Dr. rer. nat. Sebastian Kügler

 
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  • 2022 Journal Article | Research Paper | 
    ​ ​α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals​
    Leite, K.; Garg, P.; Spitzner, F. P.; Guerin Darvas, S.; Bähr, M. ; Priesemann, V.   & Kügler, S. ​ (2022) 
    Frontiers in Molecular Neuroscience15.​ DOI: https://doi.org/10.3389/fnmol.2022.868790 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article
    ​ ​Patterning inconsistencies restrict the true potential of dopaminergic neurons derived from human induced pluripotent stem cells​
    Mahajani, S.; Bähr, M.   & Kügler, S. ​ (2021) 
    Neural Regeneration Research16(4) pp. 692​.​ DOI: https://doi.org/10.4103/1673-5374.295316 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery​
    Weber-Adrian, D.; Kofoed, R. H.; Silburt, J.; Noroozian, Z.; Shah, K.; Burgess, A. & Rideout, S. et al.​ (2021) 
    Scientific Reports11(1).​ DOI: https://doi.org/10.1038/s41598-021-81046-5 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Syntenin-knock out reduces exosome turnover and viral transduction​
    Kashyap, R.; Balzano, M.; Lechat, B.; Lambaerts, K.; Egea-Jimenez, A. L.; Lembo, F. & Fares, J. et al.​ (2021) 
    Scientific Reports11(1).​ DOI: https://doi.org/10.1038/s41598-021-81697-4 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation​
    Festerling, K.; Can, K. ; Kügler, S.   & Müller, M. ​ (2020) 
    Cells9(12) pp. 2539​.​ DOI: https://doi.org/10.3390/cells9122539 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​Dopamine promotes the neurodegenerative potential of β‐synuclein​
    Raina, A.; Leite, K.; Guerin, S.; Mahajani, S. U.; Chakrabarti, K. S.; Voll, D. & Becker, S.  et al.​ (2020) 
    Journal of Neurochemistry156(5) pp. 674​-691​.​ DOI: https://doi.org/10.1111/jnc.15134 
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  • 2019 Journal Article
    ​ ​Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons​
    Raina, A.; Mahajani, S.; Bähr, M.   & Kügler, S. ​ (2019) 
    Molecular Neurobiology57(1) pp. 249​-260​.​ DOI: https://doi.org/10.1007/s12035-019-01701-x 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Probing the function of glycinergic neurons in the mouse respiratory network using optogenetics​
    Fortuna, M. G. ; Kügler, S.   & Hülsmann, S. ​ (2019) 
    Respiratory Physiology & Neurobiology265 pp. 141​-152​.​ DOI: https://doi.org/10.1016/j.resp.2018.10.008 
    Details  DOI 
  • 2019 Journal Article
    ​ ​CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies​
    Castro-Sánchez, S.; García-Yagüe, Á. J.; Kügler, S.   & Lastres-Becker, I.​ (2019) 
    Redox Biology22 pp. 101118​.​ DOI: https://doi.org/10.1016/j.redox.2019.101118 
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  • 2019 Journal Article | 
    ​ ​Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease​
    Weber-Adrian, D.; Kofoed, R. H.; Chan, J. W. Y.; Silburt, J.; Noroozian, Z.; Kügler, S.   & Hynynen, K. et al.​ (2019) 
    Theranostics9(26) pp. 8127​-8137​.​ DOI: https://doi.org/10.7150/thno.36718 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Vti1b promotes TRPV1 sensitization during inflammatory pain​
    Sondermann, J. R.; Barry, A. M.; Jahn, O. ; Michel, N.; Abdelaziz, R.; Kügler, S.   & Gomez-Varela, D. et al.​ (2019) 
    Pain160(2) pp. 508​-527​.​ DOI: https://doi.org/10.1097/j.pain.0000000000001418 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors​
    Mahajani, S.; Raina, A.; Fokken, C.; Kügler, S.   & Bähr, M. ​ (2019) 
    Cell Death & Disease10(12).​ DOI: https://doi.org/10.1038/s41419-019-2133-9 
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  • 2018 Journal Article
    ​ ​Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free “GeneSwitch” vector​
    Cheng, S.; Tereshchenko, J. ; Zimmer, V.; Vachey, G.; Pythoud, C.; Rey, M. & Liefhebber, J. et al.​ (2018) 
    Experimental Neurology309 pp. 79​-90​.​ DOI: https://doi.org/10.1016/j.expneurol.2018.07.017 
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  • 2018 Journal Article
    ​ ​Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy​
    Cuadrado, A.; Kügler, S.   & Lastres-Becker, I.​ (2018) 
    Redox Biology14 pp. 522​-534​.​ DOI: https://doi.org/10.1016/j.redox.2017.10.010 
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  • 2018 Journal Article | Research Paper | 
    ​ ​A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice​
    Al‐Moyed, H.; Cepeda, A. P. ; Jung, S. ; Moser, T. ; Kügler, S.   & Reisinger, E. ​ (2018) 
    EMBO Molecular Medicine11(1).​ DOI: https://doi.org/10.15252/emmm.201809396 
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  • 2018 Journal Article | Erratum | 
    ​ ​Correction to: Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model​
    Drinkut, A.; Tillack, K.; Meka, D. P.; Schulz, J. B. ; Kügler, S.   & Kramer, E. R.​ (2018) 
    Cell Death & Disease9(6).​ DOI: https://doi.org/10.1038/s41419-018-0636-4 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Long-Term Assessment of AAV-Mediated Zinc Finger Nuclease Expression in the Mouse Brain​
    Zahur, M. ; Tolö, J. ; Bähr, M.   & Kügler, S. ​ (2017) 
    Frontiers in Molecular Neuroscience10 art. 142​.​ DOI: https://doi.org/10.3389/fnmol.2017.00142 
    Details  DOI 
  • 2015 Journal Article | Research Paper
    ​ ​AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury​
    Challagundla, M.; Koch, J. C. ; Ribas, V. T. ; Michel, U. ; Kügler, S. ; Ostendorf, T. & Bradke, F. et al.​ (2015) 
    Journal of Neurochemistry134(2) pp. 261​-275​.​ DOI: https://doi.org/10.1111/jnc.13102 
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  • 2015 Conference Abstract
    ​ ​Employing optogenetics for auditory neuroscience and cochlear implants​
    Keppeler, D. ; Hernandez, V. H.; Gehrt, A. ; Jeschke, M. ; Wrobel, C.; Hoch, G.   & Gossler, C. et al.​ (2015)
    European Biophysics Journal44 , Dresden, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation​
    Kunadt, M.; Eckermann, K.; Stuendl, A.; Gong, J.; Russo, B.; Strauss, K. & Rai, S. et al.​ (2015) 
    Acta Neuropathologica129(5) pp. 695​-713​.​ DOI: https://doi.org/10.1007/s00401-015-1408-1 
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  • 2015 Journal Article
    ​ ​Dimerization propensities of Synucleins are not predictive for Synuclein aggregation​
    Eckermann, K.; Kügler, S.   & Bähr, M. ​ (2015) 
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease1852(8) pp. 1658​-1664​.​ DOI: https://doi.org/10.1016/j.bbadis.2015.05.002 
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  • 2015 Conference Abstract
    ​ ​In vivo application of optogenetics in the auditory system​
    Keppeler, D. ; Jeschke, M. ; Wrobel, C.; Hoch, G. ; Gossler, C.; Schwarz, U. T. & Ruther, P. et al.​ (2015)
    Acta Physiologica213 pp. 35​-36. 
    Hoboken​: Wiley-blackwell.
    Details  WoS 
  • 2015 Journal Article | Research Paper | 
    ​ ​Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload​
    Montes-Cobos, E. ; Li, X. ; Fischer, H. J. ; Sasse, A. ; Kügler, S. ; Didié, M.   & Toischer, K.  et al.​ (2015) 
    PLOS ONE10(11) art. e0143954​.​ DOI: https://doi.org/10.1371/journal.pone.0143954 
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  • 2014 Journal Article | Research Paper
    ​ ​Optogenetic stimulation of the auditory pathway​
    Hernandez, V. H.; Gehrt, A. ; Reuter, K.; Jing, Z.; Jeschke, M. ; Schulz, A. M. & Hoch, G.  et al.​ (2014) 
    Journal of Clinical Investigation124(3) pp. 1114​-1129​.​ DOI: https://doi.org/10.1172/JCI69050 
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  • 2014 Journal Article | Research Paper
    ​ ​Modes and Regulation of Endocytic Membrane Retrieval in Mouse Auditory Hair Cells​
    Neef, J. ; Jung, S. ; Wong, A. B.; Reuter, K.; Pangršič, T. ; Chakrabarti, R.   & Kügler, S.  et al.​ (2014) 
    The Journal of neuroscience34(3) pp. 705​-716​.​ DOI: https://doi.org/10.1523/JNEUROSCI.3313-13.2014 
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  • 2014 Journal Article | Research Paper
    ​ ​Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson's disease​
    Tereshchenko, J. ; Maddalena, A.; Bähr, M.   & Kügler, S. ​ (2014) 
    Neurobiology of Disease65 pp. 35​-42​.​ DOI: https://doi.org/10.1016/j.nbd.2014.01.009 
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  • 2014 Journal Article | Research Paper | 
    ​ ​Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease​
    Tönges, L. ; Szegö, E. M. ; Hause, P.; Saal, K.-A. ; Tatenhorst, L. ; Koch, J. C.   & D'Hedouville, Z. et al.​ (2014) 
    Frontiers in Aging Neuroscience6 art. UNSP 239​.​ DOI: https://doi.org/10.3389/fnagi.2014.00239 
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  • 2013 Journal Article | 
    ​ ​Adeno-associated Virus-mediated, Mifepristone-regulated Transgene Expression in the Brain​
    Maddalena, A.; Tereshchenko, J. ; Bähr, M.   & Kügler, S. ​ (2013) 
    Molecular therapy. Nucleic acids2.​ DOI: https://doi.org/10.1038/mtna.2013.35 
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  • 2013 Journal Article | Research Paper
    ​ ​β-Synuclein Aggregates and Induces Neurodegeneration in Dopaminergic Neurons​
    Taschenberger, G. ; Toloe, J. ; Tereshchenko, J. ; Akerboom, J.; Wales, P. ; Benz, R. & Becker, S.  et al.​ (2013) 
    Annals of Neurology74(1) pp. 109​-118​.​ DOI: https://doi.org/10.1002/ana.23905 
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  • 2012 Journal Article | Research Paper | 
    ​ ​HDAC1 Regulates Fear Extinction in Mice​
    Bahari-Javan, S. ; Maddalena, A.; Kerimoglu, C. ; Wittnam, J.; Held, T.; Bähr, M.   & Burkhardt, S.  et al.​ (2012) 
    The Journal of Neuroscience32(15) pp. 5062​-5073​.​ DOI: https://doi.org/10.1523/JNEUROSCI.0079-12.2012 
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  • 2012 Journal Article | Research Paper | 
    ​ ​Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons​
    Taschenberger, G. ; Garrido, M.; Tereshchenko, Y. ; Baehr, M. ; Zweckstetter, M.   & Kügler, S. ​ (2012) 
    Acta Neuropathologica123(5) pp. 671​-683​.​ DOI: https://doi.org/10.1007/s00401-011-0926-8 
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  • 2012 Journal Article | Research Paper | 
    ​ ​Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery​
    Drinkut, A.; Tereshchenko, Y. ; Schulz, J. B. ; Bähr, M.   & Kügler, S. ​ (2012) 
    Molecular Therapy20(3) pp. 534​-543​.​ DOI: https://doi.org/10.1038/mt.2011.249 
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  • 2011 Journal Article | Research Paper
    ​ ​A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity​
    Schaechinger, T. J.; Gorbunov, D.; Halaszovich, C. R.; Moser, T. ; Kügler, S. ; Fakler, B. & Oliver, D.​ (2011) 
    EMBO Journal30(14) pp. 2793​-2804​.​ DOI: https://doi.org/10.1038/emboj.2011.202 
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  • 2011 Journal Article | 
    ​ ​GSK-3 alpha/beta kinases and amyloid production in vivo​
    Jaworski, T.; Dewachter, I.; Lechat, B.; Gees, M.; Kremer, A.; Demedts, D. & Borghgraef, P. et al.​ (2011) 
    Nature480(7376) pp. E4​-E5​.​ DOI: https://doi.org/10.1038/nature10615 
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  • 2011 Journal Article | Research Paper | 
    ​ ​Sumoylation inhibits alpha-synuclein aggregation and toxicity​
    Krumova, P.; Meulmeester, E.; Garrido, M.; Tirard, M.; Hsiao, H.-H.; Bossis, G. & Urlaub, H.  et al.​ (2011) 
    The Journal of Cell Biology194(1) pp. 49​-60​.​ DOI: https://doi.org/10.1083/jcb.201010117 
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  • 2011 Journal Article | Research Paper
    ​ ​Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis​
    Reisinger, E. ; Bresee, C.; Neef, J. ; Nair, R.; Reuter, K.; Bulankina, A. & Nouvian, R.  et al.​ (2011) 
    The Journal of Neuroscience31(13) pp. 4886​-4895​.​ DOI: https://doi.org/10.1523/JNEUROSCI.5122-10.2011 
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  • 2011 Journal Article | Research Paper | 
    ​ ​Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons​
    Garrido, M.; Tereshchenko, Y. ; Zhevtsova, Z.; Taschenberger, G. ; Bähr, M.   & Kügler, S. ​ (2011) 
    Acta Neuropathologica121(4) pp. 475​-485​.​ DOI: https://doi.org/10.1007/s00401-010-0791-x 
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  • 2010 Journal Article | Research Paper
    ​ ​Evaluation of long-term upregulation of Calbindin D28K as a preventive approach for ischaemic stroke​
    Freimann, F. B. ; Crome, O.; Shevtsova, Z.; Bähr, M.   & Kügler, S. ​ (2010) 
    International Journal of Stroke5(4) pp. 319​-320​.​ DOI: https://doi.org/10.1111/j.1747-4949.2010.00446.x 
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  • 2010 Journal Article | Research Paper
    ​ ​CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis​
    Shevtsova, Z.; Garrido, M.; Weishaupt, J. ; Saftig, P. ; Bähr, M. ; Lühder, F.   & Kügler, S. ​ (2010) 
    The American Journal of Pathology177(1) pp. 271​-279​.​ DOI: https://doi.org/10.2353/ajpath.2010.091267 
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  • 2009 Conference Abstract
    ​ ​Construct of mature BDNF with secreted alkaline phosphatase signal peptide fail to be released by HEK cells​
    Ziemlinska, E.; Skup, M.; Czarkowska-Bauch, J. & Kuegler, S. ​ (2009)
    Journal of Neurochemistry110 pp. 15​-16. ​4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders​, Leipzig, GERMANY.
    Malden​: Wiley-blackwell Publishing, Inc.
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  • 2009 Conference Abstract
    ​ ​Role of the RET/GDNF signaling pathway in protection of the nigro-striatal system in a MPTP mouse model for Parkinson's disease​
    Drinkut, A.; Nagel, F.; Kramer, E. R.; Kuegler, S.   & Schulz, J. B.​ (2009)
    Journal of Neurochemistry110 pp. 49​-50. ​4th European-Society-for-Neurochemistry Conference on Advances in Molecular Mechanisms of Neurological Disorders​, Leipzig, GERMANY.
    Malden​: Wiley-blackwell Publishing, Inc.
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  • 2009 Journal Article | Research Paper
    ​ ​Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models​
    Karpinar, D. P.; Balija, M. B. G.; Kügler, S. ; Opazo, F. ; Rezaei-Ghaleh, N. ; Wender, N. & Kim, H.-Y. et al.​ (2009) 
    EMBO Journal28(20) pp. 3256​-3268​.​ DOI: https://doi.org/10.1038/emboj.2009.257 
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  • 2008 Journal Article | Research Paper
    ​ ​BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity​
    Planchamp, V. ; Bermel, C. ; Tönges, L. ; Ostendorf, T.; Kügler, S. ; Reed, J. C. & Kermer, P.  et al.​ (2008) 
    Brain131 pp. 2606​-2619​.​ DOI: https://doi.org/10.1093/brain/awn196 
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  • 2006 Journal Article | Research Paper
    ​ ​Potentiation of in vivo neuroprotection by BclX(L) and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons​
    Shevtsova, Z.; Malik, I. ; Garrido, M.; Schoell, U.; Bähr, M.   & Kügler, S. ​ (2006) 
    Gene Therapy13(22) pp. 1569​-1578​.​ DOI: https://doi.org/10.1038/sj.gt.3302822 
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  • 2006 Journal Article | Research Paper
    ​ ​Comparison of test systems for RNAinterference​
    Malik, I. ; Garrido, M.; Bähr, M. ; Kügler, S.   & Michel, U. ​ (2006) 
    Biochemical and Biophysical Research Communications341(1) pp. 245​-253​.​ DOI: https://doi.org/10.1016/j.bbrc.2005.12.173 
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  • 2006 Journal Article | Research Paper
    ​ ​Improved high-capacity adenoviral vectors for high-level neuron-restricted gene transfer to the CNS​
    Hermening, S.; Kügler, S. ; Bähr, M.   & Isenmann, S.​ (2006) 
    Journal of Virological Methods136(1-2) pp. 30​-37​.​ DOI: https://doi.org/10.1016/j.jviromet.2006.03.031 
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  • 2006 Journal Article | Research Paper
    ​ ​Evaluation of epitope tags for protein detection after in vivo CNS gene transfer​
    Shevtsova, Z.; Malik, J. M. I.; Michel, U. ; Scholl, U.; Bähr, M.   & Kugler, S. ​ (2006) 
    European Journal of Neuroscience23(8) pp. 1961​-1969​.​ DOI: https://doi.org/10.1111/j.1460-9568.2006.04725.x 
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  • 2005 Journal Article | Research Paper
    ​ ​Long-term in vivo and in vitro AAV-2-mediated RNA interference in rat retinal ganglion cells and cultured primary neurons​
    Michel, U. ; Malik, I. ; Ebert, S.; Bähr, M.   & Kugler, S. ​ (2005) 
    Biochemical and Biophysical Research Communications326(2) pp. 307​-312​.​ DOI: https://doi.org/10.1016/j.bbrc.2004.11.029 
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  • 2005 Journal Article | Research Paper
    ​ ​Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo​
    Lingor, P. ; Koeberle, P.; Kugler, S.   & Bähr, M. ​ (2005) 
    Brain128 pp. 550​-558​.​ DOI: https://doi.org/10.1093/brain/awh382 
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  • 2005 Journal Article | Research Paper
    ​ ​Long-term in vivo inhibition of CNS neurodegeneration by Bcl-X-L gene transfer​
    Malik, J. M. I.; Shevtsova, Z.; Bähr, M.   & Kugler, S. ​ (2005) 
    Molecular Therapy11(3) pp. 373​-381​.​ DOI: https://doi.org/10.1016/j.ymthe.2004.11.014 
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  • 2005 Journal Article | Research Paper
    ​ ​Functional applications of novel Semliki Forest virus vectors are limited by vector toxicity in cultures of primary neurons in vitro and in the substantia nigra in vivo​
    Lingor, P. ; Scholl, U.; Bähr, M.   & Kugler, S. ​ (2005) 
    Experimental Brain Research161(3) pp. 335​-342​.​ DOI: https://doi.org/10.1007/s00221-004-2077-9 
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  • 2005 Conference Paper | Research Paper
    ​ ​Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo​
    Shevtsova, Z.; Malik, J. M. I.; Michel, U. ; Bähr, M.   & Kugler, S. ​ (2005)
    ​Experimental Physiology (1) pp. 53​-59. (Vol. 90). ​Meeting on Viral Gene Transfer in Neuroscience​, Univ Bristol, Bristol, ENGLAND.
    Oxford​: Blackwell Publishing Ltd. DOI: https://doi.org/10.1113/expphysiol.2004.028159 
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  • 2004 Journal Article | Research Paper
    ​ ​Excess Bcl-X-L increases the intrinsic growth potential of adult CNS neurons in vitro​
    Kretz, A.; Kugler, S. ; Happold, C.; Bähr, M.   & Isenmann, S.​ (2004) 
    Molecular and Cellular Neuroscience26(1) pp. 63​-74​.​ DOI: https://doi.org/10.1016/j.mcn.2004.01.007 
    Details  DOI  PMID  PMC  WoS 
  • 2004 Journal Article | Research Paper
    ​ ​Increased protein expression from adenoviral shuttle plasmids and vectors by insertion of a small chimeric intron sequence​
    Hermening, S.; Kugler, S. ; Bähr, M.   & Isenmann, S.​ (2004) 
    Journal of Virological Methods122(1) pp. 73​-77​.​ DOI: https://doi.org/10.1016/j.jviromet.2004.08.005 
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  • 2004 Journal Article | Research Paper
    ​ ​Transfection of "naked" siRNA results in endosomal uptake and metabolic impairment in cultured neurons​
    Lingor, P. ; Michel, U. ; Scholl, U.; Bähr, M.   & Kugler, S. ​ (2004) 
    Biochemical and Biophysical Research Communications315(4) pp. 1126​-1133​.​ DOI: https://doi.org/10.1016/j.bbrc.2004.01.170 
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  • 2003 Journal Article | Research Paper
    ​ ​Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area​
    Kugler, S. ; Kilic, E.   & Bähr, M. ​ (2003) 
    Gene Therapy10(4) pp. 337​-347​.​ DOI: https://doi.org/10.1038/sj.gt.3301905 
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  • 2002 Journal Article | Research Paper
    ​ ​Adenovirus-mediated Bcl-X-L expression using a neuron-specific synapsin-1 promoter protects against disseminated neuronal injury and brain infarction following focal cerebral ischemia in mice​
    Kilic, E. ; Hermann, D. M.; Kugler, S. ; Kilic, U.; Holzmuller, H.; Schmeer, C. & Bähr, M. ​ (2002) 
    Neurobiology of Disease11(2) pp. 275​-284​.​ DOI: https://doi.org/10.1006/nbdi.2002.0552 
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  • 2002 Journal Article | Research Paper
    ​ ​Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis​
    Straten, G.; Schmeer, C.; Kretz, A.; Gerhardt, E. ; Kugler, S. ; Schulz, J. B.   & Gravel, C. et al.​ (2002) 
    Neurobiology of Disease11(1) pp. 123​-133​.​ DOI: https://doi.org/10.1006/nbdi.2002.0543 
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  • 2001 Journal Article | Research Paper
    ​ ​Intravitreal adenoviral gene transfer evokes an immune response in the retina that is directed against the heterologous lacZ transgene product but does not limit transgene expression​
    Isenmann, S.; Engel, S.; Kugler, S. ; Gravel, C.; Weller, M. & Bähr, M. ​ (2001) 
    Brain Research892(2) pp. 229​-240​.​ DOI: https://doi.org/10.1016/S0006-8993(00)02957-7 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Neuron-specific expression of therapeutic proteins: Evaluation of different cellular promoters in recombinant adenoviral vectors​
    Kügler, S. ; Meyn, L.; Holzmüller, H.; Gerhardt, E. ; Isenmann, S.; Schulz, J. B.   & Bähr, M. ​ (2001) 
    Molecular and Cellular Neuroscience17(1) pp. 78​-96​.​ DOI: https://doi.org/10.1006/mcne.2000.0929 
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  • 2001 Journal Article | Research Paper
    ​ ​Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals​
    Coelln, R. von; Kugler, S. ; Weller, M.; Dichgans, J.; Bähr, M.   & Schulz, J. B. ​ (2001) 
    Journal of Neurochemistry77(1) pp. 263​-273​.​ DOI: https://doi.org/10.1046/j.1471-4159.2001.t01-1-00236.x 
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  • 2001 Journal Article | Research Paper
    ​ ​Adenovirus-mediated glial cell line-derived neurotrophic factor (GDNF) expression protects against subsequent cortical cold injury in rats​
    Hermann, D. M.; Kilic, E. ; Kugler, S. ; Isenmann, S. & Bähr, M. ​ (2001) 
    Neurobiology of Disease8(6) pp. 964​-973​.​ DOI: https://doi.org/10.1006/nbdi.2001.0448 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand​
    Naumann, U.; Kugler, S. ; Wolburg, H.; Wick, W.; Rascher, G.; Schulz, J. B.   & Conseiller, E. et al.​ (2001) 
    Cancer research61(15) pp. 5833​-5842​.​
    Details  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice​
    Hermann, D. M.; Kilic, E. ; Kugler, S. ; Isenmann, S. & Bähr, M. ​ (2001) 
    Neurobiology of Disease8(4) pp. 655​-666​.​ DOI: https://doi.org/10.1006/nbdi.2001.0399 
    Details  DOI  PMID  PMC  WoS 
  • 2001 Journal Article | Research Paper
    ​ ​Cascade of caspase activation in potassium-deprived cerebellar granule neurons: Targets for treatment with peptide and protein inhibitors of apoptosis​
    Gerhardt, E. ; Kugler, S. ; Leist, M.; Beier, C.; Berliocchi, L.; Volbracht, C. & Weller, M. et al.​ (2001) 
    Molecular and Cellular Neuroscience17(4) pp. 717​-731​.​ DOI: https://doi.org/10.1006/mcne.2001.0962 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease​
    Eberhardt, O.; Coelln, R. V.; Kugler, S. ; Lindenau, J.; Rathke-Hartlieb, S.; Gerhardt, E.   & Haid, S. et al.​ (2000) 
    The Journal of Neuroscience20(24) pp. 9126​-9134​.​ DOI: https://doi.org/10.1523/JNEUROSCI.20-24-09126.2000 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Adenovirus-mediated expression of ciliary neurotrophic factor (CNTF) rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo​
    Weise, J.; Isenmann, S.; Klocker, N.; Kugler, S. ; Hirsch, S.; Gravel, C. & Bähr, M. ​ (2000) 
    Neurobiology of Disease7(3) pp. 212​-223​.​ DOI: https://doi.org/10.1006/nbdi.2000.0285 
    Details  DOI  PMID  PMC  WoS 
  • 1999 Journal Article | Research Paper
    ​ ​Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity​
    Roth, W.; Isenmann, S.; Naumann, U.; Kugler, S. ; Bähr, M. ; Dichgans, J. & Ashkenazi, A. et al.​ (1999) 
    Biochemical and Biophysical Research Communications265(2) pp. 479​-483​.​ DOI: https://doi.org/10.1006/bbrc.1999.1693 
    Details  DOI  PMID  PMC  WoS 
  • 1999 Journal Article | Research Paper | 
    ​ ​Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma​
    Wagenknecht, B.; Glaser, T.; Naumann, U.; Kugler, S. ; Isenmann, S.; Bähr, M.   & Korneluk, R. G. et al.​ (1999) 
    Cell Death and Differentiation6(4) pp. 370​-376​.​ DOI: https://doi.org/10.1038/sj.cdd.4400503 
    Details  DOI  PMID  PMC  WoS 
  • 1999 Journal Article | Research Paper
    ​ ​Transduction of axotomized retinal ganglion cells by adenoviral vector administration at the optic nerve stump: an in vivo model system for the inhibition of neuronal apoptotic cell death​
    Kugler, S. ; Klocker, N.; Kermer, P. ; Isenmann, S. & Bähr, M. ​ (1999) 
    Gene Therapy6(10) pp. 1759​-1767​.​ DOI: https://doi.org/10.1038/sj.gt.3301000 
    Details  DOI  PMID  PMC  WoS 

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