Niels Fischer

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  • 2020 | Journal Article
    ​ ​Atomic-resolution protein structure determination by cryo-EM​
    Yip, K. M.; Fischer, N. ; Paknia, E.; Chari, A. & Stark, H. ​ (2020) 
    Nature, 587(7832) pp. 157​-161​.​ DOI: https://doi.org/10.1038/s41586-020-2833-4 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Dynamics and Energetics of Elongation Factor SelB in the Ternary Complex and the Ribosome​
    Bock, L. V. ; Fischer, N. ; Stark, H.   & Grubmüller, H. ​ (2017) 
    Biophysical Journal, 112(3) pp. 49a​.​ DOI: https://doi.org/10.1016/j.bpj.2016.11.302 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Ribosome dynamics during decoding​
    Rodnina, M. V. ; Fischer, N. ; Maracci, C.   & Stark, H. ​ (2017) 
    Philosophical Transactions B, 372(1716) art. 20160182​.​ DOI: https://doi.org/10.1098/rstb.2016.0182 
    ​Details  DOI  PMID  PMC 
  • 2016 | Conference Abstract
    ​ ​How reliable are atomic models based on cryo-EM reconstructions? Improvements in model fitting and validation​
    Neumann, P. ; Fischer, N. ; Stark, H.   & Ficner, R. ​ (2016)
    ​Acta Crystallographica Section A, 72(Part a1) Acta Crystallographica Section A Foundations and Advances, (a1) pp. s45​-s45. (Vol. 72). , Basel, Switzerland. DOI: https://doi.org/10.1107/S2053273316099307 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper | 
    ​ ​The pathway to GTPase activation of elongation factor SelB on the ribosome​
    Fischer, N. ; Neumann, P. ; Bock, L. V. ; Maracci, C. ; Wang, Z.; Paleskava, A.   & Konevega, A. L.  et al.​ (2016) 
    Nature, 540(7631) pp. 80​-85​.​ DOI: https://doi.org/10.1038/nature20560 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM​
    Fischer, N. ; Neumann, P. ; Konevega, A. L. ; Bock, L. V. ; Ficner, R. ; Rodnina, M. V.   & Stark, H. ​ (2015) 
    Nature, 520(7548) pp. 567​-570​.​ DOI: https://doi.org/10.1038/nature14275 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space​
    Chari, A.; Haselbach, D.; Kirves, J.-M.; Ohmer, J.; Paknia, E.; Fischer, N.   & Ganichkin, O. et al.​ (2015) 
    Nature Methods, 12(9) pp. 859​-865​.​ DOI: https://doi.org/10.1038/nmeth.3493 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Fluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome​
    Adio, S. ; Senyushkina, T. ; Peske, F. ; Fischer, N. ; Wintermeyer, W.   & Rodnina, M. V. ​ (2015) 
    Nature Communications, 6 art. 7442​.​ DOI: https://doi.org/10.1038/ncomms8442 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​Ribosomal Kinetics and Concerted Motions from Nanoseconds to Seconds​
    Blau, C. ; Bock, L. V. ; Schröder, G. F.; Davydov, I. I.; Fischer, N. ; Stark, H.   & Rodnina, M. V.  et al.​ (2014)
    ​Biophysical Journal , Volume 106 , Issue 2 , 250a p. 1266-Plat. ​58th Annual Meeting of the Biophysical-Society​, San Francisco, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2013.11.1463 
    ​Details  DOI  WoS 
  • 2014 | Conference Abstract
    ​ ​Rapid and Stable Transfer RNA Translocation through the Ribosome Ensured by Specific Contact Mechanisms​
    Bock, L. V. ; Blau, C. ; Schröder, G. F.; Davydov, I. I.; Fischer, N. ; Stark, H.   & Rodnina, M. V.  et al.​ (2014)
    ​Biophysical Journal, 106(Supplement 1), 493a-493a.. ​58th Annual Meeting of the Biophysical-Society​, San Francisco, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2013.11.2758 
    ​Details  DOI  WoS 
  • 2013 | Journal Article
    ​ ​Rate Estimates from Sampling Sparse Transitions: TRNA Motion Limits Transitions between Ribosomal Translocation Intermediates​
    Blau, C. ; Bock, L. V. ; Schröder, G. F.; Fischer, N. ; Stark, H. ; Rodnina, M. V.   & Vaiana, A. C.  et al.​ (2013) 
    Biophysical Journal, 104(2) pp. 663a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.3662 
    ​Details  DOI 
  • 2013 | Journal Article
    ​ ​Modulation of Intersubunit Interactions during tRNA Translocation through the Ribosome​
    Vaiana, A. C.; Bock, L. V.; Blau, C.; Schroeder, G. F.; Fischer, N. ; Stark, H.   & Rodnina, M.  et al.​ (2013) 
    Biophysical Journal, 104(2) pp. 258a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.1447 
    ​Details  DOI 
  • 2013 | Journal Article
    ​ ​Mechanisms for Efficient TRNA Translocation through the Ribosome​
    Bock, L. V. ; Blau, C. ; Schröder, G. F.; Fischer, N. ; Stark, H. ; Rodnina, M. V.   & Vaiana, A. C.  et al.​ (2013) 
    Biophysical Journal, 104(2) pp. 16a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.118 
    ​Details  DOI 
  • 2013 | Journal Article | Research Paper
    ​ ​Energy barriers and driving forces in tRNA translocation through the ribosome​
    Bock, L. V. ; Blau, C. ; Schroeder, G. F.; Davydov, I. I.; Fischer, N. ; Stark, H.   & Rodnina, M. V.  et al.​ (2013) 
    Nature Structural & Molecular Biology, 20(12) pp. 1390​-1396​.​ DOI: https://doi.org/10.1038/nsmb.2690 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Contacts Between Ribosome Parts Refined by Molecular Dynamics Simulations​
    Blau, C. ; Bock, L. V. ; Schroeder, G. F.; Fischer, N. ; Stark, H. ; Vaiana, A. C.   & Grubmüller, H. ​ (2012) 
    Biophysical Journal, 102(3) pp. 69a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.405 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy​
    Fischer, N. ; Konevega, A. L. ; Wintermeyer, W. ; Rodnina, M. V.   & Stark, H. ​ (2010) 
    Nature, 466(7304) pp. 329​-333​.​ DOI: https://doi.org/10.1038/nature09206 
    ​Details  DOI  PMID  PMC 
  • 2007 | Journal Article
    ​ ​GraFix: sample preparation for single-particle electron cryomicroscopy​
    Kastner, B.; Fischer, N. ; Golas, M. M.; Sander, B.; Dube, P.; Boehringer, D. & Hartmuth, K. et al.​ (2007) 
    Nature Methods, 5(1) pp. 53​-55​.​ DOI: https://doi.org/10.1038/nmeth1139 
    ​Details  DOI 
  • 2007 | Journal Article | Research Paper
    ​ ​Towards understanding selenocysteine incorporation into bacterial proteins​
    Fischer, N. ; Paleskava, A. ; Gromadski, K. B.; Konevega, A. L. ; Wahl, M. C. ; Stark, H.   & Rodnina, M. ​ (2007) 
    Biological Chemistry, 388(10) pp. 1061​-1067​.​ DOI: https://doi.org/10.1515/BC.2007.108 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​Spontaneous reverse movement of mRNA-bound tRNA through the ribosome​
    Konevega, A. L. ; Fischer, N. ; Semenkov, Y. P.; Stark, H. ; Wintermeyer, W.   & Rodnina, M. ​ (2007) 
    Nature Structural & Molecular Biology, 14(4) pp. 318​-324​.​ DOI: https://doi.org/10.1038/nsmb1221 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article
    ​ ​Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation​
    Diaconu, M. ; Kothe, U.; Schlünzen, F.; Fischer, N. ; Harms, J. M.; Tonevitsky, A. G. & Stark, H.  et al.​ (2005) 
    Cell, 121(7) pp. 991​-1004​.​ DOI: https://doi.org/10.1016/j.cell.2005.04.015 
    ​Details  DOI  PMID  PMC 

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