Dr. rer. nat. Viacheslav Nikolaev

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  • 2021 Journal Article | Research Paper
    ​ ​cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias​
    Berisha, F.; Götz, K.; Wegener, J. W.; Brandenburg, S. ; Subramanian, H.; Molina, C. E. & Rueffer, A. et al.​ (2021) 
    Circulation Research,.​ DOI: https://doi.org/10.1161/CIRCRESAHA.120.318234 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​
    Hofhuis, J. ; Bersch, K.; Wagner, S. ; Molina, C. E. ; Fakuade, F. E.; Iyer, L. M.   & Streckfuß-Bömeke, K.  et al.​ (2020) 
    Europace22(7) pp. 1119​-1131​.​ DOI: https://doi.org/10.1093/europace/euaa093 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca 2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure​
    Eiringhaus, J. ; Wünsche, C. M.; Tirilomis, P.; Herting, J. ; Bork, N.; Nikolaev, V. O.   & Hasenfuss, G.  et al.​ (2020) 
    ESC Heart Failure7(5) pp. 2992​-3002​.​ DOI: https://doi.org/10.1002/ehf2.12918 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper | 
    ​ ​Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium​
    Trautsch, I.; Heta, E.; Soong, P. L. ; Levent, E. ; Nikolaev, V. O. ; Bogeski, I.   & Katschinski, D. M.  et al.​ (2019) 
    Frontiers in Physiology10.​ DOI: https://doi.org/10.3389/fphys.2019.00272 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​
    Eiringhaus, J. ; Herting, J. ; Schatter, F. ; Nikolaev, V. O. ; Sprenger, J.; Wang, Y. & Köhn, M. et al.​ (2019) 
    Basic Research in Cardiology114(2) pp. 13​.​ DOI: https://doi.org/10.1007/s00395-019-0720-7 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article
    ​ ​Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain​
    Bastug-Özel, Z.; Wright, P. T; Kraft, A. E; Pavlovic, D.; Howie, J.; Froese, A. & Fuller, W. et al.​ (2018) 
    Cardiovascular Research115(3) pp. 546​-555​.​ DOI: https://doi.org/10.1093/cvr/cvy221 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP​
    Subramanian, H.; Froese, A.; Jönsson, P.; Schmidt, H.; Gorelik, J. & Nikolaev, V. O. ​ (2018) 
    Nature Communications9(1).​ DOI: https://doi.org/10.1038/s41467-018-04891-5 
    Details  DOI 
  • 2017 Conference Abstract
    ​ ​Generation and characterization of glutathione redox potential sensor mice​
    Swain, L.; Kesemeyer, A.; Meyer-Roxlau, S.; Vettel, C.; Glintsch, A.; Zieseniss, A. & Jatho, A. et al.​ (2017)
    Acta Physiologica219 
    Hoboken​: Wiley.
    Details  WoS 
  • 2017 Journal Article | Research Paper | 
    ​ ​Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​
    Borchert, T. ; Hübscher, D. ; Guessoum, C. I. ; Lam, T. Lam, Tuan-Dinh D.; Ghadri, J. R.; Schellinger, I. N.   & Tiburcy, M.  et al.​ (2017) 
    Journal of the American College of Cardiology70(8) pp. 975​-991​.​ DOI: https://doi.org/10.1016/j.jacc.2017.06.061 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article
    ​ ​Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure​
    Abu-Taha, I. H.; Heijman, J.; Hippe, H.-J.; Wolf, N. M.; El-Armouche, A. ; Nikolaev, V. O.   & Schäfer, M.  et al.​ (2017) 
    Circulation135(9) pp. 881​-897​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.022852 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article | Research Paper | 
    ​ ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​
    Perera, R. K. ; Fischer, T. H. ; Wagner, M.; Dewenter, M. ; Vettel, C. ; Bork, N. I. & Maier, L. S.  et al.​ (2017) 
    Scientific Reports7(1) art. 15222​.​ DOI: https://doi.org/10.1038/s41598-017-15632-x 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper
    ​ ​Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy​
    Hofhuis, J. ; Bersch, K.; Büssenschütt, R.; Drzymalski, M.; Liebetanz, D. ; Nikolaev, V. O.   & Wagner, S.  et al.​ (2017) 
    Journal of Cell Science130(5) pp. 841​-852​.​ DOI: https://doi.org/10.1242/jcs.198861 
    Details  DOI  PMID  PMC 
  • 2016 Conference Abstract
    ​ ​Monitoring Local Pulmonary Camp Levels: Combining Precision Cut Lung Slice (pcls) And Fluorescence Resonance Energy Transfer (fret) Technologies In Mice​
    Zuo, H.; Poppinga, W. J.; Zeisberg, E. M. ; Nikolaev, V. O.   & Schmidt, M.​ (2016)
    American Journal of Respiratory and Critical Care Medicine193 ​International Conference of the American-Thoracic-Society (ATS)​, San Francisco, CA.
    New york​: Amer Thoracic Soc.
    Details  WoS 
  • 2016 Journal Article
    ​ ​Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice​
    Swain, L. ; Kesemeyer, A.; Meyer-Roxlau, S. ; Vettel, C. ; Zieseniss, A. ; Güntsch, A.   & Jatho, A.  et al.​ (2016) 
    Circulation Research119(9) pp. 1004​-1016​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.309551 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper | 
    ​ ​Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET​
    Sprenger, J. U.; Bork, N. I.; Herting, J. ; Fischer, T. H.   & Nikolaev, V. O. ​ (2016) 
    PLoS One11(12) art. e0167974​.​ DOI: https://doi.org/10.1371/journal.pone.0167974 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​Axial tubule junctions control rapid calcium signaling in atria​
    Brandenburg, S. ; Kohl, T. ; Williams, G. S. B.; Gusev, K.; Wagner, E. ; Rog-Zielinska, E. A. & Hebisch, E. et al.​ (2016) 
    Journal of Clinical Investigation126(10) pp. 3999​-4015​.​ DOI: https://doi.org/10.1172/JCI88241 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Book Chapter
    ​ ​Monitoring Real-Time Cyclic Nucleotide Dynamics in Subcellular Microdomains​
    Bastug, Z.& Nikolaev, V. O. ​ (2015)
    In:​Cheng, Xiaodong​ (Ed.), Cyclic Nucleotide Signaling pp. 135​-146. ​Boca Raton, Florida: ​CRC Press.
  • 2015 Book Chapter
    ​ ​Monitoring Cyclic Nucleotides Using Genetically Encoded Fluorescent Reporters​
    Bastug, Z.& Nikolaev, V. O. ​ (2015)
    In:​Cheng, Xiaodong​ (Ed.), Cyclic Nucleotide Signaling pp. 98​-115. ​Boca Raton: ​CRC Press. DOI: https://doi.org/10.1201/b18477-10 
    Details  DOI 
  • 2015 Journal Article | Research Paper
    ​ ​Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy​
    Perera, R. K. ; Sprenger, J. U.; Steinbrecher, J. H.; Hübscher, D. ; Lehnart, S. E. ; Abesser, M. & Schuh, K. et al.​ (2015) 
    Circulation Research116(8) pp. 1304​-1311​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.306082 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper | 
    ​ ​In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​
    Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Maier, L. S. ; Hasenfuß, G.   & Nikolaev, V. O. ​ (2015) 
    Nature Communications6 art. 6965​.​ DOI: https://doi.org/10.1038/ncomms7965 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​
    Fischer, T. H. ; Herting, J. ; Mason, F. E. ; Hartmann, N. ; Watanabe, S.; Nikolaev, V. O.   & Sprenger, J. U. et al.​ (2015) 
    Cardiovascular Research107(1) pp. 184​-196​.​ DOI: https://doi.org/10.1093/cvr/cvv153 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Conference Abstract
    ​ ​ANP potentiates catecholaminergic stress in early cardiac disease​
    Perera, R. K.; Steinbrecher, J. H.; Lehnart, S. E.   & Nikolaev, V. O. ​ (2014)
    Cardiovascular Research103 , Barcelona, SPAIN.
    Oxford​: Oxford Univ Press. DOI: https://doi.org/10.1093/cvr/cvu098.37 
    Details  DOI  WoS 
  • 2014 Conference Abstract
    ​ ​beta-3 adrenoreceptors protect from hypertrophic remodelling through nitric oxide synthase & AMP-activated protein kinase dependent signaling pathways​
    Dubois-Deruy, E.; Gelinas, R.; Hammond, J.; Gotz, K.; Nikolaev, V. ; Manoury, B. & Esfahani, H. et al.​ (2014)
    Cardiovascular Research103 , Barcelona, SPAIN.
    Oxford​: Oxford Univ Press. DOI: https://doi.org/10.1093/cvr/cvu087.4 
    Details  DOI  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Enhanced Expression of beta 3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling Through Nitric Oxide Synthase​
    Belge, C.; Hammond, J.; Dubois-Deruy, E.; Manoury, B.; Hamelet, J.; Beauloye, C. & Markl, A. et al.​ (2014) 
    Circulation129(4) pp. 451​-462​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.004940 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes​
    Götz, K. R.; Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Kuhn, M. & Gorelik, J. et al.​ (2014) 
    Circulation Research114(8) pp. 1235​-1245​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.114.302437 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | Research Paper
    ​ ​Tubulin polymerization disrupts cardiac beta-adrenergic regulation of late I-Na​
    Dybkova, N.; Wagner, S.; Backs, J.; Hund, T. J.; Mohler, P. J.; Sowa, T. & Nikolaev, V. O.  et al.​ (2014) 
    Cardiovascular Research103(1) pp. 168​-177​.​ DOI: https://doi.org/10.1093/cvr/cvu120 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways​
    Vettel, C. ; Lämmle, S.; Ewens, S.; Cervirgen, C.; Emmons, J.; Ongherth, A. & Dewenter, M.  et al.​ (2014) 
    American Journal of Physiology - Heart and Circulatory Physiology306(8) pp. H1246​-H1252​.​ DOI: https://doi.org/10.1152/ajpheart.00852.2013 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Conference Abstract
    ​ ​Phosphodiesterase-2 is upregulated in failing hearts and blunts beta-AR mediated chronotropic and inotropic effects​
    Vettel, C.; Mehel, H.; Emons, J.; Wittkoepper, K.; Dewenter, M.; Laemmle, S. & Seppelt, D. et al.​ (2013)
    Naunyn-Schmiedeberg s Archives of Pharmacology386 
    New york​: Springer.
    Details  WoS 
  • 2013 Journal Article | 
    ​ ​Cyclic GMP-mediated intercellular communication in mammalian ovarian follicles​
    Jaffe, L.; Egbert, J.; Shuhaibar, L.; Wen, L.; Thunemann, M.; Feil, R. & Nikolaev, V. O.  et al.​ (2013) 
    BMC Pharmacology & Toxicology14(1) pp. 1​-2​.​ DOI: https://doi.org/10.1186/2050-6511-14-S1-P31 
    Details  DOI 
  • 2013 Journal Article | 
    ​ ​PDE3 is the major cGMP-PDE in adult mouse ventricular cardiomyocytes​
    Götz, K. & Nikolaev, V. O. ​ (2013) 
    BMC Pharmacology & Toxicology14(1) pp. 1​-1​.​ DOI: https://doi.org/10.1186/2050-6511-14-S1-P26 
    Details  DOI 
  • 2013 Journal Article | Overview
    ​ ​Compartmentation of cAMP signalling in cardiomyocytes in health and disease​
    Perera, R. K. & Nikolaev, V. O. ​ (2013) 
    Acta Physiologica207(4) pp. 650​-662​.​ DOI: https://doi.org/10.1111/apha.12077 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Overview | 
    ​ ​Biophysical Techniques for Detection of cAMP and cGMP in Living Cells​
    Sprenger, J. U. & Nikolaev, V. O. ​ (2013) 
    International Journal of Molecular Sciences14(4) pp. 8025​-8046​.​ DOI: https://doi.org/10.3390/ijms14048025 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Book Chapter
    ​ ​Advances and Techniques to Measure cGMP in Intact Cardiomyocytes​
    Götz, K. R.& Nikolaev, V. O. ​ (2013)
    In:​Krieg, Thomas; Lukowski, Robert​ (Eds.), Guanylate Cyclase and Cyclic GMP. Methods and Protocols pp. 121​-129. ​Totowa, NJ: ​Humana Press. DOI: https://doi.org/10.1007/978-1-62703-459-3_7 
    Details  DOI  PMID  PMC 

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