Dr. rer. nat. Achim Dickmanns

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  • 2022 | Journal Article | Research Paper | 
    ​ ​MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression​
    Giansanti, C.; Manzini, V.; Dickmanns, A.; Dickmanns, A. ; Palumbieri, M. D.; Sanchi, A. & Kienle, S. M. et al.​ (2022) 
    Cell Reports, 39(9) art. 110879​.​ DOI: https://doi.org/10.1016/j.celrep.2022.110879 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1​
    Shaikhqasem, A.; Dickmanns, A. ; Neumann, P.   & Ficner, R. ​ (2020) 
    Journal of Medicinal Chemistry, 63(14) pp. 7545​-7558​.​ DOI: https://doi.org/10.1021/acs.jmedchem.0c00143 
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  • 2019 | Journal Article
    ​ ​Crystal structures of the c-di-AMP–synthesizing enzyme CdaA​
    Heidemann, J. L.; Neumann, P. ; Dickmanns, A.   & Ficner, R. ​ (2019) 
    Journal of Biological Chemistry, 294(27) pp. 10463​-10470​.​ DOI: https://doi.org/10.1074/jbc.RA119.009246 
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  • 2018 | Journal Article
    ​ ​Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis​
    Dickmanns, A. ; Zschiedrich, C. P.; Arens, J.; Parfentev, I.; Gundlach, J.; Hofele, R. & Neumann, P.  et al.​ (2018) 
    Journal of Biological Chemistry, 293(16) pp. 5781​-5792​.​ DOI: https://doi.org/10.1074/jbc.RA117.001289 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Validating Resolution Revolution​
    Neumann, P. ; Dickmanns, A.   & Ficner, R. ​ (2018) 
    Structure, 26(5) pp. 785​-795.e4​.​ DOI: https://doi.org/10.1016/j.str.2018.03.004 
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  • 2017 | Journal Article
    ​ ​Studying structure and function of spliceosomal helicases​
    Ficner, R. ; Dickmanns, A.   & Neumann, P. ​ (2017) 
    Methods, 125 pp. 63​-69​.​ DOI: https://doi.org/10.1016/j.ymeth.2017.06.028 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper
    ​ ​Impact of the crystallization condition on importin-β conformation​
    Tauchert, M. J. ; Hémonnot, C. ; Neumann, P. ; Köster, S. ; Ficner, R.   & Dickmanns, A. ​ (2016) 
    Acta crystallographica. Section D, Structural biology, 72(6) pp. 705​-717​.​ DOI: https://doi.org/10.1107/S2059798316004940 
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  • 2016 | Journal Article
    ​ ​Crystal structure of the 239 kDa nuclear export complex CRM1 - RanGTP - Snurportin1 - Nup214 - MBP​
    Ficner, R. ; Monecke, T. ; Port, S. A.; Weiß, M. S.; Kehlenbach, R. H.   & Dickmanns, A. ​ (2016) 
    Acta Crystallographica Section A Foundations and Advances, 72(a1) pp. s30​-s30​.​ DOI: https://doi.org/10.1107/S2053273316099526 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​Nuclear Pore Complexes and Nucleocytoplasmic Transport​
    Dickmanns, A. ; Kehlenbach, R. H.   & Fahrenkrog, B.​ (2015) 
    International Review of Cell and Molecular Biology, pp. 171​-233​.​ DOI: https://doi.org/10.1016/bs.ircmb.2015.07.010 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​Structural Basis of Targeting the Exportin CRM1 in Cancer​
    Dickmanns, A. ; Monecke, T.   & Ficner, R. ​ (2015) 
    Cells, 4(3) pp. 538​-568​.​ DOI: https://doi.org/10.3390/cells4030538 
    ​Details  DOI 
  • 2015 | Journal Article | Research Paper
    ​ ​MD Simulations and FRET Reveal an Environment: Sensitive Conformational Plasticity of Importin-beta​
    Halder, K.; Doelker, N.; Van, Q. ; Gregor, I. ; Dickmanns, A. ; Baade, I.   & Kehlenbach, R. H.  et al.​ (2015) 
    Biophysical Journal, 109(2) pp. 277​-286​.​ DOI: https://doi.org/10.1016/j.bpj.2015.06.014 
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  • 2015 | Journal Article | Research Paper
    ​ ​Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA from Listeria monocytogenes​
    Rosenberg, J. M.; Dickmanns, A. ; Neumann, P. ; Gunka, K. ; Arens, J.; Kaever, V. & Stuelke, J.  et al.​ (2015) 
    Journal of biological chemistry, 290(10) pp. 6596​-6606​.​ DOI: https://doi.org/10.1074/jbc.M114.630418 
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  • 2015 | Review
    ​ ​A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP​
    Commichau, F. M. ; Dickmanns, A. ; Gundlach, J.; Ficner, R.  & Stuelke, J. ​ (2015)
    Molecular Microbiology, 97​(2) pp. 189​-204​.​
    Wiley-blackwell. DOI: https://doi.org/10.1111/mmi.13026 
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export​
    Port, S. A.; Monecke, T. ; Dickmanns, A. ; Spillner, C.; Hofele, R.; Urlaub, H.   & Ficner, R.  et al.​ (2015) 
    Cell Reports, 13(4) pp. 690​-702​.​ DOI: https://doi.org/10.1016/j.celrep.2015.09.042 
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  • 2015 | Journal Article | Research Paper
    ​ ​Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding P-II-like Signal Transduction Protein DarA​
    Gundlach, J.; Dickmanns, A. ; Schröder-Tittmann, K. ; Neumann, P. ; Kaesler, J.; Kampf, J. & Herzberg, C. et al.​ (2015) 
    Journal of biological chemistry, 290(5) pp. 3069​-3080​.​ DOI: https://doi.org/10.1074/jbc.M114.619619 
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  • 2015 | Journal Article | Research Paper
    ​ ​Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex​
    Monecke, T. ; Dickmanns, A. ; Weiss, M. S.; Port, S. A.; Kehlenbach, R. H.   & Ficner, R. ​ (2015) 
    Acta Crystallographica Section F Structural Biology Communications, 71 pp. 1481​-1487​.​ DOI: https://doi.org/10.1107/S2053230X15021524 
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  • 2014 | Review | 
    ​ ​Allosteric control of the exportin CRM1 unraveled by crystal structure analysis​
    Monecke, T. ; Dickmanns, A.  & Ficner, R. ​ (2014)
    FEBS Journal, 281​(18) pp. 4179​-4194​.​
    Wiley-blackwell. DOI: https://doi.org/10.1111/febs.12842 
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  • 2013 | Journal Article
    ​ ​Structural Determinants of Conformational Flexibility and Long-Range Allostery of the CRM1 Export Complex​
    Monecke, T. ; Haselbach, D.; Voß, B.; Russek, A.; Neumann, P. ; Thomson, E. & Hurt, E. et al.​ (2013) 
    Biophysical Journal, 104(2, Supplement 1) pp. 68a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.411 
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  • 2013 | Journal Article | Research Paper
    ​ ​Structural basis for cooperativity of CRM1 export complex formation​
    Monecke, T. ; Haselbach, D.; Voss, B.; Russek, A.; Neumann, P. ; Thomson, E. & Hurt, E. et al.​ (2013) 
    Proceedings of the National Academy of Sciences, 110(3) pp. 960​-965​.​ DOI: https://doi.org/10.1073/pnas.1215214110 
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  • 2013 | Journal Article | Research Paper
    ​ ​Structural Determinants and Mechanism of Mammalian CRM1 Allostery​
    Doelker, N.; Blanchet, C. E.; Voss, B.; Haselbach, D.; Kappel, C.; Monecke, T.   & Svergun, D. I. et al.​ (2013) 
    Structure, 21(8) pp. 1350​-1360​.​ DOI: https://doi.org/10.1016/j.str.2013.05.015 
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  • 2013 | Journal Article | Research Paper | 
    ​ ​The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB​
    Ahmed, Y. L.; Gerke, J.; Park, H.-S.; Bayram, O.; Neumann, P. ; Ni, M. & Dickmanns, A.  et al.​ (2013) 
    PLoS Biology, 11(12) art. e1001750​.​ DOI: https://doi.org/10.1371/journal.pbio.1001750 
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  • 2012 | Journal Article | Research Paper
    ​ ​Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity​
    Neumann, P. ; Brodhun, F. ; Sauer, K.; Herrfurth, C. ; Hamberg, M.; Brinkmann, J. & Scholz, J. et al.​ (2012) 
    PLANT PHYSIOLOGY, 160(3) pp. 1251​-1266​.​ DOI: https://doi.org/10.1104/pp.112.205138 
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  • 2011 | Journal Article | Research Paper
    ​ ​Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase from Leishmania major​
    Dickmanns, A. ; Damerow, S.; Neumann, P. ; Schulz, E.-C.; Lamerz, A.-C.; Routier, F. H. & Ficner, R. ​ (2011) 
    Journal of Molecular Biology, 405(2) pp. 461​-478​.​ DOI: https://doi.org/10.1016/j.jmb.2010.10.057 
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  • 2010 | Journal Article
    ​ ​Structural basis for CRM1 nuclear export complex assembly​
    Monecke, T. ; Güttler, T.; Neumann, P. ; Doelker, N.; Blanchet, C.; Dickmanns, A.   & Görlich, D. et al.​ (2010) 
    Acta Crystallographica. Section A, Foundations and Advances, 66(a1) pp. s30​-s31​.​ DOI: https://doi.org/10.1107/S0108767310099319 
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  • 2010 | Journal Article | Research Paper
    ​ ​Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding​
    Schulz, E. C.; Dickmanns, A. ; Urlaub, H. ; Schmitt, A.; Muehlenhoff, M.; Stummeyer, K. & Schwarzer, D. et al.​ (2010) 
    Nature Structural & Molecular Biology, 17(2) pp. 210​-U11​.​ DOI: https://doi.org/10.1038/nsmb.1746 
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  • 2010 | Journal Article | Research Paper | 
    ​ ​Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry​
    Kuehn-Hoelsken, E.; Lenz, C. ; Dickmanns, A. ; Hsiao, H.-H.; Richter, F. M.; Kastner, B. & Ficner, R.  et al.​ (2010) 
    Nucleic Acids Research, 38(16) pp. 5581​-5593​.​ DOI: https://doi.org/10.1093/nar/gkq272 
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  • 2010 | Journal Article | Research Paper
    ​ ​Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA​
    Lakomek, K.; Dickmanns, A. ; Ciirdaeva, E.; Schomacher, L. & Ficner, R. ​ (2010) 
    Journal of Molecular Biology, 399(4) pp. 604​-617​.​ DOI: https://doi.org/10.1016/j.jmb.2010.04.044 
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  • 2010 | Journal Article | Research Paper
    ​ ​Structural Basis for the Recognition and Cleavage of Polysialic Acid by the Bacteriophage K1F Tailspike Protein EndoNF​
    Schulz, E. C.; Schwarzer, D.; Frank, M.; Stummeyer, K.; Muehlenhoff, M.; Dickmanns, A.   & Gerardy-Schahn, R. et al.​ (2010) 
    Journal of Molecular Biology, 397(1) pp. 341​-351​.​ DOI: https://doi.org/10.1016/j.jmb.2010.01.028 
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  • 2009 | Journal Article | Research Paper
    ​ ​Structural basis for m(7)G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1​
    Monecke, T. ; Dickmanns, A.   & Ficner, R. ​ (2009) 
    Nucleic Acids Research, 37(12) pp. 3865​-3877​.​ DOI: https://doi.org/10.1093/nar/gkp249 
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  • 2009 | Journal Article | Research Paper | 
    ​ ​Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography​
    Lakomek, K.; Dickmanns, A. ; Kettwig, M.; Urlaub, H. ; Ficner, R.   & Luebke, T.​ (2009) 
    BMC Structural Biology, 9 art. 56​.​ DOI: https://doi.org/10.1186/1472-6807-9-56 
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  • 2009 | Journal Article | Research Paper
    ​ ​De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse​
    Lakomek, K.; Dickmanns, A. ; Mueller, U.; Kollmann, K.; Deuschl, F.; Berndt, A. & Luebke, T. et al.​ (2009) 
    Acta Crystallographica Section D Biological Crystallography, 65 pp. 220​-228​.​ DOI: https://doi.org/10.1107/S0907444908041814 
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  • 2009 | Journal Article | Research Paper
    ​ ​A C-Terminal Phosphatase Module Conserved in Vertebrate CMP-Sialic Acid Synthetases Provides a Tetramerization Interface for the Physiologically Active Enzyme​
    Oschlies, M.; Dickmanns, A. ; Haselhorst, T.; Schaper, W.; Stummeyer, K.; Tiralongo, J. & Weinhold, B. et al.​ (2009) 
    Journal of Molecular Biology, 393(1) pp. 83​-97​.​ DOI: https://doi.org/10.1016/j.jmb.2009.08.003 
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  • 2009 | Journal Article | Research Paper
    ​ ​Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1​
    Monecke, T. ; Dickmanns, A. ; Strasser, A. & Ficner, R. ​ (2009) 
    Acta Crystallographica Section D Biological Crystallography, 65 pp. 332​-338​.​ DOI: https://doi.org/10.1107/S0907444909003102 
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  • 2009 | Journal Article | Research Paper
    ​ ​Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP​
    Monecke, T. ; Guettler, T.; Neumann, P. ; Dickmanns, A. ; Goerlich, D. & Ficner, R. ​ (2009) 
    Science, 324(5930) pp. 1087​-1091​.​ DOI: https://doi.org/10.1126/science.1173388 
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  • 2009 | Journal Article | Research Paper | 
    ​ ​The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival Under Heat Stress​
    Padmanabhan, N.; Fichtner, L. ; Dickmanns, A. ; Ficner, R. ; Schulz, J. B.   & Braus, G. H. ​ (2009) 
    Molecular Biology of the Cell, 20(1) pp. 68​-77​.​ DOI: https://doi.org/10.1091/mbc.E08-02-0178 
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  • 2008 | Journal Article | Research Paper
    ​ ​Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode​
    Monecke, T. ; Schell, S.; Dickmanns, A.   & Ficner, R. ​ (2008) 
    Journal of Molecular Biology, 382(4) pp. 827​-834​.​ DOI: https://doi.org/10.1016/j.jmb.2008.07.073 
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  • 2008 | Journal Article | Research Paper
    ​ ​Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)​
    Schaefer, S.; Saunders, L.; Eliseeva, E.; Velena, A.; Jung, M.; Schwienhorst, A.   & Strasser, A. et al.​ (2008) 
    Bioorganic & Medicinal Chemistry, 16(4) pp. 2011​-2033​.​ DOI: https://doi.org/10.1016/j.bmc.2007.10.092 
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  • 2007 | Journal Article | Research Paper
    ​ ​Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus​
    Wohlwend, D.; Strasser, A.; Dickmanns, A.   & Ficner, R. ​ (2007) 
    Journal of Molecular Biology, 374(4) pp. 1129​-1138​.​ DOI: https://doi.org/10.1016/j.jmb.2007.09.065 
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  • 2007 | Journal Article | Research Paper
    ​ ​Thermodynamic analysis of H1 nuclear import - Receptor tuning of importin beta/importin7​
    Wohlwend, D.; Strasser, A.; Dickmanns, A. ; Doenecke, D. & Ficner, R. ​ (2007) 
    Journal of biological chemistry, 282(14) pp. 10707​-10719​.​ DOI: https://doi.org/10.1074/jbc.M610409200 
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  • 2006 | Journal Article | Research Paper
    ​ ​Structure of the novel alpha-amylase AmyC from Thermotoga maritima​
    Dickmanns, A. ; Ballschmiter, M.; Liebl, W. & Ficner, R. ​ (2006) 
    Acta Crystallographica Section D Biological Crystallography, 62 pp. 262​-270​.​ DOI: https://doi.org/10.1107/S0907444905041363 
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  • 2005 | Book Chapter
    ​ ​Role of the 5’-cap in the biogenesis of spliceosomal snRNPs​
    Ficner, R.  & Dickmanns, A. ​ (2005)
    In:​Grosjean, Henri​ (Ed.), Fine-Tuning of RNA Functions by Modification and Editing pp. 179​-204. (Vol. 12). ​Berlin Heidelberg: ​Springer. DOI: https://doi.org/10.1007/b106799 
    ​Details  DOI 
  • 2005 | Journal Article | Research Paper
    ​ ​Crystal structure of human pFGE, the paralog of the C alpha-formylglycine-generating enzyme​
    Dickmanns, A. ; Schmidt, B. ; Rudolph, M.; Mariappan, M.; Dierks, T.; Von Figura, K.   & Ficner, R. ​ (2005) 
    Journal of biological chemistry, 280(15) pp. 15180​-15187​.​ DOI: https://doi.org/10.1074/jbc.M414317200 
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  • 2005 | Journal Article | Research Paper | 
    ​ ​Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme​
    Dierks, T.; Dickmanns, A. ; Preusser-Kunze, A.; Schmidt, B. ; Mariappan, M.; Von Figura, K.   & Ficner, R.  et al.​ (2005) 
    Cell, 121(4) pp. 541​-552​.​ DOI: https://doi.org/10.1016/j.cell.2005.03.001 
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  • 2005 | Journal Article | Research Paper
    ​ ​Expression, purification and crystallization of the ammonium transporter Amt-1 from Archaeoglobus fulgidus​
    Andrade, S.; Dickmanns, A. ; Ficner, R.   & Einsle, O.​ (2005) 
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, 61 pp. 861​-863​.​ DOI: https://doi.org/10.1107/S1744309105027004 
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  • 2005 | Journal Article | Research Paper
    ​ ​Structural basis for m(3)G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1​
    Strasser, A.; Dickmanns, A. ; Luhrmann, R. & Ficner, R. ​ (2005) 
    EMBO Journal, 24(13) pp. 2235​-2243​.​ DOI: https://doi.org/10.1038/sj.emboj.7600701 
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  • 2005 | Journal Article | Research Paper
    ​ ​Crystal Structure of a Bacterial Class 2 Histone Deacetylase Homologue​
    Nielsen, T. K. ; Hildmann, C. ; Dickmanns, A. ; Schwienhorst, A.   & Ficner, R. ​ (2005) 
    Journal of Molecular Biology, 354(1) pp. 107​-120​.​ DOI: https://doi.org/10.1016/j.jmb.2005.09.065 
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  • 2005 | Journal Article | Research Paper
    ​ ​Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F​
    Stummeyer, K.; Dickmanns, A. ; Mühlenhoff, M.; Gerardy-Schahn, R. & Ficner, R. ​ (2005) 
    Nature Structural & Molecular Biology, 12(1) pp. 90​-96​.​ DOI: https://doi.org/10.1038/nsmb874 
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  • 2005 | Journal Article | Research Paper
    ​ ​Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus​
    Andrade, S.; Dickmanns, A. ; Ficner, R.   & Einsle, O.​ (2005) 
    Proceedings of the National Academy of Sciences, 102(42) pp. 14994​-14999​.​ DOI: https://doi.org/10.1073/pnas.0506254102 
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  • 2004 | Journal Article | Research Paper
    ​ ​Purification, crystallization and preliminary crystallographic data of the m(3)G cap-binding domain of human snRNP import factor snurportin 1​
    Strasser, A.; Dickmanns, A. ; Schmidt, U.; Penka, E.; Urlaub, H. ; Sekine, M. & Luhrmann, R. et al.​ (2004) 
    Acta Crystallographica Section D Biological Crystallography, 60 pp. 1628​-1631​.​ DOI: https://doi.org/10.1107/S0907444904015380 
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  • 2003 | Journal Article | Research Paper
    ​ ​Crystal structure of the Borna disease virus nucleoprotein​
    Rudolph, M.; Kraus, I. ; Dickmanns, A. ; Eickmann, M.; Garten, W. & Ficner, R. ​ (2003) 
    Structure, 11(10) pp. 1219​-1226​.​ DOI: https://doi.org/10.1016/j.str.2003.08.011 
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Publication List

All Articles (Book & Journal) Books & Book chapters Book chapters & Review Articles & Preprints Papers (Journal & Conference)

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https://publications.goettingen-research-online.de URI: /cris/rp/rp01836
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