying neuronal death and survival in vivo​
    Kermer, P. ; Klocker, N.; Weishaupt, J. H.   & Bähr, M. ​ (2001) 
    Brain Research Protocols, 7(3) pp. 255​-260​.​ DOI: https://doi.org/10.1016/S1385-299X(01)00076-9 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3 '-kinase/protein kinase B signaling​
    Klocker, N.; Kermer, P. ; Weishaupt, J. H. ; Labes, M.; Ankerhold, R. & Bähr, M. ​ (2000) 
    The Journal of neuroscience, 20(18) pp. 6962​-6967​.​
    ​Details  PMID  PMC  WoS 

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