Dr. med. Tim Seidler

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  • 2021 | Journal Article | Research Paper
    ​ ​Exercise-Stress Real-time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The HFpEF Stress Trial​
    Backhaus, S. J; Lange, T.; George, E. F; Hellenkamp, K. ; Gertz, R. J; Billing, M. & Wachter, R.  et al.​ (2021) 
    Circulation,.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.051542 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Real-time cardiovascular magnetic resonance T1 and extracellular volume fraction mapping for tissue characterisation in aortic stenosis​
    Backhaus, S. J. ; Lange, T.; Beuthner, B. E.; Topci, R.; Wang, X.; Kowallick, J. T.   & Lotz, J.  et al.​ (2020) 
    Journal of Cardiovascular Magnetic Resonance, 22(1) pp. 46​.​ DOI: https://doi.org/10.1186/s12968-020-00632-0 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​A MACHINE LEARNING APPROACH FOR THE PREDICTION OF PULMONARY HYPERTENSION​
    Seidler, T. ; Hellenkamp, K. ; Unsoeld, B.; Mushemi-Blake, S.; Shah, A.; Hasenfuss, G.   & Leha, A. ​ (2019) 
    Journal of the American College of Cardiology, 73(9) pp. 1589​.​ DOI: https://doi.org/10.1016/S0735-1097(19)32195-3 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​A machine learning approach for the prediction of pulmonary hypertension​
    Leha, A. ; Hellenkamp, K. ; Unsöld, B.; Mushemi-Blake, S.; Shah, A. M.; Hasenfuß, G.   & Seidler, T. ​ (2019) 
    PLoS One, 14(10) pp. e0224453​.​ DOI: https://doi.org/10.1371/journal.pone.0224453 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Control of p21Cip by BRAP is Critical for Cardiomyocyte Cell Cycle Progression and Survival​
    Volland, C.; Schott, P. ; Didié, M. ; Männer, J. ; Unsöld, B.; Toischer, K.   & Schmidt, C. et al.​ (2019) 
    Cardiovascular Research,.​ DOI: https://doi.org/10.1093/cvr/cvz177 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Echocardiographic Estimation of Mean Pulmonary Artery Pressure: A Comparison of Different Approaches to Assign the Likelihood of Pulmonary Hypertension​
    Hellenkamp, K. ; Unsöld, B.; Mushemi-Blake, S.; Shah, A. M.; Friede, T. ; Hasenfuß, G.   & Seidler, T. ​ (2018) 
    Journal of the American Society of Echocardiography, 31(1) pp. 89​-98​.​ DOI: https://doi.org/10.1016/j.echo.2017.09.009 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction​
    Tita, C.; Gilbert, E. M.; Van Bakel, A. B.; Grzybowski, J.; Haas, G. J.; Jarrah, M. & Dunlap, S. H. et al.​ (2017) 
    European Journal of Heart Failure, 19(10) pp. 1321​-1332​.​ DOI: https://doi.org/10.1002/ejhf.897 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Feasibility and outcomes of interventional treatment for vascular access site complications following transfemoral aortic valve implantation​
    Seidler, T. ; Hünlich, M. ; Puls, M. ; Hasenfuß, G.   & Jacobshagen, C. ​ (2016) 
    Clinical Research in Cardiology, 106(3) pp. 183​-191​.​ DOI: https://doi.org/10.1007/s00392-016-1038-1 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival​
    Volland, C.; Bremer, S. ; Hellenkamp, K. ; Hartmann, N. H. ; Dybkova, N.; Khadjeh, S.   & Kutschenko, A. et al.​ (2016) 
    Scientific Reports, 6 art. 33853​.​ DOI: https://doi.org/10.1038/srep33853 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice​
    Unsoeld, B. W.; Teucher, N. ; Didie, M. ; Sossalla, S. ; Jacobshagen, C. ; Seidler, T.   & Schillinger, W.  et al.​ (2015) 
    Cardiovascular Therapeutics, 33(1) pp. 20​-26​.​ DOI: https://doi.org/10.1111/1755-5922.12102 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy​
    Kramann, N. ; Hasenfuß, G.   & Seidler, T. ​ (2014) 
    Cardiovascular Research, 102(1) pp. 88​-96​.​ DOI: https://doi.org/10.1093/cvr/cvu024 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​
    Unsoeld, B. W.; Kaul, A.; Sbroggi, M.; Schubert, C.; Regitz-Zagrosek, V.; Brancaccio, M. & Damilano, F. et al.​ (2014) 
    Cardiovascular Research, 101(1) pp. 97​-107​.​ DOI: https://doi.org/10.1093/cvr/cvt235 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper
    ​ ​Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP)​
    Unsoeld, B. W.; Schotola, H.; Jacobshagen, C. ; Seidler, T. ; Sossalla, S. ; Emmons, J. & Klede, S. et al.​ (2012) 
    European Journal of Heart Failure, 14(4) pp. 430​-437​.​ DOI: https://doi.org/10.1093/eurjhf/hfs020 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure​
    Seidler, T. ; Teucher, N. ; Hellenkamp, K. ; Unsoeld, B. W.; Grebe, C.; Kramps, P. & Schotola, H. et al.​ (2011) 
    Journal of Molecular and Cellular Cardiology, 50(1) pp. 33​-42​.​ DOI: https://doi.org/10.1016/j.yjmcc.2010.08.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo​
    Grebe, C.; Klingebiel, T.-M.; Grau, S. P.; Toischer, K. ; Didie, M. ; Jacobshagen, C.   & Dullin, C.  et al.​ (2011) 
    Cardiovascular Research, 90(3) pp. 521​-528​.​ DOI: https://doi.org/10.1093/cvr/cvr023 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Distribution of potassium levels on admission for CPR-Severe hypokalaemia with dysmorphophobic eating disorders​
    Seidler, T. ; Jacobshagen, C. ; Bauer, M. ; Hasenfuß, G.   & Waeschle, R. M.​ (2011) 
    Resuscitation, 82(5) pp. 535​-537​.​ DOI: https://doi.org/10.1016/j.resuscitation.2011.01.014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article
    ​ ​Proteome changes in CaMKIIδC-overexpressing cardiac myocytes​
    Schott, P. ; Jacobshagen, C. ; Köhler, J.; Seidler, T. ; Asif, A. R. ; Dihazi, H.   & Hasenfuß, G.  et al.​ (2010) 
    Cardiovascular Pathology, 19(6) pp. e241​-e250​.​ DOI: https://doi.org/10.1016/j.carpath.2009.11.005 
    ​Details  DOI 
  • 2010 | Journal Article | Research Paper
    ​ ​Overexpression of Integrin beta 5 Enhances the Paracrine Properties of Circulating Angiogenic Cells via Src Kinase-Mediated Activation of STAT3​
    Leifheit-Nestler, M. ; Conrad, G.; Heida, N.-M.; Limbourg, A.; Limbourg, F. P.; Seidler, T.   & Schroeter, M. R.  et al.​ (2010) 
    Arteriosclerosis, Thrombosis, and Vascular Biology, 30(7) pp. 1398​-U339​.​ DOI: https://doi.org/10.1161/ATVBAHA.110.206086 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum​
    Toischer, K. ; Lehnart, S. E. ; Tenderich, G.; Milting, H.; Koerfer, R.; Schmitto, J. D. & Schoendube, F. A.  et al.​ (2010) 
    Basic Research in Cardiology, 105(2) pp. 279​-287​.​ DOI: https://doi.org/10.1007/s00395-009-0057-8 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium​
    Jacobshagen, C. ; Pelster, T.; Pax, A.; Horn, W.; Schmidt-Schweda, S.; Unsoeld, B. W. & Seidler, T.  et al.​ (2010) 
    Clinical Research in Cardiology, 99(5) pp. 267​-276​.​ DOI: https://doi.org/10.1007/s00392-010-0113-2 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Differential Cardiac Remodeling in Preload Versus Afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Sossalla, S.   & Reuter, S. P. et al.​ (2010) 
    Circulation, 122(10) pp. 993​-1003​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.943431 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | Research Paper
    ​ ​Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors​
    Jacobshagen, C. ; Pax, A.; Unsoeld, B. W.; Seidler, T. ; Schmidt-Schweda, S.; Hasenfuß, G.   & Maier, L. S. ​ (2009) 
    Resuscitation, 80(11) pp. 1223​-1228​.​ DOI: https://doi.org/10.1016/j.resuscitation.2009.06.032 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Elevated Afterload, Neuroendocrine Stimulation, and Human Heart Failure Increase BNP Levels and Inhibit Preload-Dependent SERCA Upregulation​
    Toischer, K. ; Koegler, H.; Tenderich, G.; Grebe, C.; Seidler, T. ; Van, P. N. & Jung, K.  et al.​ (2008) 
    Circulation: Heart Failure, 1(4) pp. 265​-271​.​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.108.785279 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes​
    Seidler, T. ; Loughrey, C. M.; Zibrova, D.; Kettlewell, S.; Teucher, N. ; Koegler, H. & Hasenfuß, G.  et al.​ (2007) 
    Circulation Research, 101(10) pp. 1020​-1029​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.107.154609 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Review
    ​ ​Targeting altered calcium physiology in the heart: Translational approaches to excitation, contraction, and transcription​
    Seidler, T. ; Hasenfuß, G.  & Maier, L. S. ​ (2007)
    Physiology, 22​(5) pp. 328​-334​.​
    Amer Physiological Soc. DOI: https://doi.org/10.1152/physiol.00015.2007 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression​
    Koegler, H.; Schott, P. ; Toischer, K. ; Milting, H.; Van, P. N.; Kohlhaas, M. & Grebe, C. et al.​ (2006) 
    Circulation, 113(23) pp. 2724​-2732​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.608828 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy​
    Takahashi, H.; Takeishi, Y.; Seidler, T. ; Arimoto, T.; Akiyama, H.; Hozumi, Y . & Koyama, Y. et al.​ (2005) 
    Circulation, 111(12) pp. 1510​-1516​.​ DOI: https://doi.org/10.1161/01.CIR.0000159339.00703.22 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes​
    Miller, S. L. W.; Currie, S.; Loughrey, C. M.; Kettlewell, S.; Seidler, T. ; Reynolds, D. F. & Hasenfuß, G.  et al.​ (2005) 
    Cardiovascular Research, 67(4) pp. 667​-677​.​ DOI: https://doi.org/10.1016/j.cardiores.2005.04.023 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article | Research Paper
    ​ ​Evidence for altered interleukin (IL)-18 pathway in human heart failure​
    Mallat, Z.; Heymes, C.; Corbaz, A.; Logeart, D.; Alouani, S.; Cohen-Solal, A. & Seidler, T.  et al.​ (2004) 
    The FASEB journal, 18(12) pp. 1752​-+​.​ DOI: https://doi.org/10.1096/fj.04-2426fje 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article | Research Paper
    ​ ​Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes​
    Loughrey, C. M.; Seidler, T. ; Miller, S. L. W.; Prestle, J. ; MacEachern, K.; Reynolds, D. F. & Hasenfuß, G.  et al.​ (2004) 
    The Journal of Physiology, 556(3) pp. 919​-934​.​ DOI: https://doi.org/10.1113/jphysiol.2003.057166 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article | Research Paper
    ​ ​Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening​
    Teucher, N. ; Prestle, J. ; Seidler, T. ; Currie, S.; Elliott, E. B.; Reynolds, D. F. & Schott, P.  et al.​ (2004) 
    Circulation, 110(23) pp. 3553​-3559​.​ DOI: https://doi.org/10.1161/01.CIR.0000145161.48545.B3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes​
    Seidler, T. ; Miller, S. L. W.; Loughrey, C. M.; Kania, A.; Burow, A.; Kettlewell, S. & Teucher, N.  et al.​ (2003) 
    Circulation Research, 93(2) pp. 132​-139​.​ DOI: https://doi.org/10.1161/01.RES.0000081596.90205.E2 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Na+-Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury​
    Wagner, S. ; Seidler, T. ; Picht, E.; Maier, L. S. ; Kazanski, V.; Teucher, N.   & Schillinger, W.  et al.​ (2003) 
    Cardiovascular Research, 60(2) pp. 404​-412​.​ DOI: https://doi.org/10.1016/j.cardiores.2003.08.006 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Letter Note
    ​ ​Treatment of heart failure through stabilization of the cardiac ryanodine receptor​
    Hasenfuß, G.   & Seidler, T. ​ (2003) 
    Circulation, 107(3) pp. 378​-380​.​ DOI: https://doi.org/10.1161/01.CIR.0000046342.46135.CB 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​The functional effect of adenoviral Na+/Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+-ATPase​
    Schillinger, W. ; Ohler, A.; Embry, S. L.; Muller, F.; Christians, C.; Janssen, P. M. L. & Kogler, H. et al.​ (2003) 
    Cardiovascular Research, 57(4) pp. 996​-1003​.​ DOI: https://doi.org/10.1016/S0008-6363(02)00829-5 
    ​Details  DOI  PMID  PMC  WoS 

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