Prof. Dr. Stephan Elmar Lehnart

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  • 2022 | Journal Article | Research Paper
    ​ ​Modulatorische Einheiten bei Herzinsuffizienz​
    Hasenfuß, G. P. ; Kaul, A.; Lehnart, S. E. ; Linke, W. A. ; Zelarayan, L. C.   & Zimmermann, W.-H. ​ (2022) 
    Der Kardiologe, 16(2) pp. 109​-114​.​ DOI: https://doi.org/10.1007/s12181-022-00540-w 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Dysferlin facilitates the de novo biogenesis of tubular membranes in hypertrophic remodelling​
    Paulke, N.; Amlaz, S.; Fleischhacker, C.; Kohl, T.; Kownatzki-Danger, D.; Hasenfuss, G.   & Lehnart, S.  et al.​ (2022) 
    European Heart Journal, 43(Suppl. 2).​ DOI: https://doi.org/10.1093/eurheartj/ehac544.2944 
    ​Details  DOI 
  • 2022 | Journal Article | Discussion
    ​ ​New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain​
    Weninger, G. & Lehnart, S. E. ​ (2022) 
    Journal of Cellular Signaling, 3(4).​ DOI: https://doi.org/10.33696/Signaling.3.081 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes​
    Brandenburg, S. ; Pawlowitz, J.; Steckmeister, V.; Subramanian, H.; Uhlenkamp, D.; Scardigli, M. & Mushtaq, M. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology, 165 pp. 141​-157​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.01.003 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes​
    Weninger, G.; Pochechueva, T.; El Chami, D.; Luo, X.; Kohl, T. ; Brandenburg, S.   & Urlaub, H.  et al.​ (2022) 
    Scientific Reports, 12(1).​ DOI: https://doi.org/10.1038/s41598-022-14320-9 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Overview
    ​ ​The Role of Junctophilin Proteins in Cellular Function​
    Lehnart, S. E.   & Wehrens, X. H. T.​ (2022) 
    Physiological Reviews,.​ DOI: https://doi.org/10.1152/physrev.00024.2021 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Editorial: Cardiac optogenetics: Using light to observe and excite the heart​
    Bruegmann, T. ; Smith, G. L. & Lehnart, S. E. ​ (2022) 
    Frontiers in Physiology, 13 art. 1031062​.​ DOI: https://doi.org/10.3389/fphys.2022.1031062 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis​
    Brandenburg, S. ; Drews, L.; Schönberger, H.-L.; Jacob, C. F.; Paulke, N. J.; Beuthner, B. E. & Topci, R. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology, 173 pp. 1​-15​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.08.363 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool​
    Wegener, J. W.; Wagdi, A.; Wagner, E.; Katschinski, D. M.; Hasenfuß, G. ; Brügmann, T.   & Lehnart, S. E. ​ (2021) 
    Frontiers in Physiology, 12.​ DOI: https://doi.org/10.3389/fphys.2021.777770 
    ​Details  DOI  PMID  PMC 
  • 2021 | Book Chapter
    ​ ​Management of Metadata Types in Basic Cardiological Research​
    Kusch, H. ; Kossen, R. ; Suhr, M.; Freckmann, L.; Weber, L.; Henke, C.& Lehmann, C. et al.​ (2021)
    In:​Röhrig, Rainer; Beißbarth, Tim; König, Jochem; Ose, Claudia; Rauch, Geraldine; Sax, Ulrich; Schreiweis, Björn, et al.​ (Eds.), German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal pp. 59​-68.  DOI: https://doi.org/10.3233/SHTI210542 
    ​Details  DOI  PMID  PMC 
  • 2021 | Preprint
    ​ ​Analyzing cross-talk between superimposed signals: Vector norm dependent hidden Markov models and applications​
    Vanegas, L. J.; Eltzner, B.; Rudolf, D. ; Dura, M.; Lehnart, S. E.  & Munk, A. ​ (2021). DOI: https://doi.org/10.48550/arXiv.2103.06071 
    ​Details  DOI  arXiv 
  • 2021 | Research Data
    ​ ​Online Supplemental Files for "Caveolin3 Stabilizes McT1-mediated Lactate/Proton Transport in Cardiomyocytes"​
    Lehnart, S. E. ​ (2021)
     DOI: https://doi.org/10.25625/ffe7lj 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Multiphoton Imaging of Ca2+ Instability in Acute Myocardial Slices from a RyR2R2474S Murine Model of Catecholaminergic Polymorphic Ventricular Tachycardia​
    Borile, G.; Zaglia, T.; Lehnart, S. E.   & Mongillo, M.​ (2021) 
    Journal of Clinical Medicine, 10(13) pp. 2821​.​ DOI: https://doi.org/10.3390/jcm10132821 
    ​Details  DOI 
  • 2021 | Journal Article | Overview | 
    ​ ​Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review​
    Müllenbroich, M. C.; Kelly, A.; Acker, C.; Bub, G.; Brügmann, T. ; Di Bona, A. & Entcheva, E. et al.​ (2021) 
    Frontiers in Physiology, 12.​ DOI: https://doi.org/10.3389/fphys.2021.769586 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​CaMKII inhibition has dual effects on spontaneous Ca 2+ release and Ca 2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation​
    Sadredini, M.; Haugsten Hansen, M.; Frisk, M.; Louch, W. E.; Lehnart, S. E. ; Sjaastad, I. & Korseberg Stokke, M.​ (2021) 
    American Journal of Physiology-Heart and Circulatory Physiology, 321(2) pp. H446​-H460​.​ DOI: https://doi.org/10.1152/ajpheart.00011.2021 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​
    Peper, J.; Kownatzki-Danger, D.; Weninger, G.; Seibertz, F.; Pronto, J. R. D.; Sutanto, H. & Pacheu-Grau, D. et al.​ (2021) 
    Circulation Research, 128(6).​ DOI: https://doi.org/10.1161/CIRCRESAHA.119.316547 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1​
    Sadredini, M.; Manotheepan, R.; Lehnart, S. E. ; Anderson, M. E.; Sjaastad, I. & Stokke, M. K.​ (2021) 
    Physiological Reports, 9(18) art. e15030​.​ DOI: https://doi.org/10.14814/phy2.15030 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice​
    Rudolph, F.; Fink, C.; Hüttemeister, J.; Kirchner, M.; Radke, M. H.; Lopez Carballo, J. & Wagner, E.  et al.​ (2020) 
    Nature Communications, 11(1).​ DOI: https://doi.org/10.1038/s41467-020-16929-8 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation​
    Campbell, H. M.; Quick, A. P.; Abu-Taha, I.; Chiang, D. Y.; Kramm, C. F.; Word, T. A. & Brandenburg, S. et al.​ (2020) 
    Circulation, 142(12) pp. 1159​-1172​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.045791 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban​
    Menzel, J. ; Kownatzki-Danger, D.; Tokar, S.; Ballone, A.; Unthan-Fechner, K.; Kilisch, M.   & Lenz, C.  et al.​ (2020) 
    Science Signaling, 13(647) pp. eaaz1436​.​ DOI: https://doi.org/10.1126/scisignal.aaz1436 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation​
    Alsina, K. M.; Hulsurkar, M.; Brandenburg, S. ; Kownatzki-Danger, D.; Lenz, C. ; Urlaub, H.   & Abu-Taha, I. et al.​ (2019) 
    Circulation, 140(8) pp. 681​-693​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.039642 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca 2+ -Dependent Arrhythmia​
    Ottesen, A. H.; Carlson, C. R.; Eken, O. S.; Sadredini, M.; Myhre, P. L.; Shen, X. & Dalhus, B. et al.​ (2019) 
    Circulation: Arrhythmia and Electrophysiology, 12(4) art. e007045​.​ DOI: https://doi.org/10.1161/CIRCEP.118.007045 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis​
    Brandenburg, S. ; Pawlowitz, J.; Eikenbusch, B.; Peper, J.; Kohl, T. ; Mitronova, G. Y.   & Sossalla, S.  et al.​ (2019) 
    JCI insight, 4(12).​ DOI: https://doi.org/10.1172/jci.insight.127116 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes​
    Rudolph, F.; Hüttemeister, J.; da Silva Lopes, K.; Jüttner, R.; Yu, L.; Bergmann, N. & Friedrich, D. et al.​ (2019) 
    Proceedings of the National Academy of Sciences of the United States of America, 116(50) pp. 25126​-25136​.​ DOI: https://doi.org/10.1073/pnas.1904385116 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Data on differential multivariable risk prediction of appropriate shock vs. competing mortality​
    Bergau, L.; Willems, R.; Sprenkeler, D. J; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    Data in Brief, 21 pp. 2110​-2116​.​ DOI: https://doi.org/10.1016/j.dib.2018.11.025 
    ​Details  DOI  PMID  PMC 
  • 2018 | Research Data | Research Paper | 
    ​ ​Axial Tubule Junctions Activate Atrial Ca2+ Release across Species​
    Brandenburg, S. ; Pawlowitz, J.; Lehnart, S. E. ; Fakuade, F. E.; Kownatzki-Danger, D.; Kohl, T.  & Mitronova, G. Y.  et al.​ (2018)
     DOI: https://doi.org/10.3389/fphys.2018.01227 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Overview
    ​ ​Ryanodine receptor dysfunction and the resolution revolution: how Nobel Prize-winning techniques transform cardiovascular research​
    Voigt, N.   & Lehnart, S. E. ​ (2018) 
    Cardiovascular Research, 114(14) pp. e106​-e109​.​ DOI: https://doi.org/10.1093/cvr/cvy235 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy​
    Richter, K. N. ; Revelo, N. H. ; Seitz, K. J.; Helm, M. S.; Sarkar, D.; Saleeb, R. S. & d'Este, E.  et al.​ (2018) 
    The EMBO journal, 37(1) pp. 139​-159​.​ DOI: https://doi.org/10.15252/embj.201695709 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​
    Bergau, L.; Willems, R.; Sprenkeler, D. J.; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    International Journal of Cardiology, 272 pp. 102​-107​.​ DOI: https://doi.org/10.1016/j.ijcard.2018.06.103 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation​
    Danielsen, T. K.; Manotheepan, R.; Sadredini, M.; Leren, I. S.; Edwards, A. G.; Vincent, K. P. & Lehnart, S. E.  et al.​ (2018) 
    PLOS ONE, 13(11) art. e0207100​.​ DOI: https://doi.org/10.1371/journal.pone.0207100 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​A protocol for registration and correction of multicolour STED superresolution images​
    Hebisch, E.; Wagner, E. ; Westphal, V. ; Sieber, J. J. & Lehnart, S. E. ​ (2017) 
    Journal of Microscopy, 267(2) pp. 160​-175​.​ DOI: https://doi.org/10.1111/jmi.12556 
    ​Details  DOI  PMID  PMC 
  • 2017 | Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Journal Article
    ​ ​From Ribosome to Sarcomere - Titin Dynamics in Striated Muscle Cells​
    Gotthardt, M.; Rudolph, F.; Huettemeister, J.; da Sliva Lopes, K.; Yu, L.; Bergmann, N. & Fink, C. et al.​ (2017) 
    Biophysical Journal, 112(3) pp. 429a​.​ DOI: https://doi.org/10.1016/j.bpj.2016.11.2293 
    ​Details  DOI 
  • 2017 | Conference Abstract
    ​ ​How Does Calcium Overload Generate Calcium Waves in Heart?​
    Williams, G. S.; Wescott, A. P.; Lehnart, S. E.   & Lederer, W.​ (2017)
    Biophysical Journal, 112(3) p. 541a. , San Francisco, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2016.11.2923 
    ​Details  DOI  WoS 
  • 2017 | Conference Abstract
    ​ ​The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S.; Sossalla, S. T.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19 
    Hoboken​: Wiley.
    ​Details  WoS 
  • 2017 | Journal Article
    ​ ​Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant​
    Tzimas, C.; Johnson, D. M.; Santiago, D. J.; Vafiadaki, E.; Arvanitis, D. A.; Davos, C. H. & Varela, A. et al.​ (2017) 
    Cardiovascular Research, 113(11) pp. 1403​-1417​.​ DOI: https://doi.org/10.1093/cvr/cvx113 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | 
    ​ ​High-Affinity Functional Fluorescent Ligands for Human β-Adrenoceptors​
    Mitronova, G. Y. ; Lukinavičius, G.; Butkevich, A. N. ; Kohl, T. ; Belov, V. N. ; Lehnart, S. E.   & Hell, S. W. ​ (2017) 
    Scientific Reports, 7 art. 12319​.​ DOI: https://doi.org/10.1038/s41598-017-12468-3 
    ​Details  DOI  PMID  PMC 
  • 2016 | Conference Abstract
    ​ ​Role of sarcoplasmic reticulum calcium leak in heart failure​
    Mohamed, B. A. ; Richter, C.; Neef, S.; Lbik, D.; Khadjeh, S. ; Sossalla, S. T.   & Lehnart, S. E.  et al.​ (2016)
    European Heart Journal, 37 pp. 273​-274. ​Congress of the European-Society-of-Cardiology (ESC)​, Rome, ITALY.
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2016 | Conference Abstract
    ​ ​Axial Membrane Tubules in Atrial Cardiomyocytes Confine Ultrarapid Intracellular Calcium Signals through a New Super-Hub Mechanism​
    Brandenburg, S.; Kohl, T. ; Williams, G. S.; Gusev, K.; Wagner, E. ; Hebisch, E. & Ward, C. W. et al.​ (2016)
    Biophysical Journal, 110(3) p. 267a. , Los Angeles, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2015.11.1454 
    ​Details  DOI  WoS 
  • 2016 | Book Chapter
    ​ ​Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias​
    Richter, C. ; Christoph, J. ; Lehnart, S. E.  & Luther, S. ​ (2016)
    In:​Kianianmomeni, Arash​ (Ed.), Optogenetics: Methods and Protocols pp. 293​-302. ​New York: ​Humana Press. DOI: https://doi.org/10.1007/978-1-4939-3512-3_20 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​"Reduced" Coumarin Dyes with an O-Phosphorylated 2,2-Dimethyl-4-( hydroxymethyl)-1,2,3,4-tetrahydroquinoline Fragment: Synthesis, Spectra, and STED Microscopy​
    Nizamov, S.; Sednev, M. V. ; Bossi, M. L. ; Hebisch, E.; Frauendorf, H. ; Lehnart, S. E.   & Belov, V. N.  et al.​ (2016) 
    Chemistry - A European Journal, 22(33) pp. 11631​-11642​.​ DOI: https://doi.org/10.1002/chem.201601252 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Axial tubule junctions control rapid calcium signaling in atria​
    Brandenburg, S. ; Kohl, T. ; Williams, G. S. B.; Gusev, K.; Wagner, E. ; Rog-Zielinska, E. A. & Hebisch, E. et al.​ (2016) 
    Journal of Clinical Investigation, 126(10) pp. 3999​-4015​.​ DOI: https://doi.org/10.1172/JCI88241 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release​
    Manotheepan, R.; Danielsen, T. K.; Sadredini, M.; Anderson, M. E.; Carlson, C. R.; Lehnart, S. E.   & Sjaastad, I. et al.​ (2016) 
    Cardiovascular Research, 111(3) pp. 295​-306​.​ DOI: https://doi.org/10.1093/cvr/cvw095 
    ​Details  DOI  PMID  PMC 
  • 2016 | Conference Paper
    ​ ​The molecular and functional identities of atrial cardiomyocytes in health and disease​
    Brandenburg, S. ; Arakel, E. C. ; Schwappach, B.   & Lehnart, S. E. ​ (2016)
    ​Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (7, Part B) pp. 1882​-1893. (Vol. 1863). ​8th Ascona International Workshop on Cardiomyocyte Biology - Integration of Developmental and Environmental Cues​, Ascona, SWITZERLAND.
    Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.bbamcr.2015.11.025 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Super-hub mechanism of calcium signaling in atria​
    Brandenburg, S.; Kohl, T.; Gusev, K.; Wagner, E. J.; Sossalla, S. T. ; Hasenfuß, G.   & Hell, S. W.  et al.​ (2015)
    FEBS Journal, 282 , Berlin, GERMANY.
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2015 | Conference Abstract
    ​ ​Does leaky ryanodine receptors play any role in maladaptive remodeling after chronic mechanical stress in mice?​
    Mohamed, B. A.; Khadjeh, S.; Sossalla, S. T. ; Neef, S.; Lehnart, S. E. ; Hasenfuß, G.   & Toischer, K. ​ (2015)
    European Journal of Heart Failure, 17 pp. 235​-236. 
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2015 | Conference Abstract
    ​ ​Following titin in real-time: Sarcomere dynamics in myocytes.​
    Rudolph, F.; Lopes, K. da S.; Yu, L.; Bergmann, N.; Fink, C.; Wagner, E. J. & Lehnart, S. E.  et al.​ (2015)
    Molecular Biology of the Cell, 26 
    Bethesda​: Amer Soc Cell Biology.
    ​Details  WoS 
  • 2015 | Book Chapter
    ​ ​Transport of ions and small molecules across membranes​
    Lehnart, S. E.  & Marks, A. R.​ (2015)
    In:​Plopper, George; Sharp, David; Sikorski, Eric​ (Eds.), Lewin’s cells pp. 230​-300. ​Burlington, MA: ​Jones & Bartlett Learning.
    ​Details 
  • 2015 | Journal Article | Research Paper
    ​ ​Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy​
    Perera, R. K. ; Sprenger, J. U.; Steinbrecher, J. H.; Hübscher, D. ; Lehnart, S. E. ; Abesser, M. & Schuh, K. et al.​ (2015) 
    Circulation Research, 116(8) pp. 1304​-1311​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.306082 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Overview | 
    ​ ​Ca2+ signaling in the myocardium by (redox) regulation of PKA/CaMKII​
    Johnston, A. S.; Lehnart, S. E.   & Burgoyne, J. R.​ (2015) 
    Frontiers in Pharmacology, 6 art. 166​.​ DOI: https://doi.org/10.3389/fphar.2015.00166 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper | 
    ​ ​In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​
    Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Maier, L. S. ; Hasenfuß, G.   & Nikolaev, V. O. ​ (2015) 
    Nature Communications, 6 art. 6965​.​ DOI: https://doi.org/10.1038/ncomms7965 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​
    Chang Liao, M.-L.; Boer, T. P. de; Mutoh, H.; Raad, N.; Richter, C. ; Wagner, E.   & Downie, B. R. et al.​ (2015) 
    Circulation Research, 117(5) pp. 401​-412​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.117.306143 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions​
    Tzimas, C.; Terrovitis, J.; Lehnart, S. E. ; Kranias, E. G. & Sanoudou, D.​ (2015) 
    Heart Rhythm, 12(7) pp. 1599​-1610​.​ DOI: https://doi.org/10.1016/j.hrthm.2015.03.043 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper
    ​ ​Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​
    Godier-Furnemont, A. F. G.; Tiburcy, M. ; Wagner, E. ; Dewenter, M. ; Laemmle, S.; El-Armouche, A.   & Lehnart, S. E.  et al.​ (2015) 
    Biomaterials, 60 pp. 82​-91​.​ DOI: https://doi.org/10.1016/j.biomaterials.2015.03.055 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​On the Adjacency Matrix of RyR2 Cluster Structures​
    Walker, M. A.; Kohl, T. ; Lehnart, S. E. ; Greenstein, J. L.; Lederer, W. J. & Winslow, R. L.​ (2015) 
    PLOS Computational Biology, 11(11) art. e1004521​.​ DOI: https://doi.org/10.1371/journal.pcbi.1004521 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice​
    Gogiraju, R.; Xu, X.; Bochenek, M. L.; Steinbrecher, J. H.; Lehnart, S. E. ; Wenzel, P. & Kessel, M.  et al.​ (2015) 
    Journal of the American Heart Association, 4(2) art. e001770​.​ DOI: https://doi.org/10.1161/JAHA.115.001770 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper
    ​ ​Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2​
    Zaglia, T.; Pianca, N.; Borile, G.; Da Broi, F.; Richter, C. ; Campione, M. & Lehnart, S. E.  et al.​ (2015) 
    Proceedings of the National Academy of Sciences of the United States of America, 112(32) pp. E4495​-E4504​.​ DOI: https://doi.org/10.1073/pnas.1509380112 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article
    ​ ​Intensity matters: Ryanodine receptor regulation during exercise​
    Kohl, T. ; Weninger, G.; Zalk, R.; Eaton, P. & Lehnart, S. E. ​ (2015) 
    Proceedings of the National Academy of Sciences of the United States of America, 112(50) pp. 15271​-15272​.​ DOI: https://doi.org/10.1073/pnas.1521051112 
    ​Details  DOI  PMID  PMC 
  • 2014 | Conference Abstract
    ​ ​ANP potentiates catecholaminergic stress in early cardiac disease​
    Perera, R. K.; Steinbrecher, J. H.; Lehnart, S. E.   & Nikolaev, V. O. ​ (2014)
    Cardiovascular Research, 103 , Barcelona, SPAIN.
    Oxford​: Oxford Univ Press. DOI: https://doi.org/10.1093/cvr/cvu098.37 
    ​Details  DOI  WoS 
  • 2014 | Journal Article
    ​ ​P677Superresolution microscopy reveals proliferative T-Tubule remodeling as general disease mechanism in early stages of heart failure development​
    Wagner, E. ; Hebisch, E.; Steinbrecher, J. H.; Westphal, V. ; Hasenfuß, G. ; Hell, S.   & Lehnart, S. E. ​ (2014) 
    Cardiovascular Research, 103(suppl 1) pp. S123.2​-S123​.​ DOI: https://doi.org/10.1093/cvr/cvu098.101 
    ​Details  DOI 
  • 2014 | Conference Abstract
    ​ ​Super-Resolution Modeling of Calcium Release in Heart​
    Walker, M. A.; Williams, G. S. B.; Kohl, T.; Jafri, S.; Lehnart, S. E. ; Greenstein, J. L. & Lederer, W. J. et al.​ (2014)
    Biophysical Journal, 106(2) , San Francisco, CA.
    Cambridge​: Cell Press.
    ​Details  WoS 
  • 2014 | Journal Article
    ​ ​Super-Resolution Modeling of Calcium Release in Heart​
    Walker, M. A.; Williams, G. S. B.; Kohl, T.; Jafri, S.; Lehnart, S. E. ; Greenstein, J. L. & Lederer, W. J. et al.​ (2014) 
    Biophysical Journal, 106(2) pp. 318a​.​ DOI: https://doi.org/10.1016/j.bpj.2013.11.1839 
    ​Details  DOI 
  • 2014 | Journal Article | 
    ​ ​Superresolution modeling of calcium release in the heart​
    Walker, M. A.; Williams, G. S. B.; Kohl, T. ; Lehnart, S. E. ; Jafri, M. S.; Greenstein, J. L. & Lederer, W. J. et al.​ (2014) 
    Biophysical Journal, 107(12) pp. 3018​-3029​.​ DOI: https://doi.org/10.1016/j.bpj.2014.11.003 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​Analysis of tubular membrane networks in cardiac myocytes from atria and ventricles​
    Wagner, E. ; Brandenburg, S. ; Kohl, T.   & Lehnart, S. E. ​ (2014) 
    Journal of Visualized Experiments,(92) art. e51823​.​ DOI: https://doi.org/10.3791/51823 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Tuning the electrical properties of the heart by differential trafficking of K-ATP ion channel complexes​
    Arakel, E. C. ; Brandenburg, S. ; Uchida, K.; Zhang, H.; Lin, Y.-W.; Kohl, T.   & Schrul, B.  et al.​ (2014) 
    Journal of Cell Science, 127(9) pp. 2106​-2119​.​ DOI: https://doi.org/10.1242/jcs.141440 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | 
    ​ ​Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias​
    Dura, M.; Schröder-Schetelig, J. ; Luther, S.   & Lehnart, S. E. ​ (2014) 
    Frontiers in Physiology, 5 art. 337​.​ DOI: https://doi.org/10.3389/fphys.2014.00337 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes​
    Götz, K. R.; Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Kuhn, M. & Gorelik, J. et al.​ (2014) 
    Circulation Research, 114(8) pp. 1235​-1245​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.114.302437 
    ​Details  DOI  PMID  PMC 
  • 2013 | Conference Abstract
    ​ ​Analysis of protein assemblies from fluorescence data by superresolution microcopy​
    Kohl, T.; Parlitz, U.; Hell, S. W. ; Luther, S. & Lehnart, S. E. ​ (2013)
    European Biophysics Journal, 42 , Lisbon, PORTUGAL.
    New york​: Springer.
    ​Details  WoS 
  • 2013 | Journal Article
    ​ ​Analysis of Fluorescence Microscopy Super-Resolution Data of Protein Assemblies​
    Kohl, T. ; Parlitz, U. ; Hell, S. ; Luther, S.   & Lehnart, S. E. ​ (2013) 
    Biophysical Journal, 104(2) art. 444a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.2464 
    ​Details  DOI 
  • 2013 | Journal Article
    ​ ​Principles of Network Organization of T-Tubule Membranes in Health and Disease​
    Kohl, T.; Wagner, E.; Brandenburg, S.; Parlitz, U.; Lederer, W. & Lehnart, S. E. ​ (2013) 
    Biophysical Journal, 104(2) pp. 340a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.1891 
    ​Details  DOI 
  • 2013 | Conference Abstract
    ​ ​Importance of tumor suppressor gene p53-mediated endothelial cell apoptosis for cardiac angiogenesis and hypertrophy​
    Gogiraju, R.; Steinbrecher, J. H.; Lehnart, S. E. ; Kessel, M.; Dobbelstein, M.   & Schaefer, K.​ (2013)
    European Heart Journal, 34 , Amsterdam, NETHERLANDS.
    Oxford​: Oxford Univ Press.
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​Proliferative membrane changes of T-tubules and cell-wide network changes during cardiac remodeling with orphaning of Ca2+release sites are a general mechanism of heart failure​
    Lehnart, S. E. ; Kohl, T.; Westphal, V.; Parlitz, U.; Jafri, M. S.; Lederer, W. J. & Wagner, E.  et al.​ (2013)
    European Heart Journal, 34(suppl 1) , Amsterdam, NETHERLANDS.
    Oxford​: Oxford Univ Press. DOI: https://doi.org/10.1093/eurheartj/eht307.34 
    ​Details  DOI  WoS 
  • 2013 | Conference Abstract
    ​ ​Principles of Network Organization of T-Tubule Membranes in Health and Disease​
    Kohl, T.; Wagner, E. M.; Brandenburg, S.; Parlitz, U.; Lederer, W. J. & Lehnart, S. E. ​ (2013)
    Biophysical Journal, 104(2) , Philadelphia, PA.
    Cambridge​: Cell Press.
    ​Details  WoS 
  • 2013 | Journal Article | Overview
    ​ ​Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms​
    Lehnart, S. E. ​ (2013) 
    Experimental Physiology, 98(3) pp. 622​-628​.​ DOI: https://doi.org/10.1113/expphysiol.2012.068262 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Overview
    ​ ​Imaging T-tubules: dynamic membrane structures for deep functions​
    Kohl, T.   & Lehnart, S. E. ​ (2013) 
    Cardiovascular Research, 98(2) pp. 162​-164​.​ DOI: https://doi.org/10.1093/cvr/cvt058 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Overview | 
    ​ ​Superresolution microscopy in heart - Cardiac nanoscopy​
    Kohl, T. ; Westphal, V. ; Hell, S. W.   & Lehnart, S. E. ​ (2013) 
    Journal of Molecular and Cellular Cardiology, 58 pp. 13​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2012.11.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Conference Abstract
    ​ ​STED Nanoscopy of Cardiac RyR2 Clusters and Sub-Structure Analysis After Myocardial Infarction​
    Kohl, T.; Parlitz, U.; Lauterbach, M. A.; Hoang-Trong Minh Tuan, H. Hoang-Trong Minh Tuan, Hoang-Trong Minh Tuan; Williams, G. S. B.; Westphal, V. & Jafri, M. S. et al.​ (2012)
    Biophysical Journal, 102(3) , San Diego, CA.
    Cambridge​: Cell Press.
    ​Details  WoS 
  • 2012 | Journal Article
    ​ ​Live Cell Super-Resolution Imaging of Transverse Membrane Tubules in Heart Failure​
    Wagner, E.; Lauterbach, M.; Kohl, T.; Westphal, V.; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012) 
    Biophysical Journal, 102(3) pp. 223a​-224a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.1227 
    ​Details  DOI 
  • 2012 | Journal Article
    ​ ​Stochastic Simulation Assessing the Functional Changes Occurring during Heart Failure​
    Tuan Hoang-Trong, M.; Williams, G. S.; Lehnart, S. E. ; Lederer, W. J. & Jafri, M. S.​ (2012) 
    Biophysical Journal, 102(3) pp. 101a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.571 
    ​Details  DOI 
  • 2012 | Journal Article
    ​ ​STED Nanoscopy of Cardiac RyR2 Clusters and Sub-Structure Analysis After Myocardial Infarction​
    Kohl, T.; Parlitz, U.; Lauterbach, M.; Minh Tuan, H.-T.; Williams, G. S.; Westphal, V. & Jafri, M. S. et al.​ (2012) 
    Biophysical Journal, 102(3) pp. 305a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.1683 
    ​Details  DOI 
  • 2012 | Conference Abstract
    ​ ​Stochastic Simulation Assessing the Functional Changes Occurring during Heart Failure​
    Minh Tuan Hoang-Trong, M. T. H. Minh Tuan Hoang-Trong, Minh Tuan Hoang-Trong; Williams, G. S. B.; Lehnart, S. E. ; Lederer, W. J. & Jafri, M. S.​ (2012)
    Biophysical Journal, 102(3) , San Diego, CA.
    Cambridge​: Cell Press.
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​Live Cell Super-Resolution Imaging of Transverse Membrane Tubules in Heart Failure​
    Wagner, E. M.; Lauterbach, M. A.; Kohl, T.; Westphal, V.; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012)
    Biophysical Journal, 102(3) pp. 223A​-224A. , San Diego, CA.
    Cambridge​: Cell Press.
    ​Details  WoS 
  • 2012 | Journal Article
    ​ ​Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion​
    Cai, W.-F.; Pritchard, T.; Florea, S.; Lam, C.-K.; Han, P.; Zhou, X. & Yuan, Q. et al.​ (2012) 
    Cardiovascular Research, 94(2) pp. 333​-341​.​ DOI: https://doi.org/10.1093/cvr/cvs119 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper
    ​ ​Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction​
    Wagner, E. ; Lauterbach, M. A.; Kohl, T. ; Westphal, V. ; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012) 
    Circulation Research, 111(4) pp. 402​-414​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.112.274530 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype​
    Seegers, J.; Vos, M. A.; Flevari, P.; Willems, R.; Sohns, C.; Vollmann, D. & Luethje, L.  et al.​ (2012) 
    EP Europace, 14(3) pp. 416​-422​.​ DOI: https://doi.org/10.1093/europace/eur352 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Letter Note
    ​ ​Response to Letter Regarding Article, "Differential Cardiac Remodeling in Preload Versus Afterload"​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Sossalla, S. T. ; Becker, A.; Seidler, T. & Grebe, C. et al.​ (2011) 
    Circulation, 123(16).​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.017566 
    ​Details  DOI  WoS 
  • 2011 | Journal Article
    ​ ​EUTrigTreat in: European Perspectives in Cardiology - Cardiovascular Research Funding: Recipients of the European Commission’s Seventh Framework Programme​
    Lehnart, S. E.   & Kranias, E. G.​ (2011) 
    Circulation, 123(25) pp. f148​.​
    ​Details 
  • 2011 | Book Chapter | 
    ​ ​Combined Neuro-Cardiogenic Epilepsy Syndromes and Novel Mechanistic Insights​
    Lehnart, S. E. ​ (2011)
    In:​Foyaca-Sibat, Humberto​ (Ed.), Novel Aspects on Epilepsy pp. 89​-113. ​InTech. DOI: https://doi.org/10.5772/18943 
    ​Details  DOI 
  • 2011 | Journal Article | 
    ​ ​SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes​
    Petitprez, S.; Zmoos, A.-F.; Ogrodnik, J.; Balse, E.; Raad, N.; El-Haou, S. & Albesa, M. et al.​ (2011) 
    Circulation Research, 108(3) pp. 294​-304​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.110.228312 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Conference Abstract
    ​ ​Super-Resolution Imaging of Cardiac Signaling Microdomains by STED Microscopy​
    Kohl, T.; Lauterbach, M. A.; Wagner, E. J.; Westphal, V.; Hagen, B. M.; Lederer, W. J. & Hell, S. W.  et al.​ (2010)
    The Journal of General Physiology, 136(1) , Marine Biol Lab, Woods Hole, MA.
    New york​: Rockefeller Univ Press.
    ​Details  WoS 
  • 2010 | Conference Abstract
    ​ ​Solute Transport in the Transverse Tubules of Cardiac Ventricular Myocytes​
    Hagen, B. M.; Lauterbach, M. A.; Wagner, E. M.; Hell, S. W. ; Lehnart, S. E.   & Lederer, W. J.​ (2010)
    Biophysical Journal, 98(3) 
    Cambridge​: Cell Press.
    ​Details  WoS 
  • 2010 | Conference Abstract
    ​ ​Sted Based Super-Resolution Imaging of Transverse Tubules in Ventricular Myocytes​
    Wagner, E. M.; Lauterbach, M. A.; Westphal, V.; Hagen, B. M.; Lederer, W. J.; Hell, S. W.   & Lehnart, S. E. ​ (2010)
    Biophysical Journal, 98(3) 
    Cambridge​: Cell Press.
    ​Details  WoS 
  • 2010 | Conference Abstract
    ​ ​Molecular genomics of cardiac remodeling following changes in intracellular calcium release​
    Matthes, F.; Steinbrecher, J. H.; Salinas-Riester, G.; Opitz, L.; Hasenfuß, G.   & Lehnart, S. E. ​ (2010)
    Cardiovascular Research, 87 , Berlin, GERMANY.
    Oxford​: Oxford Univ Press.
    ​Details  WoS 
  • 2010 | Journal Article
    ​ ​Sted Based Super-Resolution Imaging of Transverse Tubules in Ventricular Myocytes​
    Wagner, E.; Lauterbach, M.; Westphal, V.; Hagen, B.; Lederer, W.; Hell, S. W.   & Lehnart, S. E. ​ (2010) 
    Biophysical Journal, 98(3) pp. 5a​.​ DOI: https://doi.org/10.1016/j.bpj.2009.12.034 
    ​Details  DOI 
  • 2010 | Journal Article | 
    ​ ​Ryanodin-Rezeptor-Stabilisatoren: ​Neue Strategie zur Behandlung von Herzrhythmusstörungen und Herzinsuffizienz​
    Hellenkamp, K.   & Lehnart, S. E. ​ (2010) 
    Der Kardiologe, 4(4) pp. 324​-328​.​ DOI: https://doi.org/10.1007/s12181-010-0283-1 
    ​Details  DOI 
  • 2010 | Journal Article | 
    ​ ​Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice​
    Shan, J.; Kushnir, A.; Betzenhauser, M. J.; Reiken, S.; Li, J.; Lindegger, N. & Mongillo, M. et al.​ (2010) 
    Journal of Clinical Investigation, 120(12) pp. 4388​-4398​.​ DOI: https://doi.org/10.1172/JCI32726 
    ​Details  DOI 
  • 2010 | Journal Article | 
    ​ ​An antidote for calcium leak: targeting molecular arrhythmia mechanisms​
    Lederer, W. J. & Lehnart, S. E. ​ (2010) 
    Journal of Molecular and Cellular Cardiology, 48(2) pp. 279​-282​.​ DOI: https://doi.org/10.1016/j.yjmcc.2009.11.005 
    ​Details  DOI  PMID  PMC 
  • 2010 | Journal Article | Research Paper | 
    ​ ​K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum​
    Toischer, K. ; Lehnart, S. E. ; Tenderich, G.; Milting, H.; Koerfer, R.; Schmitto, J. D. & Schoendube, F. A.  et al.​ (2010) 
    Basic Research in Cardiology, 105(2) pp. 279​-287​.​ DOI: https://doi.org/10.1007/s00395-009-0057-8 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Differential Cardiac Remodeling in Preload Versus Afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Sossalla, S.   & Reuter, S. P. et al.​ (2010) 
    Circulation, 122(10) pp. 993​-1003​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.943431 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article
    ​ ​Mutant Ryanodine Receptor-dependent Calcium Leak, RyR2 Open Probability, Calcium Sparks And Cardiac Arrhythmogenesis​
    Lehnart, S. E. ; Ward, C. W.; Sobie, E. A. & Lederer, W. J.​ (2009) 
    Biophysical Journal, 96(3) pp. 550a​.​ DOI: https://doi.org/10.1016/j.bpj.2008.12.2981 
    ​Details  DOI 
  • 2009 | Journal Article | Research Paper | 
    ​ ​Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart​
    Lehnart, S. E. ; Maier, L. S.   & Hasenfuß, G. ​ (2009) 
    Heart Failure Reviews, 14(4) pp. 213​-224​.​ DOI: https://doi.org/10.1007/s10741-009-9146-x 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article
    ​ ​Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins​
    Muchir, A.; Shan, J.; Bonne, G.; Lehnart, S. E.   & Worman, H. J.​ (2009) 
    Human Molecular Genetics, 18(2) pp. 241​-247​.​ DOI: https://doi.org/10.1093/hmg/ddn343 
    ​Details  DOI  PMID  PMC 
  • 2008 | Journal Article
    ​ ​Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice​
    Lehnart, S. E. ; Mongillo, M.; Bellinger, A.; Lindegger, N.; Chen, B.-X.; Hsueh, W. & Reiken, S. et al.​ (2008) 
    Journal of Clinical Investigation, 118(6) pp. 2230​-2245​.​ DOI: https://doi.org/10.1172/JCI35346 
    ​Details  DOI  PMID  PMC 
  • 2008 | Journal Article
    ​ ​Remodeling of ryanodine receptor complex causes leaky channels: a molecular mechanism for decreased exercise capacity​
    Bellinger, A. M.; Reiken, S.; Dura, M.; Murphy, P. W; Deng, S.-X.; Landry, D. W. & Nieman, D. et al.​ (2008) 
    Proceedings of the National Academy of Sciences of the United States of America, 105(6) pp. 2198​-2202​.​ DOI: https://doi.org/10.1073/pnas.0711074105 
    ​Details  DOI  PMID  PMC 
  • 2008 | Journal Article
    ​ ​Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency​
    Oyama, M. A.; Reiken, S.; Lehnart, S. E. ; Chittur, S. V.; Meurs, K. M.; Stern, J. & Marks, A. R.​ (2008) 
    Journal of Veterinary Cardiology, 10(1) pp. 1​-10​.​ DOI: https://doi.org/10.1016/j.jvc.2008.04.003 
    ​Details  DOI  PMID  PMC 
  • 2007 | Journal Article
    ​ ​Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function​
    Lehnart, S. E. ; Ackerman, M. J.; Benson, D. W.; Brugada, R.; Clancy, C.; Donahue, J. K. & George, A. L. et al.​ (2007) 
    Circulation, 116(20) pp. 2325​-2345​.​
    ​Details  PMID  PMC 
  • 2007 | Journal Article
    ​ ​Modulation of the Ryanodine Receptor and Intracellular Calcium​
    Zalk, R.; Lehnart, S. E.   & Marks, A. R.​ (2007) 
    Annual Review of Biochemistry, 76(1) pp. 367​-385​.​ DOI: https://doi.org/10.1146/annurev.biochem.76.053105.094237 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Inherited Arrhythmias​
    Lehnart, S. E. ; Ackerman, M. J.; Benson, D. W.; Brugada, R.; Clancy, C. E.; Donahue, J. K. & George, A. L. et al.​ (2007) 
    Circulation, 116(20) pp. 2325​-2345​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.107.711689 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Novel targets for treating heart and muscle disease – stabilizing ryanodine receptors and preventing intracellular calcium leak​
    Lehnart, S. E. ​ (2007) 
    Current Opinion in Pharmacology, 7(2) pp. 225​-232​.​ DOI: https://doi.org/10.1016/j.coph.2006.09.010 
    ​Details  DOI  PMID  PMC 
  • 2007 | Journal Article
    ​ ​Regulation of ryanodine receptors in the heart​
    Lehnart, S. E.   & Marks, A. R.​ (2007) 
    Circulation Research, 101(8) pp. 746​-749​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.107.162479 
    ​Details  DOI  PMID  PMC 
  • 2006 | Journal Article
    ​ ​Phosphodiesterase 4D and heart failure: a cautionary tale​
    Lehnart, S. E.   & Marks, A. R.​ (2006) 
    Expert Opinion on Therapeutic Targets, 10(5) pp. 677​-688​.​ DOI: https://doi.org/10.1517/14728222.10.5.677 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S.; Vest, J. A.; Wronska, A. & Marks, A. R.​ (2006) 
    Proceedings of the National Academy of Sciences, 103(3) pp. 511​-518​.​ DOI: https://doi.org/10.1073/pnas.0510113103 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias​
    Lehnart, S. E. ; Terrenoire, C.; Reiken, S.; Wehrens, X. H. T.; Song, L.-S.; Tillman, E. J. & Mancarella, S. et al.​ (2006) 
    Proceedings of the National Academy of Sciences, 103(20) pp. 7906​-7910​.​ DOI: https://doi.org/10.1073/pnas.0602133103 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation​
    Vest, J. A.; Wehrens, X. H. T.; Reiken, S. R.; Lehnart, S. E. ; Dobrev, D.; Chandra, P. & Danilo, P. et al.​ (2005) 
    Circulation, 111(16) pp. 2025​-2032​.​ DOI: https://doi.org/10.1161/01.CIR.0000162461.67140.4C 
    ​Details  DOI 
  • 2005 | Journal Article | Erratum
    ​ ​Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias​
    Lehnart, S. E. ; Wehrens, X. H.; Reiken, S.; Warrier, S.; Belevych, A. E.; Harvey, R. D. & Richter, W. et al.​ (2005) 
    Cell, 123(3) pp. 535​-536​.​ DOI: https://doi.org/10.1016/j.cell.2005.10.011 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca2+ Leak: A Novel Therapeutic Target in Heart Failure​
    Lehnart, S. E. ; Wehrens, X. H. & Marks, A. R.​ (2005) 
    Circulation, 111(25) pp. 3342​-3346​.​ DOI: https://doi.org/10.1161/circulationaha.105.551861 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias​
    Lehnart, S. E. ; Wehrens, X. H.; Reiken, S.; Warrier, S.; Belevych, A. E.; Harvey, R. D. & Richter, W. et al.​ (2005) 
    Cell, 123(1) pp. 25​-35​.​ DOI: https://doi.org/10.1016/j.cell.2005.07.030 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S.; van der Nagel, R.; Morales, R.; Sun, J. & Cheng, Z. et al.​ (2005) 
    Proceedings of the National Academy of Sciences, 102(27) pp. 9607​-9612​.​ DOI: https://doi.org/10.1073/pnas.0500353102 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Ryanodine Receptor-Targeted Anti-Arrhythmic Therapy​
    Wehrens, X. H.; Lehnart, S. E.   & Marks, A. R.​ (2005) 
    Annals of the New York Academy of Sciences, 1047(1) pp. 366​-375​.​ DOI: https://doi.org/10.1196/annals.1341.032 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca 2+ Leak​
    Lehnart, S. E. ; Wehrens, X. H. & Marks, A. R.​ (2005) 
    Circulation, 111(25) pp. 3342​-3346​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.551861 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated With Calcium Release Channel (Ryanodine Receptor) Leak​
    Lehnart, S. E. ; Wehrens, X. H.; Laitinen, P. J.; Reiken, S. R.; Deng, S.-X.; Cheng, Z. & Landry, D. W. et al.​ (2004) 
    Circulation, 109(25) pp. 3208​-3214​.​ DOI: https://doi.org/10.1161/01.cir.0000132472.98675.ec 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Intracellular calcium release and cardiac disease​
    Wehrens, X. H.; Lehnart, S. E.   & Marks, A. R.​ (2004) 
    Annual Review of Physiology, 67(1) pp. 69​-98​.​ DOI: https://doi.org/10.1146/annurev.physiol.67.040403.114521 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Cardiac Ryanodine Receptor Function and Regulation in Heart Disease​
    Lehnart, S. E. ; Wehrens, X. H.; Kushnir, A. & Marks, A. R.​ (2004) 
    Annals of the New York Academy of Sciences, 1015(1) pp. 144​-159​.​ DOI: https://doi.org/10.1196/annals.1302.012 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Calstabin deficiency, ryanodine receptors, and sudden cardiac death​
    Lehnart, S. E. ; Wehrens, X. H. & Marks, A. R.​ (2004) 
    Biochemical and Biophysical Research Communications, 322(4) pp. 1267​-1279​.​ DOI: https://doi.org/10.1016/j.bbrc.2004.08.032 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S. R. & Marks, A. R.​ (2004) 
    Circulation Research, 94(6) pp. e61​-e70​.​ DOI: https://doi.org/10.1161/01.res.0000125626.33738.e2 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Protection from Cardiac Arrhythmia Through Ryanodine Receptor-Stabilizing Protein Calstabin2​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S. R.; Deng, S.-X.; Vest, J. A.; Cervantes, D. & Coromilas, J. et al.​ (2004) 
    Science, 304(5668) pp. 292​-296​.​ DOI: https://doi.org/10.1126/science.1094301 
    ​Details  DOI 
  • 2003 | Journal Article
    ​ ​FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death​
    Wehrens, X. H. T.; Lehnart, S. E. ; Huang, F.; Vest, J. A.; Reiken, S. R.; Mohler, P. J. & Sun, J. et al.​ (2003) 
    Cell, 113(7) pp. 829​-840​.​ DOI: https://doi.org/10.1016/S0092-8674(03)00434-3 
    ​Details  DOI 
  • 2003 | Journal Article
    ​ ​Immunophilins and Coupled Gating of Ryanodine Receptors​
    Lehnart, S. E. ; Huang, F.; Marx, S. O. & Marks, A. R.​ (2003) 
    Current Topics in Medicinal Chemistry, 3(12) pp. 1383​-1391​.​ DOI: https://doi.org/10.2174/1568026033451907 
    ​Details  DOI 
  • 2003 | Book Chapter
    ​ ​Coronary Perfusion Cocktails for In Vivo Gene Transfer​
    Lehnart, S. E.  & Donahue, J. K.​ (2003)
    In: Cardiac Cell and Gene Transfer pp. 213​-218. ​Totowa, New Jersey: ​Springer. DOI: https://doi.org/10.1385/1-59259-350-X:213 
    ​Details  DOI 
  • 2003 | Journal Article
    ​ ​PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure​
    Reiken, S.; Lacampagne, A.; Zhou, H.; Kherani, A.; Lehnart, S. E. ; Ward, C. & Huang, F. et al.​ (2003) 
    The Journal of Cell Biology, 160(6) pp. 919​-928​.​ DOI: https://doi.org/10.1083/jcb.200211012 
    ​Details  DOI 
  • 2002 | Journal Article
    ​ ​Load-dependent induction of apoptosis in multicellular myocardial preparations​
    Janssen, P. M. L.; Hasenfuß, G. ; Zeitz, O.; Lehnart, S. E. ; Prestle, J. ; Darmer, D. & Holtz, J. et al.​ (2002) 
    American Journal of Physiology - Heart and Circulatory Physiology, 282(1) pp. H349​-H356​.​ DOI: https://doi.org/10.1152/ajpheart.00024.2001 
    ​Details  DOI 
  • 2002 | Journal Article | Research Paper
    ​ ​Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium​
    Hermann, H.-P.; Zeitz, O.; Lehnart, S. E. ; Keweloh, B.; Datz, N.; Hasenfuß, G.   & Janssen, P. M. L.​ (2002) 
    Cardiovascular Research, 53(1) art. PII S0008-6363(01)00437-0​.​ DOI: https://doi.org/10.1016/S0008-6363(01)00437-0 
    ​Details  DOI  PMID  PMC  WoS 
  • 2002 | Journal Article | Research Paper
    ​ ​Intracellular beta-blockade: overexpression of G alpha(i2) depresses the beta-adrenergic response in intact myocardium​
    Janssen, P. M. L.; Schillinger, W. ; Donahue, J. K.; Zeitz, O.; Embry, S. L.; Lehnart, S. E.   & Weil, J. et al.​ (2002) 
    Cardiovascular Research, 55(2) art. PII S0008-6363(02)00406-6​.​ DOI: https://doi.org/10.1016/S0008-6363(02)00406-6 
    ​Details  DOI  PMID  PMC  WoS 
  • 2001 | Conference Abstract
    ​ ​Influence of amino-pyruvate on contractility and cardiac energy metabolism in isolated rabbit myocardial trabeculae​
    Keweloh, B.; Lehnart, S. E. ; Wehling, M.; Domeier, E.; Janssen, P. & Hasenfuß, G. ​ (2001)
    Biophysical Journal, 80(1) 
    Bethesda​: Biophysical Society.
    ​Details  WoS 
  • 2001 | Journal Article
    ​ ​Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility​
    Prestle, J.; Janssen, P.; Janssen, A. P.; Zeitz, O.; Lehnart, S. E. ; Bruce, L. & Smith, G. L. et al.​ (2001) 
    Circulation Research, 88(2) pp. 188​-194​.​ DOI: https://doi.org/10.1161/01.res.88.2.188 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Conference Abstract
    ​ ​Is apoptosis in contracting myocardial preparations preload- or afterload-dependent?​
    Janssen, P.; Lehnart, S. E. ; Zeitz, O.; Hasenfuß, G. ; Darmer, D.; Holtz, J. & Schumann, H.​ (2000)
    Biophysical Journal, 78(1) 
    Bethesda​: Biophysical Society.
    ​Details  WoS 
  • 2000 | Conference Abstract
    ​ ​Gi alpha-2 overexpression depresses the beta-adrenergic response in multicellular preparations and single myocytes​
    Janssen, P.; Schillinger, W.; Donahue, J. K.; Zeitz, O.; Emami, S.; Lehnart, S. E.   & Weil, J. et al.​ (2000)
    Circulation, 102(18) 
    Philadelphia​: Lippincott Williams & Wilkins.
    ​Details  WoS 
  • 2000 | Conference Abstract
    ​ ​Potentiation of beta-adrenergic inotropic response with pyruvate in failing human heart and in healthy rabbit myocardium​
    Hermann, H.-P.; Zeitz, O.; Keweloh, B.; Datz, N.; Lehnart, S. E. ; Hasenfuß, G.   & Janssen, P.​ (2000)
    European Heart Journal, 21 
    London​: W B Saunders Co Ltd.
    ​Details  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium​
    Janssen, P. M. L.; Zeitz, O.; Keweloh, B.; Siegel, U.; Maier, L. S. ; Barckhausen, P. & Pieske, B.  et al.​ (2000) 
    Cardiovascular Research, 47(1) pp. 99​-107​.​ DOI: https://doi.org/10.1016/S0008-6363(00)00052-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Preservation of myocardial function after adenoviral gene transfer in isolated myocardium​
    Lehnart, S. E. ; Janssen, P. M. L.; Franz, W. M.; Donahue, J. K.; Lawrence, J. H.; Marbán, E. & Prestle, J. et al.​ (2000) 
    American Journal of Physiology-Heart and Circulatory Physiology, 279(3) pp. H986​-H991​.​ DOI: https://doi.org/10.1152/ajpheart.2000.279.3.H986 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article
    ​ ​Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium​
    Hasenfuß, G. ; Schillinger, W.; Lehnart, S. E. ; Preuss, M.; Pieske, B.; Maier, L. S.   & Prestle, J. et al.​ (1999) 
    Circulation, 99(5) pp. 641​-648​.​ DOI: https://doi.org/10.1161/01.CIR.99.5.641 
    ​Details  DOI 
  • 1999 | Journal Article | Research Paper
    ​ ​Preservation of contractile characteristics of human myocardium in multi-day cell culture​
    Janssen, P. M. L.; Lehnart, S. E. ; Prestle, J.   & Hasenfuß, G. ​ (1999) 
    Journal of Molecular and Cellular Cardiology, 31(8) pp. 1419​-1427​.​ DOI: https://doi.org/10.1006/jmcc.1999.0978 
    ​Details  DOI  PMID  PMC  WoS 
  • 1998 | Journal Article
    ​ ​Influence of SR Ca2+-ATPase and Na+-Ca2+-exchanger on the force-frequency relation​
    Schillinger, W. ; Lehnart, S. E. ; Prestle, J. ; Preuss, M.; Pieske, B. ; Maier, L. S.   & Meyer, M. et al.​ (1998) 
    Basic Research in Cardiology, 93(Supplement 1) pp. 38​-45​.​ DOI: https://doi.org/10.1007/s003950050208 
    ​Details  DOI 
  • 1998 | Journal Article | Research Paper
    ​ ​The trabecula culture system: a novel technique to study contractile parameters over a multiday time period​
    Janssen, P. M. L.; Lehnart, S. E. ; Prestle, J.; Lynker, J. C.; Salfeld, P.; Just, H. & Hasenfuß, G. ​ (1998) 
    American Journal of Physiology-Heart and Circulatory Physiology, 274(5) pp. H1481​-H1488​.​ DOI: https://doi.org/10.1152/ajpheart.1998.274.5.H1481 
    ​Details  DOI  PMID  PMC  WoS 
  • 1998 | Journal Article | Research Paper
    ​ ​Frequency-dependence of myocardial energetics in failing human myocardium as quantified by a new method for the measurement of oxygen consumption in muscle strip preparations​
    Meyer, M.; Keweloh, B.; Guth, K.; Holmes, J. W.; Pieske, B. ; Lehnart, S. E.   & Just, H.  et al.​ (1998) 
    Journal of Molecular and Cellular Cardiology, 30(8) pp. 1459​-1470​.​ DOI: https://doi.org/10.1006/jmcc.1998.0706 
    ​Details  DOI  PMID  PMC  WoS 
  • 1998 | Conference Paper | Research Paper
    ​ ​Sarcoplasmic reticulum proteins in heart failure​
    Lehnart, S. E. ; Schillinger, W. ; Pieske, B. ; Prestle, J. ; Just, H.   & Hasenfuß, G. ​ (1998)
    Annals of the New York Academy of Sciences, 853 pp. 220​-230. ​New-York-Academy-of-Sciences Meeting on Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility​, WASHINGTON, D.C..
    New york​: New York Acad Sciences. DOI: https://doi.org/10.1111/j.1749-6632.1998.tb08270.x 
    ​Details  DOI  PMID  PMC  WoS 
  • 1996 | Journal Article | Research Paper
    ​ ​Influence of endothelin 1 on human atrial myocardium - Myocardial function and subcellular pathways​
    Meyer, M.; Lehnart, S. E. ; Pieske, B. ; Schlottauer, K.; Munk, A. ; Holubarsch, C. & Just, H.  et al.​ (1996) 
    Basic Research in Cardiology, 91(1) pp. 86​-93​.​
    ​Details  PMID  PMC  WoS 

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