Prof. Dr. Stephan Elmar Lehnart

 
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  • 2022 Journal Article
    ​ ​Dysferlin facilitates the de novo biogenesis of tubular membranes in hypertrophic remodelling​
    Paulke, N.; Amlaz, S.; Fleischhacker, C.; Kohl, T.; Kownatzki-Danger, D.; Hasenfuss, G.   & Lehnart, S.  et al.​ (2022) 
    European Heart Journal43(Suppl. 2).​ DOI: https://doi.org/10.1093/eurheartj/ehac544.2944 
    Details  DOI 
  • 2022 Journal Article | Discussion
    ​ ​New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain​
    Weninger, G. & Lehnart, S. E. ​ (2022) 
    Journal of Cellular Signaling3(4).​ DOI: https://doi.org/10.33696/Signaling.3.081 
    Details  DOI 
  • 2022 Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Editorial: Cardiac optogenetics: Using light to observe and excite the heart​
    Bruegmann, T. ; Smith, G. L. & Lehnart, S. E. ​ (2022) 
    Frontiers in Physiology13 art. 1031062​.​ DOI: https://doi.org/10.3389/fphys.2022.1031062 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Research Paper | 
    ​ ​Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes​
    Weninger, G.; Pochechueva, T.; El Chami, D.; Luo, X.; Kohl, T. ; Brandenburg, S.   & Urlaub, H.  et al.​ (2022) 
    Scientific Reports12(1).​ DOI: https://doi.org/10.1038/s41598-022-14320-9 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Research Paper | 
    ​ ​A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes​
    Brandenburg, S. ; Pawlowitz, J.; Steckmeister, V.; Subramanian, H.; Uhlenkamp, D.; Scardigli, M. & Mushtaq, M. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology165 pp. 141​-157​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.01.003 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Overview
    ​ ​The Role of Junctophilin Proteins in Cellular Function​
    Lehnart, S. E.   & Wehrens, X. H. T.​ (2022) 
    Physiological Reviews,.​ DOI: https://doi.org/10.1152/physrev.00024.2021 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Research Paper
    ​ ​Modulatorische Einheiten bei Herzinsuffizienz​
    Hasenfuß, G. P. ; Kaul, A.; Lehnart, S. E. ; Linke, W. A. ; Zelarayan, L. C.   & Zimmermann, W.-H. ​ (2022) 
    Der Kardiologe16(2) pp. 109​-114​.​ DOI: https://doi.org/10.1007/s12181-022-00540-w 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis​
    Brandenburg, S. ; Drews, L.; Schönberger, H.-L.; Jacob, C. F.; Paulke, N. J.; Beuthner, B. E. & Topci, R. et al.​ (2022) 
    Journal of Molecular and Cellular Cardiology173 pp. 1​-15​.​ DOI: https://doi.org/10.1016/j.yjmcc.2022.08.363 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool​
    Wegener, J. W.; Wagdi, A.; Wagner, E.; Katschinski, D. M.; Hasenfuß, G. ; Brügmann, T.   & Lehnart, S. E. ​ (2021) 
    Frontiers in Physiology12.​ DOI: https://doi.org/10.3389/fphys.2021.777770 
    Details  DOI  PMID  PMC 
  • 2021 Book Chapter
    ​ ​Management of Metadata Types in Basic Cardiological Research​
    Kusch, H. ; Kossen, R. ; Suhr, M.; Freckmann, L.; Weber, L.; Henke, C.& Lehmann, C. et al.​ (2021)
    In:​Röhrig, Rainer; Beißbarth, Tim; König, Jochem; Ose, Claudia; Rauch, Geraldine; Sax, Ulrich; Schreiweis, Björn, et al.​ (Eds.), German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal pp. 59​-68.  DOI: https://doi.org/10.3233/SHTI210542 
    Details  DOI  PMID  PMC 
  • 2021 Preprint
    ​ ​Analyzing cross-talk between superimposed signals: Vector norm dependent hidden Markov models and applications​
    Vanegas, L. J.; Eltzner, B.; Rudolf, D. ; Dura, M.; Lehnart, S. E.  & Munk, A. ​ (2021). DOI: https://doi.org/10.48550/arXiv.2103.06071 
    Details  DOI  arXiv 
  • 2021 Journal Article | 
    ​ ​Multiphoton Imaging of Ca2+ Instability in Acute Myocardial Slices from a RyR2R2474S Murine Model of Catecholaminergic Polymorphic Ventricular Tachycardia​
    Borile, G.; Zaglia, T.; Lehnart, S. E.   & Mongillo, M.​ (2021) 
    Journal of Clinical Medicine10(13) pp. 2821​.​ DOI: https://doi.org/10.3390/jcm10132821 
    Details  DOI 
  • 2021 Journal Article | Research Paper
    ​ ​CaMKII inhibition has dual effects on spontaneous Ca 2+ release and Ca 2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation​
    Sadredini, M.; Haugsten Hansen, M.; Frisk, M.; Louch, W. E.; Lehnart, S. E. ; Sjaastad, I. & Korseberg Stokke, M.​ (2021) 
    American Journal of Physiology-Heart and Circulatory Physiology321(2) pp. H446​-H460​.​ DOI: https://doi.org/10.1152/ajpheart.00011.2021 
    Details  DOI  PMID  PMC 
  • 2021 Research Data
    ​ ​Online Supplemental Files for "Caveolin3 Stabilizes McT1-mediated Lactate/Proton Transport in Cardiomyocytes"​
    Lehnart, S. E. ​ (2021)
     DOI: https://doi.org/10.25625/ffe7lj 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1​
    Sadredini, M.; Manotheepan, R.; Lehnart, S. E. ; Anderson, M. E.; Sjaastad, I. & Stokke, M. K.​ (2021) 
    Physiological Reports9(18) art. e15030​.​ DOI: https://doi.org/10.14814/phy2.15030 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper
    ​ ​Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​
    Peper, J.; Kownatzki-Danger, D.; Weninger, G.; Seibertz, F.; Pronto, J. R. D.; Sutanto, H. & Pacheu-Grau, D. et al.​ (2021) 
    Circulation Research128(6).​ DOI: https://doi.org/10.1161/CIRCRESAHA.119.316547 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Overview | 
    ​ ​Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review​
    Müllenbroich, M. C.; Kelly, A.; Acker, C.; Bub, G.; Brügmann, T. ; Di Bona, A. & Entcheva, E. et al.​ (2021) 
    Frontiers in Physiology12.​ DOI: https://doi.org/10.3389/fphys.2021.769586 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban​
    Menzel, J. ; Kownatzki-Danger, D.; Tokar, S.; Ballone, A.; Unthan-Fechner, K.; Kilisch, M.   & Lenz, C.  et al.​ (2020) 
    Science Signaling13(647) pp. eaaz1436​.​ DOI: https://doi.org/10.1126/scisignal.aaz1436 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice​
    Rudolph, F.; Fink, C.; Hüttemeister, J.; Kirchner, M.; Radke, M. H.; Lopez Carballo, J. & Wagner, E.  et al.​ (2020) 
    Nature Communications11(1).​ DOI: https://doi.org/10.1038/s41467-020-16929-8 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation​
    Campbell, H. M.; Quick, A. P.; Abu-Taha, I.; Chiang, D. Y.; Kramm, C. F.; Word, T. A. & Brandenburg, S. et al.​ (2020) 
    Circulation142(12) pp. 1159​-1172​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.045791 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper | 
    ​ ​Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis​
    Brandenburg, S. ; Pawlowitz, J.; Eikenbusch, B.; Peper, J.; Kohl, T. ; Mitronova, G. Y.   & Sossalla, S.  et al.​ (2019) 
    JCI insight4(12).​ DOI: https://doi.org/10.1172/jci.insight.127116 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article
    ​ ​Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes​
    Rudolph, F.; Hüttemeister, J.; da Silva Lopes, K.; Jüttner, R.; Yu, L.; Bergmann, N. & Friedrich, D. et al.​ (2019) 
    Proceedings of the National Academy of Sciences of the United States of America116(50) pp. 25126​-25136​.​ DOI: https://doi.org/10.1073/pnas.1904385116 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | 
    ​ ​Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca 2+ -Dependent Arrhythmia​
    Ottesen, A. H.; Carlson, C. R.; Eken, O. S.; Sadredini, M.; Myhre, P. L.; Shen, X. & Dalhus, B. et al.​ (2019) 
    Circulation: Arrhythmia and Electrophysiology12(4) art. e007045​.​ DOI: https://doi.org/10.1161/CIRCEP.118.007045 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation​
    Alsina, K. M.; Hulsurkar, M.; Brandenburg, S. ; Kownatzki-Danger, D.; Lenz, C. ; Urlaub, H.   & Abu-Taha, I. et al.​ (2019) 
    Circulation140(8) pp. 681​-693​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.039642 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Data on differential multivariable risk prediction of appropriate shock vs. competing mortality​
    Bergau, L.; Willems, R.; Sprenkeler, D. J; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    Data in Brief21 pp. 2110​-2116​.​ DOI: https://doi.org/10.1016/j.dib.2018.11.025 
    Details  DOI  PMID  PMC 
  • 2018 Research Data | Research Paper | 
    ​ ​Axial Tubule Junctions Activate Atrial Ca2+ Release across Species​
    Brandenburg, S. ; Pawlowitz, J.; Lehnart, S. E. ; Fakuade, F. E.; Kownatzki-Danger, D.; Kohl, T.  & Mitronova, G. Y.  et al.​ (2018)
     DOI: https://doi.org/10.3389/fphys.2018.01227 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Overview
    ​ ​Ryanodine receptor dysfunction and the resolution revolution: how Nobel Prize-winning techniques transform cardiovascular research​
    Voigt, N.   & Lehnart, S. E. ​ (2018) 
    Cardiovascular Research114(14) pp. e106​-e109​.​ DOI: https://doi.org/10.1093/cvr/cvy235 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper | 
    ​ ​Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy​
    Richter, K. N. ; Revelo, N. H. ; Seitz, K. J.; Helm, M. S.; Sarkar, D.; Saleeb, R. S. & d'Este, E.  et al.​ (2018) 
    The EMBO journal37(1) pp. 139​-159​.​ DOI: https://doi.org/10.15252/embj.201695709 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper | 
    ​ ​Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation​
    Danielsen, T. K.; Manotheepan, R.; Sadredini, M.; Leren, I. S.; Edwards, A. G.; Vincent, K. P. & Lehnart, S. E.  et al.​ (2018) 
    PLOS ONE13(11) art. e0207100​.​ DOI: https://doi.org/10.1371/journal.pone.0207100 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | 
    ​ ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​
    Bergau, L.; Willems, R.; Sprenkeler, D. J.; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    International Journal of Cardiology272 pp. 102​-107​.​ DOI: https://doi.org/10.1016/j.ijcard.2018.06.103 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper | 
    ​ ​A protocol for registration and correction of multicolour STED superresolution images​
    Hebisch, E.; Wagner, E. ; Westphal, V. ; Sieber, J. J. & Lehnart, S. E. ​ (2017) 
    Journal of Microscopy267(2) pp. 160​-175​.​ DOI: https://doi.org/10.1111/jmi.12556 
    Details  DOI  PMID  PMC 
  • 2017 Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    Details 
  • 2017 Journal Article
    ​ ​From Ribosome to Sarcomere - Titin Dynamics in Striated Muscle Cells​
    Gotthardt, M.; Rudolph, F.; Huettemeister, J.; da Sliva Lopes, K.; Yu, L.; Bergmann, N. & Fink, C. et al.​ (2017) 
    Biophysical Journal112(3) pp. 429a​.​ DOI: https://doi.org/10.1016/j.bpj.2016.11.2293 
    Details  DOI 
  • 2017 Conference Abstract
    ​ ​How Does Calcium Overload Generate Calcium Waves in Heart?​
    Williams, G. S.; Wescott, A. P.; Lehnart, S. E.   & Lederer, W.​ (2017)
    Biophysical Journal112(3) p. 541a. , San Francisco, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2016.11.2923 
    Details  DOI  WoS 
  • 2017 Journal Article
    ​ ​Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant​
    Tzimas, C.; Johnson, D. M.; Santiago, D. J.; Vafiadaki, E.; Arvanitis, D. A.; Davos, C. H. & Varela, A. et al.​ (2017) 
    Cardiovascular Research113(11) pp. 1403​-1417​.​ DOI: https://doi.org/10.1093/cvr/cvx113 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | 
    ​ ​High-Affinity Functional Fluorescent Ligands for Human β-Adrenoceptors​
    Mitronova, G. Y. ; Lukinavičius, G.; Butkevich, A. N. ; Kohl, T. ; Belov, V. N. ; Lehnart, S. E.   & Hell, S. W. ​ (2017) 
    Scientific Reports7 art. 12319​.​ DOI: https://doi.org/10.1038/s41598-017-12468-3 
    Details  DOI  PMID  PMC 
  • 2017 Conference Abstract
    ​ ​The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S.; Sossalla, S. T.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure19 
    Hoboken​: Wiley.
    Details  WoS 
  • 2016 Conference Abstract
    ​ ​Axial Membrane Tubules in Atrial Cardiomyocytes Confine Ultrarapid Intracellular Calcium Signals through a New Super-Hub Mechanism​
    Brandenburg, S.; Kohl, T. ; Williams, G. S.; Gusev, K.; Wagner, E. ; Hebisch, E. & Ward, C. W. et al.​ (2016)
    Biophysical Journal110(3) p. 267a. , Los Angeles, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2015.11.1454 
    Details  DOI  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​Axial tubule junctions control rapid calcium signaling in atria​
    Brandenburg, S. ; Kohl, T. ; Williams, G. S. B.; Gusev, K.; Wagner, E. ; Rog-Zielinska, E. A. & Hebisch, E. et al.​ (2016) 
    Journal of Clinical Investigation126(10) pp. 3999​-4015​.​ DOI: https://doi.org/10.1172/JCI88241 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release​
    Manotheepan, R.; Danielsen, T. K.; Sadredini, M.; Anderson, M. E.; Carlson, C. R.; Lehnart, S. E.   & Sjaastad, I. et al.​ (2016) 
    Cardiovascular Research111(3) pp. 295​-306​.​ DOI: https://doi.org/10.1093/cvr/cvw095 
    Details  DOI  PMID  PMC 
  • 2016 Conference Paper
    ​ ​The molecular and functional identities of atrial cardiomyocytes in health and disease​
    Brandenburg, S. ; Arakel, E. C. ; Schwappach, B.   & Lehnart, S. E. ​ (2016)
    ​Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (7, Part B) pp. 1882​-1893. (Vol. 1863). ​8th Ascona International Workshop on Cardiomyocyte Biology - Integration of Developmental and Environmental Cues​, Ascona, SWITZERLAND.
    Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.bbamcr.2015.11.025 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Book Chapter
    ​ ​Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias​
    Richter, C. ; Christoph, J. ; Lehnart, S. E.  & Luther, S. ​ (2016)
    In:​Kianianmomeni, Arash​ (Ed.), Optogenetics: Methods and Protocols pp. 293​-302. ​New York: ​Humana Press. DOI: https://doi.org/10.1007/978-1-4939-3512-3_20 
    Details  DOI  PMID  PMC 
  • 2016 Conference Abstract
    ​ ​Role of sarcoplasmic reticulum calcium leak in heart failure​
    Mohamed, B. A. ; Richter, C.; Neef, S.; Lbik, D.; Khadjeh, S. ; Sossalla, S. T.   & Lehnart, S. E.  et al.​ (2016)
    European Heart Journal37 pp. 273​-274. ​Congress of the European-Society-of-Cardiology (ESC)​, Rome, ITALY.
    Hoboken​: Wiley-blackwell.
    Details  WoS 
  • 2016 Journal Article | Research Paper
    ​ ​"Reduced" Coumarin Dyes with an O-Phosphorylated 2,2-Dimethyl-4-( hydroxymethyl)-1,2,3,4-tetrahydroquinoline Fragment: Synthesis, Spectra, and STED Microscopy​
    Nizamov, S.; Sednev, M. V. ; Bossi, M. L. ; Hebisch, E.; Frauendorf, H. ; Lehnart, S. E.   & Belov, V. N.  et al.​ (2016) 
    Chemistry - A European Journal22(33) pp. 11631​-11642​.​ DOI: https://doi.org/10.1002/chem.201601252 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Conference Abstract
    ​ ​Does leaky ryanodine receptors play any role in maladaptive remodeling after chronic mechanical stress in mice?​
    Mohamed, B. A.; Khadjeh, S.; Sossalla, S. T. ; Neef, S.; Lehnart, S. E. ; Hasenfuß, G.   & Toischer, K. ​ (2015)
    European Journal of Heart Failure17 pp. 235​-236. 
    Hoboken​: Wiley-blackwell.
    Details  WoS 
  • 2015 Book Chapter
    ​ ​Transport of ions and small molecules across membranes​
    Lehnart, S. E.  & Marks, A. R.​ (2015)
    In:​Plopper, George; Sharp, David; Sikorski, Eric​ (Eds.), Lewin’s cells pp. 230​-300. ​Burlington, MA: ​Jones & Bartlett Learning.
    Details 
  • 2015 Journal Article | Research Paper | 
    ​ ​On the Adjacency Matrix of RyR2 Cluster Structures​
    Walker, M. A.; Kohl, T. ; Lehnart, S. E. ; Greenstein, J. L.; Lederer, W. J. & Winslow, R. L.​ (2015) 
    PLOS Computational Biology11(11) art. e1004521​.​ DOI: https://doi.org/10.1371/journal.pcbi.1004521 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper | 
    ​ ​Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice​
    Gogiraju, R.; Xu, X.; Bochenek, M. L.; Steinbrecher, J. H.; Lehnart, S. E. ; Wenzel, P. & Kessel, M.  et al.​ (2015) 
    Journal of the American Heart Association4(2) art. e001770​.​ DOI: https://doi.org/10.1161/JAHA.115.001770 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper
    ​ ​Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2​
    Zaglia, T.; Pianca, N.; Borile, G.; Da Broi, F.; Richter, C. ; Campione, M. & Lehnart, S. E.  et al.​ (2015) 
    Proceedings of the National Academy of Sciences of the United States of America112(32) pp. E4495​-E4504​.​ DOI: https://doi.org/10.1073/pnas.1509380112 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article
    ​ ​Intensity matters: Ryanodine receptor regulation during exercise​
    Kohl, T. ; Weninger, G.; Zalk, R.; Eaton, P. & Lehnart, S. E. ​ (2015) 
    Proceedings of the National Academy of Sciences of the United States of America112(50) pp. 15271​-15272​.​ DOI: https://doi.org/10.1073/pnas.1521051112 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper
    ​ ​Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy​
    Perera, R. K. ; Sprenger, J. U.; Steinbrecher, J. H.; Hübscher, D. ; Lehnart, S. E. ; Abesser, M. & Schuh, K. et al.​ (2015) 
    Circulation Research116(8) pp. 1304​-1311​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.116.306082 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Overview | 
    ​ ​Ca2+ signaling in the myocardium by (redox) regulation of PKA/CaMKII​
    Johnston, A. S.; Lehnart, S. E.   & Burgoyne, J. R.​ (2015) 
    Frontiers in Pharmacology6 art. 166​.​ DOI: https://doi.org/10.3389/fphar.2015.00166 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper | 
    ​ ​In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease​
    Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Maier, L. S. ; Hasenfuß, G.   & Nikolaev, V. O. ​ (2015) 
    Nature Communications6 art. 6965​.​ DOI: https://doi.org/10.1038/ncomms7965 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions​
    Tzimas, C.; Terrovitis, J.; Lehnart, S. E. ; Kranias, E. G. & Sanoudou, D.​ (2015) 
    Heart Rhythm12(7) pp. 1599​-1610​.​ DOI: https://doi.org/10.1016/j.hrthm.2015.03.043 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper
    ​ ​Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​
    Godier-Furnemont, A. F. G.; Tiburcy, M. ; Wagner, E. ; Dewenter, M. ; Laemmle, S.; El-Armouche, A.   & Lehnart, S. E.  et al.​ (2015) 
    Biomaterials60 pp. 82​-91​.​ DOI: https://doi.org/10.1016/j.biomaterials.2015.03.055 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Conference Abstract
    ​ ​Following titin in real-time: Sarcomere dynamics in myocytes.​
    Rudolph, F.; Lopes, K. da S.; Yu, L.; Bergmann, N.; Fink, C.; Wagner, E. J. & Lehnart, S. E.  et al.​ (2015)
    Molecular Biology of the Cell26 
    Bethesda​: Amer Soc Cell Biology.
    Details  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​
    Chang Liao, M.-L.; Boer, T. P. de; Mutoh, H.; Raad, N.; Richter, C. ; Wagner, E.   & Downie, B. R. et al.​ (2015) 
    Circulation Research117(5) pp. 401​-412​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.117.306143 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Conference Abstract
    ​ ​Super-hub mechanism of calcium signaling in atria​
    Brandenburg, S.; Kohl, T.; Gusev, K.; Wagner, E. J.; Sossalla, S. T. ; Hasenfuß, G.   & Hell, S. W.  et al.​ (2015)
    FEBS Journal282 , Berlin, GERMANY.
    Hoboken​: Wiley-blackwell.
    Details  WoS 
  • 2014 Conference Abstract
    ​ ​ANP potentiates catecholaminergic stress in early cardiac disease​
    Perera, R. K.; Steinbrecher, J. H.; Lehnart, S. E.   & Nikolaev, V. O. ​ (2014)
    Cardiovascular Research103 , Barcelona, SPAIN.
    Oxford​: Oxford Univ Press. DOI: https://doi.org/10.1093/cvr/cvu098.37 
    Details  DOI  WoS 
  • 2014 Conference Abstract
    ​ ​Super-Resolution Modeling of Calcium Release in Heart​
    Walker, M. A.; Williams, G. S. B.; Kohl, T.; Jafri, S.; Lehnart, S. E. ; Greenstein, J. L. & Lederer, W. J. et al.​ (2014)
    Biophysical Journal106(2) , San Francisco, CA.
    Cambridge​: Cell Press.
    Details  WoS 
  • 2014 Journal Article
    ​ ​Super-Resolution Modeling of Calcium Release in Heart​
    Walker, M. A.; Williams, G. S. B.; Kohl, T.; Jafri, S.; Lehnart, S. E. ; Greenstein, J. L. & Lederer, W. J. et al.​ (2014) 
    Biophysical Journal106(2) pp. 318a​.​ DOI: https://doi.org/10.1016/j.bpj.2013.11.1839 
    Details  DOI 
  • 2014 Journal Article | Research Paper
    ​ ​Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes​
    Götz, K. R.; Sprenger, J. U.; Perera, R. K. ; Steinbrecher, J. H.; Lehnart, S. E. ; Kuhn, M. & Gorelik, J. et al.​ (2014) 
    Circulation Research114(8) pp. 1235​-1245​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.114.302437 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | Research Paper
    ​ ​Analysis of tubular membrane networks in cardiac myocytes from atria and ventricles​
    Wagner, E. ; Brandenburg, S. ; Kohl, T.   & Lehnart, S. E. ​ (2014) 
    Journal of Visualized Experiments,(92) art. e51823​.​ DOI: https://doi.org/10.3791/51823 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | 
    ​ ​Toward panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias​
    Dura, M.; Schröder-Schetelig, J. ; Luther, S.   & Lehnart, S. E. ​ (2014) 
    Frontiers in Physiology5 art. 337​.​ DOI: https://doi.org/10.3389/fphys.2014.00337 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | 
    ​ ​Superresolution modeling of calcium release in the heart​
    Walker, M. A.; Williams, G. S. B.; Kohl, T. ; Lehnart, S. E. ; Jafri, M. S.; Greenstein, J. L. & Lederer, W. J. et al.​ (2014) 
    Biophysical Journal107(12) pp. 3018​-3029​.​ DOI: https://doi.org/10.1016/j.bpj.2014.11.003 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article
    ​ ​P677Superresolution microscopy reveals proliferative T-Tubule remodeling as general disease mechanism in early stages of heart failure development​
    Wagner, E. ; Hebisch, E.; Steinbrecher, J. H.; Westphal, V. ; Hasenfuß, G. ; Hell, S.   & Lehnart, S. E. ​ (2014) 
    Cardiovascular Research103(suppl 1) pp. S123.2​-S123​.​ DOI: https://doi.org/10.1093/cvr/cvu098.101 
    Details  DOI 
  • 2014 Journal Article | Research Paper | 
    ​ ​Tuning the electrical properties of the heart by differential trafficking of K-ATP ion channel complexes​
    Arakel, E. C. ; Brandenburg, S. ; Uchida, K.; Zhang, H.; Lin, Y.-W.; Kohl, T.   & Schrul, B.  et al.​ (2014) 
    Journal of Cell Science127(9) pp. 2106​-2119​.​ DOI: https://doi.org/10.1242/jcs.141440 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Principles of Network Organization of T-Tubule Membranes in Health and Disease​
    Kohl, T.; Wagner, E.; Brandenburg, S.; Parlitz, U.; Lederer, W. & Lehnart, S. E. ​ (2013) 
    Biophysical Journal104(2) pp. 340a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.1891 
    Details  DOI 
  • 2013 Conference Abstract
    ​ ​Importance of tumor suppressor gene p53-mediated endothelial cell apoptosis for cardiac angiogenesis and hypertrophy​
    Gogiraju, R.; Steinbrecher, J. H.; Lehnart, S. E. ; Kessel, M.; Dobbelstein, M.   & Schaefer, K.​ (2013)
    European Heart Journal34 , Amsterdam, NETHERLANDS.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2013 Conference Abstract
    ​ ​Proliferative membrane changes of T-tubules and cell-wide network changes during cardiac remodeling with orphaning of Ca2+release sites are a general mechanism of heart failure​
    Lehnart, S. E. ; Kohl, T.; Westphal, V.; Parlitz, U.; Jafri, M. S.; Lederer, W. J. & Wagner, E.  et al.​ (2013)
    European Heart Journal34(suppl 1) , Amsterdam, NETHERLANDS.
    Oxford​: Oxford Univ Press. DOI: https://doi.org/10.1093/eurheartj/eht307.34 
    Details  DOI  WoS 
  • 2013 Conference Abstract
    ​ ​Principles of Network Organization of T-Tubule Membranes in Health and Disease​
    Kohl, T.; Wagner, E. M.; Brandenburg, S.; Parlitz, U.; Lederer, W. J. & Lehnart, S. E. ​ (2013)
    Biophysical Journal104(2) , Philadelphia, PA.
    Cambridge​: Cell Press.
    Details  WoS 
  • 2013 Journal Article | Overview
    ​ ​Imaging T-tubules: dynamic membrane structures for deep functions​
    Kohl, T.   & Lehnart, S. E. ​ (2013) 
    Cardiovascular Research98(2) pp. 162​-164​.​ DOI: https://doi.org/10.1093/cvr/cvt058 
    Details  DOI  PMID  PMC 
  • 2013 Journal Article | Overview | 
    ​ ​Superresolution microscopy in heart - Cardiac nanoscopy​
    Kohl, T. ; Westphal, V. ; Hell, S. W.   & Lehnart, S. E. ​ (2013) 
    Journal of Molecular and Cellular Cardiology58 pp. 13​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2012.11.016 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Overview
    ​ ​Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms​
    Lehnart, S. E. ​ (2013) 
    Experimental Physiology98(3) pp. 622​-628​.​ DOI: https://doi.org/10.1113/expphysiol.2012.068262 
    Details  DOI  PMID  PMC 
  • 2013 Conference Abstract
    ​ ​Analysis of protein assemblies from fluorescence data by superresolution microcopy​
    Kohl, T.; Parlitz, U.; Hell, S. W. ; Luther, S. & Lehnart, S. E. ​ (2013)
    European Biophysics Journal42 , Lisbon, PORTUGAL.
    New york​: Springer.
    Details  WoS 
  • 2013 Journal Article
    ​ ​Analysis of Fluorescence Microscopy Super-Resolution Data of Protein Assemblies​
    Kohl, T. ; Parlitz, U. ; Hell, S. ; Luther, S.   & Lehnart, S. E. ​ (2013) 
    Biophysical Journal104(2) art. 444a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.2464 
    Details  DOI 
  • 2012 Conference Abstract
    ​ ​STED Nanoscopy of Cardiac RyR2 Clusters and Sub-Structure Analysis After Myocardial Infarction​
    Kohl, T.; Parlitz, U.; Lauterbach, M. A.; Hoang-Trong Minh Tuan, H. Hoang-Trong Minh Tuan, Hoang-Trong Minh Tuan; Williams, G. S. B.; Westphal, V. & Jafri, M. S. et al.​ (2012)
    Biophysical Journal102(3) , San Diego, CA.
    Cambridge​: Cell Press.
    Details  WoS 
  • 2012 Journal Article
    ​ ​Live Cell Super-Resolution Imaging of Transverse Membrane Tubules in Heart Failure​
    Wagner, E.; Lauterbach, M.; Kohl, T.; Westphal, V.; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012) 
    Biophysical Journal102(3) pp. 223a​-224a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.1227 
    Details  DOI 
  • 2012 Journal Article
    ​ ​Stochastic Simulation Assessing the Functional Changes Occurring during Heart Failure​
    Tuan Hoang-Trong, M.; Williams, G. S.; Lehnart, S. E. ; Lederer, W. J. & Jafri, M. S.​ (2012) 
    Biophysical Journal102(3) pp. 101a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.571 
    Details  DOI 
  • 2012 Journal Article
    ​ ​STED Nanoscopy of Cardiac RyR2 Clusters and Sub-Structure Analysis After Myocardial Infarction​
    Kohl, T.; Parlitz, U.; Lauterbach, M.; Minh Tuan, H.-T.; Williams, G. S.; Westphal, V. & Jafri, M. S. et al.​ (2012) 
    Biophysical Journal102(3) pp. 305a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.1683 
    Details  DOI 
  • 2012 Conference Abstract
    ​ ​Stochastic Simulation Assessing the Functional Changes Occurring during Heart Failure​
    Minh Tuan Hoang-Trong, M. T. H. Minh Tuan Hoang-Trong, Minh Tuan Hoang-Trong; Williams, G. S. B.; Lehnart, S. E. ; Lederer, W. J. & Jafri, M. S.​ (2012)
    Biophysical Journal102(3) , San Diego, CA.
    Cambridge​: Cell Press.
    Details  WoS 
  • 2012 Conference Abstract
    ​ ​Live Cell Super-Resolution Imaging of Transverse Membrane Tubules in Heart Failure​
    Wagner, E. M.; Lauterbach, M. A.; Kohl, T.; Westphal, V.; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012)
    Biophysical Journal102(3) pp. 223A​-224A. , San Diego, CA.
    Cambridge​: Cell Press.
    Details  WoS 
  • 2012 Journal Article
    ​ ​Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion​
    Cai, W.-F.; Pritchard, T.; Florea, S.; Lam, C.-K.; Han, P.; Zhou, X. & Yuan, Q. et al.​ (2012) 
    Cardiovascular Research94(2) pp. 333​-341​.​ DOI: https://doi.org/10.1093/cvr/cvs119 
    Details  DOI  PMID  PMC 
  • 2012 Journal Article | Research Paper
    ​ ​Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction​
    Wagner, E. ; Lauterbach, M. A.; Kohl, T. ; Westphal, V. ; Williams, G. S. B.; Steinbrecher, J. H. & Streich, J.-H. et al.​ (2012) 
    Circulation Research111(4) pp. 402​-414​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.112.274530 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper | 
    ​ ​Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype​
    Seegers, J.; Vos, M. A.; Flevari, P.; Willems, R.; Sohns, C.; Vollmann, D. & Luethje, L.  et al.​ (2012) 
    EP Europace14(3) pp. 416​-422​.​ DOI: https://doi.org/10.1093/europace/eur352 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Letter Note
    ​ ​Response to Letter Regarding Article, "Differential Cardiac Remodeling in Preload Versus Afterload"​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Sossalla, S. T. ; Becker, A.; Seidler, T. & Grebe, C. et al.​ (2011) 
    Circulation123(16).​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.017566 
    Details  DOI  WoS 
  • 2011 Journal Article
    ​ ​EUTrigTreat in: European Perspectives in Cardiology - Cardiovascular Research Funding: Recipients of the European Commission’s Seventh Framework Programme​
    Lehnart, S. E.   & Kranias, E. G.​ (2011) 
    Circulation123(25) pp. f148​.​
    Details 
  • 2011 Book Chapter | 
    ​ ​Combined Neuro-Cardiogenic Epilepsy Syndromes and Novel Mechanistic Insights​
    Lehnart, S. E. ​ (2011)
    In:​Foyaca-Sibat, Humberto​ (Ed.), Novel Aspects on Epilepsy pp. 89​-113. ​InTech. DOI: https://doi.org/10.5772/18943 
    Details  DOI 
  • 2011 Journal Article | 
    ​ ​SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes​
    Petitprez, S.; Zmoos, A.-F.; Ogrodnik, J.; Balse, E.; Raad, N.; El-Haou, S. & Albesa, M. et al.​ (2011) 
    Circulation Research108(3) pp. 294​-304​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.110.228312 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Conference Abstract
    ​ ​Super-Resolution Imaging of Cardiac Signaling Microdomains by STED Microscopy​
    Kohl, T.; Lauterbach, M. A.; Wagner, E. J.; Westphal, V.; Hagen, B. M.; Lederer, W. J. & Hell, S. W.  et al.​ (2010)
    The Journal of General Physiology136(1) , Marine Biol Lab, Woods Hole, MA.
    New york​: Rockefeller Univ Press.
    Details  WoS 
  • 2010 Journal Article
    ​ ​Sted Based Super-Resolution Imaging of Transverse Tubules in Ventricular Myocytes​
    Wagner, E.; Lauterbach, M.; Westphal, V.; Hagen, B.; Lederer, W.; Hell, S. W.   & Lehnart, S. E. ​ (2010) 
    Biophysical Journal98(3) pp. 5a​.​ DOI: https://doi.org/10.1016/j.bpj.2009.12.034 
    Details  DOI 
  • 2010 Journal Article | 
    ​ ​Ryanodin-Rezeptor-Stabilisatoren: ​Neue Strategie zur Behandlung von Herzrhythmusstörungen und Herzinsuffizienz​
    Hellenkamp, K.   & Lehnart, S. E. ​ (2010) 
    Der Kardiologe4(4) pp. 324​-328​.​ DOI: https://doi.org/10.1007/s12181-010-0283-1 
    Details  DOI 
  • 2010 Journal Article | 
    ​ ​Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice​
    Shan, J.; Kushnir, A.; Betzenhauser, M. J.; Reiken, S.; Li, J.; Lindegger, N. & Mongillo, M. et al.​ (2010) 
    Journal of Clinical Investigation120(12) pp. 4388​-4398​.​ DOI: https://doi.org/10.1172/JCI32726 
    Details  DOI 
  • 2010 Journal Article | Research Paper | 
    ​ ​K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum​
    Toischer, K. ; Lehnart, S. E. ; Tenderich, G.; Milting, H.; Koerfer, R.; Schmitto, J. D. & Schoendube, F. A.  et al.​ (2010) 
    Basic Research in Cardiology105(2) pp. 279​-287​.​ DOI: https://doi.org/10.1007/s00395-009-0057-8 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | 
    ​ ​An antidote for calcium leak: targeting molecular arrhythmia mechanisms​
    Lederer, W. J. & Lehnart, S. E. ​ (2010) 
    Journal of Molecular and Cellular Cardiology48(2) pp. 279​-282​.​ DOI: https://doi.org/10.1016/j.yjmcc.2009.11.005 
    Details  DOI  PMID  PMC 
  • 2010 Journal Article | Research Paper | 
    ​ ​Differential Cardiac Remodeling in Preload Versus Afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Sossalla, S.   & Reuter, S. P. et al.​ (2010) 
    Circulation122(10) pp. 993​-1003​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.943431 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Conference Abstract
    ​ ​Molecular genomics of cardiac remodeling following changes in intracellular calcium release​
    Matthes, F.; Steinbrecher, J. H.; Salinas-Riester, G.; Opitz, L.; Hasenfuß, G.   & Lehnart, S. E. ​ (2010)
    Cardiovascular Research87 , Berlin, GERMANY.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2010 Conference Abstract
    ​ ​Sted Based Super-Resolution Imaging of Transverse Tubules in Ventricular Myocytes​
    Wagner, E. M.; Lauterbach, M. A.; Westphal, V.; Hagen, B. M.; Lederer, W. J.; Hell, S. W.   & Lehnart, S. E. ​ (2010)
    Biophysical Journal98(3) 
    Cambridge​: Cell Press.
    Details  WoS 
  • 2010 Conference Abstract
    ​ ​Solute Transport in the Transverse Tubules of Cardiac Ventricular Myocytes​
    Hagen, B. M.; Lauterbach, M. A.; Wagner, E. M.; Hell, S. W. ; Lehnart, S. E.   & Lederer, W. J.​ (2010)
    Biophysical Journal98(3) 
    Cambridge​: Cell Press.
    Details  WoS 
  • 2009 Journal Article
    ​ ​Mutant Ryanodine Receptor-dependent Calcium Leak, RyR2 Open Probability, Calcium Sparks And Cardiac Arrhythmogenesis​
    Lehnart, S. E. ; Ward, C. W.; Sobie, E. A. & Lederer, W. J.​ (2009) 
    Biophysical Journal96(3) pp. 550a​.​ DOI: https://doi.org/10.1016/j.bpj.2008.12.2981 
    Details  DOI 
  • 2009 Journal Article
    ​ ​Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins​
    Muchir, A.; Shan, J.; Bonne, G.; Lehnart, S. E.   & Worman, H. J.​ (2009) 
    Human Molecular Genetics18(2) pp. 241​-247​.​ DOI: https://doi.org/10.1093/hmg/ddn343 
    Details  DOI  PMID  PMC 
  • 2009 Journal Article | Research Paper | 
    ​ ​Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart​
    Lehnart, S. E. ; Maier, L. S.   & Hasenfuß, G. ​ (2009) 
    Heart Failure Reviews14(4) pp. 213​-224​.​ DOI: https://doi.org/10.1007/s10741-009-9146-x 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article
    ​ ​Remodeling of ryanodine receptor complex causes leaky channels: a molecular mechanism for decreased exercise capacity​
    Bellinger, A. M.; Reiken, S.; Dura, M.; Murphy, P. W; Deng, S.-X.; Landry, D. W. & Nieman, D. et al.​ (2008) 
    Proceedings of the National Academy of Sciences of the United States of America105(6) pp. 2198​-2202​.​ DOI: https://doi.org/10.1073/pnas.0711074105 
    Details  DOI  PMID  PMC 
  • 2008 Journal Article
    ​ ​Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency​
    Oyama, M. A.; Reiken, S.; Lehnart, S. E. ; Chittur, S. V.; Meurs, K. M.; Stern, J. & Marks, A. R.​ (2008) 
    Journal of Veterinary Cardiology10(1) pp. 1​-10​.​ DOI: https://doi.org/10.1016/j.jvc.2008.04.003 
    Details  DOI  PMID  PMC 
  • 2008 Journal Article
    ​ ​Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice​
    Lehnart, S. E. ; Mongillo, M.; Bellinger, A.; Lindegger, N.; Chen, B.-X.; Hsueh, W. & Reiken, S. et al.​ (2008) 
    Journal of Clinical Investigation118(6) pp. 2230​-2245​.​ DOI: https://doi.org/10.1172/JCI35346 
    Details  DOI  PMID  PMC 
  • 2007 Journal Article
    ​ ​Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function​
    Lehnart, S. E. ; Ackerman, M. J.; Benson, D. W.; Brugada, R.; Clancy, C.; Donahue, J. K. & George, A. L. et al.​ (2007) 
    Circulation116(20) pp. 2325​-2345​.​
    Details  PMID  PMC 
  • 2007 Journal Article
    ​ ​Modulation of the Ryanodine Receptor and Intracellular Calcium​
    Zalk, R.; Lehnart, S. E.   & Marks, A. R.​ (2007) 
    Annual Review of Biochemistry76(1) pp. 367​-385​.​ DOI: https://doi.org/10.1146/annurev.biochem.76.053105.094237 
    Details  DOI 
  • 2007 Journal Article
    ​ ​Novel targets for treating heart and muscle disease – stabilizing ryanodine receptors and preventing intracellular calcium leak​
    Lehnart, S. E. ​ (2007) 
    Current Opinion in Pharmacology7(2) pp. 225​-232​.​ DOI: https://doi.org/10.1016/j.coph.2006.09.010 
    Details  DOI  PMID  PMC 
  • 2007 Journal Article
    ​ ​Regulation of ryanodine receptors in the heart​
    Lehnart, S. E.   & Marks, A. R.​ (2007) 
    Circulation Research101(8) pp. 746​-749​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.107.162479 
    Details  DOI  PMID  PMC 
  • 2007 Journal Article
    ​ ​Inherited Arrhythmias​
    Lehnart, S. E. ; Ackerman, M. J.; Benson, D. W.; Brugada, R.; Clancy, C. E.; Donahue, J. K. & George, A. L. et al.​ (2007) 
    Circulation116(20) pp. 2325​-2345​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.107.711689 
    Details  DOI 
  • 2006 Journal Article
    ​ ​Phosphodiesterase 4D and heart failure: a cautionary tale​
    Lehnart, S. E.   & Marks, A. R.​ (2006) 
    Expert Opinion on Therapeutic Targets10(5) pp. 677​-688​.​ DOI: https://doi.org/10.1517/14728222.10.5.677 
    Details  DOI 
  • 2006 Journal Article
    ​ ​Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S.; Vest, J. A.; Wronska, A. & Marks, A. R.​ (2006) 
    Proceedings of the National Academy of Sciences103(3) pp. 511​-518​.​ DOI: https://doi.org/10.1073/pnas.0510113103 
    Details  DOI 
  • 2006 Journal Article
    ​ ​Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias​
    Lehnart, S. E. ; Terrenoire, C.; Reiken, S.; Wehrens, X. H. T.; Song, L.-S.; Tillman, E. J. & Mancarella, S. et al.​ (2006) 
    Proceedings of the National Academy of Sciences103(20) pp. 7906​-7910​.​ DOI: https://doi.org/10.1073/pnas.0602133103 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation​
    Vest, J. A.; Wehrens, X. H. T.; Reiken, S. R.; Lehnart, S. E. ; Dobrev, D.; Chandra, P. & Danilo, P. et al.​ (2005) 
    Circulation111(16) pp. 2025​-2032​.​ DOI: https://doi.org/10.1161/01.CIR.0000162461.67140.4C 
    Details  DOI 
  • 2005 Journal Article | Erratum
    ​ ​Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias​
    Lehnart, S. E. ; Wehrens, X. H.; Reiken, S.; Warrier, S.; Belevych, A. E.; Harvey, R. D. & Richter, W. et al.​ (2005) 
    Cell123(3) pp. 535​-536​.​ DOI: https://doi.org/10.1016/j.cell.2005.10.011 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca2+ Leak: A Novel Therapeutic Target in Heart Failure​
    Lehnart, S. E. ; Wehrens, X. H. & Marks, A. R.​ (2005) 
    Circulation111(25) pp. 3342​-3346​.​ DOI: https://doi.org/10.1161/circulationaha.105.551861 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias​
    Lehnart, S. E. ; Wehrens, X. H.; Reiken, S.; Warrier, S.; Belevych, A. E.; Harvey, R. D. & Richter, W. et al.​ (2005) 
    Cell123(1) pp. 25​-35​.​ DOI: https://doi.org/10.1016/j.cell.2005.07.030 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S.; van der Nagel, R.; Morales, R.; Sun, J. & Cheng, Z. et al.​ (2005) 
    Proceedings of the National Academy of Sciences102(27) pp. 9607​-9612​.​ DOI: https://doi.org/10.1073/pnas.0500353102 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Ryanodine Receptor-Targeted Anti-Arrhythmic Therapy​
    Wehrens, X. H.; Lehnart, S. E.   & Marks, A. R.​ (2005) 
    Annals of the New York Academy of Sciences1047(1) pp. 366​-375​.​ DOI: https://doi.org/10.1196/annals.1341.032 
    Details  DOI 
  • 2005 Journal Article
    ​ ​Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca 2+ Leak​
    Lehnart, S. E. ; Wehrens, X. H. & Marks, A. R.​ (2005) 
    Circulation111(25) pp. 3342​-3346​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.551861 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated With Calcium Release Channel (Ryanodine Receptor) Leak​
    Lehnart, S. E. ; Wehrens, X. H.; Laitinen, P. J.; Reiken, S. R.; Deng, S.-X.; Cheng, Z. & Landry, D. W. et al.​ (2004) 
    Circulation109(25) pp. 3208​-3214​.​ DOI: https://doi.org/10.1161/01.cir.0000132472.98675.ec 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Intracellular calcium release and cardiac disease​
    Wehrens, X. H.; Lehnart, S. E.   & Marks, A. R.​ (2004) 
    Annual Review of Physiology67(1) pp. 69​-98​.​ DOI: https://doi.org/10.1146/annurev.physiol.67.040403.114521 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Cardiac Ryanodine Receptor Function and Regulation in Heart Disease​
    Lehnart, S. E. ; Wehrens, X. H.; Kushnir, A. & Marks, A. R.​ (2004) 
    Annals of the New York Academy of Sciences1015(1) pp. 144​-159​.​ DOI: https://doi.org/10.1196/annals.1302.012 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Calstabin deficiency, ryanodine receptors, and sudden cardiac death​
    Lehnart, S. E. ; Wehrens, X. H. & Marks, A. R.​ (2004) 
    Biochemical and Biophysical Research Communications322(4) pp. 1267​-1279​.​ DOI: https://doi.org/10.1016/j.bbrc.2004.08.032 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S. R. & Marks, A. R.​ (2004) 
    Circulation Research94(6) pp. e61​-e70​.​ DOI: https://doi.org/10.1161/01.res.0000125626.33738.e2 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Protection from Cardiac Arrhythmia Through Ryanodine Receptor-Stabilizing Protein Calstabin2​
    Wehrens, X. H.; Lehnart, S. E. ; Reiken, S. R.; Deng, S.-X.; Vest, J. A.; Cervantes, D. & Coromilas, J. et al.​ (2004) 
    Science304(5668) pp. 292​-296​.​ DOI: https://doi.org/10.1126/science.1094301 
    Details  DOI 
  • 2003 Journal Article
    ​ ​FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death​
    Wehrens, X. H. T.; Lehnart, S. E. ; Huang, F.; Vest, J. A.; Reiken, S. R.; Mohler, P. J. & Sun, J. et al.​ (2003) 
    Cell113(7) pp. 829​-840​.​ DOI: https://doi.org/10.1016/S0092-8674(03)00434-3 
    Details  DOI 
  • 2003 Journal Article
    ​ ​Immunophilins and Coupled Gating of Ryanodine Receptors​
    Lehnart, S. E. ; Huang, F.; Marx, S. O. & Marks, A. R.​ (2003) 
    Current Topics in Medicinal Chemistry3(12) pp. 1383​-1391​.​ DOI: https://doi.org/10.2174/1568026033451907 
    Details  DOI 
  • 2003 Book Chapter
    ​ ​Coronary Perfusion Cocktails for In Vivo Gene Transfer​
    Lehnart, S. E.  & Donahue, J. K.​ (2003)
    In: Cardiac Cell and Gene Transfer pp. 213​-218. ​Totowa, New Jersey: ​Springer. DOI: https://doi.org/10.1385/1-59259-350-X:213 
    Details  DOI 
  • 2003 Journal Article
    ​ ​PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure​
    Reiken, S.; Lacampagne, A.; Zhou, H.; Kherani, A.; Lehnart, S. E. ; Ward, C. & Huang, F. et al.​ (2003) 
    The Journal of Cell Biology160(6) pp. 919​-928​.​ DOI: https://doi.org/10.1083/jcb.200211012 
    Details  DOI 
  • 2002 Journal Article | Research Paper
    ​ ​Intracellular beta-blockade: overexpression of G alpha(i2) depresses the beta-adrenergic response in intact myocardium​
    Janssen, P. M. L.; Schillinger, W. ; Donahue, J. K.; Zeitz, O.; Embry, S. L.; Lehnart, S. E.   & Weil, J. et al.​ (2002) 
    Cardiovascular Research55(2) art. PII S0008-6363(02)00406-6​.​ DOI: https://doi.org/10.1016/S0008-6363(02)00406-6 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article | Research Paper
    ​ ​Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium​
    Hermann, H.-P.; Zeitz, O.; Lehnart, S. E. ; Keweloh, B.; Datz, N.; Hasenfuß, G.   & Janssen, P. M. L.​ (2002) 
    Cardiovascular Research53(1) art. PII S0008-6363(01)00437-0​.​ DOI: https://doi.org/10.1016/S0008-6363(01)00437-0 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article
    ​ ​Load-dependent induction of apoptosis in multicellular myocardial preparations​
    Janssen, P. M. L.; Hasenfuß, G. ; Zeitz, O.; Lehnart, S. E. ; Prestle, J. ; Darmer, D. & Holtz, J. et al.​ (2002) 
    American Journal of Physiology - Heart and Circulatory Physiology282(1) pp. H349​-H356​.​ DOI: https://doi.org/10.1152/ajpheart.00024.2001 
    Details  DOI 
  • 2001 Conference Abstract
    ​ ​Influence of amino-pyruvate on contractility and cardiac energy metabolism in isolated rabbit myocardial trabeculae​
    Keweloh, B.; Lehnart, S. E. ; Wehling, M.; Domeier, E.; Janssen, P. & Hasenfuß, G. ​ (2001)
    Biophysical Journal80(1) 
    Bethesda​: Biophysical Society.
    Details  WoS 
  • 2001 Journal Article
    ​ ​Overexpression of FK506-Binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca2+ leak from the sarcoplasmic reticulum and increases contractility​
    Prestle, J.; Janssen, P.; Janssen, A. P.; Zeitz, O.; Lehnart, S. E. ; Bruce, L. & Smith, G. L. et al.​ (2001) 
    Circulation Research88(2) pp. 188​-194​.​ DOI: https://doi.org/10.1161/01.res.88.2.188 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Conference Abstract
    ​ ​Is apoptosis in contracting myocardial preparations preload- or afterload-dependent?​
    Janssen, P.; Lehnart, S. E. ; Zeitz, O.; Hasenfuß, G. ; Darmer, D.; Holtz, J. & Schumann, H.​ (2000)
    Biophysical Journal78(1) 
    Bethesda​: Biophysical Society.
    Details  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Preservation of myocardial function after adenoviral gene transfer in isolated myocardium​
    Lehnart, S. E. ; Janssen, P. M. L.; Franz, W. M.; Donahue, J. K.; Lawrence, J. H.; Marbán, E. & Prestle, J. et al.​ (2000) 
    American Journal of Physiology-Heart and Circulatory Physiology279(3) pp. H986​-H991​.​ DOI: https://doi.org/10.1152/ajpheart.2000.279.3.H986 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium​
    Janssen, P. M. L.; Zeitz, O.; Keweloh, B.; Siegel, U.; Maier, L. S. ; Barckhausen, P. & Pieske, B.  et al.​ (2000) 
    Cardiovascular Research47(1) pp. 99​-107​.​ DOI: https://doi.org/10.1016/S0008-6363(00)00052-3 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Conference Abstract
    ​ ​Potentiation of beta-adrenergic inotropic response with pyruvate in failing human heart and in healthy rabbit myocardium​
    Hermann, H.-P.; Zeitz, O.; Keweloh, B.; Datz, N.; Lehnart, S. E. ; Hasenfuß, G.   & Janssen, P.​ (2000)
    European Heart Journal21 
    London​: W B Saunders Co Ltd.
    Details  WoS 
  • 2000 Conference Abstract
    ​ ​Gi alpha-2 overexpression depresses the beta-adrenergic response in multicellular preparations and single myocytes​
    Janssen, P.; Schillinger, W.; Donahue, J. K.; Zeitz, O.; Emami, S.; Lehnart, S. E.   & Weil, J. et al.​ (2000)
    Circulation102(18) 
    Philadelphia​: Lippincott Williams & Wilkins.
    Details  WoS 
  • 1999 Journal Article
    ​ ​Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium​
    Hasenfuß, G. ; Schillinger, W.; Lehnart, S. E. ; Preuss, M.; Pieske, B.; Maier, L. S.   & Prestle, J. et al.​ (1999) 
    Circulation99(5) pp. 641​-648​.​ DOI: https://doi.org/10.1161/01.CIR.99.5.641 
    Details  DOI 
  • 1999 Journal Article | Research Paper
    ​ ​Preservation of contractile characteristics of human myocardium in multi-day cell culture​
    Janssen, P. M. L.; Lehnart, S. E. ; Prestle, J.   & Hasenfuß, G. ​ (1999) 
    Journal of Molecular and Cellular Cardiology31(8) pp. 1419​-1427​.​ DOI: https://doi.org/10.1006/jmcc.1999.0978 
    Details  DOI  PMID  PMC  WoS 
  • 1998 Journal Article | Research Paper
    ​ ​The trabecula culture system: a novel technique to study contractile parameters over a multiday time period​
    Janssen, P. M. L.; Lehnart, S. E. ; Prestle, J.; Lynker, J. C.; Salfeld, P.; Just, H. & Hasenfuß, G. ​ (1998) 
    American Journal of Physiology-Heart and Circulatory Physiology274(5) pp. H1481​-H1488​.​ DOI: https://doi.org/10.1152/ajpheart.1998.274.5.H1481 
    Details  DOI  PMID  PMC  WoS 
  • 1998 Journal Article | Research Paper
    ​ ​Frequency-dependence of myocardial energetics in failing human myocardium as quantified by a new method for the measurement of oxygen consumption in muscle strip preparations​
    Meyer, M.; Keweloh, B.; Guth, K.; Holmes, J. W.; Pieske, B. ; Lehnart, S. E.   & Just, H.  et al.​ (1998) 
    Journal of Molecular and Cellular Cardiology30(8) pp. 1459​-1470​.​ DOI: https://doi.org/10.1006/jmcc.1998.0706 
    Details  DOI  PMID  PMC  WoS 
  • 1998 Conference Paper | Research Paper
    ​ ​Sarcoplasmic reticulum proteins in heart failure​
    Lehnart, S. E. ; Schillinger, W. ; Pieske, B. ; Prestle, J. ; Just, H.   & Hasenfuß, G. ​ (1998)
    Annals of the New York Academy of Sciences853 pp. 220​-230. ​New-York-Academy-of-Sciences Meeting on Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility​, WASHINGTON, D.C..
    New york​: New York Acad Sciences. DOI: https://doi.org/10.1111/j.1749-6632.1998.tb08270.x 
    Details  DOI  PMID  PMC  WoS 
  • 1998 Journal Article
    ​ ​Influence of SR Ca2+-ATPase and Na+-Ca2+-exchanger on the force-frequency relation​
    Schillinger, W. ; Lehnart, S. E. ; Prestle, J. ; Preuss, M.; Pieske, B. ; Maier, L. S.   & Meyer, M. et al.​ (1998) 
    Basic Research in Cardiology93(Supplement 1) pp. 38​-45​.​ DOI: https://doi.org/10.1007/s003950050208 
    Details  DOI 
  • 1996 Journal Article | Research Paper
    ​ ​Influence of endothelin 1 on human atrial myocardium - Myocardial function and subcellular pathways​
    Meyer, M.; Lehnart, S. E. ; Pieske, B. ; Schlottauer, K.; Munk, A. ; Holubarsch, C. & Just, H.  et al.​ (1996) 
    Basic Research in Cardiology91(1) pp. 86​-93​.​
    Details  PMID  PMC  WoS 

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