Dr. med. Michael Didié

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  • 2019 Journal Article
    ​ ​Control of p21Cip by BRAP is Critical for Cardiomyocyte Cell Cycle Progression and Survival​
    Volland, C.; Schott, P. ; Didié, M. ; Männer, J. ; Unsöld, B.; Toischer, K.   & Schmidt, C. et al.​ (2019) 
    Cardiovascular Research,.​ DOI: https://doi.org/10.1093/cvr/cvz177 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper | 
    ​ ​T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure​
    Gröschel, C. ; Sasse, A. ; Röhrborn, C. ; Monecke, S. ; Didié, M. ; Elsner, L.   & Kruse, V.  et al.​ (2017) 
    Scientific Reports7(1) art. 15998​.​ DOI: https://doi.org/10.1038/s41598-017-16147-1 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper | 
    ​ ​Immunological Properties of Murine Parthenogenetic Stem Cells and Their Differentiation Products​
    Johannsen, H. ; Muppala, V. ; Gröschel, C. ; Monecke, S. ; Elsner, L. ; Didié, M.   & Zimmermann, W.-H.  et al.​ (2017) 
    Frontiers in Immunology8 art. 924​.​ DOI: https://doi.org/10.3389/fimmu.2017.00924 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper | 
    ​ ​Immunological Properties of Murine Parthenogenetic Stem Cell-Derived Cardiomyocytes and Engineered Heart Muscle​
    Didié, M. ; Galla, S. ; Muppala, V. ; Dressel, R.   & Zimmermann, W.-H. ​ (2017) 
    Frontiers in Immunology8 art. 955​.​ DOI: https://doi.org/10.3389/fimmu.2017.00955 
    Details  DOI 
  • 2016 Journal Article | Research Paper
    ​ ​Axial tubule junctions control rapid calcium signaling in atria​
    Brandenburg, S. ; Kohl, T. ; Williams, G. S. B.; Gusev, K.; Wagner, E. ; Rog-Zielinska, E. A. & Hebisch, E. et al.​ (2016) 
    Journal of Clinical Investigation126(10) pp. 3999​-4015​.​ DOI: https://doi.org/10.1172/JCI88241 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper | 
    ​ ​Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival​
    Volland, C.; Bremer, S. ; Hellenkamp, K. ; Hartmann, N. H. ; Dybkova, N.; Khadjeh, S.   & Kutschenko, A. et al.​ (2016) 
    Scientific Reports6 art. 33853​.​ DOI: https://doi.org/10.1038/srep33853 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload​
    Montes-Cobos, E. ; Li, X. ; Fischer, H. J. ; Sasse, A. ; Kügler, S. ; Didié, M.   & Toischer, K.  et al.​ (2015) 
    PLOS ONE10(11) art. e0143954​.​ DOI: https://doi.org/10.1371/journal.pone.0143954 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Differential PI3K Signal Transduction in Obesity-Associated Cardiac Hypertrophy and Response to Ischemia​
    Unsoeld, B. W.; Bremen, E.; Didie, M. ; Hasenfuß, G.   & Schaefer, K. ​ (2015) 
    Obesity23(1) pp. 90​-99​.​ DOI: https://doi.org/10.1002/oby.20888 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Cardiac Engraftment of Genetically-Selected Parthenogenetic Stem Cell-Derived Cardiomyocytes​
    Yang, T.; Rubart, M.; Soonpaa, M. H.; Didie, M. ; Christalla, P.; Zimmermann, W.-H.   & Field, L. J.​ (2015) 
    PLoS ONE10(6) art. e0131511​.​ DOI: https://doi.org/10.1371/journal.pone.0131511 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice​
    Unsoeld, B. W.; Teucher, N. ; Didie, M. ; Sossalla, S. ; Jacobshagen, C. ; Seidler, T.   & Schillinger, W.  et al.​ (2015) 
    Cardiovascular Therapeutics33(1) pp. 20​-26​.​ DOI: https://doi.org/10.1111/1755-5922.12102 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Book Chapter
    ​ ​Ultrasound Techniques for the Detection of Tumors and Metastases in Small Animals​
    Didié, M.  & Zimmermann, W.-H. ​ (2014)
    In: Metastasis Research Protocols pp. 181​-190. (2. ed.. ed.). ​New York: ​Humana Press. DOI: https://doi.org/10.1007/978-1-4614-8244-4_13 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | Research Paper | 
    ​ ​Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction​
    Zafiriou, M. P. ; Noack, C. ; Unsoeld, B. W.; Didie, M. ; Pavlova, E.; Fischer, H. J.   & Reichardt, H. M.  et al.​ (2014) 
    STEM CELLS32(9) pp. 2480​-2491​.​ DOI: https://doi.org/10.1002/stem.1741 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology465(12) pp. 1763​-1773​.​ DOI: https://doi.org/10.1007/s00424-013-1316-y 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity​
    Leifheit-Nestler, M. ; Wagner, N.-M.; Gogiraju, R.; Didie, M. ; Konstantinides, S.; Hasenfuß, G.   & Schaefer, K. ​ (2013) 
    Journal of Translational Medicine11 art. 170​.​ DOI: https://doi.org/10.1186/1479-5876-11-170 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants​
    Didie, M. ; Biermann, D.; Buchert, R.; Hess, A.; Wittkoepper, K.; Christalla, P. & Doeker, S. et al.​ (2013) 
    American Journal of Physiology - Heart and Circulatory Physiology305(4) pp. H533​-H541​.​ DOI: https://doi.org/10.1152/ajpheart.00218.2013 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Parthenogenetic stem cells for tissue-engineered heart repair​
    Didie, M. ; Christalla, P.; Rubart, M.; Muppala, V. ; Doeker, S.; Unsoeld, B. W. & El-Armouche, A.  et al.​ (2013) 
    Journal of Clinical Investigation123(3) pp. 1285​-1298​.​ DOI: https://doi.org/10.1172/JCI66854 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper | 
    ​ ​Impact of AT2 Receptor Deficiency on Postnatal Cardiovascular Development​
    Biermann, D.; Heilmann, A.; Didie, M. ; Schlossarek, S.; Wahab, A.; Grimm, M.   & Roemer, M. et al.​ (2012) 
    PLoS ONE7(10) art. e47916​.​ DOI: https://doi.org/10.1371/journal.pone.0047916 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart​
    Knöll, R.; Linke, W. A. ; Zou, P.; Miocic, S.; Kostin, S.; Buyandelger, B. & Ku, C.-H. et al.​ (2011) 
    Circulation Research109(7) pp. 758​-U153​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.111.245787 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue​
    Tiburcy, M. ; Didie, M. ; Boy, O.; Christalla, P.; Doeker, S.; Naito, H. & Karikkineth, B. C. et al.​ (2011) 
    Circulation Research109(10) pp. 1105​-U46​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.111.251843 
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  • 2011 Journal Article | Research Paper
    ​ ​Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo​
    Grebe, C.; Klingebiel, T.-M.; Grau, S. P.; Toischer, K. ; Didie, M. ; Jacobshagen, C.   & Dullin, C.  et al.​ (2011) 
    Cardiovascular Research90(3) pp. 521​-528​.​ DOI: https://doi.org/10.1093/cvr/cvr023 
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  • 2011 Journal Article | Research Paper | 
    ​ ​Diastolic dysfunction and arrhythmias caused by overexpression of CaMKII delta(C) can be reversed by inhibition of late Na+ current​
    Sossalla, S. ; Maurer, U.; Schotola, H.; Hartmann, N. H. ; Didie, M. ; Zimmermann, W.-H.   & Jacobshagen, C.  et al.​ (2011) 
    Basic Research in Cardiology106(2) pp. 263​-272​.​ DOI: https://doi.org/10.1007/s00395-010-0136-x 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper
    ​ ​A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy​
    Knöll, R.; Kostin, S.; Klede, S.; Savvatis, K.; Klinge, L. ; Stehle, I. & Gunkel, S. et al.​ (2010) 
    Circulation Research106(4) pp. 695​-704​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.109.206243 
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  • 2010 Journal Article | Research Paper | 
    ​ ​Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation​
    Rudolph, V.; Andrié, R. P.; Rudolph, T. K.; Friedrichs, K.; Klinke, A.; Hirsch-Hoffmann, B. & Schwoerer, A. P. et al.​ (2010) 
    Nature Medicine16(4) pp. 470​-474​.​ DOI: https://doi.org/10.1038/nm.2124 
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  • 2010 Journal Article | Research Paper
    ​ ​PDGF-BB protects cardiomyocytes from apoptosis and improves contractile function of engineered heart tissue​
    van Tol, M.-J.; Karikkineth, B. C.; Naito, H.; Tiburcy, M. ; Didie, M. ; Nose, M. & Rosenkranz, S. et al.​ (2010) 
    Journal of Molecular and Cellular Cardiology48(6) pp. 1316​-1323​.​ DOI: https://doi.org/10.1016/j.yjmcc.2010.03.008 
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  • 2008 Journal Article | Research Paper
    ​ ​Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy​
    El-Armouche, A. ; Wittkoepper, K.; Degenhardt, F.; Weinberger, F.; Didie, M. ; Melnychenko, I. & Grimm, M.  et al.​ (2008) 
    Cardiovascular Research80(3) pp. 396​-406​.​ DOI: https://doi.org/10.1093/cvr/cvn208 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Conference Paper | Research Paper
    ​ ​Development of a biological ventricular assist device - Preliminary data from a small animal model​
    Yildirim, Y.; Naito, H.; Didie, M. ; Karikkineth, B. C.; Biermann, D.; Eschenhagen, T.   & Zimmermann, W.-H. ​ (2007)
    ​Circulation (11) pp. I16​-I23. (Vol. 116). ​79th Annual Scientific Session of the American-Heart-Association​, Chicago, IL.
    Philadelphia​: Lippincott Williams & Wilkins. DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.679688 
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  • 2007 Journal Article | Research Paper
    ​ ​Adenovirus-delivered short hairpin RNA targeting contractile function in reconstituted heart PKC alpha improves tissue​
    El-Armouche, A. ; Singh, J.; Naito, H.; Wittkoepper, K.; Didie, M. ; Laatsch, A. & Zimmermann, W.-H.  et al.​ (2007) 
    Journal of Molecular and Cellular Cardiology43(3) pp. 371​-376​.​ DOI: https://doi.org/10.1016/j.yjmcc.2007.05.021 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts​
    Zimmermann, W.-H. ; Melnychenko, I.; Wasmeier, G. H.; Didie, M. ; Naito, H.; Nixdorff, U. & Hess, A. et al.​ (2006) 
    Nature Medicine12(4) pp. 452​-458​.​ DOI: https://doi.org/10.1038/nm1394 
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  • 2006 Review
    ​ ​Heart muscle engineering: An update on cardiac muscle replacement therapy​
    Zimmermann, W.-H. ; Didie, M. ; Doeker, S.; Melnychenko, I.; Naito, H.; Rogge, C.& Tiburcy, M.  et al.​ (2006)
    Cardiovascular Research, 71​(3) pp. 419​-429​.​
    Oxford Univ Press. DOI: https://doi.org/10.1016/j.cardiores.2006.03.023 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Conference Paper | Research Paper
    ​ ​Optimizing engineered heart tissue for therapeutic applications as surrogate heart muscle​
    Naito, H.; Melnychenko, I.; Didie, M. ; Schneiderbanger, K.; Schubert, P.; Rosenkranz, S. & Eschenhagen, T.  et al.​ (2006)
    ​Circulation pp. I72​-I78. (Vol. 114). , Dallas, TX.
    Philadelphia​: Lippincott Williams & Wilkins. DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.001560 
    Details  DOI  PMID  PMC  WoS 
  • 2005 Journal Article | Research Paper
    ​ ​Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition​
    Münzel, F.; Muhlhauser, U.; Zimmermann, W.-H. ; Didie, M. ; Schneiderbanger, K.; Schubert, P. & Engmann, S. et al.​ (2005) 
    Cardiovascular Research68(3) pp. 464​-474​.​ DOI: https://doi.org/10.1016/j.cardiores.2005.06.020 
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  • 2002 Journal Article
    ​ ​3D engineered heart tissue for replacement therapy​
    Eschenhagen, T. ; Didié, M. ; Münzel, F.; Schubert, P.; Schneiderbanger, K. & Zimmermann, W.-H. ​ (2002) 
    Basic Research in Cardiology97 pp. I146​-I152​.​ DOI: https://doi.org/10.1007/s003950200043 
    Details  DOI 
  • 2002 Journal Article | Research Paper
    ​ ​Tissue engineering of a differentiated cardiac muscle construct​
    Zimmermann, W.-H. ; Schneiderbanger, K.; Schubert, P.; Didié, M. ; Münzel, F.; Heubach, J. & Kostin, S. et al.​ (2002) 
    Circulation Research90(2) pp. 223​-230​.​ DOI: https://doi.org/10.1161/hh0202.103644 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article | Research Paper
    ​ ​Cardiac tissue engineering​
    Eschenhagen, T. ; Didie, M. ; Heubach, J.; Ravens, U. & Zimmermann, W.-H. ​ (2002) 
    Transplant Immunology9(2-4) art. PII S0966-3274(02)00011-4​.​ DOI: https://doi.org/10.1016/S0966-3274(02)00011-4 
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