Prof. Dr. Ali El-Armouche

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  • 2020 Journal Article
    ​ ​Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation​
    Li, W.; Stauske, M.; Luo, X.; Wagner, S. ; Vollrath, M.; Mehnert, C. S. & Schubert, M. et al.​ (2020) 
    Frontiers in Cell and Developmental Biology8.​ DOI: 
    Details  DOI 
  • 2019 Journal Article | Research Paper
    ​ ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​
    Eiringhaus, J. ; Herting, J. ; Schatter, F. ; Nikolaev, V. O. ; Sprenger, J.; Wang, Y. & Köhn, M. et al.​ (2019) 
    Basic Research in Cardiology114(2) pp. 13​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article
    ​ ​AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload​
    Schwab, D M; Tilemann, L.; Bauer, R.; Heckmann, M.; Jungmann, A.; Wagner, M. & Burgis, J. et al.​ (2018) 
    Gene Therapy25(1) pp. 13​-19​.​ DOI: 
    Details  DOI 
  • 2018 Journal Article | Research Paper | 
    ​ ​The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation​
    Singh, S.; Lämmle, S.; Giese, H.; Kämmerer, S.; Meyer-Roxlau, S. ; Alfar, E. A. & Dihazi, H.  et al.​ (2018) 
    Scientific Reports8(1) art. 17711​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure20(12) pp. 1673​-1685​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Overview
    ​ ​PDE2 at the crossway between cAMP and cGMP signalling in the heart​
    Weber, S.; Zeller, M.; Guan, K. ; Wunder, F.; Wagner, M. & El-Armouche, A. ​ (2017) 
    Cellular Signalling38 pp. 76​-84​.​ DOI: 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure​
    Abu-Taha, I. H.; Heijman, J.; Hippe, H.-J.; Wolf, N. M.; El-Armouche, A. ; Nikolaev, V. O.   & Schäfer, M.  et al.​ (2017) 
    Circulation135(9) pp. 881​-897​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article | Research Paper
    ​ ​Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity​
    Neef, S.; Heijman, J.; Otte, K.; Dewenter, M. ; Saadatmand, A. R.; Meyer-Roxlau, S.   & Antos, C. L. et al.​ (2017) 
    Naunyn-Schmiedeberg's Archives of Pharmacology390(8) pp. 857​-862​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper
    ​ ​Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction​
    Vettel, C. ; Lindner, M.; Dewenter, M. ; Lorenz, K.; Schanbacher, C.; Riedel, M. & Lämmle, S. et al.​ (2017) 
    Circulation Research120(1) pp. 120​-132​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper | 
    ​ ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​
    Perera, R. K. ; Fischer, T. H. ; Wagner, M.; Dewenter, M. ; Vettel, C. ; Bork, N. I. & Maier, L. S.  et al.​ (2017) 
    Scientific Reports7(1) art. 15222​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper
    ​ ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​
    Dewenter, M. ; Neef, S.; Vettel, C. ; Lämmle, S.; Beushausen, C.; Zelarayan, L. C.   & Katz, S. et al.​ (2017) 
    Circulation: Heart Failure10(5) art. e003840​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article
    ​ ​Cardiac-Specific Overexpression of Phosphodiesterase 2 (PDE2) in Mouse is Cardioprotective​
    Lindner, M.; Vettel, C. ; Dewenter, M. ; Riedel, M.; Lämmle, S.; Mason, F.   & Meinecke, S. et al.​ (2016) 
    Biophysical Journal110(3) pp. 599a​.​ DOI: 
    Details  DOI 
  • 2016 Journal Article
    ​ ​Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice​
    Swain, L. ; Kesemeyer, A.; Meyer-Roxlau, S. ; Vettel, C. ; Zieseniss, A. ; Güntsch, A.   & Jatho, A.  et al.​ (2016) 
    Circulation Research119(9) pp. 1004​-1016​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy​
    Perera, R. K. ; Sprenger, J. U.; Steinbrecher, J. H.; Hübscher, D. ; Lehnart, S. E. ; Abesser, M. & Schuh, K. et al.​ (2015) 
    Circulation Research116(8) pp. 1304​-1311​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper | 
    ​ ​I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model​
    Friedrich, F. W.; Sotoud, H.; Geertz, B.; Weber, S.; Flenner, F.; Reischmann, S. & Eschenhagen, T.  et al.​ (2015) 
    IJC Heart & Vasculature8 pp. 87​-94​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper
    ​ ​Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​
    Godier-Furnemont, A. F. G.; Tiburcy, M. ; Wagner, E. ; Dewenter, M. ; Laemmle, S.; El-Armouche, A.   & Lehnart, S. E.  et al.​ (2015) 
    Biomaterials60 pp. 82​-91​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​The Janus face of BNP therapy in chronic heart failure: beneficial effects unmasked by β blockers?​
    Dewenter, M. ; Vettel, C.   & El-Armouche, A. ​ (2014) 
    Heart100(11) pp. 819​-820​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | Research Paper
    ​ ​Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​
    Unsoeld, B. W.; Kaul, A.; Sbroggi, M.; Schubert, C.; Regitz-Zagrosek, V.; Brancaccio, M. & Damilano, F. et al.​ (2014) 
    Cardiovascular Research101(1) pp. 97​-107​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes​
    Slimane, Z. H.; Bedioune, I.; Lechene, P.; Varin, A.; Lefebvre, F.; Mateo, P. & Domergue-Dupont, V. et al.​ (2014) 
    Cardiovascular Research102(1) pp. 97​-106​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways​
    Vettel, C. ; Lämmle, S.; Ewens, S.; Cervirgen, C.; Emmons, J.; Ongherth, A. & Dewenter, M.  et al.​ (2014) 
    American Journal of Physiology - Heart and Circulatory Physiology306(8) pp. H1246​-H1252​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction​
    Zafiriou, M. P. ; Noack, C. ; Unsoeld, B. W.; Didie, M. ; Pavlova, E.; Fischer, H. J.   & Reichardt, H. M.  et al.​ (2014) 
    STEM CELLS32(9) pp. 2480​-2491​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Dopamine and Lipophilic Derivates Protect Cardiomyocytes against Cold Preservation Injury​
    Vettel, C.; Hottenrott, M. C.; Spindler, R.; Benck, U.; Schnuelle, P.; Tsagogiorgas, C. & Kraemer, B. et al.​ (2014) 
    Journal of Pharmacology and Experimental Therapeutics348(1) pp. 77​-85​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Paradoxical Effects on Force Generation after Efficient beta 1-Adrenoceptor Knockdown in Reconstituted Heart Tissue​
    Neuber, C.; Mueller, O. J.; Hansen, F. C.; Eder, A.; Witten, A.; Ruehle, F. & Stoll, M. et al.​ (2014) 
    Journal of Pharmacology and Experimental Therapeutics349(1) pp. 39​-46​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Conference Abstract
    ​ ​Erythropoietin Enhances Abundance of Cardiomyogenic Precursors in vitro and in vivo​
    Zafeiriou, M. P.; Noack, C.; Unsoeld, B. W.; Didie, M.; El-Armouche, A. ; Bergmann, M. W. & Zimmermann, W.-H.  et al.​ (2013)
    Circulation Research113(4) , Las Vegas, NV.
    Philadelphia​: Lippincott Williams & Wilkins.
    Details  WoS 
  • 2013 Conference Abstract
    ​ ​Phosphodiesterase 2 activates myofibroblast formation and CTGF synthesis in cardiac fibroblasts and augments stiffness in engineered connective tissue​
    Vettel, C.; Laemmle, S.; Emons, J.; Ewens, S.; Cervirgen, C.; Wittkoepper, K. & Wuertz, C. M. et al.​ (2013)
    European Journal of Heart Failure12 
    Hoboken​: Wiley-blackwell.
    Details  WoS 
  • 2013 Journal Article | Overview
    ​ ​Function and regulation of serine/threonine phosphatases in the healthy and diseased heart​
    Heijman, J.; Dewenter, M.; El-Armouche, A.   & Dobrev, D.​ (2013) 
    Journal of Molecular and Cellular Cardiology64 pp. 90​-98​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology465(12) pp. 1763​-1773​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription​
    Renger, A.; Zafiriou, M.-P. ; Noack, C. ; Pavlova, E.; Becker, A. ; Sharkova, K. & Bergmann, M. W. et al.​ (2013) 
    Stem Cells31(5) pp. 928​-940​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Parthenogenetic stem cells for tissue-engineered heart repair​
    Didie, M. ; Christalla, P.; Rubart, M.; Muppala, V. ; Doeker, S.; Unsoeld, B. W. & El-Armouche, A.  et al.​ (2013) 
    Journal of Clinical Investigation123(3) pp. 1285​-1298​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII delta-KO mice​
    Neef, S.; Sag, C. M.; Daut, M.; Baeumer, H.; Grefe, C.; El-Armouche, A.   & DeSantiago, J. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology59 pp. 107​-116​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Development of a Colorimetric and a Fluorescence Phosphatase-Inhibitor Assay Suitable for Drug Discovery Approaches​
    Sotoud, H.; Gribbon, P.; Ellinger, B.; Reinshagen, J.; Boknik, P.; Kattner, L. & El-Armouche, A.  et al.​ (2013) 
    Journal of Biomolecular Screening18(8) pp. 899​-909​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants​
    Didie, M. ; Biermann, D.; Buchert, R.; Hess, A.; Wittkoepper, K.; Christalla, P. & Doeker, S. et al.​ (2013) 
    American Journal of Physiology - Heart and Circulatory Physiology305(4) pp. H533​-H541​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology62(17) pp. 1596​-1606​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Conference Abstract
    ​ ​Role of Erythropoietin Signaling in the Biology of Mouse Cardiac Progenitor Cells​
    Zafeiriou, M. P.; Noack, C.; Didie, M.; Unsoeld, B. W.; El-Armouche, A. ; Bergmann, M. W. & Zimmermann, W.-H.  et al.​ (2012)
    Circulation Research111(4) , New Orleans, LA.
    Philadelphia​: Lippincott Williams & Wilkins.
    Details  WoS 
  • 2012 Journal Article | Research Paper
    ​ ​Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP)​
    Unsoeld, B. W.; Schotola, H.; Jacobshagen, C. ; Seidler, T. ; Sossalla, S. ; Emmons, J. & Klede, S. et al.​ (2012) 
    European Journal of Heart Failure14(4) pp. 430​-437​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Conference Abstract
    ​ ​Ablation of Phosphatase-1-Inhibitor-1 is Detrimental in CaMKII Overexpression Despite Reduction of SR Ca2+Leak​
    Neef, S.; Wittkoepper, K.; Brammen, C.; Sowa, T.; Zimmermann, W.-H. ; Brown, J. H. & Maier, L. S.  et al.​ (2011)
    Philadelphia​: Lippincott Williams & Wilkins.
    Details  WoS 
  • 2011 Journal Article
    ​ ​Ca2+-Related Signaling and Protein Phosphorylation Abnormalities Play Central Roles in a New Experimental Model of Electrical Storm​
    Tsuji, Y.; Hojo, M.; Voigt, N. ; El-Armouche, A. ; Inden, Y.; Murohara, T. & Dobrev, D. et al.​ (2011) 
    Circulation123(20) pp. 2192​-U67​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue​
    Tiburcy, M. ; Didie, M. ; Boy, O.; Christalla, P.; Doeker, S.; Naito, H. & Karikkineth, B. C. et al.​ (2011) 
    Circulation Research109(10) pp. 1105​-U46​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​
    Wittoepper, K.; Fabritz, L.; Neef, S.; Ort, K. R.; Grefe, C.; Unsoeld, B. W. & Kirchhof, P. et al.​ (2010) 
    Journal of Clinical Investigation120(2) pp. 617​-626​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Common MicroRNA Signatures in Cardiac Hypertrophic and Atrophic Remodeling Induced by Changes in Hemodynamic Load​
    El-Armouche, A. ; Schwoerer, A. P.; Neuber, C.; Emmons, J.; Biermann, D.; Christalla, T. & Grundhoff, A. et al.​ (2010) 
    PLoS ONE5(12) art. e14263​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium​
    Sossalla, S. ; Fluschnik, N.; Schotola, H.; Ort, K. R.; Neef, S.; Schulte, T. & Wittkoepper, K. et al.​ (2010) 
    Circulation Research107(9) pp. 1150​-U215​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy​
    El-Armouche, A. ; Wittkoepper, K.; Degenhardt, F.; Weinberger, F.; Didie, M. ; Melnychenko, I. & Grimm, M.  et al.​ (2008) 
    Cardiovascular Research80(3) pp. 396​-406​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Adenovirus-delivered short hairpin RNA targeting contractile function in reconstituted heart PKC alpha improves tissue​
    El-Armouche, A. ; Singh, J.; Naito, H.; Wittkoepper, K.; Didie, M. ; Laatsch, A. & Zimmermann, W.-H.  et al.​ (2007) 
    Journal of Molecular and Cellular Cardiology43(3) pp. 371​-376​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2003 Journal Article
    ​ ​Evidence for protein phosphatase inhibitor-1 playing an amplifier role in β-adrenergic signaling in cardiac myocytes​
    El-Armouche, A. ; Rau, T.; Zolk, O.; Ditz, D.; Pamminger, T.; Zimmermann, W.-H.   & Jäckel, E.  et al.​ (2003) 
    The FASEB Journal17(3) pp. 437​-439​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2003 Journal Article | Research Paper
    ​ ​24-h Langendorff-perfused neonatal rat heart used to study the impact of adenoviral gene transfer​
    Wiechert, S.; El-Armouche, A. ; Rau, T.; Zimmermann, W.-H.   & Eschenhagen, T. ​ (2003) 
    American Journal of Physiology - Heart and Circulatory Physiology285(2) pp. H907​-H914​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 

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