Dr. rer. nat. Piotr Neumann

 
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  • 2020 Journal Article | 
    ​ ​Crystal structure of the Rab33B/Atg16L1 effector complex​
    Metje-Sprink, J.; Groffmann, J.; Neumann, P. ; Barg-Kues, B.; Ficner, R. ; Kühnel, K. & Schalk, A. M. et al.​ (2020) 
    Scientific Reports10(1).​ DOI: https://doi.org/10.1038/s41598-020-69637-0 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2​
    Hamann, F.; Schmitt, A.; Favretto, F. ; Hofele, R.; Neumann, P. ; Xiang, S. & Urlaub, H.  et al.​ (2020) 
    Proceedings of the National Academy of Sciences117(6) pp. 2948​-2956​.​ DOI: https://doi.org/10.1073/pnas.1907960117 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1​
    Shaikhqasem, A.; Dickmanns, A. ; Neumann, P.   & Ficner, R. ​ (2020) 
    Journal of Medicinal Chemistry63(14) pp. 7545​-7558​.​ DOI: https://doi.org/10.1021/acs.jmedchem.0c00143 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​A Cross-linking Mass Spectrometry Approach Defines Protein Interactions in Yeast Mitochondria​
    Linden, A.; Deckers, M. ; Parfentev, I.; Pflanz, R.; Homberg, B.; Neumann, P.   & Ficner, R.  et al.​ (2020) 
    Molecular & Cellular Proteomics19(7) pp. 1161​-1178​.​ DOI: https://doi.org/10.1074/mcp.RA120.002028 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore​
    Munzel, L.; Neumann, P. ; Otto, F. B.; Krick, R. ; Metje-Sprink, J.; Kroppen, B.   & Karedla, N.  et al.​ (2020) 
    Autophagy, pp. 1​-21​.​ DOI: https://doi.org/10.1080/15548627.2020.1766332 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Defining the architecture of the human TIM22 complex by chemical crosslinking​
    Valpadashi, A.; Callegari, S. ; Linden, A.; Neumann, P. ; Ficner, R. ; Urlaub, H.   & Deckers, M.  et al.​ (2020) 
    FEBS Letters595(2) pp. 157​-168​.​ DOI: https://doi.org/10.1002/1873-3468.13978 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article
    ​ ​Crystal structures of the c-di-AMP–synthesizing enzyme CdaA​
    Heidemann, J. L.; Neumann, P. ; Dickmanns, A.   & Ficner, R. ​ (2019) 
    Journal of Biological Chemistry294(27) pp. 10463​-10470​.​ DOI: https://doi.org/10.1074/jbc.RA119.009246 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine​
    Johannsson, S.; Neumann, P. ; Wulf, A.; Welp, L. M.; Gerber, H.-D.; Krull, M. & Diederichsen, U.  et al.​ (2018) 
    Scientific Reports8(1).​ DOI: https://doi.org/10.1038/s41598-018-27118-5 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis​
    Dickmanns, A. ; Zschiedrich, C. P.; Arens, J.; Parfentev, I.; Gundlach, J.; Hofele, R. & Neumann, P.  et al.​ (2018) 
    Journal of Biological Chemistry293(16) pp. 5781​-5792​.​ DOI: https://doi.org/10.1074/jbc.RA117.001289 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Validating Resolution Revolution​
    Neumann, P. ; Dickmanns, A.   & Ficner, R. ​ (2018) 
    Structure26(5) pp. 785​-795.e4​.​ DOI: https://doi.org/10.1016/j.str.2018.03.004 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Sem1 links proteasome stability and specificity to multicellular development​
    Kolog Gulko, M.; Heinrich, G.; Gross, C.; Popova, B. ; Valerius, O. ; Neumann, P.   & Ficner, R.  et al.​ (2018) 
    PLOS Genetics14(2) art. e1007141​.​ DOI: https://doi.org/10.1371/journal.pgen.1007141 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Crystal structure of the spliceosomal DEAH-box ATPase Prp2​
    Schmitt, A.; Hamann, F.; Neumann, P.   & Ficner, R. ​ (2018) 
    Acta crystallographica. Section D, Structural biology74(7) pp. 643​-654​.​ DOI: https://doi.org/10.1107/S2059798318006356 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation​
    Newie, J.; Neumann, P. ; Werner, M.; Mata, R. A. ; Ficner, R.   & Feussner, I. ​ (2017) 
    Scientific Reports7(1) art. 2069​.​ DOI: https://doi.org/10.1038/s41598-017-02153-w 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Studying structure and function of spliceosomal helicases​
    Ficner, R. ; Dickmanns, A.   & Neumann, P. ​ (2017) 
    Methods125 pp. 63​-69​.​ DOI: https://doi.org/10.1016/j.ymeth.2017.06.028 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism​
    Gonzalez, G. M.; Durica-Mitic, S.; Hardwick, S. W.; Moncrieffe, M. C.; Resch, M.; Neumann, P.   & Ficner, R.  et al.​ (2017) 
    Nucleic Acids Research45(18) pp. 10845​-10860​.​ DOI: https://doi.org/10.1093/nar/gkx732 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Asc1p/RACK1 Connects Ribosomes to Eukaryotic Phosphosignaling​
    Schmitt, K.; Smolinski, N.; Neumann, P. ; Schmaul, S.; Hofer-Pretz, V.; Braus, G. H.   & Valerius, O. ​ (2017) 
    Molecular and Cellular Biology37(3).​ DOI: https://doi.org/10.1128/MCB.00279-16 
    Details  DOI 
  • 2016 Journal Article | Research Paper
    ​ ​Impact of the crystallization condition on importin-β conformation​
    Tauchert, M. J. ; Hémonnot, C. ; Neumann, P. ; Köster, S. ; Ficner, R.   & Dickmanns, A. ​ (2016) 
    Acta crystallographica. Section D, Structural biology72(6) pp. 705​-717​.​ DOI: https://doi.org/10.1107/S2059798316004940 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Conference Abstract
    ​ ​How reliable are atomic models based on cryo-EM reconstructions? Improvements in model fitting and validation​
    Neumann, P. ; Fischer, N. ; Stark, H.   & Ficner, R. ​ (2016)
    ​Acta Crystallographica Section A, 72(Part a1) Acta Crystallographica Section A Foundations and Advances, (a1) pp. s45​-s45. (Vol. 72). , Basel, Switzerland. DOI: https://doi.org/10.1107/S2053273316099307 
    Details  DOI 
  • 2016 Journal Article | Research Paper
    ​ ​Crystal structure of a lipoxygenase from Cyanothece sp may reveal novel features for substrate acquisition​
    Newie, J.; Andreou, A.; Neumann, P. ; Einsle, O.; Feussner, I.   & Ficner, R. ​ (2016) 
    Journal of Lipid Research57(2) pp. 276​-287​.​ DOI: https://doi.org/10.1194/jlr.M064980 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper | 
    ​ ​The pathway to GTPase activation of elongation factor SelB on the ribosome​
    Fischer, N. ; Neumann, P. ; Bock, L. V. ; Maracci, C. ; Wang, Z.; Paleskava, A.   & Konevega, A. L.  et al.​ (2016) 
    Nature540(7631) pp. 80​-85​.​ DOI: https://doi.org/10.1038/nature20560 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper | 
    ​ ​Crystal Structure of Alcohol Oxidase from Pichia pastoris​
    Koch, C.; Neumann, P. ; Valerius, O. ; Feussner, I.   & Ficner, R. ​ (2016) 
    PLoS ONE11(2) art. e0149846​.​ DOI: https://doi.org/10.1371/journal.pone.0149846 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria​
    Melin, J. ; Kilisch, M. ; Neumann, P. ; Lytovchenko, O. ; Gomkale, R.; Schendzielorz, A. B.   & Schmidt, B.  et al.​ (2015) 
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research1853(8) pp. 1850​-1859​.​ DOI: https://doi.org/10.1016/j.bbamcr.2015.04.021 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding P-II-like Signal Transduction Protein DarA​
    Gundlach, J.; Dickmanns, A. ; Schröder-Tittmann, K. ; Neumann, P. ; Kaesler, J.; Kampf, J. & Herzberg, C. et al.​ (2015) 
    Journal of biological chemistry290(5) pp. 3069​-3080​.​ DOI: https://doi.org/10.1074/jbc.M114.619619 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM​
    Fischer, N. ; Neumann, P. ; Konevega, A. L. ; Bock, L. V. ; Ficner, R. ; Rodnina, M. V.   & Stark, H. ​ (2015) 
    Nature520(7548) pp. 567​-570​.​ DOI: https://doi.org/10.1038/nature14275 
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  • 2015 Journal Article | Research Paper
    ​ ​Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA from Listeria monocytogenes​
    Rosenberg, J. M.; Dickmanns, A. ; Neumann, P. ; Gunka, K. ; Arens, J.; Kaever, V. & Stuelke, J.  et al.​ (2015) 
    Journal of biological chemistry290(10) pp. 6596​-6606​.​ DOI: https://doi.org/10.1074/jbc.M114.630418 
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  • 2015 Journal Article | Research Paper
    ​ ​Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot​
    Wechsler, C.; Meyer, D.; Loschonsky, S.; Funk, L.-M. ; Neumann, P. ; Ficner, R.   & Brodhun, F.  et al.​ (2015) 
    ChemBioChem16(18) pp. 2580​-2584​.​ DOI: https://doi.org/10.1002/cbic.201500529 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Marvels of enzyme catalysis at true atomic resolution: distortions, bond elongations, hidden flips, protonation states and atom identities​
    Neumann, P.   & Tittmann, K. ​ (2014) 
    Current Opinion in Structural Biology29 pp. 122​-133​.​ DOI: https://doi.org/10.1016/j.sbi.2014.11.001 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP​
    Monecke, T. ; Buschmann, J.; Neumann, P. ; Wahle, E. & Ficner, R. ​ (2014) 
    PLoS ONE9(3) art. e90915​.​ DOI: https://doi.org/10.1371/journal.pone.0090915 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification​
    Neumann, P. ; Lakomek, K.; Naumann, P.-T.; Erwin, W. M.; Lauhon, C. T. & Ficner, R. ​ (2014) 
    Nucleic Acids Research42(10) pp. 6673​-6685​.​ DOI: https://doi.org/10.1093/nar/gku249 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Crystal structures of two tetrameric β‐carbonic anhydrases from the filamentous ascomycete Sordaria macrospora​
    Lehneck, R.; Neumann, P. ; Vullo, D.; Elleuche, S.; Supuran, C. T.; Ficner, R.   & Pöggeler, S. ​ (2014) 
    FEBS Journal281(7) pp. 1759​-1772​.​ DOI: https://doi.org/10.1111/febs.12738 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28​
    Moehlmann, S.; Mathew, R.; Neumann, P. ; Schmitt, A.; Luehrmann, R.   & Ficner, R. ​ (2014) 
    Acta Crystallographica Section D Biological Crystallography70 pp. 1622​-1630​.​ DOI: https://doi.org/10.1107/S1399004714006439 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Translation Initiation Factor eIF3b Contains a Nine-Bladed β-Propeller and Interacts with the 40S Ribosomal Subunit​
    Liu, Y.; Neumann, P. ; Kuhle, B.; Monecke, T. ; Schell, S.; Chari, A. & Ficner, R. ​ (2014) 
    Structure22(6) pp. 923​-930​.​ DOI: https://doi.org/10.1016/j.str.2014.03.010 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes​
    Khoshnevis, S.; Gunisova, S.; Vlckova, V.; Kouba, T.; Neumann, P. ; Beznoskova, P. & Ficner, R.  et al.​ (2014) 
    Nucleic Acids Research42(6) pp. 4123​-4139​.​ DOI: https://doi.org/10.1093/nar/gkt1369 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Structural Determinants of Conformational Flexibility and Long-Range Allostery of the CRM1 Export Complex​
    Monecke, T. ; Haselbach, D.; Voß, B.; Russek, A.; Neumann, P. ; Thomson, E. & Hurt, E. et al.​ (2013) 
    Biophysical Journal104(2, Supplement 1) pp. 68a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.411 
    Details  DOI 
  • 2013 Journal Article | Research Paper
    ​ ​Structural basis for cooperativity of CRM1 export complex formation​
    Monecke, T. ; Haselbach, D.; Voss, B.; Russek, A.; Neumann, P. ; Thomson, E. & Hurt, E. et al.​ (2013) 
    Proceedings of the National Academy of Sciences110(3) pp. 960​-965​.​ DOI: https://doi.org/10.1073/pnas.1215214110 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB​
    Ahmed, Y. L.; Gerke, J.; Park, H.-S.; Bayram, O.; Neumann, P. ; Ni, M. & Dickmanns, A.  et al.​ (2013) 
    PLoS Biology11(12) art. e1001750​.​ DOI: https://doi.org/10.1371/journal.pbio.1001750 
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  • 2013 Journal Article | Research Paper | 
    ​ ​Observation of a stable carbene at the active site of a thiamin enzyme​
    Meyer, D.; Neumann, P. ; Ficner, R.   & Tittmann, K. ​ (2013) 
    Nature Chemical Biology9(8) pp. 488​-U84​.​ DOI: https://doi.org/10.1038/nchembio.1275 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate​
    Lüdtke, S.; Neumann, P. ; Erixon, K. M.; Leeper, F.; Kluger, R.; Ficner, R.   & Tittmann, K. ​ (2013) 
    Nature Chemistry5(9) pp. 762​-767​.​ DOI: https://doi.org/10.1038/NCHEM.1728 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Crystal structure analysis of a fatty acid double-bond hydratase from Lactobacillus acidophilus​
    Volkov, A.; Khoshnevis, S.; Neumann, P. ; Herrfurth, C. ; Wohlwend, D.; Ficner, R.   & Feussner, I. ​ (2013) 
    Acta Crystallographica Section D Biological Crystallography69 pp. 648​-657​.​ DOI: https://doi.org/10.1107/S0907444913000991 
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  • 2012 Journal Article | Research Paper
    ​ ​Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin​
    Meyer, D.; Neumann, P. ; Koers, E.; Sjuts, H.; Lüdtke, S.; Sheldrick, G. M.   & Ficner, R.  et al.​ (2012) 
    Proceedings of the National Academy of Sciences109(27) pp. 10867​-10872​.​ DOI: https://doi.org/10.1073/pnas.1201280109 
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  • 2012 Journal Article | Research Paper
    ​ ​Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity​
    Neumann, P. ; Brodhun, F. ; Sauer, K.; Herrfurth, C. ; Hamberg, M.; Brinkmann, J. & Scholz, J. et al.​ (2012) 
    PLANT PHYSIOLOGY160(3) pp. 1251​-1266​.​ DOI: https://doi.org/10.1104/pp.112.205138 
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  • 2011 Journal Article | Research Paper
    ​ ​Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism​
    Lehwess-Litzmann, A.; Neumann, P. ; Parthier, C.; Luedtke, S.; Golbik, R.; Ficner, R.   & Tittmann, K. ​ (2011) 
    Nature Chemical Biology7(10) pp. 678​-684​.​ DOI: https://doi.org/10.1038/NCHEMBIO.633 
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  • 2011 Journal Article | Research Paper | 
    ​ ​Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex​
    Schulz, C. ; Lytovchenko, O. ; Melin, J. ; Chacinska, A.; Guiard, B.; Neumann, P.   & Ficner, R.  et al.​ (2011) 
    The Journal of Cell Biology195(4) pp. 643​-656​.​ DOI: https://doi.org/10.1083/jcb.201105098 
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  • 2011 Journal Article | Research Paper
    ​ ​The Crystal Structure of the C(2)A Domain of Otoferlin Reveals an Unconventional Top Loop Region​
    Helfmann, S.; Neumann, P. ; Tittmann, K. ; Moser, T. ; Ficner, R.   & Reisinger, E. ​ (2011) 
    Journal of Molecular Biology406(3) pp. 479​-490​.​ DOI: https://doi.org/10.1016/j.jmb.2010.12.031 
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  • 2011 Journal Article | Research Paper
    ​ ​Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase from Leishmania major​
    Dickmanns, A. ; Damerow, S.; Neumann, P. ; Schulz, E.-C.; Lamerz, A.-C.; Routier, F. H. & Ficner, R. ​ (2011) 
    Journal of Molecular Biology405(2) pp. 461​-478​.​ DOI: https://doi.org/10.1016/j.jmb.2010.10.057 
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  • 2010 Journal Article
    ​ ​Structural basis for CRM1 nuclear export complex assembly​
    Monecke, T. ; Güttler, T.; Neumann, P. ; Doelker, N.; Blanchet, C.; Dickmanns, A.   & Görlich, D. et al.​ (2010) 
    Acta Crystallographica. Section A, Foundations and Advances66(a1) pp. s30​-s31​.​ DOI: https://doi.org/10.1107/S0108767310099319 
    Details  DOI 
  • 2010 Journal Article | Research Paper | 
    ​ ​Crystal Structure of the RNA Recognition Motif of Yeast Translation Initiation Factor eIF3bw Reveals Differences to Human eIF3b​
    Khoshnevis, S.; Neumann, P.   & Ficner, R. ​ (2010) 
    PLoS ONE5(9) art. e12784​.​ DOI: https://doi.org/10.1371/journal.pone.0012784 
    Details  DOI  WoS 
  • 2010 Journal Article | Research Paper
    ​ ​NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1​
    Guettler, T.; Madl, T.; Neumann, P. ; Deichsel, D.; Corsini, L.; Monecke, T.   & Ficner, R.  et al.​ (2010) 
    Nature Structural & Molecular Biology17(11) pp. 1367​-U229​.​ DOI: https://doi.org/10.1038/nsmb.1931 
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  • 2010 Journal Article | Research Paper | 
    ​ ​Structure analysis of endosialidase NF at 0.98 angstrom resolution​
    Schulz, E. C.; Neumann, P. ; Gerardy-Schahn, R.; Sheldrick, G. M.   & Ficner, R. ​ (2010) 
    Acta Crystallographica Section D Biological Crystallography66 pp. 176​-180​.​ DOI: https://doi.org/10.1107/S0907444909048720 
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  • 2009 Journal Article | Research Paper
    ​ ​Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP​
    Monecke, T. ; Guettler, T.; Neumann, P. ; Dickmanns, A. ; Goerlich, D. & Ficner, R. ​ (2009) 
    Science324(5930) pp. 1087​-1091​.​ DOI: https://doi.org/10.1126/science.1173388 
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