Prof. Dr. Paul Lingor

 
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  • 2020 Journal Article
    ​ ​TDP‐43 as structure‐based biomarker in amyotrophic lateral sclerosis​
    Beyer, L.; Günther, R. ; Koch, J. C. ; Klebe, S.; Hagenacker, T.; Lingor, P.   & Biesalski, A. et al.​ (2020) 
    Annals of Clinical and Translational Neurology8(1) pp. 271​-277​.​ DOI: https://doi.org/10.1002/acn3.51256 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson’s disease​
    Maass, F. ; Michalke, B.; Willkommen, D.; Schulte, C.; Tönges, L. ; Boerger, M.   & Zerr, I.  et al.​ (2020) 
    Journal of Trace Elements in Medicine and Biology57 pp. 126412​.​ DOI: https://doi.org/10.1016/j.jtemb.2019.126412 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Elemental fingerprint: Reassessment of a cerebrospinal fluid biomarker for Parkinson's disease​
    Maass, F. ; Michalke, B.; Willkommen, D.; Leha, A. ; Schulte, C.; Tönges, L.   & Mollenhauer, B.  et al.​ (2020) 
    Neurobiology of Disease134 pp. 104677​.​ DOI: https://doi.org/10.1016/j.nbd.2019.104677 
    Details  DOI 
  • 2018 Journal Article
    ​ ​miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons​
    Roser, A.-E. ; Caldi Gomes, L.; Halder, R. ; Jain, G.; Maass, F. ; Tönges, L.   & Tatenhorst, L.  et al.​ (2018) 
    Molecular Therapy - Nucleic Acids11 pp. 9​-22​.​ DOI: https://doi.org/10.1016/j.omtn.2018.01.005 
    Details  DOI 
  • 2018 Journal Article
    ​ ​ROCK inhibition in models of neurodegeneration and its potential for clinical translation​
    Koch, J. C. ; Tatenhorst, L. ; Roser, A.-E. ; Saal, K.-A. ; Tönges, L.   & Lingor, P. ​ (2018) 
    Pharmacology & Therapeutics189 pp. 1​-21​.​ DOI: https://doi.org/10.1016/j.pharmthera.2018.03.008 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson's disease​
    Maass, F. ; Michalke, B.; Leha, A. ; Boerger, M. ; Zerr, I. ; Koch, J.-C.   & Tönges, L.  et al.​ (2018) 
    Journal of Neurochemistry145(4) pp. 342​-351​.​ DOI: https://doi.org/10.1111/jnc.14316 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation​
    Carboni, E. ; Tatenhorst, L. ; Tönges, L. ; Barski, E. ; Dambeck, V. ; Bähr, M.   & Lingor, P. ​ (2017) 
    NeuroMolecular Medicine19(2-3) pp. 309​-321​.​ DOI: https://doi.org/10.1007/s12017-017-8447-9 
    Details  DOI 
  • 2017 Journal Article | 
    ​ ​Rho Kinase Inhibition with Fasudil in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis-Symptomatic Treatment Potential after Disease Onset​
    Günther, R. ; Balck, A. ; Koch, J. C. ; Nientiedt, T.; Sereda, M. ; Bähr, M.   & Lingor, P.  et al.​ (2017) 
    Frontiers in pharmacology8 art. 17​.​ DOI: https://doi.org/10.3389/fphar.2017.00017 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article
    ​ ​Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease​
    Saal, K.-A. ; Galter, D.; Roeber, S.; Bähr, M. ; Tönges, L.   & Lingor, P. ​ (2017) 
    Brain Pathology27(1) pp. 13​-25​.​ DOI: https://doi.org/10.1111/bpa.12346 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article | Research Paper | 
    ​ ​Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration​
    Zhang, J.-N. ; Michel, U. ; Lenz, C. ; Friedel, C. C.; Köster, S. ; D'Hedouville, Z. & Tönges, L.  et al.​ (2016) 
    Scientific Reports6 art. 37050​.​ DOI: https://doi.org/10.1038/srep37050 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | 
    ​ ​Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease​
    Tatenhorst, L. ; Eckermann, K.; Dambeck, V. ; Fonseca-Ornelas, L.; Walle, H.; Lopes Da Fonseca, T. & Koch, J. C.  et al.​ (2016) 
    Acta Neuropathologica Communication4(1) art. 39​.​ DOI: https://doi.org/10.1186/s40478-016-0310-y 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper | 
    ​ ​Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons​
    Koch, J. C. ; Bitow, F.; Haack, J.; D'Hedouville, Z.; Zhang, J.-N.; Tönges, L.   & Michel, U.  et al.​ (2015) 
    Cell Death and Disease6 art. e1811​.​ DOI: https://doi.org/10.1038/cddis.2015.169 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo​
    Saal, K.-A. ; Koch, J. C. ; Tatenhorst, L. ; Szegő, É. M. ; Ribas, V. T. ; Michel, U.   & Bähr, M.  et al.​ (2015) 
    Neurobiology of Disease73 pp. 150​-162​.​ DOI: https://doi.org/10.1016/j.nbd.2014.09.013 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Rho Kinase Inhibition Modulates Microglia Activation and Improves Survival in a Model of Amyotrophic Lateral Sclerosis​
    Tönges, L. ; Günther, R. ; Suhr, M. ; Jansen, J.; Balck, A. ; Saal, K.-A.   & Barski, E.  et al.​ (2014) 
    Glia62(2) pp. 217​-232​.​ DOI: https://doi.org/10.1002/glia.22601 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​The rho kinase inhibitor Y-27632 improves motor performance in male SOD1(G93A) mice​
    Günther, R. ; Saal, K.-A. ; Suhr, M. ; Scheer, D.; Koch, J. C. ; Bähr, M.   & Lingor, P.  et al.​ (2014) 
    Frontiers in Neuroscience8 art. 304​.​ DOI: https://doi.org/10.3389/fnins.2014.00304 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells​
    Koch, J. C. ; Tönges, L. ; Michel, U. ; Bähr, M.   & Lingor, P. ​ (2014) 
    Frontiers in Cellular Neuroscience8 art. 273​.​ DOI: https://doi.org/10.3389/fncel.2014.00273 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease​
    Tönges, L. ; Szegö, E. M. ; Hause, P.; Saal, K.-A. ; Tatenhorst, L. ; Koch, J. C.   & D'Hedouville, Z. et al.​ (2014) 
    Frontiers in Aging Neuroscience6 art. UNSP 239​.​ DOI: https://doi.org/10.3389/fnagi.2014.00239 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Rho Kinase Inhibition by Fasudil in the Striatal 6-Hydroxydopamine Lesion Mouse Model of Parkinson Disease​
    Tatenhorst, L. ; Tönges, L. ; Saal, K.-A. ; Koch, J. C. ; Szegő, É. M. ; Bähr, M.   & Lingor, P. ​ (2014) 
    Journal of Neuropathology and Experimental Neurology73(8) pp. 770​-779​.​ DOI: https://doi.org/10.1097/nen.0000000000000095 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper | 
    ​ ​ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS​
    Koch, J. C. ; Tönges, L. ; Barski, E. ; Michel, U. ; Bähr, M.   & Lingor, P. ​ (2014) 
    Cell Death and Disease5 art. e1225​.​ DOI: https://doi.org/10.1038/cddis.2014.191 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro​
    Koch, J. C. ; Solis, G. P.; Bodrikov, V.; Michel, U. ; Haralampieva, D.; Shypitsyna, A. & Tönges, L.  et al.​ (2013) 
    Neurobiology of Disease51 pp. 168​-176​.​ DOI: https://doi.org/10.1016/j.nbd.2012.11.007 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper
    ​ ​Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)​
    Günther, R. ; Suhr, M. ; Koch, J. C. ; Bähr, M. ; Lingor, P.   & Tönges, L. ​ (2012) 
    Journal of Visualized Experiments,(61) art. e3936​.​ DOI: https://doi.org/10.3791/3936 
    Details  DOI  WoS 
  • 2012 Journal Article | Research Paper | 
    ​ ​Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease​
    Tönges, L. ; Frank, T. ; Tatenhorst, L. ; Saal, K. A. ; Koch, J. C. ; Szego, E. M.   & Bähr, M.  et al.​ (2012) 
    Brain135(11) pp. 3355​-3370​.​ DOI: https://doi.org/10.1093/brain/aws254 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Review | 
    ​ ​Axonal degeneration as a therapeutic target in the CNS​
    Lingor, P. ; Koch, J. C. ; Tönges, L.  & Bähr, M. ​ (2012)
    Cell and Tissue Research, 349​(1) pp. 289​-311​.​ DOI: https://doi.org/10.1007/s00441-012-1362-3 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Review | 
    ​ ​ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration​
    Tönges, L. ; Koch, J.-C. ; Bähr, M.  & Lingor, P. ​ (2011)
    Frontiers in Molecular Neuroscience, 4​.​ DOI: https://doi.org/10.3389/fnmol.2011.00039 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Imaging of rat optic nerve axons in vivo​
    Koch, J. C. ; Knöferle, J. ; Tönges, L. ; Michel, U. ; Bähr, M.   & Lingor, P. ​ (2011) 
    Nature Protocols6(12) pp. 1887​-1896​.​ DOI: https://doi.org/10.1038/nprot.2011.403 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo​
    Tönges, L. ; Ostendorf, T.; Lamballe, F.; Genestine, M.; Dono, R.; Koch, J.-C.   & Bähr, M.  et al.​ (2011) 
    Journal of Neurochemistry117(5) pp. 892​-903​.​ DOI: https://doi.org/10.1111/j.1471-4159.2011.07257.x 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​JNK Isoforms Differentially Regulate Neurite Growth and Regeneration in Dopaminergic Neurons In Vitro​
    Tönges, L. ; Planchamp, V. ; Koch, J.-C. ; Herdegen, T.; Bähr, M.   & Lingor, P. ​ (2011) 
    Journal of Molecular Neuroscience45(2) pp. 284​-293​.​ DOI: https://doi.org/10.1007/s12031-011-9519-1 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper
    ​ ​TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP​
    Knöferle, J. ; Ramljak, S. ; Koch, J. C. ; Tönges, L. ; Asif, A. R. ; Michel, U.   & Wouters, F. S.  et al.​ (2010) 
    Neurobiology of Disease38(3) pp. 395​-404​.​ DOI: https://doi.org/10.1016/j.nbd.2010.02.011 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper
    ​ ​Mechanisms of acute axonal degeneration in the optic nerve in vivo​
    Knöferle, J. ; Koch, J. C. ; Ostendorf, T.; Michel, U. ; Planchamp, V. ; Vutova, P. & Tönges, L.  et al.​ (2010) 
    Proceedings of the National Academy of Sciences107(13) pp. 6064​-6069​.​ DOI: https://doi.org/10.1073/pnas.0909794107 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Letter Note
    ​ ​Acute axonal degeneration in vivo is attenuated by inhibition of autophagy in a calcium-dependent manner​
    Koch, J. C. ; Knöferle, J. ; Tönges, L. ; Ostendorf, T.; Bähr, M.   & Lingor, P. ​ (2010) 
    Autophagy6(5) pp. 658​-659​.​ DOI: https://doi.org/10.4161/auto.6.5.12188 
    Details  DOI  PMID  PMC  WoS 
  • 2009 Journal Article | Research Paper
    ​ ​Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells​
    Bermel, C. ; Tönges, L. ; Planchamp, V. ; Gillardon, F.; Weishaupt, J. H. ; Dietz, G. P. H.   & Bähr, M.  et al.​ (2009) 
    Molecular and Cellular Neuroscience42(4) pp. 427​-437​.​ DOI: https://doi.org/10.1016/j.mcn.2009.09.005 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity​
    Planchamp, V. ; Bermel, C. ; Tönges, L. ; Ostendorf, T.; Kügler, S. ; Reed, J. C. & Kermer, P.  et al.​ (2008) 
    Brain131 pp. 2606​-2619​.​ DOI: https://doi.org/10.1093/brain/awn196 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells​
    Lingor, P. ; Tönges, L. ; Pieper, N. ; Bermel, C. ; Barski, E. ; Planchamp, V.   & Bähr, M. ​ (2008) 
    Brain131(1) pp. 250​-263​.​ DOI: https://doi.org/10.1093/brain/awm284 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Galectin-1 expression in human glioma cells: Modulation by ionizing radiation and effects on tumor cell proliferation and migration​
    Strik, H. M. ; Schmidt, K.; Lingor, P. ; Tönges, L. ; Kugler, W.; Nitsche, M.   & Rabinovich, G. A. et al.​ (2007) 
    Oncology Reports18(2) pp. 483​-488​.​ DOI: https://doi.org/10.3892/or.18.2.483 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Stearylated octaarginine and artificial virus-like particles for transfection of siRNA into primary rat neurons​
    Tönges, L. ; Lingor, P. ; Egle, R.; Dietz, G. P. H. ; Fahr, A. & Bähr, M. ​ (2006) 
    RNA12(7) pp. 1431​-1438​.​ DOI: https://doi.org/10.1261/rna.2252206 
    Details  DOI  PMID  PMC  WoS 

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